• Nuclear Engineering and Technology
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• 제48권5호
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• pp.1280-1290
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• 2016

This paper presents an advanced estimation method for obtaining the probability density functions of a damage parameter for valve leakage detection in a reciprocating pump. The estimation method is based on a comparison of model data which are simulated by using a mathematical model, and experimental data which are measured on the inside and outside of the reciprocating pump in operation. The mathematical model, which is simplified and extended on the basis of previous models, describes not only the normal state of the pump, but also its abnormal state caused by valve leakage. The pressure in the cylinder is expressed as a function of the crankshaft angle, and an additional volume flow rate due to the valve leakage is quantified by a damage parameter in the mathematical model. The change in the cylinder pressure profiles due to the suction valve leakage is noticeable in the compression and expansion modes of the pump. The damage parameter value over 300 cycles is calculated in two ways, considering advance or delay in the opening and closing angles of the discharge valves. The probability density functions of the damage parameter are compared for diagnosis and prognosis on the basis of the probabilistic features of valve leakage.

• Journal of Korean Neurosurgical Society
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• 제58권1호
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• pp.22-29
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• 2015

Objective : Perinatal hypoxic-ischemic encephalopathy (HIE) and prolonged febrile seizures (pFS) are common neurologic problems that occur during childhood. However, there is insufficient evidence from experimental studies to conclude that pFS directly induces hippocampal injury. We studied cognitive function and histological changes in a rat model and investigated which among pFS, HIE, or a dual pathologic effect is most detrimental to the health of children. Methods : A rat model of HIE at postnatal day (PD) 7 and a pFS model at PD10 were used. Behavioral and cognitive functions were investigated by means of weekly open field tests from postnatal week (PW) 3 to PW7, and by daily testing with the Morris water maze test at PW8. Pathological changes in the hippocampus were observed in the control, pFS, HIE, and HIE+pFS groups at PW9. Results : The HIE priming group showed a seizure-prone state. The Morris water maze test revealed a decline in cognitive function in the HIE and HIE+pFS groups compared with the pFS and control groups. Additionally, the HIE and HIE+pFS groups showed significant hippocampal neuronal damage, astrogliosis, and volume loss, after maturation. The pFS alone induced minimal hippocampal neuronal damage without astrogliosis or volume loss. Conclusion : Our findings suggest that pFS alone causes no considerable memory or behavioral impairment, or cellular change. In contrast, HIE results in lasting memory impairment and neuronal damage, gliosis, and tissue loss. These findings may contribute to the understanding of the developing brain concerning conditions caused by HIE or pFS.

• 대한기계학회논문집A
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• 제23권11호
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• pp.1970-1981
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• 1999

The low-cycle fatigue behaviour of a SiC-particulate-reinforced Al-Si cast alloy with two different volume fractions has been investigated from a series of strain-control led fatigue tests with zero and nonzero tensile mean strains. The composites including the unreinforced matrix alloy, exhibited cyclic hardening behaviour, with more pronounced strain-hardening for the composites with a higher volume fraction of the SiC particles. For the tensile mean strain tests, the initial high tensile mean stress relaxed to zero for the ductile Al-Si alloy, resulting in no influence of the tensile mean strain on the fatigue life of the matrix alloy. However, tensile mean strain for the composite caused tensile mean stresses and reduced fatigue life. The pronounced effects of mean strain on the low-cycle fatigue life of the composite compared to the unreinforced matrix alloy were attributed to the initial large prestrain and non-relaxing high tensile mean stress in the composite with very limited ductility and Cyclic plasticity. Fatigue damage parameter using strain energy, density efficiently accounted for the mean stress effects. Predicted fatigue life using the damage parameter correlated fairly well with the experimental life within a factor of 3. Also, the fatigue damage parameter indicated the inferior life in the low-cycle regime and superior life in the high-cycle regime for the composite, compared to the unreinforced matrix alloy.

• 동의생리병리학회지
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• 제19권4호
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• pp.993-999
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• 2005

This research was peformed to investigate protective effect of Sophora Subprostrata fractions against focal ischemic brain damage after middle cerebral artery(MCA) occlusion using intraluminal suture. Rats were divided into six groups: MCA-occluded group(Control): each administered groups with Sophora Subprostrata total phase(Total), Sophora Subprostrata Aqueous phase (Aqueous), Sophora Subprostrata BuOH phase(BuOH), and Sophora Subprostrata Alkaloid phase(Alkaloid) after MCA-occlusion; sham-operated group(Sham). The right MCA was occluded by A poly-L-lysine coated 4-0 nylon suture thread through the internal carotid artery permanently. Sophora Subprostrata and fractions were administered orally(Smg/ml) for 7 days after MCA-occlusion. The Drain tissue was stained with $2\%$ triphenyl tetrazolium chloride on ischemic brain tissue(2mm section). The results showed that 1) Sophora Subprostrata total phase reduced infarct size and total infarct volume compared to the control group at 24 hours after MCA-occlusion, 2) Sophora Subprostrata Aqueous phase reduced infarct size and total infarct volume compared to the control group at 24 hours after MCA-occlusion, 3) Sophora Subprostrata Alkaloid phase reduced infarct size compared to the control group at 24 hours after MCA-occlusion, but 4) at 7 days after MCA-occlusion, Sophora Subprostrata did not show effective recovery compared with control group. Sophora Subprostrata has protective effects against brain damage at the early stage of focal cerebral ischemia. Sophora Subprostrata total and Aqueous phase produced more pronounced protective effect against focal ischemic brain damage.

• 대한본초학회지
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• 제32권6호
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• pp.17-22
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• 2017

Objectives : Daily Dose of Apricot Kernel in Treatise on Cold Damage Diseases is usually written in the number, sometimes in the volume. The seed coat and acute end of Apricot Kernel must be removed, so author want to know its daily dose and proportion of seed coat and acute end. Methods : Assuming dosage by editions of Treatise on Cold Damage Diseases. And comparing it with measured weight of Apricot Kernel distributed in market. Results : The number of prescriptions including Apricot Kernel is ten, and eight of that are made to decoction, two of that are made to pill prescription. And two of decoction are made by reducing and uniting prescriptions. The daily dose of six decoction are 70, 47 or 35 in numbers. The 70 Apricot Kernel except seed coat and acute end are 1/2 Sheong ($33m{\ell}$) in volume, 3 Ryang (19.5 g) in weight. Weight of Apricot Kernel the most common in market is 0.28 ~ 0.38 g. 70 Apricot Kernel are 23.10 g, seed coats of that are 1.15 g, acute ends of that are 2.43 g, 70 Apricot Kernel except seed coat and acute end is 19.5 g. So, seed coat is 5%, acute end is 10% by proportion, which is the same with it assumed based on writings. Conclusions : 70 Apricot Kernel except seed coat and acute end are 1/2 Sheong, 3 Ryang, and it is 33 mL and 19.5 g respectively. It also correspond with current market goods.

• Geomechanics and Engineering
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• 제21권2호
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• pp.95-102
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• 2020

Population concentration in urban areas has led traffic management a central issue. To mitigate traffic congestions, the government has planned to construct large-cross-section tunnels deep underground. This study focuses on estimating the damage caused to frame structures owing to tunnel excavation. When constructing a tunnel network deep underground, it is necessary to divide the main tunnel and connect the divergence tunnel to the ground surface. Ground settlement is caused by excavation of the adjacent divergence tunnel. Therefore, predicting ground settlement using diverse variables is necessary before performing damage estimation. We used the volume loss and cover-tunnel diameter ratio as the variables in this study. Applying the ground settlement values to the settlement induction device, we measured the extent of damage to frame structures due to displacement at specific points. The vertical and horizontal displacements that occur at these points were measured using preattached LVDT (Linear variable differential transformer), and the lateral strain and angular distortion were calculated using these displacements. The lateral strain and angular distortion are key parameters for structural damage estimation. A damage assessment chart comprises the "Negligible", "Very Slight Damage", "Slight Damage", "Moderate to Severe Damage", and "Severe to Very Severe Damage" categories was developed. This table was applied to steel frame and concrete frame structures for comparison.

• 콘크리트학회논문집
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• 제27권4호
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• pp.411-418
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• 2015

본 연구는 섬유혼입률 및 패널 두께가 구형비상체 충격에 의한 강섬유보강 콘크리트(SFRC) 패널의 손상특성에 미치는 영향을 알아보기 위하여 실시되었다. 실험체는 $200{\times}200mm$의 각형 패널로 계획하였으며, 두께는 30 및 50 mm로 설정하였다. 비상체는 직경 20 mm의 강재이며, 속도는 350 m/s로 실험을 실시하였다. 또한 본 연구에서는 SFRC의 역학적 특성과 내충격 성능의 상호관계를 평가하였다. SFRC의 역학적특성은 압축강도, 파괴계수 및 재료의 인성을 평가하였다. 비상체 충격에 의한 패널의 전면손실률은 압축인성이 증가함에 따라 감소하였고, 파괴계수 및 휨인성이 향상됨에 따라 배면손실률이 감소하는 것으로 나타났다. 강섬유보강 콘크리트의 동적특성 평가를 위하여, 상용 프로그램인 ABAQUS/Explicit를 사용하여 유한요소해석을 실시하였다. 해석결과 파괴양상이 유사한 경우 전면 및 배면손실률을 잘 예측하는 것으로 나타났다.

• Computers and Concrete
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• 제2권3호
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• pp.189-202
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• 2005

This paper presents an analysis of some experimental results concerning micro-structural tests, permeability measurements and strain-stress tests of four types of High-Performance Concrete, exposed to elevated temperatures (up to $700^{\circ}C$). These experimental results, obtained within the "HITECO" research programme are discussed and interpreted in the context of a recently developed mathematical model of hygro-thermal behaviour and degradation of concrete at high temperature, which is briefly presented in the Part 2 paper (Gawin, et al. 2005). Correlations between concrete permeability and porosity micro-structure, as well as between damage and cracks' volume, are found. An approximate decomposition of the thermally induced material damage into two parts, a chemical one related to cement dehydration process, and a thermal one due to micro-cracks' development caused by thermal strains at micro- and meso-scale, is performed. Constitutive relationships describing influence of temperature and material damage upon its intrinsic permeability at high temperature for 4 types of HPC are deduced. In the Part II of this paper (Gawin, et al. 2005) effect of two different damage-permeability coupling formulations on the results of computer simulations concerning hygro-thermo-mechanical performance of concrete wall during standard fire, is numerically analysed.

• International Journal of Aeronautical and Space Sciences
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• 제15권1호
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• pp.20-31
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• 2014

This paper deals with the development of a realistic shape optimization of damaged columns that are subjected to conservative and non-conservative forces, using the Genetic Algorithm (GA). The analysis is based on the design of the most optimized shape of the column under the constraint of constant weight, considering the Static, Vibrational, and Flutter characteristics. Under the action of conservative and non-conservative longitudinal forces, an elastic column loses its stability. A numerical analysis based on FEM has been performed on a uniform damaged column, to compute the fundamental buckling load, vibration frequency, and flutter load, under various end restraints. An optimization search based on the Genetic Algorithm is then executed, to find the optimal shape design of the column. The optimized column references the one having the highest buckling load, highest vibration frequency, and highest flutter load, among all the possible shapes of the column, for a given volume. A comparison is then made between the values obtained for the optimized damaged column, and those obtained for the optimized undamaged column. The comparison reveals that the incorporation of damage in the column alters its optimal shape to only a certain extent. Also, the critical load and frequency values for the optimized damaged column are comparatively low, compared with those obtained for the optimized undamaged column. However, these results hold true only for moderate-intensity damage cases. For high intensity damage, the optimal shape may not remain the same, and may vary, according to the severity of damage.

• Archives of Pharmacal Research
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• 제23권4호
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• pp.413-417
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• 2000

The effect of ischemia/reperfusion-induced neuronal damage on the memory impairment were investigated using active avoidance and Morris water maze tasks in Wistar rats. Focal ischemia was induced by 1 h occlusion of the right middle cerebral artery (MCA) of Wistar male rats. Reperfusion was induced by releasing the occlusion and restoring the blood circulation for 24 h. The acquisition and preservation memory tested by active avoidance showed a significant difference between the sham and ischemia/reperfusion group. The water maze acquisition performance was also significant difference between sham and ischemia/repefusion groups in both latency and moving distance. The infarction volume was increased by the ischemia/reperfusion. Furthermore, the cresyl violet staining of the ischemia/reperfusion brain showed severe neuronal damage (pyramidal cell loss) in the cortex in addition to the striatum lesion of brain. This study shows that pyramidal cell damage in the cortex lesion may be partially related to memorial disturbance in the ischemia/reperfusion brain injury.