• JSTS:Journal of Semiconductor Technology and Science
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• v.15 no.3
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• pp.334-341
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• 2015

This research outlines the design of a HR-TDC (High Resolution Time-to-Digital Converter) for high data rate communication systems using a $0.18{\mu}m$ CMOS process. The coarse-fine architecture has been adopted to improve the resolution of the TDC. A two-stage vernier time amplifier (2S-VTA) was used to amplify the time residue, and the gain of the 2S-VTA was larger than 64. The error during time amplification was compensated using two FTDCs (Fine-TDC) with their outputs. The resolution of the HR-TDC was 0.15 ps with a 12-bit output and the power consumption was 4.32 mW with a 1.8-V supply voltage.

• Nuclear Engineering and Technology
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• v.54 no.11
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• pp.4030-4048
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• 2022

In this study, road transportation tests were conducted with surrogate fuel assemblies under normal conditions of transport to evaluate the vibration and shock load characteristics of spent nuclear fuel (SNF). The overall test data analysis was conducted based on the measured acceleration and strain data obtained from the speed bump, lane-change, deceleration, obstacle avoidance, and circular tests. Furthermore, representative shock response spectrums and power spectral densities of each test mode were acquired. Amplification or attenuation characteristics were investigated according to the load transfer path. The load attenuated significantly as it transferred from the trailer to the cask. By contrast, the load amplified as it transferred from the cask to the surrogate SNF assembly. The fuel loading location on the cask disk assembly did not exhibit a significant influence on the strain measured from the fuel rods. The principal strain was in the vertical direction, and relatively large strain values were obtained in spans with large spacing between spacer grids. The influence of the lateral location of fuel rods was also investigated. The fuel rods located at the side exhibited relatively large strain values than those located at the center. Based on the strain data obtained from the test results, a hypothetical road transportation scenario was established. A fatigue evaluation of the SNF rod was performed based on this scenario. The evaluation results indicate that no fatigue damage occurred on the fuel rods.

• Journal of the Korean GEO-environmental Society
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• v.16 no.1
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• pp.17-27
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• 2015

Recently, Korean government has tried out to set up earthquake hazards prevention system. In the system, several geotechnical hazard maps including liquefaction hazard map and landslide hazard map for the whole country have drawn to consider the domestic seismic characteristics. To draw the macro liquefaction hazard map, big data of site investigations in metropolitan areas and provincial areas has to be verified for its application. In this research, we carried out site response analyses using 522 borehole site investigation data in S city during a desirable earthquake. The soil classification was separately compared to shear wave velocity considering the uncertainty of site investigation data. Probability distribution and statistical analysis for the results of site response analyses was applied to the feasibility study. Finally, we suggest a new site amplification coefficient, hereby presented with the similar results of liquefaction hazard mapping using the calculated liquefaction potential index by the site response analyses. Above-mentioned study will be expected to help to follow research and draw liquefaction hazard map in moderate seismic region.

• Geophysics and Geophysical Exploration
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• v.14 no.1
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• pp.69-79
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• 2011

In this study, empirical site amplifications and S-wave velocity profiles for shallow and deep soils are estimated using earthquake ground motion records in metropolitan Manila, the Philippines. We first apply a spectral inversion technique to the earthquake records to estimate effects of source, path, and local site amplification. The earthquake data used were obtained during 36 moderate earthquakes at 10 strong-motion stations of an earthquake observation network in Manila. The estimated Q value of the propagation path is modelled as $54.6f^{1.1}$. Most of the source spectra can be approximated with the omega-square model. The site amplifications show characteristic features according to surface geological conditions. The amplifications at the sites in the coastal lowland and Marikina Valley shows predominant peaks at frequencies from 1 to 5 Hz, while those in the central plateau are characterised by no dominant peaks. These site amplifications are inverted to subsurface S-wave velocity. We, next, discuss the relationship between the amplifications and average S-wave velocity in the top 30m of the S-wave velocity profiles. The amplifications at low frequencies are well correlated with the averaged S-wave velocity. However, high-frequency amplifications cannot be sufficiently explained by the averaged S-wave velocity in the top 30 m. They are correlated more with the average of S-wave velocity over depths less than 30 m.

• Anxiety and mood
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• v.3 no.2
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• pp.116-122
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• 2007

Objective : The purpose of this study was to investigate the strategies used to cope with stress and the cognitive characteristics of somatic symptom perception in patients with panic disorder. Methods : A total of 101 patients who met the DSM-IV criteria for panic disorder and 60 normal controls were recruited for participation in this study. We evaluated the subjects using The Way of Stress Coping Questionnaire (SCQ), Somato-Sensory Amplification Scale (SSAS), Symptom Interpretation Questionnaire (SIQ), and the Panic Disorder Severity Scale (PDSS). We analyzed the data using an independent t-test and Pearson correlation analysis (p<0.05). Results : The patients who used emotionally focused coping strategies scored significantly lower on the SCQ. The patients with panic disorder showed greater amplification of body sensations in the SSAS, a significantly higher score on the physical interpretation subset of the SIQ, and a lower score on the environmental interpretation subset of the SIQ than the normal controls. The PDSS scores were positively correlated with the SSAS score and physical interpretation score on the SIQ. Conclusion : These results show that patients with panic disorder have poor emotionally focused strategies for coping with stress, greater amplification of body sensations, and a tendency towards a physical interpretation of somatic symptoms.

• Journal of the Korean Society of Marine Environment & Safety
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• v.27 no.6
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• pp.846-855
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• 2021

Eco-friendly and renewable energy sources are actively being researched in recent times, and of shore wind power generation requires advanced design technologies in terms of increasing the capacities of wind turbines and enlarging wind turbine installation vessels (WTIVs). The WTIV ensures that the hull is situated at a height that is not affected by waves. The most important part of the WTIV is the leg structure, which must respond dynamically according to the wave, current, and wind loads. In particular, the wave load is composed of irregular waves, and it is important to know the exact dynamic response. The dynamic response analysis uses a single degree of freedom (SDOF) method, which is a simplified approach, but it is limited owing to the consideration of random waves. Therefore, in industrial practice, the time-domain analysis of random waves is based on the multi degree of freedom (MDOF) method. Although the MDOF method provides high-precision results, its data convergence is sensitive and difficult to apply owing to design complexity. Therefore, a dynamic amplification factor (DAF) estimation formula is developed in this study to express the dynamic response characteristics of random waves through time-domain analysis based on different variables. It is confirmed that the calculation time can be shortened and accuracy enhanced compared to existing MDOF methods. The developed formula will be used in the initial design of WTIVs and similar structures.

• Korean Journal of Psychosomatic Medicine
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• v.29 no.2
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• pp.102-110
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• 2021

Objectives : The purpose of this study is to investigate the characteristics of the perception of the somatic symptoms and the cognitive emotion regulation strategies in patients with posttraumatic stress disorder (PTSD). Methods : A total of 48 patients meeting DSM-5 criteria for PTSD and 48 normal controls were recruited for participation in this study. We evaluated subjects using Clinician-Administered PTSD Scale (CAPS), Somato-Sensory Amplification Scale (SSAS), Hamilton Anxiety Scale (HAM-A) and Cognitive Emotion Regulation Questionnaire (CERQ). We analyzed data using an independent t-test and Pearson's correlation analysis. Results : In terms of SSAS, PTSD patients presented higher average SSAS scores than normal controls but the result is not statistically significant. In PTSD patients, the severity of PTSD is significantly correlated with CERQ-rumination and CERQ-catastrophizing. The SSAS scores of PTSD patients show the significant positive correlation with PTSD hyperarousal symptoms, CERQ-catastrophizing and CERQ-blaming others. Conclusions : These results reveal that patients with PTSD have maladaptive cognitive emotion regulation strategies such as rumination and catastrophizing. Somato-sensory amplification seems to be related with PTSD hyperarousal, CERQ-catastrophizing and CERQ-blaming others. Therefore, reducing somato-sensory amplification, rumination and catastrophizing can be helpful to reduce PTSD symptoms and somatic symptoms in PTSD patients.

• Journal of Food Hygiene and Safety
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• v.34 no.3
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• pp.290-295
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• 2019

Salmonella spp. are frequently associated with food and are among the most important foodborne pathogens. The recent Salmonella out breaks in Korea was associated with chocolate mousse cakes served with school meals during September 2018. The objective of this research was to compare the 3M Molecular Detection Assay 2 - Salmonella and the Korean Standard Method of Salmonella in artificially inoculated mousse (chocolate and cheese) and tiramisu cakes. Mousse (chocolate and cheese) and tiramisu cakes were artificially inoculated with S. Typhimurium. Twenty five gram of sample was enriched with 225 mL buffered peptone water for incubation at $37^{\circ}C$ for 24 h. After enrichment, the cultures were analyzed by using the 3M Molecular Detection Assay 2 - Salmonella and the Korean Standard Method. Most of the inoculated samples showed similar results except the chocolate mousse cakes, in which real-time PCR was unable to detect S. Typhimurium even after $10^4CFU/25g$ of inoculation. However, S. Typhimurium inoculated at a concentration of $10^0CFU/25g$ was detected by using 3M Molecular Detection Assay 2 - Salmonella. In chocolate mousse, detection of S. Typhimurium using real-time PCR was partially successful when dark chocolate was added at less than 15%. Negative results in real-time PCR and 3M Molecular Detection Assay 2 - Salmonella were confirmed by gel electrophoresis. The data indicated that dark chocolate could inhibit amplification of the target gene in the PCR reactions. In conclusion, the 3M Molecular Detection Assay 2 - Salmonella was better than the Korean Standard Method (real-time PCR) for the detection of S. Typhimurium in chocolate mousse cakes and chocolate mousse.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.26 no.5
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• pp.314-326
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• 2014

On 31 March 2007, the abnormal wave occurred along the western coast of Korea. In order to investigate the generation mechanism of abnormal waves and to understand the amplification process of the abnormal waves, the observed data were analyzed and one-dimensional numerical model experiments were performed by using both the linear shallow water equation and the linear Boussinesq equation models. Various types of pressure jump for the abnormal waves previously proposed by other researchers were reviewed. As a result, it was not possible to reproduce the abnormal waves from the previously proposed pressure jumps. In this study, we proposed a new form of pressure jump, and numerical simulations were performed in order to check the validity of the proposed pressure jump. The numerical results showed that the calculated period of abnormal waves and the maximum water elevations agreed reasonably well with those of the observations.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.11
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• pp.4623-4627
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• 2014

Background: The epidermal growth factor receptor (EGFR) plays a vital role in the activation and inactivation of receptor tyrosine kinases. Mutations in exons 19 and 21 of EGFR are commonly found to be associated with non small cell lung carcinoma and triple negative breast cancer, enhancing sensitivity to EGFR targeting chemotherapeutic agents. Since amplification and prolonged activation of EGFR molecules have been identified in oral squamous cell carcinomas (OSCC), we investigated whether OSCCs carried mutations in exons 19 and 21 of EGFR to their incidence. Materials and Methods: Tumor chromosomal DNA isolated from forty surgically excised oral squamous cell carcinoma tissues was subjected to PCR amplification with intronic primers flanking exons 19 and 21 of the EGFR gene. The PCR amplicons were subsequently subjected to direct sequencing to elucidate the mutation status. Results: Data analysis of the EGFR exon 19 and 21 coding sequences did not show any mutations in the forty OSCC samples that were analyzed. Conclusions: To the best of our knowledge, this is the first study to have investigated the genetic status of exons 19 and 21 of EGFR in Indian OSCCs and identified that mutation in EGFR exon 19 and 21 may not contribute towards their genesis. The absence of mutations also indicates that oral cancerous lesions may not be as sensitive as other cancers to chemotherapeutic agents targeting EGFR.