• 대한본초학회지
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• 제26권4호
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• pp.1-7
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• 2011

Objectives : In this study, we investigated the effect of modified-Okbyungpoongsan (mOP) on mast cell-mediated allergic response in basophilic leukemia cell line, RBL-2H3 mast cells. Methods : Cells were stimulated with anti-DNP-IgE after the treatment of DNP-HSA (AI/D), and then incubated with different concentrations of mOP (0.1, 0.2, 0.5 and 1 mg/$m{\ell}$) in RBL-2H3 cells. Cell toxicity was determined by WST-1 assay. The degranulation of mast cells was observed by microscope with toluidine blue staining and also the levels of beta-hexosaminidase, histamine and TNF-alpha were measured in culture supernatants by enzyme-linked immunosorbant assay. Results : mOP inhibited anti-DNP-IgE-imduced degranulation of mast cells in RBL-2H3 cells. mOP also significantly decreased the levels of histamine and inflammatory cytokine, TNF-alpha in RBL-2H3 cells, but slightly decreased the level of beta-hexosaminidase. Conclusions : These results indicate that mOP, an oriental prescription could be inhibit the allergic response through suppressing the mast cell activation.

• 성인간호학회지
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• 제27권3호
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• pp.304-313
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• 2015

Purpose: Aspiration pneumonia (AP) is the major complication of dysphagia in patients with acute stroke. Nursing management for dysphagia influences on patients' health outcomes. The purpose of this study was to develop and evaluate the effects of Dysphagia Nursing Protocol (DNP) for patients with acute stroke. We aimed to examine the incidence of AP and the dependency rate at the discharge. Methods: We used a non-equivalent control group posttest only design in this study. DNP was developed with content validity index > 0.75 in all items. This protocol was composed of the evaluation, education, complication prevention, and checking phases. After training the staff nurses, we applied DNP protocol to the experimental group. The control group was enrolled from June to August 2013 (n=80), and the experimental group was June to August 2014 (n=64). Results: The incidence of AP was 16.3% in control group while 4.7% in experimental group (p=.028), and the Odds Ratio (OR) was 0.26 (p=.045). The dependency ratio was 66.3% in control group while 43.8% in experimental group (p=.011), and the OR was 0.33 (p=.011). Conclusion: DNP was beneficial for the reducing the risk of AP and the improved the functional status.

• 디지털융복합연구
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• 제17권8호
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• pp.257-264
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• 2019

본 연구는 부채마 70% 에탄올 추출물(DR)이 RBL-2H3 마스트 세포에서 항원에 의한 세포활성의 영향과 BALB/c 쥐에서 dinitrofluorobenzene에 의해 유도된 마스트 세포-매개 알레르기 접촉성피부염에 미치는 영향을 조사했다. DNP-HSA 항원과 Anti-DNP IgE 항체에 의해 활성 된 RBL-2H3 세포에서 에탄올 추출물은 급성 항원반응 표지인 ${\beta}$-hexosaminidase 분비와 히스타민 등을 억제하였고, 후기 항원반응 표지인 IL-4와 $TNF-{\alpha}$ 생성을 억압하였다. DNFB-유도 접촉성 알러지성 피부염 동물 모델에서 에탄올 추출물 처리는 귀 부기를 감소시키고 혈청 히스타민과 IL-4 분비를 억제시켰으며, DR 처리는 피부염 유발 부분에서 마스트 세포 유입을 효과적으로 방지하였다. 이러한 결과로, 에탄올 추출물은 아토피 피부염과 같은 마스트 세포-매개 알러지성 질병의 치료제로 사용할 수 있을 것이다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2015년도 제46회 하계학술대회
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• pp.47-48
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• 2015

As the power system develops rapidly into a smarter and more flexible state, so must the communication technologies that support it. Machine to machine (M2M) communication in Smart Grid environment has been discussed in European Telecommunications Standards Institute (ETSI). The power system is not easily replaceable, due to system replacement cost. The M2M gateway is required in other to improve interoperability in M2M environment. The Distributed Network Protocol 3.0 (DNP3.0) is the most important standard in the SCADA systems for the power. It has been used for device data collection/control in Substation Systems, Distribution Automation System. If the DNP3.0 data model is combined with a set of contemporary web protocols, it can result in a major shift. We selected Constrained Application Protocol (CoAP) based on RESTful as M2M protocol. It is a specialized web transfer protocol for use with constrained nodes and constrained networks. We have used the OPNET Modeler 17.1 in order to verity the SOAP versus CoAP. In this paper, we propose the CoAP-based M2M Gateway to Distribution Automation system using DNP3.0 in Smart Grid Environment.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 추계학술대회 논문집 전력기술부문
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• pp.382-384
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• 2008

D-TRS is a method of wireless communication. This method will be able to use several frequency for multiple user used chanel together. TETRA of D-TRS technology is not rented network. Using TETRA network has the strong point which cost better than CDMA network of rental network. Master server of SCADA(Supervisory Control And Data Acquisition) system is realtime supervise control and a data acquire the control system or the RTU(Remote Terminal Unit). The present paper is developed and proposal the gateway platform for electronic power backbone network based on D-TRS. This gateway platform is converted DNP3.0 messages with TETRA PDU and converted TETRA PDU with DNP3.0 messages. Master server and FRTU will be able to send and receive DNP3.0 message via TETRA network using this gateway platform.

• 전기전자학회논문지
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• 제14권2호
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• pp.41-50
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• 2010

TETRA는 ETSI에서 제안한 디지털 주파수 공용 통신의 표준 규격이다. 현재 한국에서 전력IT 무선 백본 망으로 채택되었다. 경찰서와 소방서는 TETRA 망을 사용한다. 현재 전력자동화 프로토콜로는 배전 자동화에 사용되는 DNP3.0, 원격 검침에 사용되는 DLMS, 변전소 자동화에 사용되는 IEC61850 프로토콜이 있다. 이러한 전력 자동화 프로토콜들은 CDMA나 WCDMA 모뎀을 이용하여 송수신되고 있다. 만약 전력자동화 프로토콜을 TETRA 네트워크로 전송 한다면, 경찰서나 소방서와의 시스템과 상호 운용성을 확보할 수 있다. 그리고 재난 발생 시 효과적인 상황 대처를 가능하게 해줄 것이다. 따라서, 본 논문은 TETRA를 이용하는 전력자동화 프로토콜로 전송 할수 있는 전력자동화 게이트웨이 시스템을 제안한다.

• Journal of Acupuncture Research
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• 제22권3호
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• pp.23-35
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• 2005

본 연구에서는 전침자극이 면역계의 THl/TH2 분화평형에 미치는 영향과 opioid system 과의 관계를 알아보고자 DNP-KLH의 자극을 통해 IgE 매개 알러지 반응모델을 구축하고 족삼리(足三里).에 전침자극을 가한 후 TH1/TH2 분화평형 및 opioid receptor antagonist인 naloxone에 의 한 반전여부를 확인하기 위해 total IgE, antigen-specific IgE, IFN-${\gamma}$ 및 IL-4 mRNA 발현량을 측정하여 다음과 같은 결과를 얻었다. 1. 전침자극은 DNP-KLH로 인해 과도하게 생산 된 혈청 total IgE 및 antigen-specific IgE를 감소시킴으로서 알러지 반응에 대한 유의한 억제능을 발휘하였으며, naloxone 투여로 전침 의 효과가 상쇠된 것으로 미루어 opioid system이 전침에 의한 항알러지 효과에 중요한 역할을 하는 것으로 추정된다. 2. 또한 전침자극은 DNP-KLH로 인한 TH2 cytokine의 편향상태에 대하여 TH1/TH2 평형조절능을 가진다는 것을 확인하였으며, naloxone으로 반전되지 않는 것으로 미루어 전침이 미치는 보조 T cell 분화에 대한 효과 는 opioid system에 의존하지 않는 것으로 추정된다.

• 한국통신학회논문지
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• 제39C권4호
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• pp.362-369
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• 2014

열차전력원격감시제어시스템은 열차 운행에 필요한 전력을 공급하는 제어시스템이다. 열차전력원격감시제어시스템은 관제실에서 원격지의 RTU(Remote Terminal Unit) 장치에 제어명령을 내리면, RTU는 이를 해석하여 입출력 모듈을 제어하고, 각 입출력 모듈로부터 수집된 데이터는 사령실로 전송함으로써, 사령실에서 열차에 공급되는 전력 상태를 감시 및 제어하는 시스템이다. 본 논문은 열차전력원격감시제어시스템의 구성요소인 VxWorks 실시간 운영체제 기반의 RTU에서 동작하는 DNP3 제어프로토콜 통신 소프트웨어의 취약점을 검출하기 위한 퍼징 기술에 대하여 제안한다. VxWorks는 동작중인 프로세스의 상태를 감시하기 위한 모니터링 에이전트를 설치할 수 없기 때문에, 모니터링 에이전트 없이 프로세스의 상태 정보를 획득하기 위해서 VxWorks의 디버그 채널을 이용하였다. 또한 DNP3 제어프로토콜은 제어명령을 순서대로 전송하지 않을 경우 패킷을 무시하기 때문에 제어프로토콜 함수코드 순서를 고려한 퍼징을 수행하였다. 이러한 두 가지 기술을 이용하여 VxWorks 기반의 RTU에서 실행되는 DNP3 제어프로토콜 응용프로그램의 취약점을 시험할 수 있었다.

• Advances in Traditional Medicine
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• 제3권2호
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• pp.56-62
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• 2003

The effect of aqueous extract of Terminalia chebula fruit (Combretaceae) (TCAE) by anal administration on mast cell-dependent immediate-type anaphylactic reactions was investigated. TCAE (0.005 to 1 g/kg) inhibited systemic anaphylaxis induced by compound 48/80 in mice. When TCAE was pretreated at the same concentrations with systemic anaphylaxis, the plasma histamine levels were reduced in a dose-dependent manner. TCAE (0.1 and 1 g/kg) also significantly inhibited local anaphylaxis activated by anti-DNP IgE. TCAE (0.001 to 1 mg/ml) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. Moreover, TCAE (0.01 and 0.1 mg/ml) had a significant inhibitory effect on anti-DNP IgE-mediated tumor necrosis $factor-{\alpha}$ $(TNF-{\alpha})$ production from RPMC. These results provide evidence that anal therapy of TCAE may be beneficial in the treatment of systemic and local mast cell-dependent anaphylaxis.

• Biomolecules & Therapeutics
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• 제16권3호
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• pp.237-242
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• 2008

The effect of Picrorrhiza Rhizoma (PR) aqueous extracts were evaluated on 2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis, type I allergic model. Contact dermatitis was induced by sensitization with dinitrophenyl-derivatized ovalbumin (DNP-OVA) and DNFB challenge as antigen. Three different concentrations of PR extracts (300,150 and 75mg/kg) were orally administered to DNP-OVA sensitization mice once a day for 7 days with reference materials; dexamethasone (15mg/kg, intraperitoneal treatment). End of 7 days oral administration of PR extracts or intraperitoneal treatment of dexamethasone, the changes on the edematous changes and scratching behavior were measured. Immediate after DNFB challenge on ear or paw of DNP-OVA sensitized mice, increases of ear and paw thicknesses and weights were detected with anterior ear skin (dermis to epidermis) thickness and paw scratching behavior increases. However, these DNFB-induced increases on ear and paw thicknesses, weights and scratching behaviors were decreased by treatment of all three different dosages of PR extracts and dexamethasone, respectively. In addition, the increases of anterior skin thicknesses were also dramatically inhibited by treatment of all three different dosages of PR extracts and dexamethasone at histopathological observations. The results obtained in this study suggest that oral treatment of PR extracts also has relatively favorable effects on allergic dermatitis.