• Journal of the Korean Society of Food Science and Nutrition
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• v.39 no.8
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• pp.1179-1186
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• 2010

The antiradical property of hot water extract from dried radish (DR) or dried radish roasted with pressure (DRRP) was investigated in vitro and in LLC-PK1 cell system. The contents of total free amino acid and reducing sugar in DR were decreased by 72.86% and 3.17%, respectively, after pressurized roasting. In vitro test, $IC_{50}$ for DR and DRRP for DPPH radical scavenging activity were 646.70 and $135.45\;{\mu}g/mL$, 896.10 and $566.98\;{\mu}g/mL$ for superoxide anion radical, and 722.26 and $531.84\;{\mu}g/mL$ for hydroxy radical, respectively. The radical scavenging effects of DRRP was significantly greater than those for DR (p<0.001). These radical scavenging effects of DR and DRRP were confirmed in LLC-$PK_1$ at which oxidative stresses were induced by superoxide, nitric oxide and peroxynitrite generated in the treatment of pyrogallol, SNP, and SIN-1, respectively. Cell viability was increased in the presence of DR or DRRP, dose dependently (p<0.05), and TBARS formation was decreased. The protective effects of DRRP against oxidative damage in LLC-$PK_1$ were greater than those of DR at the same concentration tested (p<0.05). This superior antiradical activity of DRRP might be due to the products produced during the pressurized roasting in addition to the antioxidative compounds originally present in the radish. 5-hydroxyl methyl furfural (5-HMF) known as an intermediate product of the maillard reaction was detected in DRRP (0.57 mg/g), but not from DR. In conclusion, daily consumption of DRRP may prevent oxidative damage by retarding oxidative stress.

• Journal of the Korean Geotechnical Society
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• v.23 no.10
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• pp.47-56
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• 2007

In this research, the effects of the gravel content on the liquefaction behavior for both of the isotropically and $K_0-anisotropically$ consolidated gravel-sand mixtures are investigated. for this purpose, the cyclic triaxial tests for the specimens with the same relative density (Dr=40%) and variations of gravel content were performed. On the other hand, a series of undrained cyclic triaxial tests were carried out on the isotropically consolidated gravel-sand mixtures with the same void ratio (e=0.7) and from 0% to 30% gravel contents. Void ratios of gravel-sand mixtures with the same relative density (Dr=40%) are found to decrease significantly with the increase of the gravel content from 0% to about 70% and increase thereafter. But the void ratio of the sand matrix among the gravel skeleton increases with the increase of the gravel contents. Test results are as follows : for the isotropically consolidated specimen with 40% of relative density and low gavel contents (GC=0%, 20%, 40%), pore water pressure development and axial strain behavior during undrained cyclic loading show similar behavior to those of the loose sand because of high void ratio, and the specimens with high gravel content (70%) both pore pressure and strata behaviors are similar to those of dense sand. And the isotropically consolidated specimens with the same void ratio (e=0.7) and higher gravel contents show the same behavior of pore water pressure and axial strain as that of the loose sand, but for the lower gravel content this behavior shows similar behavior to that of dense sand. The liquefaction strength of the isotropically consolidated specimens with the same relative density increases with gravel content up to 70%, and the strength decreases with the increase of the gravel content at the same void ratio. Thus, it is confirmed that the liquefaction strength of the gravel-sand mixtures depends both on relative density and void ratio of the whole mixture rather than the relative density of the sand matrix filled among gravels. On the other hand, the behavior of pore water pressure and axial strain for the $K_0-anisotropically$ consolidated gravel-sand mixtures shows almost the same cyclic behavior of the sand with no stress reversal even with some stress reversal of the cyclic loading. Namely, even the stress reversal of about 10% of cyclic stress amplitude, the permanent strain with small cyclic strain increases rapidly with the number of cycles, and the initial liquefaction does not occur always with less than maximum pore water pressure ratio of 1.0. The liquefaction resistance increases with the gravel contents between 0% and 40%, but tends to decrease beyond 40% of gravel content. In conclusion, the cyclic behavior of gravel-sand mixtures depends on factors such as gravel content, void ratio, relative density and consolidation condition.

• Journal of the Korean Society of Radiology
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• v.14 no.6
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• pp.763-772
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• 2020

During X-ray examinations in the DR system, the scattered X-rays physically generated by the patient cause image blurring in poor quality. Although X-rays to increase the contrast of images, this increases the patient's exposure dose and is likely to result in grid induced artifacts. Therefore, the purpose of this study is obtain images similar to those of real-grid with non-grid level conditions using a VGR (Virtual Grid Role) algorithm that serves as a virtual grid. Comparing MTF, SNR and CNR of non-grid and VGR algorithm images obtained with 70% exposure conditions of real-grid images showed that the MTF0.5 differed from 0.265 to 0.350 and the MTF0.1 from 0.412 to 0.467 and the SNR, CNR were also different. In addition, comparing MTF, SNR and CNR of VGR algorithm and real-grid images showed that the MTF0.5 differed from 0.350 to 0.367 and the MTF0.1 from 0.467 to 0.483 and the SNR, CNR by little.

• Journal of the Korean Geotechnical Society
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• v.38 no.6
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• pp.5-16
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• 2022

In the case of domestic seismic design, deformation of structures and ground is reviewed through undrained condition analysis and applied to design and maintenance. However, when the ground undergoes dissipation after liquefaction due to a dynamic load such as an earthquake, additional displacement occurs and greater damage occurs. Therefore, it is necessary to additionally analyze the drained conditions, It is necessary to grasp the exact ground behavior such as calculating and reviewing the amount of subsidence of the ground that has undergone the loss process after an earthquake and apply it to design and maintenance together. Therefore, in this study, numerical analysis was performed assuming undrained and drained conditions by dividing pure sandy soil into loose soil with Dr=30% and high-density soil with Dr=70%. In particular, when a dynamic load such as an earthquake is applied, considering the drained conditions of the ground, the settlement amount and the pore water pressure ratio of loose and dense ground are compared, This study focused on comparative analysis of settlement amount and pore water pressure ratio in the process of ground loss after an earthquake. As a result, the amount of subsidence during the dissipation process was 30 to 60 times greater than that of the earthquake.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.1989-1992
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• 2014

Background: The aim of this study was to assess the response rates (clinical and pathological ) with docetaxel and epirubicin combination chemotherapy and its effect on outcome. Materials and Methods: We retrospectively analysed locally advanced breast cancer (LABC) patients who received NACT from January 2008 to December 2012 in our tertiary care centre. LABC constituted 37% of all breast cancer cases and 120 patients fulfilled the eligibility criteria. The regimens used for NACT were, six cycles of DEC (docetaxel $75mg/m^2$, epirubicin $75mg/m^2$, cyclophosphamide $50mg/m^2$ on Day 1, 3 weekly) and a sequential regimen (4 cycles of FEC, 5-flurouracil $600mg/m^2$, epirubicin $75mg/m^2$, cyclophosphamide $600mg/m^2$ followed by 4 cycles of docetaxel $85mg/m^2$). Results: The median age was 47 years (range 23-72). Ninety six ( 80 %) had T4 disease and 90% had clinically palpable lymph nodes at diagnosis. The median size of primary tumor at presentation was 5.9 cm. Hormone receptor positivity was seen in 55% and HER2/neu positivity, in 25%. Triple negative breast cancers constituted 25 % of the cases. The overall clinical response rate (complete or partial ) was 85% and pathological complete responses were obtained in 15%. Four cases defaulted, 5 patients died of treatment related toxicity and 15% developed febrile neutropenia on DEC. The median duration of follow up was 22 months. The median time to relapse was 20 months and the 3 year relapse free and overall survival rates were 50% and 70% respectively. Conclusions: LABC constituted 37% of all breast cancer cases at our institute. With NACT, pCR was seen in 15% of the cases. Sequential chemotherapy was better tolerated than concurrent anthracyline and taxane chemotherapy with a similar pCR.

• Development and Reproduction
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• v.19 no.3
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• pp.135-144
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• 2015

Heat shock protein (HSP) 70, the highly conserved stress protein families, plays important roles in protecting cells against heat and other stresses in most animal species. In the present study, we identified and characterized four Hsp70 (RuHSP4, RuHSC70, RuHSP12A, RuGRP78) family proteins based on the expressed sequence tag (EST) analysis of the Korean rose bitterling R. uyekii cDNA library. The deduced RuHSP70 family has high amino acid identities of 72-99% with those of other species. Phylogenetic analysis revealed that RuHsp70 family clustered with fish groups (HSP4, HSC70, HSP12A, GRP78) proteins. Quantitative RT-PCR analysis showed the specific expression patterns of RuHsp70 family members in the early developmental stages and several tissues in Korean rose bitterling. The expression of 4 groups of Hsp70 family was detected in all tested tissue. Particularly, Hsp70 family of Korean rose bitterling is highly expressed in hepatopancreas and sexual gonad (testis and ovary). The expression of Hsp70 family was differentially regulated in accordance with early development stage of Rhodeus uyekii.

• Archives of Craniofacial Surgery
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• v.24 no.3
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• pp.111-116
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• 2023

Background: In Indonesia, the prevalence of cleft lip and palate increased from 0.08% to 0.12% between 2013 and 2018. Children with cleft deformities typically undergo staged surgery. However, the coronavirus disease 2019 (COVID-19) pandemic has had negative impacts on the healthcare sector, including the suspension of elective procedures; this has raised concerns about the safety of performing surgery and the functional consequences of delaying treatment, the latter of which is associated with poor prognosis. The purpose of this study was to report the characteristics of clefts treated by the Bandung Cleft Lip and Palate Center team during the pandemic period. Methods: This brief comparative study based on a chart review was conducted at the Bandung Cleft Lip and Palate Center. We statistically evaluated data from all patients treated between September 2018 and August 2021. Frequency analysis was performed to analyze the average number of each procedure by age before and during the COVID-19 pandemic. Results: Data from 18-month periods before (n= 460) and during (n= 423) the pandemic were compared. Cheiloplasty procedures were examined (pre-pandemic, n= 230; pandemic, n= 248); before the pandemic, 86.1% were performed according to the treatment protocol (patient < 1 year old), and this proportion non-significantly dropped to 80.6% during the pandemic (p= 0.904). Palatoplasty procedures were also compared (pre-pandemic, n= 160; pandemic, n= 139); the treatment protocol (patient 0.5-2 years old) was followed for 65.5% of procedures before the pandemic and 75.5% during the pandemic (p= 0.509). Additionally, 70 (mean age, 7.94 years) revision and other procedures were performed before the pandemic and 36 (mean age, 8.52 years) during the pandemic. Conclusion: The cleft procedures performed at the Bandung Cleft Lip and Palate Center did not significantly change during the COVID-19 pandemic.

• Journal of Korean Neurosurgical Society
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• v.46 no.6
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• pp.558-563
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• 2009

Objective : Moyamoya disease (MMD) is an uncommon cerebrovascular disorder, characterized by progressive occlusion at the terminal portion of the internal carotid artery. Incidence of the disease is high in East Asia and familial MMD accounts for about 15% of the disease. Although the pathogenesis is unknown, association of HLA class I or II alleles with MMD has been reported with conflicting results. We investigated whether there is a difference in HLA class II association between familial and non-familial forms of the disease. Methods : A total of 70 Korean children with MMD, including 16 familial cases (10 probands), and 207 healthy controls were studied. Among familial cases, only 10 probands were used for the HLA frequency analysis. High resolution HLA-DRB1 and DQB1 genotyping was performed using polymerase chain reaction (PCR)-sequence specific oligonucleotide hybridization and PCR-single strand conformation polymorphism methods. Results : The phenotype frequencies of HLA-DRB1*1302 (70.0%) and DQB1*0609 (40.0%) were significantly increased in familial MMD compared to both controls [vs. 15.5%, corrected p ($p_c$) = 0.008, odds ratio (OR) = 12.76; vs. 4.3%, $p_c\;=\;0.02$, OR = 14.67] and non-familial MMD patients (vs. 14.8%, $p_c\;=\;0.02$, OR = 13.42; vs. 1.9%, $p_c\;=\;0.02$, OR = 35.33). The frequencies of DRB1 and DQB1 alleles in non-familial MMD patients were not significantly different from those in controls. Conclusion : Our findings suggest that the genetic polymorphism of HLA class II genes or other closely linked disease relevant gene(s) could be a genetic predisposing factor for familial MMD.

• The Korean Journal of Pesticide Science
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• v.2 no.1
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• pp.97-103
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• 1998

Effects of safener fluxofenim was investigated for crop injury of acetanilide's upland herbicides and for enzyme activity of glutathione S-transferase (GST) in grain sorghum. Bioassay with etiolated grain sorghum [Sorghum bicolor (L.) Moench. cv. 'G522DR'] seedlings grown in agar containing metolachlor or alachlor showed that they are strong inhibitors on root growth of grain sorghum ($GI_{50}=4.5{\mu}M$ for metolachlor and $6.2{\mu}M$ for alachlor). The safener fluxofenim applied by seed soaking protected growth of grain sorghum from crop injury of metolachlor or alachlor at the concentrations of 1 to 10 ${\mu}M$. There was a significant increase in glutathione-herbicide conjugates in root tissues of fluxofenim-treated seedlings. Activities of $GST_{-metolachlor}$ and $GST_{-CDNB}$ were increased by 82% and 70%, respectively, in the cytosolic fraction of roots with fluxofenim treatment.

• Korean Journal of Food Science and Technology
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• v.29 no.3
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• pp.522-526
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• 1997

Soy isoflavones could be recovered with adsorption resin column chromatography from soybean cooking water produced during soymilk or tofu manufacturing process. The main isoflavones in the soybean cooking water were genistin and daidzin, and their concentration was $0.083{\pm}0.019$ and $0.11{\pm}0.017\;mM$, respectively. Their aglycones were not detected. pH of soybean cooking water was critical in this chromatographic process and the recovery of isoflavones, both genistin and daidzin, was maximum at pH 4.0. Adsorption of genistin on the resin was stronger than that of daidzin. Elution rate and height/diameter ratio also affected the recovery yield. Under the optimal conditions, about 85% of genistin and 70% of daidzin could be isolated from soybean cooking water. Soy saponins were also recovered with isoflavones.