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검색결과 59건 처리시간 0.022초

A novel tetrapeptide for the treatment of hair loss identified in ginseng berry: in silico characterization and molecular docking with TGF-β2

  • Sung-Gyu Lee;Sang Moon Kang;Hyun Kang
    • Journal of Plant Biotechnology
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    • 제49권4호
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    • pp.316-324
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    • 2022
  • Hair loss causes psychological stress due to its effect on appearance. Therefore, the global market for hair loss treatment products is rapidly growing. The present study demonstrated that ginseng berry-derived and sequence-modified peptides promoted the proliferation rate of dermal papilla (DP) cells and keratinocytes, in addition to having antioxidant properties. Moreover, the potential role of these ginseng berry peptides as TGF-β2 antagonists was confirmed through in silico computer docking. In addition to promoting the growth of ,the ginseng berry-derived peptides also promoted the proliferation of keratinocytes experimental Particularly, an unmodified ginseng berry-derived peptide (GB-1) and two peptides with sequence modifications (GB-2 and GB-3) decreased ROS generation and exhibited a protective effect on damaged HaCaT keratinocytes. Computer-aided peptide discovery was conducted to identify the potential interactions of important proteins with transforming growth factor-beta 2 (TGF-β2), a key protein that plays a crucial role in the human hair growth cycle. Our results demonstrated that MAGH, an amino acid sequence present in herbal supplements and plant-based natural compounds, can inhibit TGF-β2.

지자기교란시 극전리층의 전자기적인 특성 (THE ELECTROMAGNETIC CHARACTERISTICS OF THE POLAR IONOSPHERE DURING A MODERATELY DISTURBED PERIOD)

  • 안병호
    • Journal of Astronomy and Space Sciences
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    • 제12권2호
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    • pp.216-233
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    • 1995
  • Kamide et al.(1981)이 개발한 지자기기록 연전방법인 KRM 방법과 Ahn et al.(1995)이 개발한 전기전도도모델을 이용하여 지자기활동이 중간정도로 교란된 기간동안의 극전리층의 전기전도도, 전위, 수평전류, 연자기력선전류, Joule 열 발생, 오로라입자에 의한 에너지유입 등의 분포 및 하강오로라입자의 에너지스펙트럼상의 특성을 조사하였다. 지상지자기자료는 단일 자력계망(Alsaka meridian chain)에서 장기간 (1978년 3월 9일부터 4월 27일까지)에 걸쳐 얻어진 자료이므로 극전리층의 평균적인 전자기상태를 보여줄 것으로 기대되낟. 본연구에서 얻어진 몇가지 결론은 다음과 같다. (1) 전위분포는 소위 두개의 대류 cell이라 불리우는 형태를 나타내며 아침영역의 양의 전위 cell이 저녁영역의 음의 전위 cell로 깊숙히 진입된 모습을 보이고 있다. (2) 이 기간동안 오로라제트전류대가 잘 발달되어 있으며 DP-1 및 DP-2 전류계가 확인되었다. 아침영역의 서향제트전류대의 극쪽영역은 전기장이 전기전도도보다 전류의 밀도를 증가시키는데 더 중요한 구실을 하는 반면 적도쪽은 전기전도도가 상대적으로 중요한 역할을 담당하고 있다. (3) 전지구적인 규모의 연자기력선전류의 분포는 Iijima & Potemra(1976)가 구한 통계적인 분포와 유사했다. 그러나 이미 지적된 바(Kamide 1988)와 같이 영역 1의 전류밀도가 영역 2보다 현저하게 높았다. (4) Joule 열발생은 섬처럼 격리된 영역에 집중되어 나타났다. 하나는 서향제트전류대의 극쪽사면을 따라 나타나고 다른 하나는 오후영역의 동향전류대를 따라 나타났다. (5) 하강오로라입자의 최대 평균 에너지는 아침시간대(07~08 MLT)에 나타나는 반면 최대에너지유입은 02 MLT 시간대에 관측되었다. 그래서 지자기활동이 증가할 때 수반되는 오로라밝기의 증가와 전기전도도의 강화는 하강전자의 평균에너지의 증가보다는 에너지속의 증가와 더 밀접한 관계가 있는 것 같다.

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"Leak Current" correction for critical current measurement of no-insulation HTS coil

  • Song, Jung-Bin;Hahn, Seungyong
    • 한국초전도ㆍ저온공학회논문지
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    • 제19권2호
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    • pp.48-52
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    • 2017
  • Discrepancy between a power supply current and an actual "spiral" coil current makes the conventional 4-probe measurement of a critical current ($I_c$) of a no-insulation (NI) high temperature superconductor (HTS) coil inaccurate and time-consuming. This paper presents a fast and accurate approach for $I_c$ measurement of NI HTS coils. With an NI HTS coil energized at a constant ramping rate, a complete analytic expression for the spiral coil current was obtained from a first-order partial differential equation that derived from an equivalent circuit model of the NI coil. From the analytic solution, both spiral coil current and radial leak current can be obtained simultaneously, which enables fast and accurate measurement of the NI coil $I_c$. To verify the proposed approach, an NI double-pancake (DP) coil, wound with GdBCO tapes of $6mm{\times}0.1mm$, was constructed and its $I_c$ was repeatedly measured with various ramping rates in a bath of liquid nitrogen at 77 K. The measured results agreed well with the calculated ones, which validates the proposed approach to measure $I_c$ of an NI HTS coil.

Douglas Peucker 근사화 알고리즘과 빈 분류 기반 벡터 맵 데이터 압축 (Vector Map Data compression based on Douglas Peucker Simplification Algorithm and Bin Classification)

  • 박진혁;장봉주;권오준;정재진;이석환;권기룡
    • 한국멀티미디어학회논문지
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    • 제18권3호
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    • pp.298-311
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    • 2015
  • Vector data represents a map by its coordinate and Raster data represents a map by its pixel. Since these data types have very large data size, data compression procedure is a compulsory process. This paper compare the results from three different methodologies; GIS (Geographic Information System) vector map data compression using DP(Douglas-Peucker) Simplification algorithm, vector data compression based on Bin classification and the combination between two previous methods. The results shows that the combination between the two methods have the best performance among the three tested methods. The proposed method can achieve 4-9% compression ratio while the other methods show a lower performance.

Performance Comparison of MISP-based MANET Strong DAD Protocol

  • Kim, Sang-Chul
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • 제9권9호
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    • pp.3449-3467
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    • 2015
  • A broadcast operation is the fundamental transmission technique in mobile ad-hoc networks (MANETs). Because a broadcast operation can cause a broadcast storm, only selected forwarding nodes have the right to rebroadcast a broadcast message among the one-hop and two-hop neighboring nodes of a sender. This paper proposes the maximum intersection self-pruning (MISP) algorithm to minimize broadcasting redundancy. Herein, an example is given to help describe the main concept of MISP and upper bounds of forward node have been derived based on induction. A simulation conducted demonstrated that when conventional blind flooding (BF), self-pruning (SP), an optimized link state routing (OLSR) multipoint relay (MPR) set, and dominant pruning (DP), are replaced with the MISP in executing Strong duplicate address detection (DAD), the performances in terms of the energy consumption, upper bounds of the number of forward nodes, and message complexity have been improved. In addition, to evaluate the performance in reference to the link error probability, Pe, an enhancement was achieved by computing a proposed retransmission limit, S, for error recovery based on this probability. Retransmission limit control is critical for efficient energy consumption of MANET nodes operating with limited portable energy where Strong DAD reacts differently to link errors based on the operational procedures.

구조적 접근방식의 온라인 자동 서명 겁증 기법 (A Structural Approach to On-line Signature Verification)

  • 김성훈
    • 한국컴퓨터정보학회논문지
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    • 제10권4호
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    • pp.385-396
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    • 2005
  • 이 논문에서는 온라인 서명 검증에 대한 새로운 접근 방법으로, 서명을 필기의 기본 구성 요소들로 표현하는 구조적인 접근 방법을 제시한다. 속력의 국부 극소점을 분할점으로 하여 얻어지는 부분을 원시 패턴으로 정의하였고, 서브패턴으로서 방향 변화에 의해 얻어지는 단순 회전형 성분, 첨형 성분, 종형 성분의 세 가지 종류를 정의하여 서명을 구조적으로 표현하였다. 그리고 서브패턴을 기본 단위로 한 동적 계획정합 알고리듬을 제시하였다. 또한, 학습 샘플로부터 국부적인 부분에 대한 변화도와 복잡도를 추출하여 참조 패턴의 학습과 진위 판단 임계치를 설정하였다. 실험을 통하여, 함수적 접근과 매개변수적 접근 그리고 제안된 구조적 접근 방법을 동일 조건에서 검증률, 처리시간, 메모리의 측면에서 비교하였다. 제안된 방법에서는, 서명의 국부적인 가중치를 적용하고 복잡도를 판단임계치의 설정에 사용함으로써 평균 오류율이 14.2%에서 4.05%로 검증률이 크게 향상되었다. 또한, 시간과 메모리의 측면에서 함수적 접근 방법에 비해 효과적이면서도 함수적 접근 방법의 최고 성능에 근접한 검증률을 얻을 수 있었다.

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농도의 기층 및 보조기층 공법연구 -노상 및 시멘트 안정 처리층의 Mr 특성을 중심으로- (Study on the Base and Subbase Method of Agricultural Road -On the Resilient Modulus Characteristics of the Subgrade and Cement Treated Base-)

  • 도덕현
    • 한국농공학회지
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    • 제31권2호
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    • pp.66-81
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    • 1989
  • The characteristics of resilient modulus(Mr) which dominates the life of pavement and the design of pavement were investigated on the test specimens which were cement treated and non-treated of the three different soil types. The results are summarized as follows : 1. The resilient modulus was decreased by increasing the cyclic deviator stress ($\sigma$d) , especially the resilient modulus was gradually decreased or sometimes increased when the value of ad was greater than 0.75- 1. 0kg/cm$^2$. 2. The resilient modulus was increased by increasing the homogeneous confined stress ($\sigma$do) and such phenomena were distinct on the coarse soils. 3. The resilient modulus was increased by increasing the ratio of confined stress(Kc), and this phenomena were eminent on the coarse soils too, and the higher permanent strain was showed by increasing the value of Kc. 4. In the drained cyclic triaxial compression test, the value of ad, Kc, and (Oho) was introduced by the following interrelated equations which were similar to the Mr model of Cole. Kcn/Mr=K1(J$_2$/ $\tau$oct)K2 ............. (coarse soli) Mcn/Mr=K3($\sigma$dp/ $\tau$f)k4 ...............(fine soils) 5. The stress path was not much affected by the value of Mr, however, moisture content, dry desity, and contant of fines affected the value of Mr. 6. In the soil-cement specimens, the resilient compression strain($\varepsilon$d) was decreased by the increment of the $\sigma$ho, and Mr was decreased by increasing the $\sigma$d 7. In the flexible pavement. the cement treated layer should be designed not to fail by the fatigue before the designed traffic load, and actually the pavement could cover the traffic load to a certain extent under the post-crack phase, therefore farther studies on this phenomena' are required in the design analysis. 8. The finite element computer program (ANALYS) was used for displacement analysis of pavement containing the cement-treated layer, The result showed that the program used for this analysis was proved to be usable.

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무선 ATM망에서 동적 변수를 이용한 비디오 데이터의 대역폭 할당방식에 대한 연구 (A Study on the Bandwidth Assignment Scheme for Video Data Using Dynamic Parameters in the Wireless ATM Networks)

  • 장동혁;김승환;이선숙;권오석
    • 정보처리학회논문지C
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    • 제9C권1호
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    • pp.73-78
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    • 2002
  • 무선 ATM망에서 동적 슬롯할당을 행하기 위해서는 이동국(MT)에서 요구되는 슬롯량은 이동국의 트래픽 특성을 반영하는 동적 변수들(DPs)에 의해 예측된다. VBR 트래픽에서 슬롯할당은 시의존성 특성 및 서비스품질(QoS) 요구를 고려하여 이동국에서 행해진다. 본 논문에서는 동적 변수들-버퍼상태 정보와 버퍼상태 변화-이 대역내 신호방식으로 전송된다. 또한, 기지국(BS)은 각 이동국의 트래픽 특성을 고려하여 동적 슬롯할당을 수행한다 다시 말해서, 이동국 버퍼가 특정한 임계값을 넘으면 버퍼상태 정보는 기지국에게 '버퍼풀 상태'의 가능성을 알리며, 버퍼상태 변화는 이동국에게 입력 셀에 대한 버퍼상태의 변화를 알려준다 만약 버퍼상태 정보가 '낮음(임계값보다 큰 경우)'과 '급상승' 상태이면 셀 전송지연과 셀 손실이 발생하는 '버퍼풀'을 가져온다. 이때 기지국은 이동국에게 부가적인 슬롯을 할당하며 이동국은 버퍼내의 셀들을 전송한다. 시뮬레이션을 통해 제안된 방식이 EPSA 대역내 신호방식보다 샌 지연과 셀 손실에 대한 성능이 우수함을 보여준다.

현대 여성 수트에 있어서 남성성(masculinity)을 나타내는 색채 특성 - 2004~2006년 F/W의 파리, 런던, 뉴욕, 밀라노 컬렉션을 중심으로 - (The Color Characteristics of Masculinity Presented in Modern Women's Suit - Focus on the Paris, London, New York and Milan Collections from 2004 F/W to 2006 F/W -)

  • 권지현;김영인
    • 복식
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    • 제58권2호
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    • pp.62-77
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    • 2008
  • This study aims to analyze color characteristics centered by women's suit styles that represent masculinity remarkably. Through this, it figures out color's type and continuance availability as a representing tool to express masculinity to provide useful color information which can be applied effectively to various color planning. For this research, related images were collected among women's pants suits appeared in $2004{\sim}2006's$ Paris, London, New York and Milan collection F/W that are most similar to modern man's suit. Among them, the study analyzes 319 pictures where the features of masculinity were represented effectively. The referred color values were earned by converting $L^*a^*b^*$ values measured through the color extracting tool of Computer program (Adobe Photoshop CS) and color tone characteristic were analyzed by classifying 12 color PCCS and 5 achromatic colors. The result of the study are as follows: First, based on standard of color hue and tone, in terms of color hue, PB, YR, Y were frequently shown up but G, BG series were not found much after analyzing overall women's pants suit color characteristics shown in $2004{\sim}2006$ Paris, London, New York and Milan collection. Second, the color analysis about 3years of $2004{\sim}2006$ tells that achromatic colors have been most widely used in every year. In terms of color hue, PB, YR, Y series were appeared most popular and G, BG classes weren't appeared frequently. In addition, once looking at yearly color tone distribution trend, like overall color tone distribution result, Bk, w, dkg, g, p were highly used as sequential and b, v, dp, sf, ItGy series show low distribution level. And such a distribution level of low and high in frequency has been showed continuously as a similar style. Accordingly, through the study, as a tool to express masculinity in women's suit, achromatic colors like black and white series and PB, YR, Y series color were investigated as most popular uses. And as color tones, Bk, w, dkg, g, p were used frequently.