• Preventive Nutrition and Food Science
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• v.5 no.1
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• pp.37-41
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• 2000

The protective effects of the ethylacetate fraction of persimmon leaves(PEF) against experimentally induced gastric mucosal damage and gastric ulcers were evaluated in ratss. In prophylatic study, 100 mg/kg ethylacetate fraction of persimmon leaves (PEFH) exhibited a total protection of 73.8% and 65.7% against HCl-ethanol and 0.2N NaOH-induced gastric mucosal membrane lesions, respectively, which was superior to cimetidine 50 mg/kg, a commonly used anti-ulcer drug. PEFH showed excellent anti-ulcer effects against pylorus ligation induced gastric ulcers, compared to the control group, however, 50 mg/kg ethylacetate fraction of persimmon leaves (PEFL) and PEFH did not affect ulcers induced by water immersion stress, and that is inferior to cimetidine 50 mg/kg. In conclusion, the results suggest that the ethylacetate fraction of persimmon leaves can be used both in prevention and treatment of experimentally induced gastric mucosal damage and ulcers.

• Journal of the Korea Institute of Military Science and Technology
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• v.13 no.6
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• pp.1106-1112
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• 2010

One of the considerations in weapon systems procurement is the objective of maximizing the current force. Also, offensive effects, rather than defense are valued in weapons system development and procurement. Especially, the survivability of a naval ship is equally important as the offensive effect of onboard weapons. In case of naval ships, development of attack tactics and research regarding damage minimization must be conducted through live fire exercise against actual targets in order to minimize damage from the enemy. However, it is difficult to conduct such adequate measures due to realistic limitations such as time and budget in order to verify and calculate a weapon system's attack and damage effects along with the lack of practical studies in this subject despite numerous interests. Research are being conducted utilizing M&S to estimate attack effects and study damages due to such reason, but the lack of authoritative data and development ability are limiting calculation of reliable results. Therefore, this study will propose a measure to increase survivability of a weapon system(ship/vessel) utilizing research of vulnerability from enemy attacks analysis method against a naval ship(Craft Air Cushion).

• Archives of Pharmacal Research
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• v.29 no.8
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• pp.699-706
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• 2006

The present study evaluated antioxidant and neuroprotective activities of hesperidin, a flavanone mainly isolated from citrus fruits, and its aglycone hesperetin using cell-free bioassay system and primary cultured rat cortical cells. Both hesperidin and hesperetin exhibited similar patterns of 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities. While hesperidin was inactive, hesperetin was found to be a potent antioxidant, inhibiting lipid peroxidation initiated in rat brain homogenates by $Fe^{2+}$ and L-ascorbic acid. In consistence with these findings, hesperetin protected primary cultured cortical cells against the oxidative neuronal damage induced by $H_2O_2$ or xanthine and xanthine oxidase. In addition, it was shown to attenuate the excitotoxic neuronal damage induced by excess glutamate in the cortical cultures. When the excitotoxicity was induced by the glutamate receptor subtype-selective ligands, only the N-methyl-D-aspartic acid-induced toxicity was selectively and markedly inhibited by hesperetin. Furthermore, hesperetin protected cultured cells against the $A_{{\beta}(25-35)}-induced$ neuronal damage. Hesperidin, however, exerted minimal or no protective effects on the neuronal damage tested in this study. Taken together, these results demonstrate potent antioxidant and neuroprotective effects of hesperetin, implying its potential role in protecting neurons against various types of insults associated with many neurodegenerative diseases.

• Journal of Korean society of Dental Hygiene
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• v.19 no.2
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• pp.241-249
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• 2019

Objectives: This study aimed to investigate the effects of verbal violence experience on stress and positive psychological capital as well as the mediating effects of positive psychological capital. Methods: A survey was conducted with dental hygienists working at university hospitals, general hospitals, and dental hospitals and clinics in Busan, Gyeongnam, and Ulsan areas.Of the 230 questionnaires distributed, 206 were used in the analysis after excluding 24 completed questionnaires that had errors or missing answers. Results: As a result of identifying the relationships between verbal violence damage, positive psychological capital, and stress, verbal violence damage was negatively correlated with positive psychological capital (r=-0.28, p<0.001) and positively correlated with stress (r=0.40, p<0.001). Positive psychological capital had a negative correlation with stress (r=-0.25, p<0.001). As a result of verifying the mediating effects of positive psychological capital on the relationship between verbal violence damage and stress among dental hygienists, it was found that verbal violence had a significant effect on stress and positive psychological capital in the first and second stages. In the third stage, the effect of positive psychological capital on stress was significant, showing that there was a mediating effect. Conclusions: Therefore, sound work environments should aim to reduce verbal violence while increasing support systems to reduce negative emotional and psychological states.

• Smart Structures and Systems
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• v.20 no.2
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• pp.207-217
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• 2017

Because of the inevitable uncertainties such as structural parameters, external excitations and measurement noises, the effects of uncertainties should be taken into consideration in structural damage detection. In this paper, two probabilistic structural damage detection approaches are proposed to account for the underlying uncertainties in structural parameters and external excitation. The first approach adopts the statistical moment-based structural damage detection (SMBDD) algorithm together with the sensitivity analysis of the damage vector to the uncertain parameters. The approach takes the advantage of the strength SMBDD, so it is robust to measurement noise. However, it requests the number of measured responses is not less than that of unknown structural parameters. To reduce the number of measurements requested by the SMBDD algorithm, another probabilistic structural damage detection approach is proposed. It is based on the integration of structural damage detection using temporal moments in each time segment of measured response time history with the sensitivity analysis of the damage vector to the uncertain parameters. In both approaches, probability distribution of damage vector is estimated from those of uncertain parameters based on stochastic finite element model updating and probabilistic propagation. By comparing the two probability distribution characteristics for the undamaged and damaged models, probability of damage existence and damage extent at structural element level can be detected. Some numerical examples are used to demonstrate the performances of the two proposed approaches, respectively.

• Smart Structures and Systems
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• v.14 no.2
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• pp.85-104
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• 2014

Damage detection is a challenging, complex, and at the same time very important research topic in civil engineering. Identifying the location and severity of damage in a structure, as well as the global effects of local damage on the performance of the structure are fundamental elements of damage detection algorithms. Local damage detection is essential for structural health monitoring since local damages can propagate and become detrimental to the functionality of the entire structure. Existing studies present several methods which utilize sensor data, and track global changes in the structure. The challenging issue for these methods is to be sensitive enough in identifYing local damage. Autoregressive models with exogenous terms (ARX) are a popular class of modeling approaches which are the basis for a large group of local damage detection algorithms. This study presents an algorithm, called Influence-based Damage Detection Algorithm (IDDA), which is developed for identification of local damage based on regression of the vibration responses. The formulation of the algorithm and the post-processing statistical framework is presented and its performance is validated through implementation on an experimental beam-column connection which is instrumented by dense-clustered wired and wireless sensor networks. While implementing the algorithm, two different sensor networks with different sensing qualities are utilized and the results are compared. Based on the comparison of the results, the effect of sensor noise on the performance of the proposed algorithm is observed and discussed in this paper.

• Computers and Concrete
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• v.2 no.3
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• pp.203-214
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• 2005

In the Part 1 paper (Gawin, et al. 2005) some experimental results concerning micro-structural tests, permeability measurements and stress-strain tests of four types of High Performance Concrete, exposed to elevated temperatures (up to $700^{\circ}C$) are presented and discussed. On the basis of these experimental results parameters of the constitutive relationships describing influence of damage and temperature upon material intrinsic permeability at high temperature were determined. In this paper the effects of various formulations of damage-permeability coupling on results of computer simulations are analysed and compared with the results obtained by means of the previously proposed approach, that does not take into account the thermo-chemical concrete damage directly. Numerical solutions are obtained using the recently developed fully coupled model of hygro-thermal and damage phenomena in concrete at elevated temperatures. High temperature effects are considered by means of temperature and pressure dependence of several material parameters. Based on the mathematical model, the computer code HITECOSP was developed. Material parameters of the model were measured by several European laboratories, which participated in the "HITECO" research project. A model problem, concerning hygro-thermal behaviour and degradation of a HPC structure during fire, is solved. The influence of two different constitutive descriptions of the concrete permeability changes at high temperature, including thermo-chemical and mechanical damage effects, upon the results of computer simulations is analysed and discussed.

• Molecular & Cellular Toxicology
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• v.4 no.1
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• pp.66-71
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• 2008

Long term exposure of Jurkat cells to 2 ATA pressure resulted in the inhibition of cell growth. Under a 2 ATA pressure, the morphological changes in the cells were visualized by electron microscopy. The cells exhibited significant inhibitory responses after three passages. However, short-term exposure study was carried out, 2 ATA pressure may have beneficial effects. The Jurkat cells were exposed to $H_2O_2$ (25 and $50{\mu}M$) in order to induce DNA damage, and then incubated under at either normal pressure or 2 ATA for 1 or 2 hours in order to recover the DNA damage. The extent of DNA damage was determined via Comet assay. More recovery from DNA damage was observed at 2 ATA than at normal pressure. The activity of the DNA repair enzymes, DNA polymerase-$\beta$, was also evaluated at both normal pressure and 2 ATA. The activity of DNA polymerase-$\beta$ was observed to have increased significantly at the 2 ATA than at normal pressure. In conclusion, the effects of hyperbaric pressure from 1 ATA to 2 ATA on biochemical systems can be either beneficial or harmful. Long term exposure to hyperbaric pressure clearly inhibited cell proliferation and caused genotoxic effects, but short-term exposure to hyperbaric pressure proved to be beneficial in terms of bolstering the DNA repair system. The results of the present study have clinical therapeutic application, and might prove to be an useful tool in the study of genotoxicity in the future.

• Journal of the Korean Institute of Gas
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• v.3 no.3 s.8
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• pp.45-50
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• 1999

The LPG refueling station's explosion at Bucheon city was a major accident which with rare frequency of occurrence and large damage effect. Therefore, to prevent similar accident in the future from LPG charging stations which located in urban area. It needs to identify the damage effects of such facilities by comparing theoretically quantities risk and actual damage. The BLEVE effects from the accident showed similar damage effect in case of heat flux, however, the overpressure level reflected at the reduced distance by $15\%$. The structure damage to the near by area showed comparatively large heat radiation damage to the concrete structure strength and shape changes through heat flux while the overpressure effect was small.

• KCI Concrete Journal
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• v.13 no.2
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• pp.26-32
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• 2001

A simple expected damage cost model is developed and a systematic approach to evaluate the economic effects of seismic hazards to reinforced concrete structures is presented. An expected damage cost function during a specific lifetime is modeled by a Poisson's process with uniform continuous cash flow assumption. It is possible that the proposed method can decouple the damage cost effect from random earthquake events. Thus, expected damage cost function can be formulated as a combination of three independent terms; a present worth factor of Poisson's process, a damage cost interpolation function and a mean occurrence rate of earthquake intensity. The validity of the proposed method is demonstrated by a comparative study of LCC evaluations with the previous study.