• 천문학회보
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• 제45권1호
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• pp.33.3-34
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• 2020

The Milky Way (MW) and other systems including M31 and Cen A have flattened structures of their satellites (Disk of Satellites, DoS). Such structures are rare in simulations under the ΛCDM paradigm. DoS is known to depend mainly on 1) the alignment of satellite orbits and 2) the degree of central concentration of satellites. In this work, we examine quantitatively how these two parameters affect the flatness of a system. We find that the MW-like DoS is rare in IllustrisTNG100 simulation because its two parameters are out of the 1-s range and furthermore the MW has a structure more flattened than the other systems having similar parameters. Besides, we propose a new criterion for the MW-like systems superseding the conventional ones such as major-minor axis ratio of the MW's DoS with a value of 0.183. Each satellite system has a specific orbital combination and thus has a particular distribution of its parameters (and thus flatness). The median of the distribution is set as the representative value of each system. And the representative value of the MW can be used as a new criterion for classifying the MW-like DoS. We reconstruct the orbital combination of the observed MW satellites using GAIA DR2 data and find the systems in the simulation that have representative values similar to the new criterion from the reconstructed MW system. This allows us a new interpretation on the rarity of MW-like DoS in cosmological simulations.

• Journal of Acupuncture Research
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• 제17권2호
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• pp.119-138
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• 2000

This study was designed to evaluate the effect of the bee venom(BV) aqua-acupuncture on the neuronal activities of serotonergic(5-HT) system in the brainstem. After the BV aqua-acupuncture was applied on Chok-Samni(ST36) and the gluteal part(Blank locus) in rats, the number of Fos immunoreactive neurons was counted by using computerized image analyzing system. Also, the number of colocalization between 5-HT containing neurons Fos immunoreactive neurons were analyzed by using the double immunohistochemical technique. The results of the experiments were summarized as follows : 1. In almost every neucli, the Chok-Samni group and Blank locus group showed more increase in the number of Fos immunoreactive neurons than the control group. Especially, in Arc, DR, LC, RMg, Gi, PAG Rost and PAG LV, the Chok-Samni group showed more significant increase than the control group. Also, in PAG LV Mid and Arc, Chok-Samni group showed more significant increase than the Blank locus group. 2. In DR and PAG LV Mid, Chok-Samni group and the Blank locus group showed more significant increase in the number of colocalization between 5-HT containing neurons and Fos immunoreactive neurons than the control group after the BV aqua- acupuncture. Also, the Chok-Samni group showed more significant increase than the Blank locus group. Consequently, the BV aqua-acupuncture increased more potent the number of Fos immunoreactive neurons and the activity of serotonergic neurons. Furthermore, the BV aqua-acupuncture was more effective on Chok-Samni than Blank locus group. These results indicate that the BV aqua-acupuncture is very effective therapy to control pain. The therapeutic effect of BV aqua-acupunture may associated with the endogenous modulatory system such as serotonin Those data from the study can be applied to establish the effective treatment of the BV for pain control in the clinical field.

• 한국미생물·생명공학회지
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• 제49권1호
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• pp.75-87
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• 2021

Type I Interferons (IFNα) are known for their role as biological anticancer agents owing to their cell-apoptosis inducing properties. Development of an appropriate, cost-effective host expression system is crucial for meeting the increasing demand for proteins. Therefore, this study aims to develop codon-optimized IFNα-2b in L. lactis NZ3900. These cells express extracellular protein using the NICE system and Usp₄₅ signal peptide. To validate the mature form of the expressed protein, the recombinant IFNα-2b was screened in a human colorectal cancer cell line using the cytotoxicity assay. The IFNα-2b was successfully cloned into the pNZ8148 vector, thereby generating recombinant L. lactis pNZ8148-SP_Usp45-IFNα-2b. The computational analysis of codon-optimized IFNα-2b revealed no mutation and amino acid changes; additionally, the codon-optimized IFNα-2b showed 100% similarity with native human IFNα-2b, in the BLAST analysis. The partial size exclusion chromatography (SEC) of extracellular protein yielded a 19 kDa protein, which was further confirmed by its positive binding to anti-IFNα-2b in the western blot analysis. The crude protein and SEC-purified partial fraction showed IC₅₀ values of 33.22 ㎍/ml and 127.2 ㎍/ml, respectively, which indicated better activity than the metabolites of L. lactis NZ3900 (231.8 ㎍/ml). These values were also comparable with those of the regular anticancer drug tamoxifen (105.5 ㎍/ml). These results demonstrated L. lactis as a promising host system that functions by utilizing the pNZ8148 NICE system. Meanwhile, codon-optimized usage of the inserted gene increased the optimal protein expression levels, which could be beneficial for its large-scale production. Taken together, the recombinant L. lactis IFNα-2b is a potential alternative treatment for colorectal cancer. Furthermore, its activity was analyzed in the WiDr cell line, to assess its colorectal anticancer activities in vivo.

• 지식경영연구
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• 제23권2호
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• pp.277-299
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• 2022

관광산업에서 발생하는 방대한 카드 거래 데이터는 관광객의 소비 행태와 패턴을 암시하는 중요한 자원이 되었다. 거래 데이터에 기반을 둔 스마트 서비스 시스템을 개발하는 것은 관광산업과 지식관리시스템 개발자들의 주요한 목표들 중 하나이다. 그러나 기존 추천 기법의 근간이 되어 온 평점을 활용하기 어렵다는 점은 시스템 설계자들이 학습 과정을 평가하기 어렵게 한다. 또한 시간적, 공간적, 인구통계학적 정보와 같이 추천 성과를 높일 수 있는 보조 요소들을 적절히 활용하는 방법도 어려운 상황이다. 이러한 문제들에 대하여 본 논문은 카드 거래 데이터를 기반으로 관광 서비스를 추천하는 새로운 방식인 CTDDTR을 제안한다. 먼저 Doc2Vec를 이용하여 시간성 선호도를 임베딩하여 관광객 그룹과 서비스 벡터로 데이터를 표현하였다. 다음 단계로 딥러닝 기술 중 하나인 다중 계층 퍼셉트론을 도입하여 얻어진 벡터와 관광 RDF로부터 도출한 보조 요소를 통합하여 심층 추천 모듈을 구성하였다. 추가로, 지식경영 분야의 RFM 분석 기법을 심층 추천 모듈에 도입하여 심층 신경망을 학습하는데 사용되는 평점을 생성함으로써 평점 부재 문제에 대응하였다. 제안한 CTDDTR의 추천 성능을 평가하기 위해 제주도에서 8년 동안 발생한 카드 거래 데이터를 사용하였고, 제안된 방법의 우수한 추천 성능과 보조 요소의 효과를 증명하였다.

• Journal of Electrical Engineering and Technology
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• 제9권3호
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• pp.1125-1131
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• 2014

Application of residential demand response (DR) programs are currently realized up to a limited extent due to customers' difficulty in manually responding to the time-differentiated prices. As a solution, this paper proposes an automatic home load management (HLM) framework to achieve the household minimum payment as well as meet the operational constraints to provide customer's comfort. The projected HLM method controls on/off statuses of responsive appliances and the charging/discharging periods of plug-in hybrid electric vehicle (PHEV) and battery storage at home. This paper also studies the impacts of different time-varying tariffs, i.e., time of use (TOU), real time pricing (RTP), and inclining block rate (IBR), on the home load management (HLM). The study is effectuated in a smart home with electrical appliances, a PHEV, and a storage system. The simulation results are presented to demonstrate the effectiveness of the proposed HLM program. Peak of household load demand along with the customer payment costs are reported as the consequence of applying different pricings models in HLM.

• International Journal of Quality Innovation
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• 제3권2호
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• pp.113-131
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• 2002

The relationships among multi-dimensional data (such as medical examination data) with ambiguity and variation are difficult to explore. The traditional approach to building a data classification system requires the formulation of rules by which the input data can be analyzed. The formulation of such rules is very difficult with large sets of input data. This paper first describes two classification approaches using back-propagation (BP) neural network and Mahalanobis distance (MD) classifier, and then proposes two classification approaches for multi-dimensional feature selection. The first one proposed is a feature selection procedure from the trained back-propagation (BP) neural network. The basic idea of this procedure is to compare the multiplication weights between input and hidden layer and hidden and output layer. In order to simplify the structure, only the multiplication weights of large absolute values are used. The second approach is Mahalanobis-Taguchi system (MTS) originally suggested by Dr. Taguchi. The MTS performs Taguchi's fractional factorial design based on the Mahalanobis distance as a performance metric. We combine the automatic thresholding with MD: it can deal with a reduced model, which is the focus of this paper In this work, two case studies will be used as examples to compare and discuss the complete and reduced models employing BP neural network and MD classifier. The implementation results show that proposed approaches are effective and powerful for the classification.

• 대한화학회지
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• 제53권4호
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• pp.407-414
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• 2009

o-phenylenediamine, 3-acetyl-6-methyl-(2H) pyran, 2,4 (3H)-dione (dehydroacetic acid or DHA) 및 살리실 알데히드로부터 유도한 4-hydroxy-3-(1-{2-(2-hydroxy-benzylidene)-amino phenylimino}-ethyl)-6- methy-pyran-2-one (H2L) 의 Cu(II), Ni(II), Co(II), Mn(II) 및 Fe(III) 고체 착물을 합성한 후, 원소분석, 전도 도법, 수자율, 자외선-가시선, 적외선, $^1H$-NMR 스펙트라, X-선 회절, 열분석을 통해 특성을 규명하고 항균 활성을 조사하였다. IR 스펙트럼 데이터로부터 이 리간드가 중심 금속이온에 대해 ONNO 주개원자 배열을 갖는 이염기성 네자리 리간드로 행동함을 제안하였다. 원소분석 데이터로부터 이들 착물의 화학량론이 1:1 (금속:리간드)임을 알았다. 물리-화학적 데이타로부터 Cu(II) 및 Ni(II) 착물이 사각평면 기 하구조, 그리고 Co(II), Mn(II) 및 Fe(III) 착물이 팔면체 기하구조임을 제안하였다. X-선 회절 데이터로 부터 Cu(II) 착물이 사방정계(orthorhombic) 결정계, Ni(II), Co(II) 및 Fe(III) 착물이 단사계(monoclinic) 결정계 그리고 Mn(II) 착물이 정방정계(tetragonal) 결정계임을 제안하였다. 착물의 열적 행동(TG/DTA) 을 연구하였으며 Coats-Redfern 방법으로 반응속도 파라메터를 결정하였다. 리간드와 이들 금속 착물을 이용하여 Staphylococcus aureus 및 Escherichia coli에 대한 향균 활성과 Aspergillus Niger 및 Trichoderma 에 대한 살균 활성을 조사하였다.

• Restorative Dentistry and Endodontics
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• 제24권4호
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• pp.639-646
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• 1999

The dental care delivery system and the dental specialty system have a very close relationship each other. Compared to Korea. Western European countries with predominant public sector in dental service have recognized merely 2 or 3 dental specialties, while North American countries with predominant private sector, 8 or 9 ones. It is desirable to adopt the dental specialty system as soon as possible in Korea to encourage scientific development in various dental specialties and qualitative advance in dental service. We, however, have to establish equitable dental care delivery system which can use limited dental resources efficiently as follows. 1. clarifying the different roles in assignments between general dentists and specialists by the amendment of the related laws such as the Medical Act and establishing the organic patient-referral system. 2. adopting the dental specialty system and expanding personnel and equipments so that the dental college hospitals, especially dental divisions of general hospitals, night function as secondary care facilities with specialties. 3. determining the size of dental specialists according to the national needs for dental specialized service's, whose number is to be not more than 10% of the total dentists. 4. transferring the function of accredating dental specialists to the efficient, self-controlled professional organization such as the Korean Dental Association rather than putting it under the governmental control. 5. conducting a comprehensive review of specialty education and practice for re-recognition, and maintaining competence of specialists by re-accredating them periodically. I expect this article to contribute to further discussion about the dental specialty system in Korea in productive and practical way. I am sure that we can Establish this system in the near future when people in every walks of life-the academic circle, the press, the authority concerned, consumer groups and the Korean Dental Association-take part in the discussion with special concern.

• 한국발생생물학회지:발생과생식
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• 제17권4호
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• pp.337-343
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• 2013

Post-thawed larval rearing in Pacific oyster Crassostrea gigas was performed to investigate the survival rate with time course in three kinds of larvae cryopreserved. The highest survival rate and larval activity index (LAI) of post-thawed larvae were obtained from the permeation in 0.2 M sucrose and 2.0 M ethylene glycol (EG) at $-1^{\circ}C/min$ in freezing speed showing the survival rates just after thawing of 63.8% in trochophore, 84.1% in D-shaped veliger and 56.3% in early umbo veliger. In post-thawed larval rearing with food supply, the larvae lasted their lives until 24 hours in trochophore, 75 hours in D-shaped veliger and 57 hours in early umbo veliger. The results suggested that each larval stage post-thawed revealed no more further development to subsequent respective stage.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.637-640
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• 2012

The Delhi Population Based Cancer Registry data during the period 2003-2007 were used to describe the epidemiology of primary malignant brain and central nervous system tumors in Delhi. A total of 1989 brain and CNS tumors cases in 1291 males and 698 females were registered during the period 1st January 2003 to 31st December 2007. The age adjusted (world population) incidence rates were 3.9 per 100,000 for males and 2.4 per 100,000 for females. Gliomas were the most frequently reported histology both in males (26.6%) and females (23.2%). A male predominance in incidence was observed for all histological classifications. The rates in Delhi are low compared to the incidences reported from developed countries.