• Clinical and Experimental Pediatrics
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• v.64 no.7
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• pp.313-321
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• 2021

Here we describe the neurodevelopmental outcomes of very low birth weight (VLBW) infants (birth weight ≤1,500 g) at 3 years of age in the Neonatal Research Network of Japan (NRNJ) database in the past decade and review the methodological issues identified in follow-up studies. The follow-up protocol for children at 3 years of chronological age in the NRNJ consists of physical and comprehensive neurodevelopmental assessments in each participating center. Neurodevelopmental impairment (NDI)-moderate to severe neurological disability-is defined as cerebral palsy (CP) with a Gross Motor Function Classification System score ≥2, visual impairment such as uni- or bilateral blindness, hearing impairment requiring hearing amplification, or cognitive impairment with a developmental quotient (DQ) of Kyoto Scale of Psychological Development score <70 or judgment as delayed by pediatricians. We used death or NDI as an unfavorable outcome in all study subjects and NDI in survivors using number of assessed infants as the denominator. Follow-up data were collected from 49% of survivors in the database. Infants with follow-up data had lower birth weights and were of younger gestational age than those without follow-up data. Mortality rates of 40,728 VLBW infants born between 2003 and 2012 were 8.2% before discharge and 0.7% after discharge. The impairment rates in the assessed infants were 7.1% for CP, 1.8% for blindness, 0.9% for hearing impairment, 15.9% for a DQ <70, and 19.1% for NDI. The mortality or NDI rate in all study subjects, including infants without follow-up data, was 17.4%, while that in the subjects with outcome data was 32.5%. The NRNJ follow-up study results suggested that children born with a VLBW remained at high risk of NDI in early childhood. It is important to establish a network follow-up protocol and complete assessments with fewer dropouts to enable clarification of the outcomes of registered infants.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.3 no.4
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• pp.255-260
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• 1991

A voltage measuring system specified for the voltage fluctuation of the Pusan-Hamada submarine cable is developed by adding circuits of differential amplification and analog-to-digital conversion to a microprocessor-based data logger with a data modem. This system is charaterized by its small size. no power failure. fully unmanned operation. and precise instrumental drift correction. In addition to the cable voltage and current it measures an ambient temperature and a mercury cell voltage in order to calibrate temperature effect and check its long-term stability. The data acquired by this system show that the voltage signal. comprising fast random noises with a constant width of about 0.2V. fluctuates within a range of about 1V and the fluctuation frequency is similar to that of tidal motion. The source voltage of power feeding equipment (PFE) for the cable system seems to be affected when the room temperature changes rapidly.

• Korean Journal of Remote Sensing
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• v.27 no.6
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• pp.703-715
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• 2011

Forests have been considered one of the most important ecosystems on the earth, affecting the lives and environment. The sustainable forest management requires accurate and timely information of forest and tree parameters. Appropriately interpreted remotely sensed imagery can provide quantitative data for deriving forest information temporally and spatially. Especially, analysis of individual tree detection and crown delineation is significant issue, because individual trees are basic units for forest management. Individual trees in aerial imagery have reflectance characteristics according to tree species, crown shape and hierarchical status. This study suggested a method that identified individual trees and delineated crown boundaries through adopting gradient method algorithm to amplified greenness data using red and green band of aerial imagery. The amplification of specific band value improved possibility of detecting individual trees, and gradient method algorithm was performed to apply to identify individual tree tops. Additionally, tree crown boundaries were explored using spectral intensity pattern created by geometric characteristic of tree crown shape. Finally, accuracy of result derived from this method was evaluated by comparing with the reference data about individual tree location, number and crown boundary acquired by visual interpretation. The accuracy ($\hat{K}$) of suggested method to identify individual trees was 0.89 and adequate window size for delineating crown boundaries was $19{\times}19$ window size (maximum crown size: 9.4m) with accuracy ($\hat{K}$) at 0.80.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.8
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• pp.3733-3736
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• 2016

HER2/neu is a well-established prognostic and predictive factor for invasive breast cancer. However, the role of HER2/neu in ductal breast carcinoma in situ (DCIS) is debated and recent data have suggested that it is mainly linked to in situ local recurrence. Although molecular data suggest that atypical ductal hyperplasia (ADH) and duct carcinoma in situ (DCIS) are related lesions, albeit with vastly different clinical implications, the role of HER2/neu expression in atypical ductal hyperplasia is not well defined either. The aim of this study was to evaluate over expression of HER2/neu in DCIS and cases of ADH in comparison with invasive breast carcinoma. Archival primary breast carcinoma paraffin blocks (n=15), DCIS only (n=10) and ductal epithelial hyperplasia and other breast benign lesions (n=25) were analyzed for HER2/neu immunoexpression. Follow up was available for 40% of the patients. HER2/neu was positive in 80%of both DCIS and invasive carcinoma, and 67% of atypical ductal hyperplasia (ADH) cases. Thus at least a subset of patients with preinvasive breast lesions were positive, which strongly suggests a role for Her2/neu in identifying high-risk patients for malignant transformation. Although these are preliminary data, which need further studies of gene amplification within these patients as well as a larger patient cohort with longer periods of follow up, they support the implementation of routine Her2/neu testing in patients diagnosed as pure DCIS and in florid ADH.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.23 no.1
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• pp.15-21
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• 2023

This paper is a study on the development of an artificial intelligence model that recognizes a hole cup on a golf green. A CNN-based object detection algorithm was used to recognize the hole cup on the green. Also, Apple's CreateML was used to create a model of the object detection algorithm. This paper created a JSON file with 120 training images and annotations to meet the needs of CreateML. In addition, for more accurate learning, data amplification algorithm was used for learning data and 288 learning data were used for learning. By changing the Iterations, Batch size, and Grid size required by CreateML, we found parameter values that improve the performance of the model. A prototype app was developed by applying the developed model, and performance was measured on an actual golf course green using the prototype app. As a result of the measurement, it was found that the hole cup was accurately recognized within 10m, which is the typical golfer's putting distance.

• Journal of Plant Biotechnology
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• v.1 no.2
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• pp.109-115
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• 1999

A linkage map of Capsicum annuum L. was constructed by random amplified polymorphic DNA (RAPD) markers followed in a backcross population of an intraspecific cross between cultivars HDA210 and Yatsufusa. A total of 420 random primers were tested and 311 polymorphic bands were generated by 158 random primers. Among them, 86 Yatsufusa specific bands generated by 52 primers were examined for mapping. Most bands except three segregated in Mendelian fashion fitting the expected 1:1 ratio. The total length of the map was 533 cM distributed in 15 linkage groups. The map distance between adjacent markers ranged 0 to 32.8 cM, with an average distance of 9.1 cM (63 markers). Some markers were clustered and this may be due to the amplification of a repetitive sequence by the RAPDs. Primer pairs for a sequence characterized amplified region (SCAR) were developed and the segregation scores by the SCAR primers were in accordance with the RAPD data. Two QTL markers for number of axillary shoots and for early flowering were developed. One QTL for early flowering located in the linkage group 3 and explained 61 "io of the phenotypic variation. The other QTL for the number of axillary shoots located in the linkage group 4 explained 55 % of the phenotypic variation.tion.

• Journal of the korean society of oceanography
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• v.39 no.3
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• pp.163-171
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• 2004

Sequences of the large subunit ribosomal (LSD) rDNA D1-D2 region of Alexandrium catenella(=A. sp. cf. catenella) and A. tamarense isolates, which were collected along the Korea coasts, were analyzed to understand their phylogenetic relationships and geographical distributions. All A. catenella and A. tamarense isolates belonged to the A. tamarense/catenella/fundyense complex and were grouped with the North American and temperate Asian ribotypes, respectively, regardless of the presence or absence of a ventral pore in the first apical plate. A consistent and peculiar characteristic that differentiated the Alexandrium isolates was amplification of a second PCR product with a lower molecular weight in addition to the predicted one; ten A. catenella isolates belonging to the temperate Asian ribotype yielded this additional PCR product. Sequence alignment revealed that the shorter PCR product resulted from an unusual large deletion of 87 bp in the LSD rDNA D1 domain. The North American and temperate Asian ribotypes were prevalent along the Korean coasts without geographical separation. Given the high genetic homogeneity among widely distributed Alexandrium populations, each ribotype appeared to be pandemic rather than to constitute a distinct regional population.

• IMMUNE NETWORK
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• v.2 no.2
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• pp.79-85
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• 2002

Background: In contrast to evidences of Ig H chain receptor editing in transformed cell lines and transgenic mouse models, there has been no direct evidence that this phenomenon occurs in human developing B cells. Methods: $V_HDJ_H$ rearrangements were obtained from genomic DNA of individual $IgM^-$ B cells from liver and $IgM^+B$ cells from bone marrow of 18 wk of gestation human fetus by PCR amplification and direct sequencing. Results: We found three examples of H chain receptor editing from $IgM^+$ and $IgM^-human$ fetal B cells. Two types of $V_H$ replacements were identified. The first involved $V_H$ hybrid formation, in which part of a $V_H$ gene from the initial VDJ rearrangement is replaced by part of an upstream $V_H$ gene at the site of cryptic RSS. The second involved a gene conversion like replacement of CDR2, in which another $V_H$ gene donated a portion of its CDR2 sequence to the initial VDJ rearrangement. Conclusion: These data provide evidence of receptor editing at the H chain loci in developing human B cells, and also the first evidence of a gene conversion event in human Ig genes.

• Journal of the Earthquake Engineering Society of Korea
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• v.22 no.3
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• pp.219-224
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• 2018

The The purpose of this study is to investigate the actual liquefaction occurrence site in Pohang area and to analyze the ground characteristics of Pohang area using the data of the National Geotechnical Information DB Center and to calculate the liquefaction potential index. Based on the results, the distribution of soil classification in Pohang area and the risk of liquefaction under various earthquake accelerations were prepared. As a result of the study, soils in Pohang has the soil characteristics that can cause the site amplification phenomenon. In the analysis through liquefaction hazard maps under earthquake scenarios, it is found that the liquefaction occurred in the area of Heunghae town is more likely to be liquefied than other areas in Pohang. From these results, it is expected that the study on the preparation of liquefaction hazard maps will contribute to the preparation of countermeasures against liquefaction by predicting the possibility in the future.

• Journal of Wellbeing Management and Applied Psychology
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• v.2 no.2
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• pp.19-37
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• 2019

Over the last few decades, the atmospheric carbon dioxide emission has been amplified to a great extent in Turkey. This amplification may cause global warming, climate change and environmental degradation in Turkey. Consequently, ecological condition and human life may suffer in the near future from these indicated threats. Therefore, an attempt was made to test the relationship among a number of expected factors and carbon dioxide emissions in the case of Turkey. The study covers the time series data over the period of 1970-2017. We employed the modern econometric techniques such as Johansen co-integration, ARDL bound testing approach and the block exogeneity. The results of the Johansen co-integration test show that there is a significant long-run relationship between carbon dioxide emissions and expected factors. The long-run elasticities of the ARDL model show that a 1% increase in the GDP per capita, electric consumption, fiscal development and trade openness will increase carbon dioxide emissions by 0.14, 0.52, 0.09 and 0.20% respectively. Further, our findings reveal that the environmental Kuznets curve (EKC) hypothesis and inverted U-shaped relationship between carbon dioxide emission and economic growth prevails. Therefore, the EKC hypothesis is valid and prevailing in the Turkish economy. The diagnostic test results show that the parameters of the ARDL model are credible, sTable and reliable in the current form. Finally, Block exogeneity analysis displays that all the expected factors are contributing significantly to carbon dioxide emissions in the Turkish economy.