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Fingerprint of Carcinogenic Semi-Volatile Organic Compounds (SVOCs) during Bonfire Night

  • Pongpiachan, Siwatt
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.5
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    • pp.3243-3254
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    • 2013
  • It is well known that increased incidences of lung, skin, and bladder cancers are associated with occupational exposure to PAHs. Animal studies show that certain PAHs also can affect the hematopoietic and immune systems and can produce reproductive, neurologic, and developmental effects. As a consequence, several studies have been attempted to investigate the fate of PAHs in atmospheric environment during the past decades. However, there is still a lack of information in regard to the atmospheric concentration of PAHs during the "Bon Fire Night". In this study, twenty-three polycyclic aromatic hydrocarbons and twenty-eight aliphatics were identified and quantified in the $PM_{10}$ and vapour range in Birmingham ($27^{th}$ November 2001-$19^{th}$ January 2004). The measured concentrations of total particulate and vapour (P+V) PAHs were consistently higher at the BROS in both winter and summer. Arithmetic mean total (P+V) PAH concentrations were $51.04{\pm}47.62$ ng $m^{-3}$ and $22.30{\pm}19.18$ ng $m^{-3}$ at the Bristol Road Observatory Site (BROS) and Elms Road Observatory Site (EROS) respectively. In addition arithmetic mean total (P+V) B[a]P concentrations at the BROS were $0.47{\pm}0.39$ ng $m^{-3}$ which exceeded the EPAQS air quality standard of 0.25 ng $m^{-3}$. On the other hand, the arithmetic mean total (P+V) aliphatics were $81.80{\pm}69.58$ ng $m^{-3}$ and $48.00{\pm}35.38$ ng $m^{-3}$ at the BROS and EROS in that order. The lowest average of CPI and $C_{max}$ measured at the BROS supports the idea of traffic emissions being a principle source of SVOCs in an urban atmosphere. The annual trend of PAHs was investigated by using an independent t-test and oneway independent ANOVA analysis. Generally, there is no evidence of a significant decline of heavier MW PAHs from the two data sets, with only Ac, Fl, Ph, An, 2-MePh, 1+9-MePh, Fluo and B[b+j+k]F showing a statistically significant decline (p<0.05). A further attempt for statistical analysis had been conducted by dividing the data set into three groups (i.e. 2000, 2001-2002 and 2003-2004). For lighter MW compounds a significant level of decline was observed by using one-way independent ANOVA analysis. Since the annual mean of $O_3$ measured in Birmingham City Centre from 2001 to 2004 increased significantly (p<0.05), it may be possible to attribute the annul reduction of more volatile PAHs to the enhanced level of annual average $O_3$. By contrast, the heavier MW PAHs measured at the BROS did not show any significant annual reduction, implying the difficulties of 5- and 6-ring PAHs to be subject to photochemical decomposition. The deviation of SVOCs profile measured at the EROS was visually confirmed during the "Bonfire Night" festival closest to the $6^{th}$ November 2003. In this study, the atmospheric PAH concentrations were generally elevated on this day with concentrations of Fl, Ac, B[a]A, B[b+j+k]F, Ind and B[g,h,i]P being particularly high.

Dietary Intakes and Food Sources of Total Sugars from Korean National Health and Nutrition Examination Survey 2001-2002 (한국인의 총당류 섭취실태와 급원식품에 대한 연구 -2001년과 2002년도 국민건강영양조사 자료를 이용하여-)

  • Chung, Chin-Eun
    • Journal of Nutrition and Health
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    • v.40 no.sup
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    • pp.9-21
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    • 2007
  • This study aimed to assess the total sugar intake for Korean and to identify major food sources contributing to those food components. Korean adults aged over 20 years old from the Korean National Health and Nutrition Examination Survey (KNHANES) 2001 and 2002 were selected. The data were analyzed to obtain nationally and seasonally representative information on the health and nutritional status of the Korean. Forty food groups were used in identifying food sources of total sugar and energy intake. Total sugar contents of foods in the KNHANES data sets were estimated by food code matching technique with Release 18 of the USDA National Nutrient Database for Standard Reference. Sample weighted means, standard errors, and population percentages were calculated using SAS and SUDAAN. The mean total sugar intake of the Korean was 60.3g in 2001, 40.9g in spring 2002, 45.7g in summer 2002, and 52.1g in fall 2002, which were 30-44% of intake of US people. Fresh fruit was identified as the most significant food source for total sugar intake in Korean population in all age groups and all seasons. The next major food sources following fresh fruits were candy/jelly/syrup/honey, coffee/coffee caream, vegetables, Kimchi, soft drinks, milk, fruit juice, cookie/cracker/cake, and vegetable juice/grain juice, which showed similar results through the seasons. While carbonated soft drink was the most significant food sources for total sugar or added sugar intakes for US people. The total sugar intakes were significantly higher in women, higher educational level, and residing in metropolitan area. As intake of total sugar increased, intakes of protein, fiber, calcium, phosphorus, iron, Vit A, B1, B2, C, niacin showed significantly increased, while high intakes of added sugars showed low intakes of some micronutrients in the US people. Percentages of people who consumed nutrients below EAR were less in higher total sugar intake group than in lower intake group. From these results, we can conclude that the food consumption habits including the total sugar intake of Korean people seems relatively good so far. More reliable database of total sugar and added sugar composition tables in public domain should be established in the future, and also more researches about total sugar and added sugar for Koreans should be continued.

Comparative analysis on genome-wide DNA methylation in longissimus dorsi muscle between Small Tailed Han and Dorper×Small Tailed Han crossbred sheep

  • Cao, Yang;Jin, Hai-Guo;Ma, Hui-Hai;Zhao, Zhi-Hui
    • Asian-Australasian Journal of Animal Sciences
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    • v.30 no.11
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    • pp.1529-1539
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    • 2017
  • Objective: The objective of this study was to compare the DNA methylation profile in the longissimus dorsi muscle between Small Tailed Han and Dorper${\times}$Small Tailed Han crossbred sheep which were known to exhibit significant difference in meat-production. Methods: Six samples (three in each group) were subjected to the methylated DNA immunoprecipitation sequencing (MeDIP-seq) and subsequent bioinformatics analyses to detect differentially methylated regions (DMRs) between the two groups. Results: 23.08 Gb clean data from six samples were generated and 808 DMRs were identified in gene body or their neighboring up/downstream regions. Compared with Small Tailed Han sheep, we observed a tendency toward a global loss of DNA methylation in these DMRs in the crossbred group. Gene ontology enrichment analysis found several gene sets which were hypomethylated in gene-body region, including nucleoside binding, motor activity, phospholipid binding and cell junction. Numerous genes were found to be differentially methylated between the two groups with several genes significantly differentially methylated, including transforming growth factor beta 3 (TGFB3), acyl-CoA synthetase long chain family member 1 (ACSL1), ryanodine receptor 1 (RYR1), acyl-CoA oxidase 2 (ACOX2), peroxisome proliferator activated receptor-gamma2 (PPARG2), netrin 1 (NTN1), ras and rab interactor 2 (RIN2), microtubule associated protein RP/EB family member 1 (MAPRE1), ADAM metallopeptidase with thrombospondin type 1 motif 2 (ADAMTS2), myomesin 1 (MYOM1), zinc finger, DHHC type containing 13 (ZDHHC13), and SH3 and PX domains 2B (SH3PXD2B). The real-time quantitative polymerase chain reaction validation showed that the 12 genes are differentially expressed between the two groups. Conclusion: In the current study, a tendency to a global loss of DNA methylation in these DMRs in the crossbred group was found. Twelve genes, TGFB3, ACSL1, RYR1, ACOX2, PPARG2, NTN1, RIN2, MAPRE1, ADAMTS2, MYOM1, ZDHHC13, and SH3PXD2B, were found to be differentially methylated between the two groups by gene ontology enrichment analysis. There are differences in the expression of 12 genes, of which ACSL1, RIN2, and ADAMTS2 have a negative correlation with methylation levels and the data suggest that DNA methylation levels in DMRs of the 3 genes may have an influence on the expression. These results will serve as a valuable resource for DNA methylation investigations on screening candidate genes which might be related to meat production in sheep.

Labial and buccal surface contours of Korean normal occlusion in a three-dimensional digital model (한국인 정상교합자의 3차원 디지털 모형을 이용한 순,협측 치면 곡률)

  • Chae, Ji-Hyeon;Song, Jin-Wook;Cha, Jung-Yul;Choi, Jung-Soo;Park, Young-Chel
    • The korean journal of orthodontics
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    • v.38 no.2
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    • pp.95-103
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    • 2008
  • Objective: This study was performed to investigate the labio/buccal clinical crown curvatures of Korean permanent teeth and to obtain the curve-ratio data in an attempt to fabricate bracket bases fit for each individual Korean permanent tooth. Methods: Three-dimensional digital models were made from 30 sets of dental casts with normal anatomic structures. According to the FA points, horizontal and vertical reference planes were established and lines were drawn on the tooth surfaces in reference to these planes. The curvature was expressed as the coefficient of a quadratic equation. Lines mesial, distal, gingival and occlusal to the horizontal, vertical reference planes and the FA point were drawn. Results: The curvature measured for each line revealed that there are no significant differences between male and female, except for maxillary canines and maxillary second bicuspids (p > 0.05). There were notable differences in the mesio-distal or gingivo-occlusal curvatures among the mandibular lateral incisors, maxillary canines, maxillary and mandibular first and second bicuspids and first molars (p < 0.05). Conclusions: The labial & buccal crown curvatures of teeth in Korean normal occlusion were measured on the mesial and distal, gingival and occlusal sides respectively in this study. Based on these data, a SWA can be developed to fit the individual features of Korean tooth crowns.

Design of a Deep Neural Network Model for Image Caption Generation (이미지 캡션 생성을 위한 심층 신경망 모델의 설계)

  • Kim, Dongha;Kim, Incheol
    • KIPS Transactions on Software and Data Engineering
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    • v.6 no.4
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    • pp.203-210
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    • 2017
  • In this paper, we propose an effective neural network model for image caption generation and model transfer. This model is a kind of multi-modal recurrent neural network models. It consists of five distinct layers: a convolution neural network layer for extracting visual information from images, an embedding layer for converting each word into a low dimensional feature, a recurrent neural network layer for learning caption sentence structure, and a multi-modal layer for combining visual and language information. In this model, the recurrent neural network layer is constructed by LSTM units, which are well known to be effective for learning and transferring sequence patterns. Moreover, this model has a unique structure in which the output of the convolution neural network layer is linked not only to the input of the initial state of the recurrent neural network layer but also to the input of the multimodal layer, in order to make use of visual information extracted from the image at each recurrent step for generating the corresponding textual caption. Through various comparative experiments using open data sets such as Flickr8k, Flickr30k, and MSCOCO, we demonstrated the proposed multimodal recurrent neural network model has high performance in terms of caption accuracy and model transfer effect.

Prediction of the Fractures at Inexcavation Spaces Based on the Existing Data (터널의 굴착면 전반부에 분포하는 절리의 예측)

  • Hwang, Sang-Gi
    • The Journal of Engineering Geology
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    • v.24 no.4
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    • pp.643-648
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    • 2014
  • Understanding of fracture networks and rock mass properties during tunnel construction is extremely important for the prediction of dangers during excavation, and for deciding on appropriate excavation techniques and support. However, rapid construction process do not allow sufficient time for surveys and interpretations for spatial distributions of fractures and rock mass properties. This study introduces a new statistical approach for predicting joint distributions at foreside of current excavation face during the excavation process. The proposed methodology is based on a cumulative space diagram for joint sets. The diagram displays the cumulative spacing between adjacent joints on the vertical axis and the sequential position of each joint plotted at equally spaced intervals on the horizontal axis. According to the diagram, the degree of linearity of points representing the regularity of joint spacing; a linear trend of the points indicates that the joints are evenly spaced, with the slope of the line being directly related to the spacing. The linear points which are stepped indicates that the fracture set show clustered distribution. A clustered pattern within the linear group of points indicates a clustered joint distribution. Fractures surveyed from an excavated space can be plotted on this diagram, and the diagram can then be extended further according to the plotted diagram pattern. The extension of the diagram allows predictions about joint spacing in areas that have not yet been excavated. To test the model, we collected and analyzed data during excavation of a 10-m-long tunnel. Fractures in a 3-m zone behind the excavation face were predicted during the excavation, and the predictions were compared with observations. The methodology yielded reasonably good predictions of joint locations.

An Esitimation of Lognitudinal Dispersion Coefficient in Natural Stram Using Hydraulic Model (수리모형을 이용한 자연하천에서 종확산계수 추정)

  • Yun, Se-Ui;Han, Geon-Yeon;Han, Jeong-Seok;Kim, Jeong-Su
    • Journal of Korea Water Resources Association
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    • v.33 no.4
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    • pp.407-417
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    • 2000
  • To estimate the longitudinal dispersion coefficient at the downstream of Jungrang-River, the undistorted 1/20 scale hydraulic model was used in this study. Experiments were conducted for dry season discharge, and Rhodamine B was used as a tracer. The relationship curve between concentration and conductivity of Rhodamine B was otained by laboratory test, and the conductivity which was measured in hydraulic model was converted to concentration using this curve. The longitudinal dispersion coefficient was calculated using the relationship between the peak concentration and the time to peak concentration. The results of this study were compared with the calculated values by the empirical equations for the longitudinal dispersion coefficient and with the field data. The results of comparison show that Parker's equation underestimates, and Liu'g equation and Iwasa and Aya's one overestimate, and McQuivey and Keefer's equations, Fischer's one, Magazine's one, and Seo and Cheong's one predict relatively well. The measured data sets were relatively close to the observed ones in natural river. The longitudinal dispersion coefficient at the downstream of Jungrang-River was estimated $10\textrm{m}^2/s$.

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Size-resolved Source Apportionment of Ambient Particles by Positive Matrix Factorization at Gosan, Jeju Island during ACE-Asia (PMF 분석을 이용한 ACE-Asia 측정기간 중 제주 고산지역 입자상 물질의 입경별 발생원 추정)

  • Moon K.J.;Han, J.S.;Kong, B.J.;Jung, I.R.;Cliff Steven S.;Cahill Thomas A.;Perry Kelvin D.
    • Journal of Korean Society for Atmospheric Environment
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    • v.22 no.5
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    • pp.590-603
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    • 2006
  • Size-and time-resolved aerosol samples were collected using an eight-stage Davis rotating unit for monitoring (DRUM) sampler from 23 March to 29 April 2001 at Gosan, Jeju Island, Korea, which is one of the super sites of Asia-Pacific Regional Aerosol Characterization Experiment(ACE-Asia). These samples were analyzed using synchrotron X-ray fluorescence for 3-hr average concentrations of 19 elements including Al, Si, S, Cl, K, Ca, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, As, Se, Br, Rb, and Pb. The size-resolved data sets were then analyzed using the positive matrix factorization(PMF) technique to identify possible sources and estimate their contributions to particulate matter mass. PMF analysis uses the uncertainty of the measured data to provide an optimal weighting. Twelve sources were resolved in eight size ranges($0.09{\sim}12{\mu}m$) and included continental soil, local soil, sea salt, biomass/biofuel burning, coal combustion, oil combustion, municipal incineration, nonferrous metal source, ferrous metal source, gasoline vehicle, diesel vehicle, and volcanic emission. The PMF result of size-resolved source contributions showed that natural sources represented by local soil, sea salt, continental soil, and volcanic emission contributed about 79% to the predicted primary particulate matter(PM) mass in the coarse size range ($1.15{\sim}12{\mu}m$) while anthropogenic sources such as coal combustion and biomass/biofuel burning contributed about 58% in the fine size range($0.56{\sim}2.5{\mu}m$). The diesel vehicle source contributed mostly in ultra-fine size range($0.09{\sim}0.56{\mu}m$) and was responsible for about 56% of the primary PM mass.

A Study on Calibration of Underestimated Wave Heights Measured by Wave and Tide Gauge (WTG) (저평가된 수압식 파고계(WTG) 관측 파고값 보정방안 연구)

  • Jeong, Weon Mu;Chang, Yeon S.;Oh, Sang-Ho;Baek, Won Dae
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.32 no.5
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    • pp.296-306
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    • 2020
  • It has been reported that the wave heights measured by Wave and Tide gauges (WTG) have been underestimated, and thus it is important to improve its measuring accuracy for enhancing estimation of harbor tranquility. In this study, the significant wave heights from WTG were calibrated using measured data from AWAC and Waverider buoys moored at the same four locations with the WTG. It was observed that the product of significant wave height and peak wave period, HT, was not underestimated but linearly proportional between the measurements by two instruments. This linearity was applied to develop 3rd order polynomial functions that best represented the relationship between HT and significant wave heights measured by WTG. These functions were then applied to calibrate the WTG significant wave heights that were lower than 0.7 m, the critical value established for the low waves in this study. The results showed that the linearity between the AWAC (or Waverider buoy) and calibrated wave heights were improved, and the magnitude of underestimated WTG wave heights were increased to be more realistic. The results of this study are expected to be effectively applied for other data sets obtained by WTG only, to increase the observation accuracy of WTG and to improve the estimation of harbor tranquility.

Evaluation of the Impact of Land Surface Condition Changes on Soil Moisture Field Evolution (지표면 조건의 변화에 따른 토양수분의 변화 평가)

  • Yu, Cheol-Sang
    • Journal of Korea Water Resources Association
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    • v.31 no.6
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    • pp.795-806
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    • 1998
  • Soil moisture is affected by regional climate, soil characteristics and land surface condition, etc,. Especially, the changes in land surface condition is more than other factors, which is mainly due to rapid urbanization and industrialization. This study is to evaluate how the change of land surface condition impacts on soil moisture field evolution using a simple model of soil moisture dynamics. For the quantification of soil moisture field, the first half of the paper is spared for the statistical characterization based on the first- and second-order statistics of Washita '92 and Monsoon '90 data. The second half is for evaluating the impact of land cover changes through simulation study using a model for soil moisture dynamics. The model parameters, the loss rate and the diffusion coefficient, have been estimated using the observed data statistics, where the changes of surface conditions are considered into the model by applying various parameter sets with different second-order statistics. This study is concentrated on evaluating the impact due to the changes of land surface condition variability. It is because we could easily quantify the impact of the changes of its areal mean based on the linear reservoir concept. As a result of the study, we found; (1)as the variability of land surface condition, increases, the soil moisture field dries up more easily, (2)as the variabilit y of the soil moisture field is the highest at the beginning of rainfall and decreases as time goes on to show the variability of land surface condition, (3)the diffusion effect due to surface runoff or water flow through the top soil layer is limited to a period of surface runoff and its overall impact is small compared to that of the loss rate field.

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