• Earthquakes and Structures
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• v.10 no.2
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• pp.367-388
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• 2016

Eccentrically braced frames (EBFs) represent an attractive lateral load resisting steel system to be used in areas of high seismicity. In order to assess the likely damage for a given intensity of ground shaking, fragility functions can be used to identify the probability of exceeding a certain damage limit-state, given a certain response of a structure. This paper focuses on developing a set of fragility functions for EBF structures, considering that damage can be directly linked to the interstorey drift demand at each storey. This is done by performing a Monte Carlo Simulation of an analytical expression for the drift capacity of an EBF, where each term of the expression relies on either experimental testing results or mechanics-based reasoning. The analysis provides a set of fragility functions that can be used for three damage limit-states: concrete slab repair, damage requiring heat straightening of the link and damage requiring link replacement. Depending on the level of detail known about the EBF structure, in terms of its link section size, link length and storey number within a structure, the resulting fragility function can be refined and its associated dispersion reduced. This is done by using an analytical expression to estimate the median value of interstorey drift, which can be used in conjunction with an informed assumption of dispersion, or alternatively by using a MATLAB based tool that calculates the median and dispersion for each damage limit-state for a given set of user specified inputs about the EBF. However, a set of general fragility functions is also provided to enable quick assessment of the seismic performance of EBF structures at a regional scale.

• International Journal of Naval Architecture and Ocean Engineering
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• v.10 no.1
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• pp.9-20
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• 2018

Due to integrated stochastic wind and wave loads, the supporting platform of a Floating Offshore Wind Turbine (FOWT) has to bear six Degrees of Freedom (DOF) motion, which makes the random cyclic loads acting on the structural components, for instance the tower base, more complicated than those on bottom-fixed or land-based wind turbines. These cyclic loads may cause unexpected fatigue damages on a FOWT. This paper presents a study on short-term fatigue damage at the tower base of a 5 MW FOWT with a spar-type platform. Fully coupled time-domain simulations code FAST is used and realistic environment conditions are considered to obtain the loads and structural stresses at the tower base. Then the cumulative fatigue damage is calculated based on rainflow counting method and Miner's rule. Moreover, the effects of the simulation length, the wind-wave misalignment, the wind-only condition and the wave-only condition on the fatigue damage are investigated. It is found that the wind and wave induced loads affect the tower base's axial stress separately and in a decoupled way, and the wave-induced fatigue damage is greater than that induced by the wind loads. Under the environment conditions with rated wind speed, the tower base experiences the highest fatigue damage when the joint probability of the wind and wave is included in the calculation. Moreover, it is also found that 1 h simulation length is sufficient to give an appropriate fatigue damage estimated life for FOWT.

• Nuclear Engineering and Technology
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• v.55 no.6
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• pp.2053-2068
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• 2023

Following a loss of coolant accident (LOCA), prestressing concrete containment vessels (PCCVs) may experience high thermal load as well as internal pressure. The high temperature stress would increase the risk of premature damage to the containment, which reduces the safety margin during the increasing internal pressure. However, current investigations cannot clearly address the issues of thermal-pressure coupling effect on damage propagation and thus safety of the containment. Thus, this paper offers three simple and powerful damage parameters to differentiate the severity of damage of the containment. Moreover, despite of the temperature action severely threatening the pressure performance of the containment, the research regarding the improvement of the resistant performance of the containment is quite scarce. Therefore, in this paper, a comprehensive comparison of damage propagation and mechanism between conventional and fiber-reinforced concrete (FRC) containments is performed. The effects of fiber characteristics parameters on damage propagation of structures following the LOCA are also specifically revealed. It is found that the proposed damage indices can properly indicate state of damage in the containment body and the addition of fiber can be used to obviously mitigate the damage propagation in PCCV considering the thermal-pressure coupling.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5941-5948
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• 2013

Tumor response to antineoplastic drugs is not always predictable. This is also true for bladder carcinoma, a highly recurrent neoplasia. Currently, the combination of cisplatin and gemcitabine is well accepted as a standard protocol for treating bladder carcinoma. However, in some cases, this treatment protocol causes harmful side effects. Therefore, we investigated the roles of the genes TP53, RASSF1A (a tumor suppressor gene) and hMLH1 (a gene involved in the mismatch repair pathway) in cell susceptibility to cisplatin/gemcitabine treatment. Two bladder transitional carcinoma cell (TCC) lines, RT4 (wild-type TP53) and 5637 (mutated TP53), were used in this study. First, we evaluated whether the genotoxic potential of cisplatin/gemcitabine was dependent on TP53 status. Then, we evaluated whether the two antineoplastic drugs modulated RASSF1A and hMLH1 expression in the two cell lines. Increased DNA damage was observed in both cell lines after treatment with cisplatin or gemcitabine and with the two drugs simultaneously, as depicted by the comet assay. A lack of RASSF1A expression and hypermethylation of its promoter were observed before and after treatment in both cell lines. On the other hand, hMLH1 downregulation, unrelated to methylation status, was observed in RT4 cells after treatment with cisplatin or with cisplatin and gemcitabine simultaneously (wild-type TP53); in 5637 cells, hMLH1 was upregulated only after treatment with gemcitabine. In conclusion, the three treatment protocols were genotoxic, independent of TP53 status. However, cisplatin was the most effective, causing the highest level of DNA damage in both wild-type and mutated TP53 cells. Gemcitabine was the least genotoxic agent in both cell lines. Furthermore, no relationship was observed between the amount of DNA damage and the level of hMLH1 and RASSF1A expression. Therefore, other alternative pathways might be involved in cisplatin and gemcitabine genotoxicity in these two bladder cancer cell lines.

• Journal of the Earthquake Engineering Society of Korea
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• v.22 no.5
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• pp.271-280
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• 2018

This paper presents a framework for developing aftershock fragility curves for reinforced concrete bridges initially damaged by mainshocks. The presented aftershock fragility is a damage-dependent fragility function, which is conditioned on an initial damage state resulting from mainshocks. The presented framework can capture the cumulative damage of as-built bridges due to mainshock-aftershock sequences as well as the reduced vulnerability of bridges repaired with CFRP pier jackets. To achieve this goal, the numerical model of column jackets is firstly presented and then validated using existing experimental data available in literature. A four-span concrete box-girder bridge is selected as a case study to examine the application of the presented framework. The aftershock fragility curves are derived using response data from back-to-back nonlinear dynamic analyses under mainshock-aftershock sequences. The aftershock fragility curves for as-built bridge columns are firstly compared with different levels of initial damage state, and then the post-repair effect of FRP pier jacket is examined through the comparison of aftershock fragility curves for as-built and repaired piers.

• Molecules and Cells
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• v.20 no.3
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• pp.331-338
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• 2005

Ionizing radiation and doxorubicin both produce oxidative damage and double-strand breaks in DNA. Double-strand breaks and oxidative damage are highly toxic and cause cell cycle arrest, provoking DNA repair and apoptosis in cancer cell lines. To investigate the response of normal human cells to agents causing oxidative damage, we monitored alterations in gene expression in F65 normal human fibroblasts. Treatment with ${\gamma}$-irradiation and doxorubicin altered the expression of 23 and 68 known genes, respectively, with no genes in common. Both agents altered the expression of genes involved in cell cycle arrest, and arrested the treated cells in $G_2M$ phase 12 h after treatment. 24 h after ${\gamma}$-irradiation, the percentage of $G_1$ cells increased, whereas after doxorubicin treatment the percentage of $G_2M$ cells remained constant for 24 h. Our results suggest that F65 cells respond differently to ${\gamma}$-irradiation- and doxorubicin-induced DNA damage, probably using entirely different biochemical pathways.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.10 no.6
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• pp.63-69
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• 2011

This study analyzes stress, fatigue and vibration on main rotor and body of helicopter. The maximum stress is shown on adjoint part between body and main rotor at the lower position of main rotor. As the maximum displacement amplitude is happened at 4000Hz, there is no resonance and the state of helicopter becomes safe at hovering without the abnormal air current and the disabled rotor. Among the cases of nonuniform fatigue loads, 'SAE bracket history' with the severest change of load becomes most unstable but 'Sample history' becomes most stable. In case of 'Sample History' with the average stress of 0MPa to $-10^5MPa$ and the amplitude stress of 0MPa to $8.539{\times}10^5MPa$, the possibility of maximum damage becomes 3%. This stress state can be shown with 5 times more than the damage possibility of 'SAE bracket history' or 'SAE transmission'. The structural result of this study by using the analysis of vibration and fatigue can be effectively utilized for safe and durable design of helicopter.

• Journal of the Society of Disaster Information
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• v.11 no.3
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• pp.406-412
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• 2015

Recently, frequent earthquakes can cause serious damage to the bridge. So newly constructed bridge is considered earthquake resistant design, and for the existing old bridge evaluation of damage state is needed. In this paper, replacement of US-artificial earthquakes which are used for the construction of fragility curve for evaluating damage state to Korean artificial earthquakes to meet the Korean specifications is studied. For the generation of artificial earthquakes, the fragility curves are constructed for the PGA, for the cases of having isolated bearing and not having that.

• Tribology and Lubricants
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• v.25 no.1
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• pp.56-60
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• 2009

A journal bearing is used in a hydrodynamic lubrication state, but it becomes a boundary lubrication state that asperity of a contact part touch each other when pressure is too high and an enough oil film is not formed by viscosity change due to lubricating oil temperature. At this time, abrasion due to contact between a journal and a bearing is unavoidable, and scuffing damage that the journal adheres to the bearing occurs if the process is repeated. Damage of the journal bearing is an important problem because it gives huge damage to a machine and can generate large accidents such as economic loss and human life damage. In this study, method for using the pull-up resistor concept was introduced as the monitoring technology. This monitoring system is important to enhance reliability of the engine.

• Smart Structures and Systems
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• v.23 no.2
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• pp.195-205
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• 2019

An accurate non-model-based method for delamination identification of laminated composite plates is proposed in this work. A weighted mode shape damage index is formulated using squared weighted difference between a measured mode shape of a composite plate with delamination and one from a polynomial that fits the measured mode shape of the composite plate with a proper order. Weighted mode shape damage indices associated with at least two measured mode shapes of the same mode are synthesized to formulate a synthetic mode shape damage index to exclude some false positive identification results due to measurement noise and error. An auxiliary mode shape damage index is proposed to further assist delamination identification, by which some false negative identification results can be excluded and edges of a delamination area can be accurately and completely identified. Both numerical and experimental examples are presented to investigate effectiveness of the proposed method, and it is shown that edges of a delamination area in composite plates can be accurately and completely identified when measured mode shapes are contaminated by measurement noise and error. In the experimental example, identification results of a composite plate with delamination from the proposed method are validated by its C-scan image.