• Journal of Nutrition and Health
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• v.44 no.5
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• pp.366-377
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• 2011

Glutathione S-transferase (GST) is a multigene family of phase II detoxifying enzymes that metabolize a wide range of exogenous and endogenous electrophilic compounds. GSTM1 and GSTT1 gene polymorphisms may account for inter-individual variability in coping with oxidative stress. We investigated the relationships between the level of lymphocyte DNA and antioxidative parameters and the effect on GST genotypes. GSTM1 and GSTT1 were characterized in 301 young healthy Korean adults and compared with oxidative stress parameters such as the level of lymphocyte DNA, plasma antioxidant vitamins, and erythrocyte antioxidant enzymes in smokers and non smokers. GST genotype, degree of DNA damage in lymphocytes, erythrocyte activities of superoxide dismutase, catalase, and glutathione peroxidase (GSH-Px), and plasma concentrations of total radical-trapping antioxidant potential (TRAP), vitamin C, ${\alpha}$- and ${\gamma}$-tocopherol, ${\alpha}$- and ${\beta}$-carotene, and cryptoxanthin were analyzed. Lymphocyte DNA damage assessed by the comet assay was higher in smokers than that in non-smokers, but the levels of plasma vitamin C, ${\beta}$-carotene, TRAP, erythrocyte catalase, and GSH-Px were lower than those of non-smokers (p < 0.05). Lymphocyte DNA damage was higher in subjects with the GSTM1- or GSTT1-present genotype than those with the GSTM1-present or GSTT1- genotype. No difference in erythrocyte antioxidant enzyme activities, plasma TRAP, or vitamin levels was observed in subjects with the GSTM1 or GSTT1 genotypes, except ${\beta}$-carotene. Significant negative correlations were observed between lymphocyte DNA damage and plasma levels of TRAP and erythrocyte activities of catalase and GSH-Px after adjusting for smoking pack-years. Negative correlations were observed between plasma vitamin C and lymphocyte DNA damage only in individuals with the GSTM1-present or GSTT1- genotype. The interesting finding was the significant positive correlations between lymphocyte DNA damage and plasma levels of ${\alpha}$-carotene, ${\beta}$-carotene, and cryptoxanthin. In conclusion, the GSTM1- and GSTT1-present genotypes as well as smoking aggravated antioxidant status through lymphocyte DNA damage. This finding confirms that GST polymorphisms could be important determinants of antioxidant status in young smoking and non-smoking adults. Consequently, the protective effect of supplemental antioxidants on DNA damage in individuals carrying the GSTM1- or GSTT1-present genotypes might show significantly higher values than expected.

• Earthquakes and Structures
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• v.15 no.5
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• pp.463-471
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• 2018

The virtual forces of the original local flexibility method are restricted to inducing stress on the local parts of a structure. To circumvent this restriction, we developed a pseudo local flexibility (PLFM) method that can successfully detect damage to hyperstatic beam structures using fewer modes. For this study, we further developed the PLFM so that it could detect damage in plate structures. We also devised the theoretical background for the PLFM with non-local virtual forces for plate structures, and both the lateral and rotary degree of freedom (DOF) measurements were considered separately. This study investigates the effects of the number of modes, the actual location that sustained damage, multiple damage locations, and noise in modal parameters for the damage detection results obtained from damaged numerical plates. The results revealed that the PLFM can be used for damage detection, localization, and quantification for plate structures, regardless of the use of the lateral DOF and/or rotary DOF.

• Journal of Korean Society of Steel Construction
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• v.9 no.1 s.30
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• pp.95-105
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• 1997

Structures subjected to strong seismic excitation may undergo inelastic deformation cycles. The resulting cumulative fatigue damage process reduces the ability of structures and components to withstand seismic loads. Yet, the present earthquake resistance design methods focus mainly on the maximum displacement ductility, ignoring the effect of the cyclic responses. The damage parameters closely related to the cumulative damage need to be properly reflected on the aseismic design methods. In this study, two cumulative damage assessment methods derived from the plastic fatigue theory are investigated. The one is based on the hysteretic ductility amplitude, and the other is based on the dissipated hysteretic energy. Both methods can consider the maximum ductility and the cyclic behavior of structural response. The validity of two damage methods has been examined for single degree of freedom structures with various natural frequencies against two different earthquake excitations.

• Structural Engineering and Mechanics
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• v.33 no.6
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• pp.657-674
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• 2009

In this paper a 3-D continuum damage mechanics formulation for composite laminates and its implementation into a finite element model that is based on the layer-wise laminate plate theory are described. In the damage formulation, each composite ply is treated as a homogeneous orthotropic material exhibiting orthotropic damage in the form of distributed microscopic cracks that are normal to the three principal material directions. The progressive damage of different angle ply composite laminates under quasi-static loading that exhibit the free edge effects are investigated. The effects of various numerical modeling parameters on the progressive damage response are investigated. It will be shown that the dominant damage mechanism in the lay-ups of [+30/-30]s and [+45/-45]s is matrix cracking. However, the lay-up of [+15/-15] may be delaminated in the vicinity of the edges and at $+{\theta}/-{\theta}$ layers interfaces.

• Structural Engineering and Mechanics
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• v.33 no.3
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• pp.325-337
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• 2009

Structural damage detection, damage localization and severity estimation of jacket platforms, based on calculating modal strain energy is presented in this paper. In the structure, damage often causes a loss of stiffness in some elements, so modal parameters; mode shapes and natural frequencies, in the damaged structure are different from the undamaged state. Geometrical location of damage is detected by computing modal strain energy change ratio (MSECR) for each structural element, which elements with higher MSECR are suspected to be damaged. For each suspected damaged element, by computing cross-modal strain energy (CMSE), damage severity as the stiffness reduction factor -that represented the ratios between the element stiffness changes to the undamaged element stiffness- is estimated. Numerical studies are demonstrated for a three dimensional, single bay, four stories frame of the existing jacket platform, based on the synthetic data that generated from finite element model. It is observed that this method can be used for damage detection of this kind of structures.

• Journal of the Korean Society of Hazard Mitigation
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• v.5 no.2 s.17
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• pp.9-16
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• 2005

This paper presents the use of an Artificial Neural Network (ANN) as a viable means of forecasting Inundation Damage Area (IDA) in many watersheds. In order to develop the forecasting model with various environmental factors, we selected 108 watershed areas in South Korea and collected 49 damage data sets from 1990 to 2000, of which each set is composed of 27 parameters including the IDA, rainfall amount, and land use. After successful training processes of the ANN, a good agreement (R=0.92) is obtained (under present conditions) between the measured values of the IDA and those predicted by the developed ANN using the remaining 26 data sets as input parameters. The results indicate that the inundation damage is affected by not only meteorological information such as the rainfall amount, but also various environmental characteristics of the watersheds. So, the ANN proves its present ability to predict the IDA caused by an event of complex factors in a specific watershed area using accumulated temporal-spatial information, and it also shows a potential capability to handle complex non-linear dynamic phenomena of environmental changes. In this light, the ANN can be further harnessed to estimate the importance of certain input parameters to an output (e.g., the IDA in this study), quantify the significance of parameters involved in pre-existing models, and contribute to the presumption, selection, and calibration of input parameters of conventional models.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.275-275
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• 2022

Tsunamis triggered by undersea earthquakes have the characteristic of longer wavelengths and can propagate a very long distance. Although the occurrence frequency of tsunami is low, it can cause casualties and properties. Historically, tsunamis that occurred on the western coast of Japan attacked the eastern coast of the Korean Peninsula and damaged the property and the loss of human life in 1983 and 1993. By tsunami in 1983 especially, 2 people were killed, and more than 200 casualties occurred. In addition, it caused 2 million dollars in property damage at Imwon Port. In 2011, The eastern cities of Japan: Iwate, Miyagi, Ibaraki, and Fukushima were damaged by a tsunami that occurred near onshore along the Pacific ocean and caused more than 300 billion dollars in property damage, and 20,000 casualties occurred. Moreover, those provoked nuclear power plant meltdown at Fukushima. In this study, it was carried out a relationship between maximum tsunami heights and fault parameters of earthquake: strike angle, dip angle, and slip angle at Imwon port. Those fault parameters are known that it does not relate to the magnitude of earthquake directly. Virtual tsunamis, which could be triggered by probable undersea earthquakes in the future, were investigated and mutual information based on probability and information theory was introduced to figure out the relationship between maximum tsunami height and fault parameters. Fault parameters were evaluated according to the strong relationship with maximum tsunami heights finally.

• Journal of the Korean Society for Nondestructive Testing
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• v.19 no.6
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• pp.439-447
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• 1999

One of the problems for practical use of fiber-reinforced plastics is the performance degradation by fatigue damage in the joints. The study is to develop a nondestructive technique for real-time evaluation of adhesively bonded composite-metal joints. From the prior study we confirmed that the bonding strength can be estimated from the correlation between the qualify of bonded parts and AUP's. We obtained a curve showing the correlation between the degree of fatigue damage and AUP's calculated from signals acquired during fatigue loading of single-lap and double-lap joints of CFRP and Al6061. The curve is an analogy to the one showing stiffness reduction ($E/E_o$) of polymer matrix composites by fatigue damage. From those facts, it is plausible to predict the degree of fatigue damage in real-time. Amplitude and AUP2 appeared to be optimal parameters to provide more reliable results for single-lap joints whereas Amplitude and AUP2 did for double-lap joints. It is recommended to select optimal parameters for different geometries in the application for real structures.

• The Korean Journal of Food And Nutrition
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• v.31 no.6
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• pp.828-835
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• 2018

The objective of this study was to examine the biochemical parameters of hepatic function such as serum level of ALT (alanine aminotransferase), AST (aspartate aminotransferase), ALP (alkaline phosphatase), LDH (lactate dehydrogenase), and content of TG (triglyceride) and cholesterol, and tissue immunological changes of the $CCl_4$-treated rats with administration of the mixed sample extract (MSE). The liver weight in $CCl_4$-administered experimental control group (EC) was slightly higher than that of normal control (NC) group. Hepatic damage parameters (ALT, AST, ALP, LDH & TG) in serum of the EC group were significantly higher than those in serum of the NC and silymarin-treated positive control (PC) group. On the other hand, these hepatic damage parameters of MSE-treated experimental (E1 & E2) groups were significantly lower than those of EC group. The number of WBC, neutrophils, lymphocytes and platelets, and the contents of hemoglobin, and hematocrit in EC group were significantly higher than those of NC group. However, the number of WBC and lymphocytes in E1 and E2 groups were significantly lower than those of EC group. Also, the collagen developmental areas in the liver of NC and PC groups by hepatic immuno-histological findings were found slightly positive. Whereas, hepatic fibrous developmental tissue of EC group was strongly positive brown color band, those of E1 & E2 groups were decreased. Therefore, it was concluded that the induction of hepatic fibrous tissue activation had a preventive effect of MSE against the $CCl_4$-induced hepatic damage in rats. However, further study is needed in this filed.

• Composites Research
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• v.36 no.1
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• pp.59-67
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• 2023

Damage caused by impact on a vehicle composed of CFRP(carbon fiber reinforced plastic) composite to reduce weight in the aerospace industries is related to the safety of passengers. Therefore, it is important to understand the damage behavior of materials that is invisible in impact situations, and research through the FEM(finite element model) is needed to simulate this. In this study, FEM suitable for predicting damage behavior was constructed for impact analysis of unidirectional laminated composite. The calibration parameters of the MAT_54 Enhanced Composite Damage material model in LS-DYNA were acquired by inverse estimation through ANN(artificial neural network) model. The reliability was verified by comparing the result of experiment with the results of the ANN model for the obtained parameter. It was confirmed that accuracy of FEM can be improved through optimization of calibration parameters.