• 한국독성학회:학술대회논문집
• /
• 한국독성학회 2006년도 추계학술대회
• /
• pp.55-64
• /
• 2006

The fetal central nervous system (CNS) is sensitive to diverse environmental factors, such as alcohol, heavy metals, irradiation, mycotoxins, neurotransmitters, and DNA damage, because a large number of processes occur during an extended period of development. Fetal neural damage is an important issue affecting the completion of normal CNS development. As many concepts about the brain development have been recently revealed, it is necessary to compare the mechanism of developmental abnormalities induced by extrinsic factors with the normal brain development. To clarify the mechanism of fetal CNS damage, we used one experimental model in which 5-azacytidine (5AZC), a DNA damaging and demethylating agent, was injected to the dams of rodents to damage the fetal brain. 5AzC induced cell death (apoptosis)and cell cycle arrest in the fetal brain, and it lead to microencephaly in the neonatal brain. We investigated the mechanism of apoptosis and cell cycle arrest in the neural progenitor cells in detail, and demonstrated that various cell cycle regulators were changed in response to DNA damage. p53, the guardian of genome, played a main role in these processes. Further, using DNA microarray analysis, tile signal cascades of cell cycle regulation were clearly shown. Our results indicate that neural progenitor cells have the potential to repair the DNA damages via cell cyclearrest and to exclude highly affected cells through the apoptotic process. If the stimulus and subsequent DNA damage are high, brain development proceeds abnormally and results in malformation in the neonatal brain. Although the mechanisms of fetal brain injury and features of brain malformation afterbirth have been well studied, the process between those stages is largely unknown. We hypothesized that the fetal CNS has the ability to repair itself post-injuring, and investigated the repair process after 5AZC-induced damage. Wefound that the damages were repaired by 60 h after the treatment and developmental processes continued. During the repair process, amoeboid microglial cells infiltrated in the brain tissue, some of which ingested apoptotic cells. The expressions of genes categorized to glial cells, inflammation, extracellular matrix, glycolysis, and neurogenesis were upregulated in the DNA microarray analysis. We show here that the developing brain has a capacity to repair the damage induced by the extrinsic stresses, including changing the expression of numerous genes and the induction of microglia to aid the repair process.

• 터널과지하공간
• /
• 제19권6호
• /
• pp.545-557
• /
• 2009

단계별 손상에 따른 취성재료의 동적손상메커니즘을 파악하고자 국내암석을 대상으로 스플릿 홉킨슨 압력바 시스템을 이용한 단계적 충격하중실험을 수행하였다. 실험시료 내 동적손상을 평가하기 위하여 고해상도 X-ray 단층촬영 시스템을 적용하였다. 그 결과 낮은 충격하중에서는 시료 내 전반적으로 축방향 균열 즉 수직균열이 발생하지만, 충격속도가 증가함에 따라 시료와 입사바 또는 전달바와의 접촉면에 구속효과가 발생하여 입사바와의 접촉면 중심부에 균열이 사라지는 경향을 보였다. 그러나 구속력을 적게 받는 시료의 원주표면 부근에서는 박리균열을 보였다.

• 콘크리트학회논문집
• /
• 제11권4호
• /
• pp.107-116
• /
• 1999

The damage in concrete structures generally starts with microcracking and thus it is important to find and explore these microcracks in concrete in order to ensure appropriate safety and serviceability. The purpose of the present study is to identify the damage characteristics of concrete structures due to cracking by employing the acoustic emission techniques. A comprehensive experimental study has been done. The cracking damage under tensile and flexural loadings have been identified and the bond damage between steel and concrete have been also characterized. It is seen that the amplitudes and energy level of Acoustic Emission(AE) events are found to be relatively small for bond cracking damages and large for tensile cracking damages. The characteristic equations of the AE events for various cracking damages have been proposed based on the present test data. The internal microcracks are progressively developed ahead of a visible actual crack and the present study clearly exhibits these damage mechanism for various types of cracking in concrete. The present study provides useful data which can be used to identify the various types of cracking damages in concrete structures. This will allow efficient maintenance of concrete structures through monitoring of internal cracking based on acoustic emission.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2010년도 제39회 하계학술대회 초록집
• /
• pp.188-188
• /
• 2010

동일한 에너지와 일정한 dose량을 유지하고 dose rate만을 변화시켜가며 이온을 Si(100) 표면에 주입하였다. 이러한 조건하에서 이온의 dose rate가 커지게 되면 시료 내에서 relaxation되는 시간이 짧아져서 damage의 양이 증가하게 되고 depth profile의 꼬리부분이 표면 쪽으로 올라오게 된다. 이와 같은 damage profile의 변화가 sheet resistance에 영향을 준다는 실험결과가 있다. 본 연구에서는 Crystal-TRIM computer simulation을 통해서 depth profile과 damage profile의 결과를 얻고, dose rate가 커질수록 시료표면 근방에 잔류 damage의 양이 높게 나타나는 것을 확인할 수 있다. 또한, 잔류 damage의 표면근방에서의 분포가 annealing 이후 sheet resistance를 변화시키는데 이에 대한 mechanism을 규명하고자 한다.

• 동력기계공학회지
• /
• 제12권4호
• /
• pp.64-71
• /
• 2008

This study is on pedestrian protection device using pneumatic cylinder and simple link mechanism when vehicle collide with pedestrian. This study ensured the safety space between engine and hood after it applies to simple link mechanism and pneumatic cylinder. It can absorb the damage which measure the specific device if vehicle collide with pedestrian. Combination of simple link mechanism and pneumatic cylinder was more superior than the present pedestrian protection device. Simple link mechanism could confirm superior height and survival probability than when only cylinder operated. It also ensured enough space between engine and hood. And if a cylinder is not working because of old cylinder, poor repair or damage of accident vertical cylinder would be difficult to execute because there exists the irregular space between engine and hood. If simple link mechanism operates with only one cylinder it could ensure the regular space because simple link mechanism set up at the middle of hood. So this device could confirm high safety for pedestrian.

• 대한기계학회논문집A
• /
• 제21권1호
• /
• pp.104-111
• /
• 1997

Accounting for the additional damages come out from non-proportional loading path effect, material damage according to crystal structure dependence was studied. Microscopic observations of damaged material by SEM(Scanning Electron Microscope) showed crystal structure dependence. Biaxial in-phase loaded specimens showed the slips of same direction, which pararell each other, but biaxial 90.deg. out-of-phase loaded specimens showed multiply crossed slips. S. H. Doong and D. F. Socie reported that wavy/planar or planar slip material showed the increase in the cyclic hardening level during non-proportional cycling. From these results, the additional hardening and non-proportional loading effects were related with slip mechanism, and the slip mechanism was related with crystal structure. In the present study, a damage mechanism which accounts for the non-proportional loading effect from crystal structure dependence was considered and applied to A17075-T651.

• Bulletin of the Korean Chemical Society
• /
• 제35권1호
• /
• pp.117-122
• /
• 2014

As a Chinese herbal medicine used in East Asia for thousands years, Cortex Magnoliae Officinalis (CMO) was observed to possess a protective effect against OH-induced DNA damage in the study. To explore the mechanism, the antioxidant effects and chemical contents of five CMO extracts were determined by various methods. On the basis of mechanistic analysis, and correlation analysis between antioxidant effects & chemical contents, it can be concluded that CMO exhibits a protective effect against OH-induced DNA damage, and the effect can be attributed to the existence of phenolic compounds, especially magnolol and honokiol. They exert the protective effect via antioxidant mechanism which may be mediated via hydrogen atom transfer (HAT) and/or sequential electron proton transfer (SEPT). In the process, the phenolic-OH moiety in phenylpropanoids is oxidized to the stable quinine-like form and the stability of quinine-like can be ultimately responsible for the antioxidant.

• Corrosion Science and Technology
• /
• 제20권6호
• /
• pp.384-390
• /
• 2021

In this paper, durability evaluation and surface damage mechanism were investigated through solid particle erosion (SPE) test after applying hot-dip aluminizing (HDA) technology for the purpose of maintenance of marine economizer tube. Damaged surface shape was analyzed using SEM and 3D microscope. Compositional changes and microstructure of the HDA layer were analyzed through EDS and XRD. Durability was evaluated by analyzing weight loss and surface damage depth after SPE. HDA was confirmed to have a two-layer structure of Al and Al₅Fe₂. HDA+HT was made into a single alloy layer of Al₅Fe₂ by diffusion treatment. In the microstructure of HDA+HT, void and crack defect were induced during the crystal phase transformation process. The SPE damage mechanism depends on material properties. Plastic deformation occurred in the substrate and HDA due to ductility, whereas weight loss due to brittleness occurred significantly in HDA+HT. As a result, the substrate and HDA showed better SPE resistance than HDA+HT.

• Steel and Composite Structures
• /
• 제51권1호
• /
• pp.53-61
• /
• 2024

Aluminum foams sandwich panel (AFSP) has been used in engineering field, where cyclic loading is used in most of the applications. In this paper, the fatigue life of AFSP prepared by the bonding method was investigated through a three-point bending test. The mathematical statistics method was used to analyze the influence of different plate thicknesses and core densities on the bending fatigue life. The macroscopic fatigue failure modes and damage mechanisms were observed by scanning electron microscopy (SEM). The results indicate that panel thickness and core layer density have a significant influence on the bending fatigue life of AFSP and their dispersion. The damage mechanism of fatigue failure to cells in aluminum foam is that the initial fatigue crack begins the cell wall, the thinnest position of the cell wall or the intersection of the cell wall and the cell ridge, where stress concentrations are more likely to occur. The fatigue failure of aluminum foam core usually starts from the semi-closed unit of the lower layer, and the fatigue crack propagates layer by layer along the direction of the maximum shear stress. The results can provide a reference for the practical engineering design and application of AFSP.

• 한국지진공학회논문집
• /
• 제23권1호
• /
• pp.43-54
• /
• 2019

Existing reinforced concrete frame buildings designed for only gravity loads have been seismically vulnerable due to their inadequate column detailing. The seismic vulnerabilities can be mitigated by the application of a column retrofit technique, which combines high-strength near surface mounted bars with a fiber reinforced polymer wrapping system. This study presents the full-scale shaker testing of a non-ductile frame structure retrofitted using the combined retrofit system. The full-scale dynamic testing was performed to measure realistic dynamic responses and to investigate the effectiveness of the retrofit system through the comparison of the measured responses between as-built and retrofitted test frames. Experimental results demonstrated that the retrofit system reduced the dynamic responses without any significant damage on the columns because it improved flexural, shear and lap-splice resisting capacities. In addition, the retrofit system contributed to changing a damage mechanism from a soft-story mechanism (column-sidesway mechanism) to a mixed-damage mechanism, which was commonly found in reinforced concrete buildings with strong-column weak-beam system.