• Biomolecules & Therapeutics
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• 제32권5호
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• pp.640-646
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• 2024

Hair growth cycles are mainly regulated by human dermal papilla cells (hDPCs) and human outer root sheath cells (hORSCs). Protecting hDPCs from excessive oxidative stress and hORSCs from glycogen phosphorylase (PYGL) is crucial to maintaining the hair growth phase, anagen. In this study, we developed a new PYGL inhibitor, hydroxytrimethylpyridinyl methylindolecarboxamide (HTPI) and assessed its potential to prevent hair loss. HTPI reduced oxidative damage, preventing cell death and restored decreased level of anagen marker ALP and its related genes induced by hydrogen peroxide in hDPCs. Moreover, HTPI inhibited glycogen degradation and induced cell survival under glucose starvation in hORSCs. In ex-vivo culture, HTPI significantly enhanced hair growth compared to the control with minoxidil showing comparable results. Overall, these findings suggest that HTPI has significant potential as a therapeutic agent for the prevention and treatment of hair loss.

• 패션비즈니스
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• 제12권6호
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• pp.1-10
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• 2008

Public interest in healthy hairs gets growing as damaged hairs are seen more frequently with the generalization of heat permanent waves. For this study, experiments have been conducted to understand the influences on the changes in physical and morphological features of wave forms and damaged hairs, by collecting virgin hairs from the women in their mid-20's, who had not experienced chemical applications, and by dividing the applications of heat perm hair treatments, PPT(for pre-treatment) and LPP(for post-treatment), into the pre-treatment, the post-treatment, the pre & post-treatment, and the non-treatment. For the wave formations, curl waves were investigated by the bare eyes using the pictures taken by a digital camera. For the comparison of physical features, the experiments of tensile strength and elongation were done and their mean values were found. For the observations of morphological features, the pictures were taken by SEM for comparison. As for the findings, regarding the curl wave shapes of hairs, the most even and elastic S curl was formed in the case of non-treatment. In the physical features, both of the tensile strength and elongation showed a decreasing tendency in line with the hair damage levels, and the case of the pre & post-treatment indicated the tendency most similar to the control group. In the morphological features of the cuticle, observed with an SEM, the pre-treatment showed the higher possibility of reducing the cuticle damages than the post-treatment did. LPP was found to play the role of protective membrane for the post-treatment, and the pre & post-treatment turned out to reduce most effectively the cuticle damages.

• 한국응용과학기술학회지
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• 제39권3호
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• pp.471-478
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• 2022

본 연구는 손상된 모발의 개선 효과를 알기 위해 바바수오일을 첨가한 모질 개선 제형제를 제조 후 손상된 모발에 도포하여 실험 하였다. 실험 원료로 바바수오일 함량을 0 g, 3 g, 6 g, 9 g 으로 다르게 하여 펌 베이스제에 첨가하였다. 제조한 제형제로 8레벨의 탈색한 시료 모발에 도포하여 각 시료와 손상모를 측정하여 비교 분석하였다. 측정방법은 모질 개선 효과를 알기 위해 인장강도, 메틸렌블루를 이용한 흡광도, 광택을 측정하였다. 연구결과의 신뢰성을 위해 통계분석을 하였다. 연구결과로 인장강도 측정결과는 바바수오일을 첨가하여 도포 한 모든 시료에서 손상모보다 인장강도가 증가함을 알 수 있었다. 메틸렌블루를 이용한 흡광도 분석결과 모든 시료에서 손상모보다 흡광도가 감소함을 알 수 있었다. 광택 측정결과는 모든 시료에서 손상모보다 광택이 증가함을 알 수 있었다. 결론은 바바수오일이 손상된 모발에 개선 효과가 있는 것을 알 수 있었다.

• 대한한방내과학회지
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• 제11권1호
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• pp.141-146
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• 1990

The skin is related the lung as follows ; 1. The lung control skin and give a nutrition to skin. The skin and hair 'hab' (合) the lung. 2. As a damage of lung is a damage of skin, skin and hair 'chi-lag' (聚落) 3. A defensive energy of lung give a nutrition to skin, and strengthen the body surface. 4. Dryness damage the lung, and so damage the skin. According to the above findings, we know the body surface are closely related to the lung functionally.

• 한국의류산업학회지
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• 제7권6호
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• pp.641-649
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• 2005

This study is to make pH 9 reduction by adding NaOH to 1, 3, 5, 7, 9, 11% solution of thioglycollic acid, cysteine, cysteamin, to add it on helically winded natural hair and colored hair and leave them for 20, 40, 60 minutes, to add $NaBrO_3$ oxidant for 15 minutes and to compare and analyze the wave form. This study showed the results of permanent using thioglycollic acid, cysteine, cysteamin. In the permanent wave form according to the kind of reductant, concentration, and processing time, there were a little difference between thioglycollic acid and cysteine. But cysteamine not only showed apparent difference but also formed strong and elastic wave. The permanent wave is affected by the diagonosis of hair, the choice of permanent solution and the processing time. Therefore the scientific diagonosis of hair is to be considered first of all. By choosing the kind of solution, the concentration and the processing time according to the results of hair diagonosis and wave form, we can prevent the lengthening and damage of hair.

• 한국의류산업학회지
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• 제1권4호
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• pp.393-396
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• 1999

The purpose of this study was to suggest the knowledge and scientific information of the damage and improvement according to hair coloring manipulation. The study investigated variations of mechanical, nourishment(amino acid cystine) shape of cuticle characteristics according to hair coloring during 40, 50 minute. The results were as follows; Tensile strength was decreased variations of 6.62%, 13.68%, extension rate was increased variations of 10.58%, 12.28%, thickness was increased variations of 9.15%, 15.64% in 40 min. and 50 min. hair coloring. Content of amino acid cystine was lowered variations of 23.00%, 30.49% according to time of manipulation. A shape of cuticles was disfigured and brocken by reason of hair coloring manipulation.

• 패션비즈니스
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• 제10권1호
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• pp.120-131
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• 2006

Recently, it has been reported that chemical hair coloring can cause allergic reactions, the toxicity issue of chemical hair color was issued. Therefore, there is an increasing interest in the hair coloration technique using non-toxic and bio-compatible hair color gotten from natural resource. In this study, the possibility using fermented Indigo as natural hair coloring agent was investigated. Bleached hair samples were dyed using Indigo, and the effect of dyeing frequency, the physical change after dyeing, color, surface and cross-section characteristics, and tensile property were also studied. In addition, the protection property of cationic detergent finishing on damaged hair samples were also studied. The following conclusions are made; 1. While bleached hair samples with low value showed the negligible effect of repeated dyeing, bleached hair samples with high value showed the good effect of repeated dyeing. 2. Hair sample dyed with Indigo showed a high light-fastness, however, tensile strength and elongation showed very low values (high damage on hair sample). 3. Cationic detergent finishing did not affect on the colorfastness because of decoloration after dyeing, however, it increased the smoothness of hair sample, and therefore, can use as protectant of damaged hair. 4. Hair scale was damaged after dyeing. It seemed that the alkali, potassium carbonate, increased pH of dyeing bath to 11, as a result, the hair was swollen, weaken, and dissolved on the prolonged dyeing time. Dyed hair sample became stiff and fine. 5. The color difference was 4.62 (a high fastness value) in the test of sunlight exposure, shampoo, cationic detergent finishing, and acid perspiration fastness.

• 융합정보논문지
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• 제11권12호
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• pp.221-228
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• 2021

본 연구는 염색 과정에 유기산을 이용한 후처리를 적용하여 염색의 지속성을 높이고 모발의 손상을 억제하고자 하였다. 체리레드와 블루실버 색상으로 탈색모를 염색하는 과정에 succinic acid와 tartaric acid를 이용하여 후처리 하고 염색된 모발의 색 지속성, 인장강도, 기공, 표면 특성을 알아보았다. 반복적인 샴푸 세척을 진행한 후 모발의 색상변화를 측정한 결과 succinic acid와 tartaric acid 실험군은 대조군 보다 효율적으로 모발의 색상을 유지할 수 있었다. 염색 후 모발의 손상도를 측정한 결과, succinic acid와 tartaric acid 실험군은 대조군 보다 높은 인장강도, 낮은 기공도, 매끄러운 표면 특성을 나타내어 모발 보호 효과를 나타냈다. 특히, tartaric acid는 succinic acid 보다 높은 효율로 염색모의 색을 지속시키고, 모발을 보호할 수 있었다.

• 한국발생생물학회지:발생과생식
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• 제25권4호
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• pp.279-291
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• 2021

Hair loss is one of the most common chronic diseases, with a detrimental effect on a patient's psychosocial life. Hair loss results from damage to the hair follicle (HF) and/or hair regeneration cycle. Various damaging factors, such as hereditary, inflammation, and aging, impair hair regeneration by inhibiting the activation of hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs). Formyl peptide receptor 2 (FPR2) regulates the inflammatory response and the activity of various types of stem cells, and has recently been reported to have a protective effect on hair loss. Given that stem cell activity is the driving force for hair regeneration, we hypothesized that FPR2 influences hair regeneration by mediating HFSC activity. To prove this hypothesis, we investigated the role of FPR2 in hair regeneration using Fpr2 knockout (KO) mice. Fpr2 KO mice were found to have excessive hair loss and abnormal HF structures and skin layer construction compared to wild-type (WT) mice. The levels of Sonic hedgehog (Shh) and β-catenin, which promote HF regeneration, were significantly decreased, and the expression of bone morphogenetic protein (Bmp)2/4, an inhibitor of the anagen phase, was significantly increased in Fpr2 KO mice compared to WT mice. The proliferation of HFSCs and DPCs was significantly lower in Fpr2 KO mice than in WT mice. These findings demonstrate that FPR2 impacts signaling molecules that regulate HF regeneration, and is involved in the proliferation of HFSCs and DPCs, exerting a protective effect on hair loss.

• 융합정보논문지
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• 제11권3호
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• pp.212-219
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• 2021

본 연구는 시어버터를 처방한 헤어트리트먼트가 탈색 모발에 미치는 영향을 확인하고, 모발 보호 효과가 있는지를 알아보기 위해 수행하였다. 시어버터의 함량을 0%, 1%, 3%, 5%로 다르게 첨가하여 트리트먼트를 제조하고, 트리트먼트 도포 전후의 모발의 굵기, 아미노산 분석, 모발의 표면 색상 변화, 주사전자현미경을 이용한 모발 표면을 분석하였다. 모발의 굵기는 시어버터를 5%로 처방한 모발에서 굵기가 가장 높게 증가하였다. 모발의 아미노산 함량도 시어버터를 5% 처방한 트리트먼트 시료의 함량이 높게 나타났다. 모발의 표면 색상을 비교한 결과, 시어버터를 5% 처방한 트리트먼트를 처리했을 시에 L⁎값과 b⁎값은 낮게 측정이 되었으며, a⁎값은 높게 측정되었다. 주사전자현미경으로 관찰한 결과, 시어버터를 처방한 트리트먼트 모발의 표면이 탈색 모발에 비해 매끄럽게 개선되는 것을 확인할 수 있었다. 이를 통해 천연 소재인 시어버터가 탈색으로 손상된 모발을 보호하는 모발 화장품으로 사용 가능할 것으로 사료된다.