• 한국해양공학회지
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• 제35권5호
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• pp.327-335
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• 2021

Microcracks can rapidly grow and develop in high-strength steels used in offshore structures. It is important to render these microcracks harmless to ensure the safety and reliability of offshore structures. Here, the dependence of the aspect ratio (As) of the maximum depth of harmless crack (a_hlm) was evaluated under three different conditions considering the threshold stress intensity factor (Δk_th) and residual stress of offshore structural steel F690. The threshold stress intensity factor and fatigue limit of fatigue crack propagation, dependent on crack dimensions, were evaluated using Ando's equation, which considers the plastic behavior of fatigue and the stress ratio. a_hlm by peening was analyzed using the relationship between Δk_th obtained by Ando's equation and Δk_th obtained by the sum of applied stress and residual stress. The plate specimen had a width 2W = 12 mm and thickness t = 20 mm, and four value of As were considered: 1.0, 0.6, 0.3, and 0.1. The a_hlm was larger as the compressive residual stress distribution increased. Additionally, an increase in the values of As and Δk_th(l) led to a larger a_hlm. With a safety factor (N) of 2.0, the long-term safety and reliability of structures constructed using F690 can be secured with needle peening. It is necessary to apply a more sensitive non-destructive inspection technique as a non-destructive inspection method for crack detection could not be used to observe fatigue cracks that reduced the fatigue limit of smooth specimens by 50% in the three types of residual stresses considered. The usefulness of non-destructive inspection and non-damaging techniques was reviewed based on the relationship between a_hlm, a_NDI (minimum crack depth detectable in non-destructive inspection), a_{cr N} (crack depth that reduces the fatigue limit to 1/N), and As.

• 생물정신의학
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• 제14권4호
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• pp.221-231
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• 2007

Recent researches have shown that important cellular-based autoprotective mechanisms are mediated by heat-shock proteins(HSPs), also called 'molecular chaperones'. HSPs as molecular chaperones are the primary cellular defense mechanism against damage to the proteome, initiating refolding of denatured proteins and regulating degradation after severe protein damage. HSPs also modulate multiple events within apoptotic pathways to help sustain cell survival following damaging stimuli. HSPs are induced by almost every type of stresses including physical and psychological stresses. Our nervous system in the brain are more vulnerable to stress and damage than any other tissues due to HSPs insufficiency. The normal function of HSPs is a key factor for endogenous stress adaptation of neural tissues. HSPs play an important role in the process of neurodevelopment, neurodegeneration, and neuroendocrine regulation. The altered function of HSPs would be associated with the development of several neuropsychiatric disorders. Therefore, an understanding of HSPs activities could help to improve autoprotective mechanism of our neural system. This paper will review the literature related to the significance of HSPs in neuropsychiatric field.

• Journal of Nutrition and Health
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• 제36권8호
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• pp.851-858
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• 2003

Sister chromatid exchange (SCE) has recently become a common cytogenic assay system for detecting exposure to chemical mutagens and carcinogens. One application of SCE is the monitoring of populations believed to have been exposed to such agents. A cross-sectional study of SCE frequency in peripheral blood lymphocytes from 45 Koreans aged 61 to 84 years was conducted. The effect of cigarette smoking and age on SCE was assessed by different degrees of smoking status such as smokers (n = 14), ex-smokers (n = 16) and non-smokers (n = 15). Mean spontaneous SCE per cell for the smokers (11.5 $\pm$ 1.1) was significantly higher (p < 0.05) than that for the non-smokers (8.8 $\pm$ 0.3). However, mean SCE frequencies per cell for the ex-smokers (10.3 $\pm$ 0.6) were not significantly different from those of the smokers or the non-smokers. The smokers showed an increased number of high SCE frequency cells (HFCs) when compared to the ex-smokers and non-smokers (p < 0.05). The mean SCE frequencies of the non-smokers showed a statistically significant increase (p < 0.05) with the subject's age. These results show that age and smoking habits contribute a great deal in setting a higher degree of basal DNA damage in elderly Koreans, and smoking appeared to be a more significant damaging factor than age.

• International Journal of Advanced Culture Technology
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• 제8권3호
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• pp.54-60
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• 2020

Online cybercrime has various causes. The criminal guilty language, Criminal lingo is active in the shaded area with the bilateral aspect of the word on cyber. It has been continuously producing massive risk factors in cyberspace. Criminals are shared and disseminated online. It has been linked with fake news and aids to suicide that has recently become an issue. Thus the criminal lingo has become a real danger factor on cyber interface. Recently, Criminal lingo is shared and distributed as cyber hazard information. It is transformed that damaging to the youth and ordinary people through the internet and social networks. In order to take action, it is necessary to construct an expert system based on AI to implement a smart management architecture with block-chain technology. In this paper, we study technically a new smart management architecture which uses artificial intelligence based decision algorithm and block-chain tracking technology to prevent the spread of criminal lingo factors in the evolving cyber world. In addition, through the off-line regular patrol program of police units, we proposed the conversion of online regular patrol program for "cyber harem area".

• BMB Reports
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• 제44권3호
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• pp.211-216
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• 2011

Vitamin C (VC) is an important antioxidant and enzyme co-factor that works by stimulating the immune system and protecting against infections. It is well known that melanoma cells are more susceptible to VC than any other tumor cells. However, the role of VC in the treatment of colon cancer has not been studied. Cisplatin (CDDP) is a DNA damaging agent and is widely used for treating cancer, while the role of p53 in CDDP-induced cell death has been stressed. Using cell growth assays, morphological methods, Western blotting, flow cytometry, and DNA fragmentation analysis, we measured the expression of p53 level involved in the effect of VC on CDDP-induced apoptosis of HCT116, a human colon cancer cell line. CDDP plus VC treatment resulted in significantly increased apoptosis along with upregulation of p53 compared to untreated cells and/or CDDP-treated cells. These results suggest that VC enhanced CDDP sensitivity and apoptosis via upregulation of p53.

• The Journal of Asian Finance, Economics and Business
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• 제5권4호
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• pp.67-72
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• 2018

The purpose of this study is to investigate the effect of quality of management discussion and analysis (MD&A) disclosure on stock price crash risk. The MD&A can be seen to reflect the management's intention on public announcement and reveals directly what the management says to communicate with outside investors. A firm's high-quality MD&A implies the management's commitment to communicating with the market, not allowing the managers to have incentives to hoard unfavorable news, which if revealed to the public, may lead to downward stock price corrections, damaging corporate values. The high-quality MD&A is, thus, likely to reduce the stock price crash risk. We use a logistic regression to test whether MD&A influences crash risk using listed companies in the Korean Stock Exchange (KSE) stock market between 2010 and 2013. Findings of the empirical test show that the higher the quality of MD&A, the less likely crash risk appears, implying that the MD&A disclosed adequately can be one of the factors mitigating firm's stock price crash risk. This study has implications as it presents the MD&A disclosure as a factor influencing stock price crash risk and suggests voluntary disclosure as well as mandatory disclosure acts as a variable that explains the risk of stock price crash.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2014년도 추계학술대회 논문집
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• pp.273-276
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• 2014

The development of a vehicle-mounted radar to detect the location of enemy artillery is mainly mounted during operation to the mobility of the equipment and efficiency of utilization range. It is equipped with an electronic device responsible for the operation of the radar system. Electronic equipments is performed functionality imparted without an error-specific in spite of disturbances such as vibration / shock caused by vehicle movement. Therefore, vibration / shock resistance is held to prevent damaging from vibration / shock generated from the outside environment during operation. In addition, a standardized and specified cabinet structure equipped with electronic equipment is placed in shelter to ensure additional safety for vibration / shock. In this study, it is evaluated by analytical method with vibration / shock resistance of the cabinet structures for ensuring structural safety factor is applied to the aluminum. It is verified the reliability of the structure and structural dynamics to verify by calculated natural frequencies adding the weight of the cabinet structure and the structural displacement and stress results confirmed with vibration / shock caused by the vehicle movement.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2003년도 추계학술발표논문집 (하)
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• pp.2021-2024
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• 2003

Information security is becoming a more important factor in distribution of digital contents. Generally, illegal facsimile of high-quality multimedia products such as DVDs, MP3s and AACs is possible without damaging quality. Thus, the illegal distribution of duplicated contents on the Web is causing digital content providers great economic loss. Therefore, a study of security and efficient distribution of digital contents is required. The most important issues in the design of a digital content distribution system are user convenience, execution speed and security. In this study, we designed a digital contents distribution system that uses web caching technology and encryption/decryption techniques in hierarchical structures. We propose a digital content distribution system that improves user convenience, security and execution speed. The superior performance of the proposed system has been proven in the tests. The results of experiment show that the developed system has improved the security of DC without decreasing process speed.

• 한방안이비인후피부과학회지
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• 제17권2호
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• pp.59-71
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• 2004

Melanin pigmentation has an essential role in protecting human skin against the damaging effects of ultra violet radiation, infection, environmental factor, etc. However abnormal melanin pigmentation can directly cause a number of congenital and acquired pigmentary skin disease. This study conducted to evaluate the effects of various partition extracts of Codonopsis lanceolata on the melanogenesis in the B 16 melanoma cells. The cells were treated for 3 days with various partition extracts of Codonopsis lanceolata. While treatment with the BuOH partition extract of Codonopsis lanceolata increased significantly the tyrosinase activity and melanin content, the n-Hexane or ethyl acetate partition extract dose-dependently suppressed them compared with untreated control. But ethyl acetate partition significantly decreased the cell viability. The H2O partiton extract at various concentrations did not exhibit any significant change on the melanogenesis. These results indicate that treatment with the n-Hexane partition extract inhibits the melanogenesis in B16 melanoma cells, and raise the possibility that this extract may be effective in the abnormal melanin pigmentation as well as the whitening agent for the skin.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2012년도 학술발표회
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• pp.381-381
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• 2012

가뭄은 이수에 영향을 주는 피해 중 가장 대표적인 예라고 할 수 있다. 가뭄은 장기간에 걸쳐서 강수량이 부족하거나, 지속적인 일사량의 증가로 인하여 수문학적 물 균형이 깨어져서 물 부족 현상이 발생하는 것을 의미한다. 우리나라는 2001년에 기상관측 이래 때 이른 무더위와 극심한 가뭄으로 강원도지역을 중심으로 전국적인 피해를 입었다. 미국 해양기상청(NOAA, National Oceanic and Atmospheric Administration)에서는 20세기 최대의 자연재해 중 5위권내에 가뭄으로 인한 재해가 무려 4개나 랭크된바 있다. 하지만 우리나라에서는 홍수 등에 대비해서는 수해방지종합대책등 사전대책을 마련하여 방지대책을 세우지만, 가뭄에 대해서는 종합적인 사전예방대책보다는 복구 위주로 진행되고 있다. 이로 인해 가뭄으로 인한 피해상황 및 피해유발인자의 파악이 어렵고 객관적으로 표현할 수 있는 지표도 명확하지 않기 때문에 이에 대한 체계적인 연구가 시급한 실정이다(이주헌과 이길재, 2006). 본 연구에서는 가뭄으로 인한 피해유발인자를 파악하기 위하여 UNDP(United Nations Development Programme, 2004)에서 제공하는 물리적 노출(Physical Exposure)정도를 1990년~2007년간의 유역별 월강수량 자료를 이용하여 가뭄의 발생 빈도별로 산정한 후에 가뭄으로 인한 농작물피해 및 제한급수에 영향을 미치는 인자들에 대하여 분석을 실시하였다.