• The Journal of Korean Obstetrics and Gynecology
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• v.29 no.1
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• pp.1-13
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• 2016

Objectives The purpose of this study is to find out the effect of various concentrations of Hwangnyeonhaedok-tang (HTT) pharmacopuncture on ST25 (天樞) in rats with dextran sulfate sodium (DSS)-induced colitis.Methods Colitis was experimentally induced by feeding rats with water mixed with 5% (w/v) DSS for 20 days. The rats were divided into 5 groups: the normal group (Nor, n=5), the control group - colitis induced rats with no treatment (Con, n=5), the acupuncture group - colitis induced rats with acupuncture applied on ST25 (Acu, n=5), the pharmacopuncture group 1 - colitis induced rats with 0.729 mg/250 g/40 μl of pharmacopuncture applied on ST25 (PA-1, n=5), the pharmacopuncture group 2 - colitis induced rats with 3.645 mg/250 g/40 μl of pharmacopuncture applied on ST25 (PA-2, n=5). The changes in weight, excrement concentration and hemafecia were observed 5 times every 2 days. The colon lengths were measured from appendix to the end of colon after the experiment. Hematological and serological exams were conducted the day after the last treatment by cardiac puncturing anesthetized rats.Results ST25 is the abdominal front point (募穴) of large intestine meridian and is known to have effect in colitis. Various concentrations of HTT pharmacopuncture (HTTP) applied on ST25, in rats with DSS-induced colitis inhibited decrease in colon lengths and body weight in both PA-1 and PA-2 groups. Hematological and serological exam results also showed that HTTP has significant effect on colitis in both PA-1 and PA-2 groups.Conclusions Colon lengths were significantly increased in the acupuncture group, PA-1 group and PA-2 group, compared to the control group. The body weight was significantly increased (p<0.05) in PA-2 group after the first treatment, compared to the control group. TNF-α, IL-6, AST were significantly decreased in PA-1 and PA-2 groups, compared to the control group.

• Korean Journal of Plant Resources
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• v.31 no.4
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• pp.275-282
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• 2018

Paeoniae Radix has been used as a traditional medicine for various diseases including hepatic disease. However, the inhibitory effect of Paeoniae Radix on intestinal inflammation has not been fully understood yet. The aim of this study was to evaluate the effect of Paeoniae Radix on colitis induced by dextran sulfate sodium in mice. To investigate the protective effects of Paeoniae Radix, the colitis mice were induced by drinking water containing 5% dextran sulfate sodium for 7 days. Mice were randomized into groups receiving Paeoniae Radix (100 mg/kg), sulfasalazine (150 mg/kg) as a positive control, or water as a negative control. We evaluated the effects of Paeoniae Radix on clinical signs induced by dextran sulfate sodium, measuring weight loss, colon length, and disease activity index. Additionally, to find a possible explanation for the anti-inflammatory effects of Paeoniae Radix, we evaluated the effects of Paeoniae Radix on the interleukin-6 and cyclooxygenase-2 levels in colitis tissue. The results indicated that mice treated with dextran sulfate sodium showed measurable clinical signs, including weight loss and reduced colon length. However, Paeoniae Radix treatment significantly improved the weight loss and disease activity index as clinical symptoms. Moreover, Paeoniae Radix inhibited the interleukin-6 and cyclooxygenase-2 expression levels in colon tissues treated with dextran sulfate sodium. Taken together, the findings of this study suggest that Paeoniae Radix may be useful for treating intestinal inflammation, including ulcerative colitis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.3
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• pp.104-116
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• 2021

In order to reduce the social and economic costs due to the increase in dementia patients, which is a representative senile disease in an aging society, it will be important to prevent dementia and to detect and treat early in high-risk groups. This study reported the results of treatment for the elderly with high risk of dementia and depression who received Korean medicine (KM) treatment in 9 KM clinics. Medical charts were surveyed on 116 patients with high risk of dementia and depression who received KM treatment at 9 KM clinics in Gangseo-gu from September 1, 2020 to December 31, 2020. The majority of the patients were female(76.72%), the average age was 71.66±7.18 years old, and the average education level was 8.96±3.91 years. The average treatment period was 61.47±10.30 days, the average number of treatments was 15.38±1.06 times, and both acupuncture and herbal medicine were administered. After receiving KM treatment, cognitive assessment scores such as MMSE-DS and MoCA-K, depression-related GDSSF-K score, dementia knowledge, attitude, and preventive behavior, blood debilitation scale, and GQOL-D score were improved compared to before. There was no specific adverse reaction except that one patient with elevated AST and ALT levels was observed. This study showed improvement in cognitive function, depression, dementia-related scale, and quality of life in high-risk groups for dementia and depression over 60 years old who received KM treatment. More systematic and large-scale planned clinical studies will be needed.

• 재활복지
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• v.22 no.3
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• pp.23-39
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• 2018

The fourth industrial revolution and technological innovation will make the job factor of people with disabilities complicated and difficult. Thus, this study analyzed the technical factors influencing the job structure and tried to find a way to develop the job of the people with disabilities in response to the 4th Industrial Revolution by changing the labor market and changing the trend of the employment by industry. The methods for this study are literature research and FGI. First, technological factors affecting the job structure of the Fourth Industrial Revolution are artificial intelligence, Internet and networking of things, 3D printing, big data, Second, technological innovation due to the industrial revolution was a major factor in the job structure. As the industrial revolution and technological innovation progressed, the job structure shifted rapidly from the manufacturing industry to the service industry, Third, as the measures of the 4th Industrial Revolution and the change of the job structure, it is necessary to make preemptive investment for the development of competency to cope with technological innovation, Finally, in order to respond to the Fourth Industrial Revolution and the rapidly changing technological innovation, the basic data of people with disabilities should be able to be big data.

• Journal of Society of Occupational Therapy for the Aged and Dementia
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• v.12 no.2
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• pp.107-115
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• 2018

Objective : The purpose of this study is to investigate the effect of a group occupational therapy program on the depression and quality of life of the elderly with Mild Cognitive Impairment(MCI). Method : The elderly with Mild Cognitive Impairment were selected based on the Mini Mental State Examination-Dementia Screening(MMSE-DS). The group occupatinal therapy program consisted of various cognitive domains and was performed 12 times for 6 weeks. The Geriatric Depression Scale(SGDS-K) and Quality of Life(QOL) were used to assess depression and quality of life of the subjects before and after the intervention. Result : The elderly with MCI improved significantly on the SGDS-K and QOL after the intervention program(p<0.05). Particularly, in some items of the QOL, there was a statistically significant difference, but the results of the SGDS-K and QOL did not show any correlation(p>0.05). Conclusion : In the case of the elderly with MCI, the QOL scale and the depressive symptom test were statistically significant when the group occupational therapy program was applied for 6 weeks.

• Korean Journal of Plant Taxonomy
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• v.48 no.4
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• pp.363-369
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• 2018

Since the establishment of the Korean Society of Plant Taxonomists (KSPT) on Dec. 13, 1968, the professional manpower training and research activities have been analyzed. The survey method was based on the homepage of the KSPT and the Korean J. Pl. Taxon, and on data provided by each university about professional manpower. Over the past 50 years, a total of 680 specialists in plant taxonomy have been trained, consisting of 537 master's degree holders (274 males, 263 females) from 30 universities and 143 PhDs (97 males, 46 females) from 26 universities, and the number has increased significantly since 1998. With regard to changes in the field of research over the last ten years, revision papers were the most common in the period of 1988-1997 (72%), but this rate has decreased to 51% over the last ten years, while the number of unrecorded papers has increased to 28%. In the 629 revision papers on taxa, 49% of the taxa belong to Asteraceae, Ranunculaceae, Cyperaceae, Liliaceae, Rosaceae, Fabaceae, Apiaceae, Lamiaceae, Orchidaceae, Oleaceae, Euphorbiaceae, Polygonaceae, and Amaryllidaceae. With regard to changes in research methods, the number of morphological papers increased from 6% to 51%, while pollen papers have decreased from a rate of 20% to only 2%. Chromosome studies account for 3-4%, chemotaxonomic studies 2%, and DNA studies remain low at 3-16%. The percentage of papers in English now stands at 43%, mainly due to the increased number of papers on unrecorded species.

• Journal of Energy Engineering
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• v.28 no.2
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• pp.1-17
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• 2019

This article analyzes causal relationships among gross domestic product(GDP), electricity consumption, carbon dioxide($CO_2$) emission and foreign direct investments(FDI) inflow of Korea over the period from 1976 to 2014, using unit root test, cointegration test, and vector error correction model(VECM). As the results, this article found (1) a long-run bi-directional causality between GDP and electricity consumption, which may imply a negative impact of electricity consumption-saving policy on economic growth, (2) uni-directional short- and long-run causalities running from $CO_2$ emission to GDP, and a uni-directional long-run causality running from $CO_2$ emission to electricity consumption, which can result in a negative impact of $CO_2$ emission reduction policy on economic growth and electricity consumption, (3) a uni-directional long-run causality running from FDI to GDP, and uni-directional short- and long-run causalities running from FDI to electricity consumption, which may result from relatively lower electricity prices than investing countries, (4) no causality between FDI and $CO_2$ emission, which is based on the characteristics of FDI composed of service industries. Considering the above causal relationships among the four variables, the policy implication needs to focus on the electricity demand management based on the relevant R&Ds, and on the gradual transition from fossil fuel- to renewable-energy. Adaptive policy to increase the FDI inflow is also needed.

• The Journal of the Convergence on Culture Technology
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• v.5 no.3
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• pp.317-326
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• 2019

The present study aimed to investigate the comparative evaluation of pharmacological efficacy between sulfasalazine alone and combination with herbal medicine on dextran sodium sulfate (DSS)-induced UC in mice. Balb/c mice received 5% DSS in drinking water for 7 days to induce colitis. Animals were divided into five groups (n = 9): group I-normal group, group II-DSS control group, group III-DSS + sulfasalazine (30 mg/kg), group IV-DSS + sulfasalazine (60 mg/kg), group V-DSS + sulfasalazine (30 mg/kg) + Radish Extract mixture (30 mg /kg) (SRE). DSS-treated mice developed symptoms similar to those of human UC, such as severe bloody diarrhea and weight loss. SRE supplementation, as well as sulfasalazine, suppressed colonic length and mucosal inflammatory infiltration. In addition, SRE treatment significantly reduced the expression of pro-inflammatory signaling molecules through suppression both MAPK) and nuclear factor-kappa B (NF-${\kappa}B$) signaling pathways, and prevented the apoptosis of colon. Moreover, SRE administration significantly led to the up-regulation of anti-oxidant enzyme including SOD and Catalase. This is the first report that Radish extract mixture combined with sulfasalazine protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazin.

• Journal of Korean society of Dental Hygiene
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• v.19 no.1
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• pp.55-64
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• 2019

Objectives: The purpose of this study was to compare the differences in oral health-related quality of life among elderly people aged over 65 years, in terms of physical, mental and oral health status and to analyze factors affecting their oral health-related quality of life. Methods: From May 9 to June 23, 2017, we randomly visited aged-care community centers in the metropolitan area, and recruited 222 elderly, aged 65 or older. First, each participant completed a questionnaire consisting of 4 general items: 1 systematic disease, and 3 subjective oral conditions. Afterwards, the researchers interviewed the participants to assess their mental status, using MMSE-DS and recorded the responses. Finally, an oral examination was performed to determine the number of remaining teeth. The average oral health-related quality of life according to each characteristic was analyzed by t-test and ANOVA. Hierarchical multiple regression analysis and Pearson's correlation coefficient analysis were used to analyze the correlations between factors and the factors affecting oral health-related quality of life. Results: The mean oral health-related quality of life was 4.15. Participants with 20 or more remaining teeth demonstrated better oral health-related quality of life than those with 19 or less teeth. Higher oral health-related quality of life was also found among elderly without gingival bleeding, self-reported halitosis and dry mouth. In addition, positive correlation with the number of remaining teeth and negative correlation with gingival bleeding, self-reported halitosis and dry mouth, were noted. Finally, the results of the hierarchical multiple regression analysis indicated that remaining teeth, gingival bleeding, self-reported halitosis and education were influential factors in determining the oral health-related quality of life among the elderly. Conclusions: The results of this study confirmed the necessity of better policy support, and the importance of implementing delivered, elderly-centered oral health education program by professionals to prevent tooth loss and manage periodontal diseases.

• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.202-202
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• 2018

본 논문에서는 분포형 강우-유출 모형인 GRM(Grid based Rainfall-runoff Model)(최윤석, 김경탁, 2017)을 이용해서 낙동강 유역을 대상으로 대유역 홍수해석시스템을 구축하고, 유출해석을 위한 실행시간을 평가하였다. 유출모형은 낙동강의 주요 지류와 본류를 소유역으로 구분하여 모형을 구축하고, 각 소유역의 유출해석 결과를 실시간으로 연계할 수 있도록 하여 낙동강 전체 유역의 유출모형을 구축하였다. 이와 같이 하나의 대유역을 다수의 소유역시스템으로 분할하여 모형을 구축할 경우, 유출해석시스템 구성이 복잡해지는 단점이 있으나, 소유역별로 각기 다른 자료를 이용하여 다양한 해상도로 유출해석을 할 수 있으므로, 소유역별 특성에 맞는 유출모형 구축이 가능한 장점이 있다. 또한 각 소유역시스템은 별도의 프로세스로 계산이 진행되므로, 대유역을 고해상도로 해석하는 경우에도 계산시간을 단축할 수 있다. 본 연구에서는 낙동강 유역을 20개(본류 구간 3개, 1차 지류 13개, 댐상류 4개)의 소유역으로 분할하여 계산 시간을 검토하였으며, 최종적으로 21개(본류 구간 3개, 1차 지류 13개, 댐상류 5개)의 소유역으로 분할하여 유출해석시스템을 구축하였다. 댐 상류 유역은 댐하류와 유량전달이 없이 독립적으로 모의되고, 댐과 연결된 하류 유역은 관측 방류량을 상류단 하천의 경계조건으로 적용한다. 지류 유역은 본류 구간과 연결되고, 지류의 계산 유량은 본류와의 연결지점에 유량조건으로 실시간으로 입력된다. 이때 본류와 지류의 유량 연계는 데이터베이스를 매개로 하였다. 유출해석시스템의 성능을 평가하기 위해서 Microsoft 클라우드 서비스인 Azure를 이용하였다. 낙동강 유역을 20개 소유역으로 구성한 경우에서의 유출해석시스템의 속도 평가 결과 Azure virtual machine instance DS15 v2(OS : Windows Server 2012 R2, CPU : 2.4 GHz Intel $Xeon^{(R)}$ E5-2673 v3 20 cores)에서 1.5분이 소요 되었다. 계산시간 평가시 GRM은 'IsParallel=false' 옵션을 적용하였으며, 모의 기간은 24시간을 기준으로 하였다. 연구결과 분포형 모형을 이용한 대유역 유출해석시스템 구축이 가능했으며, 계산시간도 충분히 단축할 수 있었다. 또한 추가적인 CPU와 병렬계산을 적용할 경우, 계산시간은 더 단축될 수 있으며, 이러한 기법들은 분포형 모형을 이용한 대유역 유출해석시스템 구축시 유용하게 활용될 수 있을 것으로 판단된다.