• International Journal of Control, Automation, and Systems
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• v.3 no.spc2
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• pp.278-287
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• 2005

In this paper a new excitation control scheme that improves the transient stability of multi machine power systems is proposed. To this end the backstepping technique is used to transform the system to a suitable partially linear form. On this system, a combination of both feedback linearization and adaptive control techniques are used to confront the nonlinearities. As shown in the paper, the resulting nonlinear control law ensures the uniform boundedness of all the state and estimated variables. Furthermore, it is proven that all the error variables are uniformly ultimately bounded (DUB) i.e. they converge to arbitrarily selected small regions around zero in finite-time. Simulation tests on a two generator infinite bus power system demonstrate the effectiveness of the proposed control.

• BMB Reports
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• v.51 no.6
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• pp.261-262
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• 2018

Aurora B is an important kinase involved in dynamic cellular events in mitosis. Aurora B activity is controlled by several post-translational modifications (PTMs). Among them, E3 ubiquitin ligase-mediated ubiquitination plays crucial roles in controlling the relocation and degradation of Aurora B. Aurora B, ubiquitinated by different E3 ligases, moves to the exact site for its mitotic function during metaphase-anaphase transition and is then degraded for cell cycle progression at the end of mitosis. However, how the stability of Aurora B is maintained until its degradation has been poorly understood. Recently, we have found that USP35 acts as a deubiquitinating enzyme (DUB) for Aurora B and affects its stability during cell division, thus being involved in the regulation of mitosis. In this review, we discuss the USP35-mediated deubiquitination of Aurora B and the regulation of mitotic progression by USP35.

• Journal of Ocean Engineering and Technology
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• v.1 no.2
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• pp.101-112
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• 1987

Fracture toughness characterization in the transition region is examined for heat-treated and ionnitrided Ni-Cr-Mo steel. After heat treatment for the specimens of Ni-Cr-Mo steel, organizations of specimens-specimens which are heat-treated and ion-nitrided for 4 hours at 500 .deg. C and 5 torr in 25%N/dub 2/-75%H/sub 2/mixed gas-, hardness variety, and X-ray diffraction pattern of the ion-nitriding compound layer are observed. Fracture toughenss test of unloading compliance method were conducted over the regions from room trmperature to -70.deg. C. The compound layer was consisted of r'=Fe/sub 4/N phase and ion-nitrided layer's depth was 200mm from surface. The transition regions of heat-treated and ion-nitrided specimens were about -30.deg. C and -50.deg. C, respectively. The transition region of ion-nitrided specimens is estimated less than that of heat-treated one, and this is the effect of ion-nitriding.

• Proceedings of the Korean Society of Marine Engineers Conference
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• 2001.05a
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• pp.168-172
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• 2001

The subsurface stress field beneath the roller due to the lubricant film pressure acting on the roller surface has been calculated. Main purpose of this study in view of engineering is to prove the validity of the numerical profile roller presented by Koo et al who obtained the lubricant film pressure by elastohydrodynamic lubrication analysis on the cam-roller mechanism. The stress field for the numerical profile roller was compared with the one for the existing dub-off profile roller.

• Journal of Advanced Marine Engineering and Technology
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• v.26 no.2
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• pp.174-180
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• 2002

The subsurface stress field beneath the roller's contacting surface due to the contact pressure in lubricating condition has been calculated. Main purpose of this study in view of engineering is to prove the validity of the numerical profile roller presented by Koo et al. The Love's rectangular patch solution was used to obtain the subsurface stress field. The stress field of the numerical profile roller was compared with the one of the existing dub-off profile roller The analysis results show reduced subsurface stresses for the numerical profile roller.

• BMB Reports
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• v.56 no.8
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• pp.451-456
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• 2023

Deubiquitinases (DUBs) are an essential component of the ubiquitin-proteasome system (UPS). They trim ubiquitin from substrate proteins, thereby preventing them from degradation, and modulate different cellular processes. Ubiquitin-specific protease 14 (USP14) is a DUB that has mainly been studied for its role in tumorigenesis in several cancers. In the present study, we found that the protein levels of USP14 were remarkably higher in gastric cancer tissues than in the adjacent normal tissues. We also demonstrated that the inhibition of USP14 activity using IU1 (an USP14 inhibitor) or the inhibition of USP14 expression using USP14-specific siRNA markedly reduced the viability of gastric cancer cells and suppressed their migratory and invasive abilities. The reduction in gastric cancer cell proliferation due to the inhibition of USP14 activity was a result of the increase in the degree of apoptosis, as evidenced by the increased expression levels of cleaved caspase-3 and cleaved PARP. Furthermore, an experiment using the USP14 inhibitor IU1 revealed that the inhibition of USP14 activity suppressed 5-fluorouracil (5-FU) resistance in GC cells. Collectively, these findings indicate that USP14 plays critical roles in gastric cancer progression and suggest its potential to serve as a novel therapeutic target for gastric cancer treatment.

• Culinary science and hospitality research
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• v.22 no.3
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• pp.212-223
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• 2016

The purpose of this study is to verify information spillover effects using returns of macroeconomic variables and hotel leisure stock index daily data from January 4, 2000 to December 30, 2015. The findings and implications of the research can be summarized as follows. First, based on time-varying AR(1)-GARCH(1,1) models no evidence of statistically significant conditional mean and volatility spillover effects from returns of macroeconomic variables on the hotel leisure stock index was observed. In addition, no evidence of price volatility spillover from macroeconomic variables on the hotel leisure market was observed. Second, it was discovered that there exists a significantly negative relationship between the return of ER and hotel leisure stock prices, but a positive relationship between the KOSPI and hotel leisure stock prices. Finally, the study also found that was a significantly positive relationship between the volatility of DUB and hotel leisure market, and an adversely negative relationship between the volatility of ER and hotel leisure market. The results of this study are expected to contribute by providing useful information for investment strategies, as well as for risk management for investors and managers.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2004.11a
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• pp.108-113
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• 2004

Marinas are often located in prime port side locations. hi Korea these locations are already developed and reclamation of the existing properties poses many difficulties and financial overhead. Also, to develop a standard marina in Korea with tide ranges up to 6 meters would require considerable dredging and reclamation works needing long lead times and large SOC costs. The Ocean Space's floating marina system is an independent offshore floating static level system that does not require fixed location breakwaters. The entire marina floats with the tide giving a calm consistent berthing condition for vessels irrespective of the surrounding tide and weather conditions. The floating marina system provides also for all of functions needed to marina comprising a breakwater to protect the vessels, the pontoon system to house the vessels, a dub house and retail tourism precinct, fuel reservoir and associated support facilities in a turn key self contained unit. The modular nature of the system will mean that initial demand can be met with simple units and then further modules can be added quite easily without the related expansion difficulties or infrastructure. This paper contains the main characteristics of the floating marina system and tire design process of the structure. The mooring, motion & stability analysis, the overall & local structural design and the mooring & anchor system design are introduced in this paper.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.45 no.2
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• pp.131-138
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• 2019

Carbonylated proteins (CPs) are synthesized by the chemical reaction of basic amino acid residues in proteins with aldehyde compounds yielded by lipid peroxidation. CPs are excited by a range of light from UVA to blue light, and resulted in the generation of superoxide anion radicals ($^{\cdot}O_2{^-}$) by photosensitizing reaction. Then, they CPs induce new protein carbonylation in stratum corneum through ROS generation. Furthermore, the superoxide anion radicals produce CPs in the stratum corneum (SC) through lipid peroxidation and finally affects skin conditions including color and moisture functions. The purpose of this study was to investigate the relationship between the production of stratum corneum carbonylated protein (SCCP) and the skin elasticity. 46 healthy female Koream at the ages of 30 ~ 50 years old were participated in this study for 8 weeks. The skin test was experiment conducted into two groups; placebo group (N = 23) used cream that did not contain active ingredients, and the other group (N = 23) used cream containing the elasticity improving ingredients. Test areas were the crow 's feet and the cheek. Various non-invasive methods were carried out to measure biophysical parameters on human skin indicating that dermis density and skin wrinkle were measured by using DUB scanner and Primos premium, respectively. Skin elasticity were measured using dermal torque meter (DTM310) and balistometer (BLS780). SCCP was assessed in a simple and non-invasive method using skin surface biopsy on the cheek of the subject. The amount of SCCP was determined using image analysis. All measurements were taken at 0, 4 and 8 8week. Results revealed that the amount of CP in SC was reduced when the skin wrinkle and skin elasticity related parameters were improved. This indicates that the correlation between the elasticity improvement and the amount of CP can be used as a anti-aging indicator and applicable to the skin clinical test for the measurement of skin aging in the future.

• Korean Journal of Veterinary Research
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• v.6 no.1
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• pp.10-17
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• 1966

The antigenecity of somatic substances of S. pullorum standard strain and variant strain extracted byheat treatment, acid treatment and their modification, ammonium sulfate saturation (60 per cent), trypsin digestion was tested by indirest hemagglutination test and precipitation test and following results were optained. 1. Teatment at $100^{\circ}C$ for an hour of the bacteria could extract the antigen of S. pullorum standard strain and variant strain which was demonstrable by hemagglutination reaction with the human a group and chicken red blood cell. 2. Trypsin digestion was more enhanced its antigenecity in acid extracted antigen of S. pullorum variant strain compare with the S. pullorum standard strain. 3. The extracted antigenic substances of S. pullorum standard strain existed chiefly in the elicited fraction of precipitate at the treatment of ammonium sulfate saturation and after trypsin digestion, its antigenecity was demonstrated by hemagglutination. 4. At the treatment of ammonium sulfate treatment, did not occur the precipicate in acid extracted antigens of S. pullorum variant strain, however, the heal extracted antigen, positive reactions were obtained in both of the precipitate and supernatant fraction of the S. pullorum variant strain by hemagglutination reaction. After trypsin digestion, these fraction also exhibited positive reactions. 5. Precipitation test also tested dub could not detect in any soft of the antigens.