• Journal of Nutrition and Health
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• 제44권5호
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• pp.366-377
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• 2011

Glutathione S-transferase (GST) is a multigene family of phase II detoxifying enzymes that metabolize a wide range of exogenous and endogenous electrophilic compounds. GSTM1 and GSTT1 gene polymorphisms may account for inter-individual variability in coping with oxidative stress. We investigated the relationships between the level of lymphocyte DNA and antioxidative parameters and the effect on GST genotypes. GSTM1 and GSTT1 were characterized in 301 young healthy Korean adults and compared with oxidative stress parameters such as the level of lymphocyte DNA, plasma antioxidant vitamins, and erythrocyte antioxidant enzymes in smokers and non smokers. GST genotype, degree of DNA damage in lymphocytes, erythrocyte activities of superoxide dismutase, catalase, and glutathione peroxidase (GSH-Px), and plasma concentrations of total radical-trapping antioxidant potential (TRAP), vitamin C, ${\alpha}$- and ${\gamma}$-tocopherol, ${\alpha}$- and ${\beta}$-carotene, and cryptoxanthin were analyzed. Lymphocyte DNA damage assessed by the comet assay was higher in smokers than that in non-smokers, but the levels of plasma vitamin C, ${\beta}$-carotene, TRAP, erythrocyte catalase, and GSH-Px were lower than those of non-smokers (p < 0.05). Lymphocyte DNA damage was higher in subjects with the GSTM1- or GSTT1-present genotype than those with the GSTM1-present or GSTT1- genotype. No difference in erythrocyte antioxidant enzyme activities, plasma TRAP, or vitamin levels was observed in subjects with the GSTM1 or GSTT1 genotypes, except ${\beta}$-carotene. Significant negative correlations were observed between lymphocyte DNA damage and plasma levels of TRAP and erythrocyte activities of catalase and GSH-Px after adjusting for smoking pack-years. Negative correlations were observed between plasma vitamin C and lymphocyte DNA damage only in individuals with the GSTM1-present or GSTT1- genotype. The interesting finding was the significant positive correlations between lymphocyte DNA damage and plasma levels of ${\alpha}$-carotene, ${\beta}$-carotene, and cryptoxanthin. In conclusion, the GSTM1- and GSTT1-present genotypes as well as smoking aggravated antioxidant status through lymphocyte DNA damage. This finding confirms that GST polymorphisms could be important determinants of antioxidant status in young smoking and non-smoking adults. Consequently, the protective effect of supplemental antioxidants on DNA damage in individuals carrying the GSTM1- or GSTT1-present genotypes might show significantly higher values than expected.

• Earthquakes and Structures
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• 제15권5호
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• pp.463-471
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• 2018

The virtual forces of the original local flexibility method are restricted to inducing stress on the local parts of a structure. To circumvent this restriction, we developed a pseudo local flexibility (PLFM) method that can successfully detect damage to hyperstatic beam structures using fewer modes. For this study, we further developed the PLFM so that it could detect damage in plate structures. We also devised the theoretical background for the PLFM with non-local virtual forces for plate structures, and both the lateral and rotary degree of freedom (DOF) measurements were considered separately. This study investigates the effects of the number of modes, the actual location that sustained damage, multiple damage locations, and noise in modal parameters for the damage detection results obtained from damaged numerical plates. The results revealed that the PLFM can be used for damage detection, localization, and quantification for plate structures, regardless of the use of the lateral DOF and/or rotary DOF.

• 한국강구조학회 논문집
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• 제9권1호통권30호
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• pp.95-105
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• 1997

Structures subjected to strong seismic excitation may undergo inelastic deformation cycles. The resulting cumulative fatigue damage process reduces the ability of structures and components to withstand seismic loads. Yet, the present earthquake resistance design methods focus mainly on the maximum displacement ductility, ignoring the effect of the cyclic responses. The damage parameters closely related to the cumulative damage need to be properly reflected on the aseismic design methods. In this study, two cumulative damage assessment methods derived from the plastic fatigue theory are investigated. The one is based on the hysteretic ductility amplitude, and the other is based on the dissipated hysteretic energy. Both methods can consider the maximum ductility and the cyclic behavior of structural response. The validity of two damage methods has been examined for single degree of freedom structures with various natural frequencies against two different earthquake excitations.

• Structural Engineering and Mechanics
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• 제33권6호
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• pp.657-674
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• 2009

In this paper a 3-D continuum damage mechanics formulation for composite laminates and its implementation into a finite element model that is based on the layer-wise laminate plate theory are described. In the damage formulation, each composite ply is treated as a homogeneous orthotropic material exhibiting orthotropic damage in the form of distributed microscopic cracks that are normal to the three principal material directions. The progressive damage of different angle ply composite laminates under quasi-static loading that exhibit the free edge effects are investigated. The effects of various numerical modeling parameters on the progressive damage response are investigated. It will be shown that the dominant damage mechanism in the lay-ups of [+30/-30]s and [+45/-45]s is matrix cracking. However, the lay-up of [+15/-15] may be delaminated in the vicinity of the edges and at $+{\theta}/-{\theta}$ layers interfaces.

• Structural Engineering and Mechanics
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• 제33권3호
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• pp.325-337
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• 2009

Structural damage detection, damage localization and severity estimation of jacket platforms, based on calculating modal strain energy is presented in this paper. In the structure, damage often causes a loss of stiffness in some elements, so modal parameters; mode shapes and natural frequencies, in the damaged structure are different from the undamaged state. Geometrical location of damage is detected by computing modal strain energy change ratio (MSECR) for each structural element, which elements with higher MSECR are suspected to be damaged. For each suspected damaged element, by computing cross-modal strain energy (CMSE), damage severity as the stiffness reduction factor -that represented the ratios between the element stiffness changes to the undamaged element stiffness- is estimated. Numerical studies are demonstrated for a three dimensional, single bay, four stories frame of the existing jacket platform, based on the synthetic data that generated from finite element model. It is observed that this method can be used for damage detection of this kind of structures.

• 한국방재학회 논문집
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• 제5권2호
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• pp.9-16
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• 2005

본 논문에서는 유역 내 침수피해를 예측할 수 있는 실현가능한 수단으로써 인공신경망의 활용에 대해 제안하고자 한다. 유역 내 다양한 환경인자에 의한 침수피해 예측모형의 구축을 위해 108개 중유역을 대상으로 1990년부터 2000년까지 강우량, 침수피해면적, 토지이용 등 총 27개의 매개변수를 선정하여 총 49개의 데이터 세트를 구성하였다. 연구결과, 침수피해는 강우량과 같은 기상정보 뿐 만 아니라 다양한 유역환경의 특성에 영향을 받는 것으로 나타났으며 인공신경망 모형에 의해 R=0.92 수준에서 예측값과 관측값이 잘 일치하는 것으로 나타났다. 따라서 인공신경망은 입력값들과 대응된 출력값들을 알고 있는 경우 과거와 현재의 시공간 정보를 활용하여 특정유역의 강우량에 따른 침수피해면적을 산정 할 수 있으며, 복잡하고 비선형적 역동성을 지니고 있는 유역 내 환경변화에 대한 예측모형으로 활용이 가능하다고 판단된다. 또한 인공신경망은 입력자료의 중요도를 평가하는데 이용될 수 있으며, 기존 모형에서 다루어지는 매개변수중요도를 정량화 시킬 수 있어 다른 모형의 매개변수 추정이나 보정에 도움을 줄 수 있을 것으로 판단된다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2022년도 학술발표회
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• pp.275-275
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• 2022

Tsunamis triggered by undersea earthquakes have the characteristic of longer wavelengths and can propagate a very long distance. Although the occurrence frequency of tsunami is low, it can cause casualties and properties. Historically, tsunamis that occurred on the western coast of Japan attacked the eastern coast of the Korean Peninsula and damaged the property and the loss of human life in 1983 and 1993. By tsunami in 1983 especially, 2 people were killed, and more than 200 casualties occurred. In addition, it caused 2 million dollars in property damage at Imwon Port. In 2011, The eastern cities of Japan: Iwate, Miyagi, Ibaraki, and Fukushima were damaged by a tsunami that occurred near onshore along the Pacific ocean and caused more than 300 billion dollars in property damage, and 20,000 casualties occurred. Moreover, those provoked nuclear power plant meltdown at Fukushima. In this study, it was carried out a relationship between maximum tsunami heights and fault parameters of earthquake: strike angle, dip angle, and slip angle at Imwon port. Those fault parameters are known that it does not relate to the magnitude of earthquake directly. Virtual tsunamis, which could be triggered by probable undersea earthquakes in the future, were investigated and mutual information based on probability and information theory was introduced to figure out the relationship between maximum tsunami height and fault parameters. Fault parameters were evaluated according to the strong relationship with maximum tsunami heights finally.

• 비파괴검사학회지
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• 제19권6호
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• pp.439-447
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• 1999

복합재료-금속 접착접합부가 사용 중 반복하중을 받을 때 발생하는 피로손상을 실시간에 평가할 수 있는 기법으로 음향초음파(acousto-ultrasonics; AU)법을 채택하였으며, 피로시험 중의 단일겹치기(single-lap) 및 이중겹치기 (double-lap) 평판형 시험편에서 취득한 신호로부터 계산된 음향초음파변수(acousto-ultrasonic parameters: AUP)와 피로손상도 사이의 상관관계를 나타내는 곡선을 얻을 수 있었다. 곡선은 피로손상에 의한 고분자기지 복합재료의 강성율 저하($E/E_o$)를 나타내는 곡선과 매우 유사하며, 이를 바탕으로 피로손상도의 실시간 예측이 가능하다. 다만 단일겹치기 시험편의 경우에는 Amplitude와 AUP2를, 이중겹치기 시험편의 경우에는 Amplitude와 AUP1을 기준 변수로 채택할 때 보다 일관성 있는 결과를 얻고 있는 점으로부터 실제 구조물에 적용함에 있어서는 각각의 형상에 따른 최적변수를 선택하여 활용해야 할 것으로 사료된다.

• 한국식품영양학회지
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• 제31권6호
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• pp.828-835
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• 2018

The objective of this study was to examine the biochemical parameters of hepatic function such as serum level of ALT (alanine aminotransferase), AST (aspartate aminotransferase), ALP (alkaline phosphatase), LDH (lactate dehydrogenase), and content of TG (triglyceride) and cholesterol, and tissue immunological changes of the $CCl_4$-treated rats with administration of the mixed sample extract (MSE). The liver weight in $CCl_4$-administered experimental control group (EC) was slightly higher than that of normal control (NC) group. Hepatic damage parameters (ALT, AST, ALP, LDH & TG) in serum of the EC group were significantly higher than those in serum of the NC and silymarin-treated positive control (PC) group. On the other hand, these hepatic damage parameters of MSE-treated experimental (E1 & E2) groups were significantly lower than those of EC group. The number of WBC, neutrophils, lymphocytes and platelets, and the contents of hemoglobin, and hematocrit in EC group were significantly higher than those of NC group. However, the number of WBC and lymphocytes in E1 and E2 groups were significantly lower than those of EC group. Also, the collagen developmental areas in the liver of NC and PC groups by hepatic immuno-histological findings were found slightly positive. Whereas, hepatic fibrous developmental tissue of EC group was strongly positive brown color band, those of E1 & E2 groups were decreased. Therefore, it was concluded that the induction of hepatic fibrous tissue activation had a preventive effect of MSE against the $CCl_4$-induced hepatic damage in rats. However, further study is needed in this filed.

• Composites Research
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• 제36권1호
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• pp.59-67
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• 2023

항공우주산업에서 경량화를 위해 사용되는 CFRP 복합재료로 구성된 차체의 충격에 따른 파손은 탑승자의 안전과 직결된다. 따라서 충돌 상황에서 육안으로 확인하기 힘든 재료의 손상거동을 파악하는 것이 중요하며, 이를 구현할 수 있는 유한요소모델을 통한 연구가 필요하다. 본 연구에서는 일방향 적층 복합재료의 충돌 해석에 대해 파손 거동 예측에 적합한 유한요소모델을 구축하였다. 인공신경망 모델을 통해 LS-DYNA에서 제공하는 MAT_54 Enhanced Composite Damage 재료 모델의 교정 파라미터를 역추정하여 획득하였다. 획득한 파라미터에 대한 인공신경망 모델의 결과를 실험결과와 비교하여 신뢰성을 검증하였다. 그 결과, 교정 파라미터의 최적화를 통해 실험에 대한 정확도를 향상시킨 유한요소모델을 구축할 수 있음을 확인하였다.