• Korean Journal of Occupational Health Nursing
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• v.6 no.1
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• pp.53-71
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• 1997

Across sectional study was performed to evaluate the chronic effects on central nerve system(CNS) of cumulative exposure of complex organic solvents, using neurobehavioral test. Subjects were 66 (male) dock yard painters of some large ship industry which is located in Ulsan. The neurobehavioral test battery used in this study was NCTB (Neurabehavioral Core Test Battery recommended by WHO(World Health Organization), which consisted of 7 items-Profile of mood states (POMS), Simple reaction time, Santa Ana dexterity test. Digit span, Digit symbol, Benton visual retention test and Pursuit aiming. The subjects were classified by 3 groups according to duration of employment(group 1 ; less than 9 years, group 2 ; 10-14 years, group 3 ; more than 15 years). The results of performance were analyzed considering of work duration, age, educational level, alcohol drinking, smoking and testing time as confounding factors. Benton visual retention test, pursuit aiming correct dot and sum of dot showed significant differences among the groups, and decreased with increasing work duration. It indicated that the mean scores of performance ability were lowering according to work duration. Besides, the tests that didn't show statistical significances but showed linear trends were depression-dejection, vigor, fatigue of POMS, slowest time of simple reaction time and digit span forward. Most of the neurobehavioral test items were correlated with age and educational level. After controlling of confounding factors-age and educational level, the results followed ; digit span backward was different significantly. Tension-anxiety, depression-dejection, anger-hostility of POMS, SD and slowest time of simple reaction time, Santa Ana dexterity test non-preferred hand, digit span forward, Benton visual retention test and pursuit aiming correct dot decreased with increasing of work duration. The correlation analysis was done in order to find out the relationship between subjective symptom and the scores of neurobehavioral core test battery. According to the results of analysis there were no items that had statistical significant relationship(p<0.05).

• Bulletin of the Korean Chemical Society
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• v.29 no.5
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• pp.921-927
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• 2008

Discovery of $\alpha$-glucosidase inhibitors has been actively pursued with the aim to develop therapeutics for the treatment of diabetes and the other carbohydrate mediated diseases. As a method for the discovery of new novel inhibitors of $\alpha$-glucosidase, we have addressed the performance of the computer-aided drug design protocol involving the homology modeling of $\alpha$-glucosidase and the structure-based virtual screening with the two docking tools: FlexX and the automated and improved AutoDock implementing the effects of ligand solvation in the scoring function. The homology modeling of $\alpha$-glucosidase from baker’s yeast provides a high-quality 3-D structure enabling the structure-based inhibitor design. Of the two docking programs under consideration, AutoDock is found to be more accurate than FlexX in terms of scoring putative ligands to the extent of 5-fold enhancement of hit rate in database screening when 1% of database coverage is used as a cutoff. A detailed binding mode analysis of the known inhibitors shows that they can be stabilized in the active site of $\alpha$- glucosidase through the simultaneous establishment of the multiple hydrogen bond and hydrophobic interactions. The present study demonstrates the usefulness of the automated AutoDock program with the improved scoring function as a docking tool for virtual screening of new $\alpha$-glucosidase inhibitors as well as for binding mode analysis to elucidate the activities of known inhibitors.

• Journal of Navigation and Port Research
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• v.44 no.3
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• pp.181-186
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• 2020

Until now, the development of design and operation model for automated container terminals has been mainly performed based on the western ports model, specializing in basic loading, and discharging operations. In the case of the Busan port, terminal operators provide basic stevedoring, as well as an additional logistics service known as 'On Dock Service' not suitable for the currently commercialized automated container terminal model. This study diagnosed the current Busan port's throughput structure and terminal operational characteristic, and proposed a modified perpendicular layout container terminal transport model named 'Interchange Transport Model' for effective management of empty container and operation costs. Although the 'Interchange Transport Model' requires an additional number of transport equipment (AGV), concerning operational efficiency and cost saving, a simulation showed 22% reduction of TAT and 9.4% reduction of annual terminal operational costs in comparison to the basic perpendicular layout model.

• Korean Journal of Agricultural Science
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• v.45 no.4
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• pp.707-713
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• 2018

This study was done to search for positional candidate genes associated with the back fat thickness trait using a Genome-Wide Association Study (GWAS) in purebred Yorkshires (N = 1755). Genotype and phenotype analyses were done for 1,642 samples. As a result of the associations with back fat thickness using the Gemma program (ver. 0.93), when the genome-wide suggestive threshold was determined using the Bonferroni method ($p=1.61{\times}10^{-5}$), the single nucleotide polymorphism (SNP) markers with suggestive significance were identified in 1 SNP marker on chromosome 2 (MARC0053928; $p=3.65{\times}10^{-6}$), 2 SNP markers on chromosome 14 (ALGA0083078; $p=7.85{\times}10^{-6}$, INRA0048453; $p=1.27{\times}10^{-5}$), and 1 SNP marker on chromosome 18 (ALGA0120564; $p=1.44{\times}10^{-5}$). We could select positional candidate genes (KCNQ1, DOCK1, LOC106506151, and LOC110257583), located close to the SNP markers. Among these, we identified a potassium voltage-gated channel subfamily Q member gene (KCNQ1) and the dedicator of cytokinesis 1 (DOCK1) gene associated with obesity and Type-2 diabetes. The SNPs and haplotypes of the KCNQ1 and DOCK1 genes can contribute to understanding the genetic structure of back fat thickness. Additionally, it may provide basic data regarding marker assisted selection for a meat quality trait in pigs.

• Journal of the Korean Society of Marine Environment & Safety
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• v.25 no.7
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• pp.898-905
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• 2019

As the positive feedback between the absorption of chromophoric dissolved organic matter (CDOM) and acceleration of ice melt can impact the aquatic biota and dynamic heat budget, long-term monitoring of the CDOM variation in the polar ocean is necessary. However, the monitoring of CDOM is not easy because of harsh weather and difficult access, especially in the Antarctic Ocean. Therefore, the purpose of this study was to find a suitable long-term monitoring site for CDOM variation; we selected Maxwell Bay and Marian Cove at Sejong Base and horizontal and vertical distributions of CDOM were measured. After a 72 hr time-series measurement test of the CDOM variation at Sejong Dock and Sejong Cape in Maxwell Bay, Sejong Dock was selected, as it does not haveland discharge effects. The seasonal variation of CDOM was evident and the average CDOM concentration of Maxwell Bay was comparable with the adjacent sea. The CDOM at Sejong Dock from February to November 2010 was the highest in the fall and winter and the lowest during spring and summer. Thus, based on our one-year CDOM data, we suggest that Sejong Dock in Maxwell Bay is suitable for long-term monitoring of CDOM as an indicator of photochemical and biological environmental change and an important factor in determining the heating budget in the Antarctic Ocean.

• Journal of Korean Port Research
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• v.4 no.1
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• pp.33-43
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• 1990

우리나라에서는 70년대 이후 컨테이너 수송체계가 도입되어 운영되어 왔으나 차량의 급격한 증가와 더불어 컨테이너 수송체계는 도시교통에 있어서 많은 문제를 야기시키는 것으로 논란이 되고 있다. 특히, 부산항은 우리나라 최대의 국제 무역항으로써 전 컨테이너 수송화물의 90%이상을 처리하고 있고, 또한 수출입항으로서 제 역할을 다하고 있으나 낮은 도로율(12.45%)과 산재해 있는 30여개의 Off-Dock CY로 인해서 도심을 통과하는 컨테이너 수송차량은 많은 교통문제를 유발시키고 있다. 본 연구는 1) 부산시에 산재해 있는 30여개의 Off-Dock CY에 이르는 주요 도로상에서 컨테이너 수송량의 신간별 분포에 따라 컨테이너의 운행시간대를 첨두 시간대, 비첨두 시간대 및 심야 시간대로 분류하여 각 시간대별 평균 수송 시간 및 교통 체증으로 인한 수송 지체수준을 확인하였고, 2) 컨테이너 전용부두로 부터 Off-Dock CY에 이르는 도시 고속도로 및 주요간선도로상에서의 수송시간 및 수송 지체수준을 비교 분석하였으며, 3) 마지막으로, 효율적인 컨테이너 수송체계를 위한 최적 수송시간대 및 도로체계를 제시할 수 있었다. 특히, 컨테이너 수송시간 및 지체수준은 각 운행 시간대에 따라 현저한 차이를 보이고 있었는데, 심야 시간대를 이용하여 컨테이너 수송을 할 경우에는 다른 시간대에 비하여 50%정도의 수송시간 절감효과를 기대할 수 있었으며, 도시 고속도로를 이용할 경우에는 도시 간선도로에 비하여 30%정도의 수송시간을 절약할 수 있었다. 따라서 도시지역의 교통체중을 완화시키기 위해서 심야 시간대에 보다 많은 컨테이너 수송차량이 이용할 수 있는 컨테이너 수송체계가 확립되어야 하고, 산재해 있는 Off-Dock CY를 몇개의 ODCY그룹이나 단지까지 컨테이너 전용 고속도로의 건설이 바람직하고 생각된다.리구에서 조사한 결과 $10^{-3}$ M MGBG 단독 처리구에서 에틸렌 생성량이 가장 높았으며, spermidine과 spermine의 함량은 가장 낮았다. 부정근 형성능이 다소 회복된 $10^{-3}$ M MGBG+ $10^{-5}$M spermine 혼합처리구에서의 에틸렌 생성량은 대조구보다는 다소 높게 나타났다. 부정근 회복능이 가장 높았던 $10^{-3}$ M MGBG+ $10^{-5}$ M spermine + $10^{-4}$ M Cocl$_2$ 혼합처리구에서 에틸렌 생성량은 가장 낮게 나타났으며, polyamine 함량은 가장 높게 나타났다.(Cyperaceae), 명아주과(Chenopodiaceae) 같은 풀들이 하구언(estuary)의 해안가에 주로 서식하였던 것으로 나타났다. 이 시기동안에 해양성조류인 와편모류와 담수성 조류가 동시에 다양하게 산출되는 것은 하구언 퇴적환경이었음을 잘 지시해 준다. 제II화분대(고도, 43.72{\sim}3.36\;m$)가 시작되면서 혼합림은 침엽수림으로 바뀌었으며, 낙엽활엽수들의 서식지가 2엽소나무로 대치되면서 침엽수가 주요 수종을 이루었던 것으로 나타났다. 아마도 이런 산림형태는 자연 기후환경변화 뿐만 아니라 인간간섭에 의해 나타난 결과로 생각된다. 이 시기에 경작식물인 벼과(Gramineae), 옥수수(Zea), 메밀(Fagopyrum)과 논밭의 뚝 등지 에서 서식하는 돼지풀(Ambrosia) 등이 처음으로 산출되는 것으로 보아 인간간섭이 행해졌음을 잘 뒷 받침해준다. 또한 담수성 조류는 변함없이 산출되는 반면, 해양성조류인 와편모류가 산출되지 않는 것으로 보아 해안환경에서 다소 멀 어진

• Proceedings of the Korean Nuclear Society Conference
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• 2001.05a
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• pp.76-76
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• 2001

• The Korean Nurse
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• s.4
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• pp.88-90
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• 1963

금번 연세대학교 의과대학 세브란스 병원에 건강진단센터가 설치되고 여기서 complete health examination(종합건강진단)을 하는 여러 가지 준비를 갖추어 환자를 받기 시작하였으니 이것이 바로 인간$\ulcorner$독크$\lrcorner$라는 것이다 즉 periodic health examination(정기적 건강검진)과 periodic health evaluation(정기적 건강평가)을 하는 것이다.

• Journal of Ocean Engineering and Technology
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• v.17 no.1
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• pp.1-7
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• 2003

Autonomous underwater vehicles (AUVs) are unmanned, underwater vessels that are used to investigate sea environments in the study of oceanography. Docking systems are required to increase the capability of the AUVs, to recharge the batteries, and to transmit data in real time for specific underwater works, such as repented jobs at sea bed. This paper presents a visual :em control system used to dock an AUV into an underwater station. A camera mounted at the now center of the AUV is used to guide the AUV into dock. To create the visual servo control system, this paper derives an optical flow model of a camera, where the projected motions of the image plane are described with the rotational and translational velocities of the AUV. This paper combines the optical flow equation of the camera with the AUVs equation of motion, and deriver a state equation for the visual servo AUV. Further, this paper proposes a discrete-time MIMO controller, minimizing a cost function. The control inputs of the AUV are automatically generated with the projected target position on the CCD plane of the camera and with the AUVs motion. To demonstrate the effectiveness of the modeling and the control law of the visual servo AUV simulations on docking the AUV to a target station are performed with the 6-dof nonlinear equations of REMUS AUV and a CCD camera.

• Journal of Advanced Research in Ocean Engineering
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• v.1 no.3
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• pp.148-156
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• 2015

Deck plates of ships or offshore structures would make out-of-plane distortion for their thin thickness. These distortions are usually straightened by thermal straightening such as flame heating method. After thermal straightening, the blocks are lifted and moved by cranes to assemble it at dry-dock stage. After this lifting process, out-of-plane deformation again happens frequently. And then, they continuously cause quality and accuracy problems in the final dry-dock process. So, it takes more time for repair and correction working. According to preceding research, the lifting process by cranes would offset the effect on thermal straightening. The target of this study is to develop a methodology analyzing the remaining efficiency of thermal straightening after block lifting. The development was based on the assumption of yield state at straightening region. Therefore the remaining efficiency was obtained by different stiffness slope while lifting & relieving. The efficiency formula was designed using inherent strain, and we made a table of zero-efficiency by cooling speed and class rule's steels. As a result, if the stress orthogonal to straightened line is calculated during lifting analysis by FEA, the efficiency can be obtained linearly to the values in the table. Finally, even optimized carling position can be designed by considering the regional data from series project and welding region on deck.