• Journal of Chest Surgery
• /
• v.28 no.6
• /
• pp.549-556
• /
• 1995

We investigated the effects of aprotinin, a protease inhibitor, on isolated rat heart subjected to cardioplegia and global ischemia for 4 hours and then reperfused for 40 minutes. Before ischemia, hearts were perfused with either aprotinin 1x105KIU/L[Aprotinin group,n=8 or no aprotinin[control group,n=8 added to Krebs-Henseleite solution for 30 minutes. Hemodynamic and biochemical parameters such as heart rate, LVP, dP/dt, coronary flow and creatine kinase were measured before cardioplegia and after reperfusion 10,20,30,40 minutes. After completion of experiment, wet and dry heart weight were measured for tissue water and water content evaluation. On reperfusion, recovery of LVP of aprotinin group at each time point was significantly better than that of control group[p<0.05 , and of dP/dt at reperfusion 40 minutes[p=0.034 . No statistically significant differences in heart rate, coronary flow and CK were observed between the two groups, but aprotinin group seemed to have better recovery. No significant differences in tissue water and water content were observed between the two group.These results suggest that pretreatment of aprotinin is effective in myocardial preservation in prolonged hypothermic ischemia and reperfusion.

• Korean Journal of Veterinary Service
• /
• v.32 no.1
• /
• pp.61-76
• /
• 2009

At the present study, it was aimed to explore the molecular genetic characterization of multiple antimicrobial resistant Salmonella spp. isolates from pigs and cattle. A total of 138 Salmonella Typhimurium (S. Typhimurium) isolates were typed with phage, among them, 83.3% of S. Typhimurium tested could divide into a 10 phage types. Definitive type 193 (DT193) (25.4%) and DT195 (24.6%) were exhibited as the dominant types. DT104 and U302 were found from pigs and cattle. On the other hand, S. Enteritidis had 6 phage types, of them, phage type 21 (PT21) and PT11b were the popular types. In the plasmid profiles, 135 of S. Typhimurium isolates were exhibited 1 to 6 plasmid bands which molecular weight ranged from 90 to 2kb. 35 isolates (25.4%) harbored a 90kb plasmid which is thought to be the serotype specific virulence plasmid. Two of twenty five S. Enteritidis had common plasmids at 2 and 1.5kb. With multiplex polymerase chain reaction, virulence genes (invA and spvC) were detected from all Salmonella spp. from 167 of S. Typhimurium, S. Enteritidis and chloramphenicol resistant S. Schwarzengrund, but some drug resistant genes, such as PSE-1, cml/tetR and flo were not determined but other drug resistant genes, for example TEM and int were found. The detection rates of spvC, TEM and int gene was 35.3%, 29.3% and 72.5%, respectively. The TEM gene was highly popular in S. Typhimurium, which was detected from ampicillin and amoxicillin resistant strains as 95.9%. int gene was able to detect from all the isolates identified as multidrug resistsnt (MDR), particularly DT193 was thought as the most prevalent virulence and multidrug resistance isolate. The major plasmid profile and drug resistance pattern of DT193 were 90, 40, 10.5, 6.3, 3.0kb and ACCbDNaPSSuT, respectively. MDR was commonly found in other phage types, particularly DT104, U302 and DT203.

• Journal of Microbiology and Biotechnology
• /
• v.4 no.1
• /
• pp.36-40
• /
• 1994

A water sample was taken from a black smoker chimney of a deep-sea hydrothermal vent by using an unmanned submersible "Dolphin 3K". The temperature of the hydrothermal fluid from the black smoker was $276^{\circ}C$. After isolation by repeated serial dilutions, An extremely thermophilic bacterial strain was selected. The strain designated as DT1331, was an anaerobic, non-motile, coccoid shaped bacterium with about 0.5 to $1.0\;\mu\textrm{m}$ in diameter. The strain DT1331 could grow up to $93^{\circ}C$, but the optimum temperature of this strain was $80^{\circ}C$. The growth occurred in the pH range of 4.5 to 8.5 and the optimum pH was 6.0. The strain DT1331 required 1% to 5% NaCl for growth and cell lysis was observed below 1% NaCl concentration. The bacterium could grow on polypeptides such as tryptone, peptone, soytone and on proteins such as casein or gelatin. However, no growth was observed on single amino acids, sugar and organic acids. Hydrogen gas was detected slightly during growth. This bacterium obligately required elemental sulfur and hydrogen sulfide gas was produced during growth.

• Journal of Korean Society for Atmospheric Environment
• /
• v.24 no.4
• /
• pp.393-403
• /
• 2008

In an effort to estimate secondary $PM_{10}$ concentrations and their diurnal variations at different photochemical activities, $PM_{10}$, CO, and $O_3$ concentrations obtained from the ambient air quality network located in Seoul are analyzed for the period from 2000 to 2005. In order to classify the photochemical activities on a daily basis, measured ${\Delta}O_{3,\;max-min}$ (maximum $O_3$-minimum $O_3$) and ${\int}(hv)dt$ which represents accumulated daily insolation, were used to classify each day into three regimes: 1) low photochemical reactivity; ${\Delta}O_{3,\;max-min}\;{\leq}\;40\;ppb$, and ${\int}(hv)dt\;{\leq}\;4000\;W/m^2$, 2) moderate photochemical reactivity; $40\;ppb\;<\;{\Delta}O_{3,\;max-min}\;{\leq}\;60\;ppb$, and $4000\;{\leq}\;{\int}(hv)de\;{\leq}\;6000\;W/m^2$, and 3) high photochemical reactivity; ${\Delta}O_{3,\;max-min}\;>\;60\;ppb$, and ${\int}(hv)dt\;{\geq}\;6000\;W/m^2$. The ratio of ($PM_{10}$/CO) obtained at low photochemical activity regime was used as an index of tracer for the estimation of secondary $PM_{10}$ at higher photochemical activity regimes. The results show that the estimated secondary $PM_{10}$ concentrations for moderate and high photochemical regimes are found to be 18.8% ($10.9\;{\mu}g/m^3$), and 35.0% ($26.2\;{\mu}g/m^3$), respectively. Diurnal variation of secondary $PM_{10}$ for the moderate photochemical regime shows weak but noticeable patterns. However, the highly activated photochemical regime shows strong diurnal variations of secondary $PM_{10}$ concentrations with the maximum value of $35.1\;{\mu}g/m^3$ at 1300LST.

• Korean Journal of Psychosomatic Medicine
• /
• v.26 no.2
• /
• pp.77-85
• /
• 2018

Objectives : This study aimed to investigate the level of distress using the distress thermometer (DT) and the factors associated with distress in postoperative breast cancer (BC) patients. Methods : DT and WHOQOL-BREF (World Health Organization Quality of Life Scale Abbreviated Version) along with sociodemographic variables were assessed in patients undergoing surgery for their first treatment of BC within one week postoperatively. The distress group consisted of participants with a DT score ${\geq}4$. The prevalence and associative factors of distress were examined by descriptive, univariable, and logistic regression analysis. Results : Three hundred seven women were recruited, and 264 subjects were finally analyzed. A total of 173 (65.5%) were classified into the distress group. The distress group showed significantly younger age (p=0.045), living without a spouse (p=0.032), and worse quality of life (QOL) as measured by overall QOL (p=0.009), general health (p=0.005), physical health domain (p<0.000), and psychological health domain (p=0.002). The logistic regression analysis showed that patients aged 40-49 years were more likely to experience distress than those aged ${\geq}60years$ (Odds ratios [OR]=2.992, 95% confidence interval [CI] 1.241-7.215). Moreover, the WHOQOL-BREF physical health domain was a predictive factor of distress (OR=0.777, 95% CI 0.692-0.873). Conclusions : A substantial proportion of patients are experiencing significant distress after BC surgery. It would be expected that distress management, especially in the middle-aged patients and in the domain of physical QOL (e.g., pain, insomnia, fatigue), from the early BC treatment stage might reduce chronic distress.

• Bulletin of the Korean Mathematical Society
• /
• v.40 no.1
• /
• pp.159-165
• /
• 2003

We consider the stochastic differential inclusion of the form $dX_t\;\in\;\sigma(t,\;X_t)db_t+b(t,\;X_t)dt$, where $\sigma$, b are set-valued maps, B is a standard Brownian motion. We prove the boundedness of solutions under the assumption that $\sigma$ and b satisfy the local Lipschitz property and linear growth.

• YAKHAK HOEJI
• /
• v.41 no.6
• /
• pp.829-836
• /
• 1997

Studies on the effect of quinones on cardiac function has been conducted with normal hearts. But not with injured hearts, I.e. ischemia/reperfusion-injured heart. Quinone compounds are known to produce oxygen free radicals during metabolism, and for this reason, quinones are implicated in the aggravation of ischemia/reperfusion injury or cardioprotection, as in the case of ischemic preconditioning depending on the experimental conditions. The present study was carried out to examine the effect of 2-chloro-3-(4-cyanophenylamino)-1.4-naphthoquinone (NQ-Y15) on cardiac function of ischemic/reperfused and normal rat hearts. In isolated perfused hearts, various functional parameters such as left ventricular developed pressure (LVDP), left ventricular end-diastolic pressure (EDP) and maximum positive and negative dP/dt ($[\pm}dP/dt_{max}$), time to contracture, heart rate (HR) and coronary flow rate (CFR) were measured before and 30 min after dosing and following 25 min ischemia/30min reperfusion. NQ-Y15 increased LVDP, +dP/$d_{max}$and -dP/$dt_{min}$ by 18%. 30%, and 40%, respectively. There were no significant changes in other haemodynamic parameters. After ischemia/reperfusion injury, pretreatment with NQ-Y15 induced a significant decrease in LVDP and $[\pm}dP/dt_{max}$, but an increase in EDP. LDH-release was not significantly increased. These results suggested that NQ-Y15 may augment the ventricular contractility but it makes hearts more vulnerable to ischemia/reperfusion injury.

• Journal of Oral Medicine and Pain
• /
• v.46 no.2
• /
• pp.41-48
• /
• 2021

Purpose: To evaluate compliance by analyzing and comparing treatment duration, degree of improvement after treatment and treatment response of oral lichen planus (OLP) patients according to characteristics of them and the severity of the lesion. Methods: According to treatment process, 132 subjects with OLP who first visited the Department of Oral Medicine at the Pusan National University Dental Hospital from January 2017 to December 2020were classified into three groups: Treatment completed (CT) group, Under treatment (UT) group, and Dropped out during follow-up (DT) group. The reticulation/keratosis, erythema, and ulceration (REU) scoring system was used to assess the severity of OLP. The degree of improvement after treatment was evaluated in CT group. Results: There were 53 (40.15%) CT, 27 (20.45%) UT and 52 (39.39%) DT. In CT group, according to initial REU score there was a statistical difference in the degree of improvement, but not in the length of time to complete treatment. There was no statistical difference between the days it took for patients to feel symptom relief, and the days of entire treatment among three groups. However, there was a positive correlation between the REU score of gingiva and duration of treatment in DT group. In the CT and DT groups, there was a correlation between the length of time taken to relieve symptoms and the duration of treatment. Conclusions: The severity of the gingival lesion and the initial response to treatment have a large effect on the entire treatment period and prognosis, so it should be considered when explaining the disease prognosis and treatment period to patients, and the clinician needs to focus on initial symptom relief.

• YAKHAK HOEJI
• /
• v.40 no.4
• /
• pp.438-441
• /
• 1996

The therapeutic activity of LB20304a was examined on experimental respiratory tract infection (RTI) caused by Klebsiella pneumoniae DT-S in mice. A single oral dose of LB 20304a (1.2mg/mouse) showed a rapid bacteriocidal activity in lung tissue at 4,7 and 24h after administration of drug. The in vivo activity of LB20304a was comparable to that of ciprofloxacin against K. pneumoniae infection, although in vitro MIC of LB20304a was four-fold higher than that of ciprofloxacin.

• Publications of The Korean Astronomical Society
• /
• v.30 no.2
• /
• pp.211-214
• /
• 2015

We investigated the period variation for 79 eclipsing binary systems using 20 years (1990-2009) of EROS, Macho, and OGLE survey observations. We discovered 9 apsidal motions, 8 mass transfers, 5 period increasing and decreasing systems, 12 light-travel-time effects, 5 eccentric systems and 40 other systems showing no period variations. We select 3 representative eclipsing binary systems; EROS 1052 for apsidal motion, EROS 1056 for mass transfer, and EROS 1037 for the light-travel-time effect. We determine the period variation rate (dP/dt), orbital parameters of the 3rd body (e3, ${\omega}_3$, $f(m_3)$, $P_3$, $T_3$), apsidal motion parameters ($d{\omega}/dt$, U, Ps, Pa, e) and apsidal motion period by analyzing the light curves and O-C diagrams.