• 한국환경과학회지
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• 제14권6호
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• pp.613-619
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• 2005

Recently, we are suffered enormous loss from a natural disaster and making an effort to prepare measures for dealing with disasters. This study shows the major causes of natural disasters and stricken area with the analysis of meteorological data based on the Korean Meteorological Administration and the Central Disaster Relief Center records during 1987-2003 and classifies natural disasters according to the causes and damaged conditions. In this study, the most damaged area were Gangwon, Gyeongnam and Gyeongi province as a result of a typhoon and a localized heavy rain. To establish an effective disaster measure for these area, detailed prevention plans should be established by its causes after investigating precise regional damage data analysis.

• 정보보호학회논문지
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• 제25권6호
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• pp.1435-1447
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• 2015

금융회사에서는 내부자에 의한 개인정보유출 방지 및 내부통제 강화를 위하여 E-DRM(Enterprise-Digital Right Management), 개인정보검색, DLP(Data Loss Prevention), 출력물보안, 인터넷 망 분리시스템, 개인정보모니터링 시스템 등의 보안 솔루션을 도입 운영하고 있다. 하지만 개인정보유출 사고는 계속해서 발생하고 있으며, 이 기종 보안 솔루션간의 독립적인 로그 체계로 인하여 개인정보문서의 회사 내부유통 및 외부반출 관련한 정합성 있는 유통경로의 연관 분석이 어렵다. 본 논문은 보안문서를 기반으로 하여 업무시스템 및 이 기종 보안 솔루션간의 로그를 유기적으로 정합성 있게 연관 분석할 수 있는 연결고리 체계 방안을 제시하고, 업무시스템을 통하여 개인PC에 생성되는 보안문서나 개인이 작성한 보안문서에 대한 Life-Cycle 관리방안 및 개인정보가 포함된 보안문서에 대한 유통경로 추적을 위한 효율적인 탐지 방안을 제안하고자 한다.

• 정보보호학회논문지
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• 제24권5호
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• pp.961-968
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• 2014

내부자에 의한 개인정보유출 사고를 방지하기 위하여 다수의 기업은 문서 DRM(Digital Right Management), DLP(Data Loss Prevention), 개인정보 검색시스템 등과 같은 PC보안솔루션을 지속적으로 도입하여 운영하고 있다. 하지만 이러한 투자에도 불구하고 개인정보유출 사건들은 지속적으로 발생하고 있다. PC보안솔루션의 단순 구축이 아닌 기업에 적합한 보안 정책을 사전에 수립하고 정책에 맞는 시스템을 운영한다면 개인정보유출 사고를 미연에 방지할 수 있을 것이다. 또한 로그분석을 통하여 수립한 보안정책의 효과성을 검증할 수 있으며 로그분석결과를 바탕으로 보안정책의 수정 보완이 가능할 것이다. 본 논문은 다양한 PC보안솔루션 중 개인정보유출 방지를 위해 PC에 필수 설치되는 보안솔루션을 정의하고, 필수보안 솔루션을 개인정보보호 관점에서 통합 운영하는 방안, 그리고 로그분석을 통해 개인정보유출 사고 방지를 위한 효과적인 보안정책을 제안하고자 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2489-2493
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• 2015

Background: Loss of heterozygosity (LOH) on chromosomal regions is crucial in tumor progression and this study aimed to identify genome-wide LOH in pancreatic cancer. Materials and Methods: Single-nucleotide polymorphism (SNP) profiling data GSE32682 of human pancreatic samples snap-frozen during surgery were downloaded from Gene Expression Omnibus database. Genotype console software was used to perform data processing. Candidate genes with LOH were screened based on the genotype calls, SNP loci of LOH and dbSNP database. Gene annotation was performed to identify the functions of candidate genes using NCBI (the National Center for Biotechnology Information) database, followed by Gene Ontology, INTERPRO, PFAM and SMART annotation and UCSC Genome Browser track to the unannotated genes using DAVID (the Database for Annotation, Visualization and Integration Discovery). Results: The candidate genes with LOH identified in this study were MCU, MICU1 and OIT3 on chromosome 10. MCU was found to encode a calcium transporter and MICU1 could encode an essential regulator of mitochondrial $Ca^{2+}$ uptake. OIT3 possibly correlated with calcium binding revealed by the annotation analyses and was regulated by a large number of transcription factors including STAT, SOX9, CREB, NF-kB, PPARG and p53. Conclusions: Global genomic analysis of SNPs identified MICU1, MCU and OIT3 with LOH on chromosome 10, implying involvement of these genes in progression of pancreatic cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.2079-2084
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• 2013

Background: Breast cancer is the most prevalent cancer among Iranian women and mastectomy comprises 81% of surgeries for treatment of breast cancer. Mastectomy may create feelings such as deformation or impairment in patients, cause body-image disorder, and reduce sexuality and sexual activity which in turn may entail mental disorders. The study aimed to elaborate coping processes. Materials and Methods: A grounded theory method was used in conducting this study. Twenty Iranian participants undergoing mastectomy were recruited with purposive sampling. An open, semi-structured questionnaire were developed. Obtaining consent, conversations were recorded and immediately transcribed after each session. Data analysis was carried out with the constant comparative method using the Strauss Corbin approach. Results: Analyzing the collected data, the study came up with seven main categories which affected the coping process in patients with breast cancer, namely: reactions to mastectomy; loss and death contest; reconstruction of evaluation system; consent for undergoing mastectomy; reactions and troubles after loss; confrontation of loss and health; and reorganization and compatibility with changes. Conclusions: The results of the study indicated: when patients become informed of their breast cancer and the necessity of undergoing mastectomy as the treatment, they probably pass through seven categories to adapt after mastectomy. Having insight about them is likely to contribute medical personnel in leading patients to the highest degree of feeling healthy.

• BMB Reports
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• 제42권7호
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• pp.444-449
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• 2009

Different neurodegenerative disorders like prion disease, is caused by protein misfolding conformers. Reverse-transfected cytosolic prion protein (PrP) and PrP expressed in the cytosol have been shown to be neurotoxic. To investigate the possible mechanism of neurotoxicity due to accumulation of PrP in cytosol, a PrP mutant lacking the signal and GPI (CytoPrP) was introduced into the SH-SY5Y cell. MTT and trypan blue assays indicated that the viability of cells expressing CytoPrP was remarkably reduced after treatment of MG-132. Obvious apoptosis phenomena were detected in the cells accumulated with CytoPrP, including loss of mitochondrial transmembrane potential, increase of caspase-3 activity, more annexin V/PI-double positive-stained cells and reduced Bcl-2 level. Moreover, DNA fragmentation and TUNEL assays also revealed clear evidences of late apoptosis in the cells accumulated CytoPrP. These data suggest that the accumulation of CytoPrP in cytoplasm may trigger cell apoptosis, in which mitochondrial relative apoptosis pathway seems to play critical role.

• 한국학교ㆍ지역보건교육학회지
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• 제14권2호
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• pp.93-112
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• 2013

Objectives: This study was conducted to investigate the incidence rate of noise-induced hearing loss (NIHL) in Korean youths using the National Health Insurance Data Methods: We obtained the case of NIHL with the National Health Insurance Data and calculated the incidence rate of NIHL after classifying them by year (from 2005 through 2008), age, gender, birth cohort. Results: The age-adjusted incidence rate by year of NIHL per 100,000 population increased by 40.6% from 13.8 persons in 2005 to 19.4 persons in 2008, which showed a increasing trend every year. In particular, the incidence rate per 100,000 population among the adolescents (15-19 years of age) shot up by 78.2% from 8.7 persons in 2005 to 15.5 persons in 2008. According to the incidence rate by birth cohort of NIHL, the birth cohorts showed the gradually increase in incidence rate as time passed by. Adolescents in early 20s (20-24 years of age) had a higher incidence rate than teenage and men had a higher incidence rate than women. Conclusions: The results suggest that incidence rate of NIHL in Korean youths has rapidly increased among adolescents. Therefore, it is required to educate adolescents about the risk of hearing loss due to noise, establish program to prevent NIHL among adolescents and provide them with health education on hearing loss prevention.

• 한국가족관계학회지
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• 제22권3호
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• pp.73-101
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• 2017

Objectives: This study is to understand the experiences of overcoming pain of loss of family survivors in Suicide Bereavement Support Group(SBSG). Method: Experiential data was collected by in-depth interview(FGI, individual) to 10 family survivors(over 19) who having an experience participating in SBSG over 5months and analyzed using qualitative methodology. Results: We drew the result that 'SPACE model' which structuralize by 5 stages of suicide survivors' experience of SBSG of time path. SPACE model configured as follow: Stage1, Space in vacuum, the time to feel a sense of overwhelming feeling like pain, fear, alienation after loss of suicide, Stage2, Probing, when to find informations and resources to help survivors themselves, Stage3, Acclimation, having experiences empathy and healing as in SBSG, Stage4, Composure, accepting SBSG meaning as a part of their lives, loss of my family by suicide, and the beginning of bereavement, Stage5, Endurance, overcoming suffering through SBSG and try to help other survivors. Conclusions: SBSG is the opportunity for family survivors to overcome the pains from loss of suicide, shock, anger, grief, etc., and to empower them to help other suicide survivors.

• 대한안전경영과학회지
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• 제15권4호
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• pp.131-136
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• 2013

Automobile was first introduced in 1903 in South Korea, the masses of the car was carried out rapidly compared to other countries. However, many people were killed in a traffic accidents and economic loss was occurred due to the spread of the automobile. In South Korea, 2012, traffic accident occurred 223,656 times, 5,392 fatality, 344,565 injured people. In the last five years, about 224,000 accidents per year were occurring. In other words, 610 traffic accidents occur and about 15 people pass away in one day. In addition, the proportion of traffic accidents is first place in the OECD countries and it is very high in the world. Understand occurrence tendency of traffic accident, accident frequency rate of the driver who drives more than 10 years was higher than the novice driver. In addition, as a result of examining the cause of the traffic accident, breach of safe driving obligation appears highest case (125,391 times), and followed by signal violation, break safety distance. Therefore, the majority of traffic accidents occurred by the lack of safety awareness of the driver. In this study, prevent the loss of human life and property in traffic disaster, by establish disaster prevention measures that investigated by questionnaire survey and statistical data of the state of consciousness and driving posture in response to the driving history of the driver.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.447-450
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• 2012

Video-assisted thoracic surgery (VATS) has been recommended as more optimal surgical technique than traditional thoracotomy for lobectomy in lung cancer, but it is not well defined. Here, we compared VATS and traditional thoracotomy based on clinical data. From November 2008 to November 2010, 180 patients underwent lobectomy for non-small-cell lung cancer (NSCL) identified by computerized tomography. Of them, 83 cases were performed with VATS and 97 by thoracotomy. Clinical parameters, consisting of blood loss, operating time, number of lymph node dissection, days of pleural cavity drainage, and length of stay were recorded and evaluated with t test. No significant difference was observed between the VATS and thoracotomy groups in the average intraoperative blood loss, number of lymph node dissections, and days of pleural cavity drainage. While the average operating time in the VATS group was significantly longer than that in thoracotomy group, recurrence was only present in one case, as opposed to 7 cases in the thoracotomy group In conclusion, similar therapeutic effects were demonstrated in VATS and thoracotomy for NSCL. However, VATS lobectomy was associated with fewer complications, recurrence and shorter length of stay.