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Improving Participation in Colorectal Cancer Screening: a Randomised Controlled Trial of Sequential Offers of Faecal then Blood Based Non-Invasive Tests

  • Symonds, Erin L;Pedersen, Susanne;Cole, Stephen R;Massolino, Joseph;Byrne, Daniel;Guy, John;Backhouse, Patricia;Fraser, Robert J;LaPointe, Lawrence;Young, Graeme P
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.18
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    • pp.8455-8460
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    • 2016
  • Background: Poor participation rates are often observed in colorectal cancer (CRC) screening programs utilising faecal occult blood tests. This may be from dislike of faecal sampling, or having benign bleeding conditions that can interfere with test results. These barriers may be circumvented by offering a blood-based DNA test for screening. The aim was to determine if program participation could be increased by offering a blood test following faecal immunochemical test (FIT) non-participation. Materials and Methods: People were invited into a CRC screening study through their General Practice and randomised into control or intervention (n=600/group). Both groups were mailed a FIT (matching conventional screening programs). Participation was defined as FIT completion within 12wk. Intervention group non-participants were offered a screening blood test (methylated BCAT1/IKZF1). Overall participation was compared between the groups. Results: After 12wk, FIT participation was 82% and 81% in the control and intervention groups. In the intervention 96 FIT nonparticipants were offered the blood test - 22 completed this test and 19 completed the FIT instead. Total screening in the intervention group was greater than the control (88% vs 82%, p<0.01). Of 12 invitees who indicated that FIT was inappropriate for them (mainly due to bleeding conditions), 10 completed the blood test (83%). Conclusions: Offering a blood test to FIT non-participants increased overall screening participation compared to a conventional FIT program. Blood test participation was particularly high in invitees who considered FIT to be inappropriate for them. A blood test may be a useful adjunct test within a FIT program.

Steady State Design for the Separation of Acetone-Chloroform Maximum Boiling Azeotrope Using Three Different Solvents

  • Pokhrel, Manish;Owusu, Asante Daniel;Cho, Jungho
    • Korean Chemical Engineering Research
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    • v.55 no.4
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    • pp.490-496
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    • 2017
  • We have designed an extractive distillation for separating maximum boiling azeotrope of acetone-chloroform system. PRO/II 9.4 was used to simulate the overall process. The VLE data adopted from Dortmund data bank was regressed to obtain a new set of binary interaction parameters. Three different entrainers were used for the separation process--dimethyl sulfoxide (DMSO), ethylene glycol (EG) and benzene--to test their viability for the acetone-chloroform system. Thermodynamic feasibility analysis was done through ternary map diagrams. Two different thermodynamic models, NRTL and UNIQUAC, were explored for the study of overall process.

A Novel Approach to Trojan Horse Detection in Mobile Phones Messaging and Bluetooth Services

  • Ortega, Juan A.;Fuentes, Daniel;Alvarez, Juan A.;Gonzalez-Abril, Luis;Velasco, Francisco
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.5 no.8
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    • pp.1457-1471
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    • 2011
  • A method to detect Trojan horses in messaging and Bluetooth in mobile phones by means of monitoring the events produced by the infections is presented in this paper. The structure of the detection approach is split into two modules: the first is the Monitoring module which controls connection requests and sent/received files, and the second is the Graphical User module which shows messages and, under suspicious situations, reports the user about a possible malware. Prototypes have been implemented on different mobile operating systems to test its feasibility on real cellphone malware. Experimental results are shown to be promising since this approach effectively detects various known malware.

Finite element simulation of traditional and earthquake resistant brick masonry building under shock loading

  • Daniel, A. Joshua;Dubey, R.N.
    • Coupled systems mechanics
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    • v.4 no.1
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    • pp.19-36
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    • 2015
  • Modelling and analysis of a brick masonry building involves uncertainties like modelling assumptions and properties of local material. Therefore, it is necessary to perform a calibration to evaluate the dynamic properties of the structure. The response of the finite element model is improved by predicting the parameter by performing linear dynamic analysis on experimental data by comparing the acceleration. Further, a nonlinear dynamic analysis was also performed comparing the roof acceleration and damage pattern of the structure obtained analytically with the test findings. The roof accelerations obtained analytically were in good agreement with experimental roof accelerations. The damage patterns observed analytically after every shock were almost similar to that of experimental observations. Damage pattern with amplification in roof acceleration exhibit the potentiality of earthquake resistant measures in brick masonry models.

Practical Implementation and Stability Analysis of ALOHA-Q for Wireless Sensor Networks

  • Kosunalp, Selahattin;Mitchell, Paul Daniel;Grace, David;Clarke, Tim
    • ETRI Journal
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    • v.38 no.5
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    • pp.911-921
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    • 2016
  • This paper presents the description, practical implementation, and stability analysis of a recently proposed, energy-efficient, medium access control protocol for wireless sensor networks, ALOHA-Q, which employs a reinforcement-learning framework as an intelligent transmission strategy. The channel performance is evaluated through a simulation and experiments conducted using a real-world test-bed. The stability of the system against possible changes in the environment and changing channel conditions is studied with a discussion on the resilience level of the system. A Markov model is derived to represent the system behavior and estimate the time in which the system loses its operation. A novel scheme is also proposed to protect the lifetime of the system when the environment and channel conditions do not sufficiently maintain the system operation.

Nonlinear finite element analysis of four-pile caps supporting columns subjected to generic loading

  • de Souza, Rafael Alves;Kuchma, Daniel Alexander;Park, Jung-Woong;Bittencourt, Tulio Nogueira
    • Computers and Concrete
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    • v.4 no.5
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    • pp.363-376
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    • 2007
  • The paper presents the development of an adaptable strut-and-tie model that can be applied to the design or analysis of four-pile caps that support axial compression and biaxial flexure from a supported rectangular column. Due to an absence of relevant test data, the model is validated using nonlinear finite element analyses (NLFEA). The results indicate that the use of the proposed model would lead to safe and economical designs. The proposed model can be easily extended to any number of piles, providing a rational procedure for the design of wide range of pile caps.

Mobile Payment Use in Light of Privacy Protection and Provider's Market Control

  • Mohammad Bakhsh;Hyein Jeong;Lingyu Zhao;One-Ki Daniel Lee
    • Asia pacific journal of information systems
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    • v.31 no.3
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    • pp.257-276
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    • 2021
  • This study investigates the factors that facilitate or hinder people to use mobile payment, especially drawing upon the theoretical perspectives on individual's privacy protection motivation and perceived market condition. Survey data (n = 200) were collected through a web-based platform and used to test a theoretical model. The results show that one's privacy protection power is formed by various individual and technological factors (i.e., perceived data exposure, self-efficacy, and response efficacy), and in turn it determines his/her intention to use mobile payment. Moreover, the relationship between privacy protection power and mobile payment use is conditional on the perceived market control by the service provider - with a perception of the high level of provider's market control, one uses mobile payment regardless of his/her privacy protection power, while under the low level of provider's market control, the decision depends on the degree of privacy protection power. The findings would help our understanding of why some people are more susceptible to mobile payment and others are not.

Atypical Antidepressant Activity of 3,4-Bis(3,4-Dimethoxyphenyl) Furan-2,5-Dione Isolated from Heart Wood of Cedrus deodara, in Rodents

  • Kumar, Nitesh;Dhayabaran, Daniel;Nampoothiri, Madhavan;Nandakumar, Krishnadas;Puratchikody, A.;Lalani, Natasha;Dawood, Karima;Ghosh, Aanesha
    • The Korean Journal of Physiology and Pharmacology
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    • v.18 no.5
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    • pp.365-369
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    • 2014
  • Cedrus deodara (Pinaceae) has been used traditionally in Ayurveda for the treatment of central nervous system disorders. 3,4-bis(3,4-dimethoxyphenyl)furan-2,5-dione (BDFD) was isolated from heart wood of Cedrus deodara and was shown to have antiepileptic and anxiolytic activity. Thus, the present study was aimed to explore its anti-depressant effect and to correlate the effect with serotonin and nor adrenaline levels of brain. Albino mice were used as experimental animal. Animals were divided in to three groups; vehicle control, imipramine (30 mg/kg i.p.), BDFD (100 mg/kg i.p.). Tail suspension test (TST) and forced swim test (FST) was performed to evaluate antidepressant effect of BDFD. BDFD (100 mg/kg, i.p.) showed a significant decrease in immobility time when subjected to FST whereas immobility time was not significantly altered in TST. BDFD treatment increased serotonin and noradrenaline levels in the brain which is indicative of BDFD having possible atypical antidepressant action.

A Study of Improvement Pile friction in Marine Clay using Electrokinetics Treatment (전기동역학을 이용한 해성 점토 지반내의 말뚝 마찰지지력 향상에 관한 연구)

  • Lee, Kwang-Yeol;Gu, Tae-Gon;Tjandra, Daniel;Hyun, Jae-Duck
    • Proceedings of the Korean Geotechical Society Conference
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    • 2004.03b
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    • pp.211-218
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    • 2004
  • The objective of this study is to enhance the ultimate bearing capacity of piles embedded in marine clay by electrokinetic(EK). The focus of improvement is at interlace between soil and pile. A series laboratory test was performed in EK cell. In each of test, the pile in the centre as anode is surrounded by cathode and it was installed in the vicinity of pile with triangular layout. The pile was made by stainless and embedded with 30cm of depth. Afterward, the DC voltage was applied to electrode over period of time. It caused flowing water from anode to cathode, thus the soil in the center of box has higher bearing capacity value than in the side of box has. It is shown by increasing of un-drained shear strength(Cu) near the pile and also ultimate bearing capacity of pile increase after EK treatment. In the future work, the continuous of this study is finding the effective DC voltage and makes EK treatment more applicable in the field.

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Yield stress measurements in suspensions: an inter-laboratory study

  • Nguyen, Q. Dzuy;Akroyd, Timothy;Kee, Daniel C. De;Zhu, Lixuan
    • Korea-Australia Rheology Journal
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    • v.18 no.1
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    • pp.15-24
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    • 2006
  • The first international inter-laboratory study, involving six laboratories, has been conducted to examine issues associated with yield stress measurements in suspensions. The initial focus of the project was to evaluate the reliability and reproducibility of several common yield stress measuring techniques employed in different laboratories and with different instruments. Aqueous suspensions of colloidal $TiO_2$ at concentrations of 40-70 wt% solids were used as the test fluids. A wide range of instruments and techniques employing both direct and indirect methods were used to determine the yield stress of the samples prepared according to a prescribed procedure. The results obtained indicated that although variations of results existed among different techniques, direct yield stress measurements using static methods produced more reliable and repeatable results than other methods. Variability of the yield stress measured using different techniques within any laboratory however was less significant than variability of the results among different laboratories. The nature and condition of the test suspensions was identified as the most likely factor responsible for the poor reproducibility of yield stress measurements from different laboratories.