• The Korea Journal of Herbology
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• v.26 no.4
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• pp.1-7
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• 2011

Objectives : In this study, we investigated the effect of modified-Okbyungpoongsan (mOP) on mast cell-mediated allergic response in basophilic leukemia cell line, RBL-2H3 mast cells. Methods : Cells were stimulated with anti-DNP-IgE after the treatment of DNP-HSA (AI/D), and then incubated with different concentrations of mOP (0.1, 0.2, 0.5 and 1 mg/$m{\ell}$) in RBL-2H3 cells. Cell toxicity was determined by WST-1 assay. The degranulation of mast cells was observed by microscope with toluidine blue staining and also the levels of beta-hexosaminidase, histamine and TNF-alpha were measured in culture supernatants by enzyme-linked immunosorbant assay. Results : mOP inhibited anti-DNP-IgE-imduced degranulation of mast cells in RBL-2H3 cells. mOP also significantly decreased the levels of histamine and inflammatory cytokine, TNF-alpha in RBL-2H3 cells, but slightly decreased the level of beta-hexosaminidase. Conclusions : These results indicate that mOP, an oriental prescription could be inhibit the allergic response through suppressing the mast cell activation.

• Korean Journal of Adult Nursing
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• v.27 no.3
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• pp.304-313
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• 2015

Purpose: Aspiration pneumonia (AP) is the major complication of dysphagia in patients with acute stroke. Nursing management for dysphagia influences on patients' health outcomes. The purpose of this study was to develop and evaluate the effects of Dysphagia Nursing Protocol (DNP) for patients with acute stroke. We aimed to examine the incidence of AP and the dependency rate at the discharge. Methods: We used a non-equivalent control group posttest only design in this study. DNP was developed with content validity index > 0.75 in all items. This protocol was composed of the evaluation, education, complication prevention, and checking phases. After training the staff nurses, we applied DNP protocol to the experimental group. The control group was enrolled from June to August 2013 (n=80), and the experimental group was June to August 2014 (n=64). Results: The incidence of AP was 16.3% in control group while 4.7% in experimental group (p=.028), and the Odds Ratio (OR) was 0.26 (p=.045). The dependency ratio was 66.3% in control group while 43.8% in experimental group (p=.011), and the OR was 0.33 (p=.011). Conclusion: DNP was beneficial for the reducing the risk of AP and the improved the functional status.

• Journal of Digital Convergence
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• v.17 no.8
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• pp.257-264
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• 2019

This study was conducted to investigate the effect of 70% ethanol extract (DR) on the mast cell-mediated allergic contact dermatitis induced by dinitrofluorobenzene in BALB / c mice, which affects the cell activity by antigen in RBL-2H3 mast cells Respectively. The ethanol extracts of RBL-2H3 cells activated by DNP-HSA and anti-DNP IgE antibodies inhibited the secretion of ${\beta}$-hexosaminidase, histamine, and IL-4 and $TNF-{\alpha}$ Production was suppressed. In the DNFB-induced contact allergic dermatitis animal model, treatment with ethanol extract reduced ear swelling and inhibited serum histamine and IL-4 secretion, and DR treatment effectively prevented mast cell infiltration in dermatitis-induced areas. As a result, the ethanol extract may be used as a therapeutic agent for mast cell-mediated allergic diseases such as atopic dermatitis.

• Proceedings of the KIEE Conference
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• 2015.07a
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• pp.47-48
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• 2015

As the power system develops rapidly into a smarter and more flexible state, so must the communication technologies that support it. Machine to machine (M2M) communication in Smart Grid environment has been discussed in European Telecommunications Standards Institute (ETSI). The power system is not easily replaceable, due to system replacement cost. The M2M gateway is required in other to improve interoperability in M2M environment. The Distributed Network Protocol 3.0 (DNP3.0) is the most important standard in the SCADA systems for the power. It has been used for device data collection/control in Substation Systems, Distribution Automation System. If the DNP3.0 data model is combined with a set of contemporary web protocols, it can result in a major shift. We selected Constrained Application Protocol (CoAP) based on RESTful as M2M protocol. It is a specialized web transfer protocol for use with constrained nodes and constrained networks. We have used the OPNET Modeler 17.1 in order to verity the SOAP versus CoAP. In this paper, we propose the CoAP-based M2M Gateway to Distribution Automation system using DNP3.0 in Smart Grid Environment.

• Proceedings of the KIEE Conference
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• 2008.11a
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• pp.382-384
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• 2008

D-TRS is a method of wireless communication. This method will be able to use several frequency for multiple user used chanel together. TETRA of D-TRS technology is not rented network. Using TETRA network has the strong point which cost better than CDMA network of rental network. Master server of SCADA(Supervisory Control And Data Acquisition) system is realtime supervise control and a data acquire the control system or the RTU(Remote Terminal Unit). The present paper is developed and proposal the gateway platform for electronic power backbone network based on D-TRS. This gateway platform is converted DNP3.0 messages with TETRA PDU and converted TETRA PDU with DNP3.0 messages. Master server and FRTU will be able to send and receive DNP3.0 message via TETRA network using this gateway platform.

• Journal of IKEEE
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• v.14 no.2
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• pp.41-50
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• 2010

TETRA is the standard of Digital Trunked Radio System suggested by the ETSI(European Telecommunications Standards Institut ). It is adopted as Electric Power IT Wireless Backbone Network in Korea. Police station and Fire Station are using TETRA network. Currently, Power Automation Protocols are DNP3.0 in Distribution Automation System, DLMS in Auto Metering Infrastructure, IEC61850 in Substation Automation. These protocols are transmissions using CDMA or WCDMA modem. If Power Automation protocol uses TETRA networks, it can be interoperable with the systems in police or fire stations. And it has outstanding ability to handle problems in a disaster situation. So, This paper propose a gateway system of Power Automation which can transmit the power automation protocol using TETRA.

• Journal of Acupuncture Research
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• v.22 no.3
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• pp.23-35
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• 2005

Objective : The aim of the study is to investigate the effect of electro-acupuncture (EA) on ST36 to modulate immune reaction in BALB/c mice immunized intraperitoneally with 2,4-dinitrophenylated keyhole limpet protein(DNP-KLH). Methods : Experimental mice were divided into four groups : 1) Normal group was not performed by any operation. 2) IM(Immunized) group was immunized intraperitoneally with DNP-KLH and aluminum hydroxide without electro-acupunture stimulation. 3) IM-EA(immunized-elctro- acupuncture) group was performed by successive electro-acupuncture on the ST36 acupoint after immunization. 4) IM-NA(immunized-naloxone) group was performed by immunization and electro-acupuncture with same method, but naloxone was injected intraperitoneally 30 minutes before eletro-acupuncture to inhibit the opiate receptor in spleen. Serum total immunoglobulin I(IgE) and antigen-specific IgE was measured in each group. The expression of interferon-${\gamma}$ and interleukin-4 mRNA in spleen was researched by real-time RT-PCR Results : Serum total-IgE and antigen-specific IgE were significantly decreased only in IM-EA group. The expression of interleukin-4 in spleen cell was significantly reduced not only in IM-EA group, but also in IM-EA group. Conclusions : Above results indicate that the mechanism of immunomodulatory effect of electro-acupuncture is related to opioid system especially in B-cell immune reaction. Further research on the T-cell immunity is necessary to explain the mechanism of immunomodulatory effect of electro-acupuncture.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39C no.4
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• pp.362-369
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• 2014

A railway SCADA system is a control systems that provide the trains with the electricity. A railway SCADA system sends commands to the RTUs(remote terminal unit) and then it gathers status information of the field devices in the RTUs or controls field devices connected with the RTUs. The RTU can controls input output modules directly, gathers the status information of the field devices connected with it, and send the information to the control center. In this way, a railway SCADA system monitors and controls the electricity power for running trains. The cyber attackers may use some vulnerabilities in the railway SCADA system software to attack critical infrastructures. The vulnerabilities might be created in the railway software development process. Therefore it need to detect and remove the vulnerabilities in the control system. In this paper we propose a new control protocol fuzzing method to detect the vulnerabilities in the DNP3 protocol based application running on VxWorks in RTU(Remote Terminal Unit) that is a component of the centralized traffic control system for railway. Debug-channel based fuzzing method is required to obtain process status information from the VxWorks.

• Advances in Traditional Medicine
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• v.3 no.2
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• pp.56-62
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• 2003

The effect of aqueous extract of Terminalia chebula fruit (Combretaceae) (TCAE) by anal administration on mast cell-dependent immediate-type anaphylactic reactions was investigated. TCAE (0.005 to 1 g/kg) inhibited systemic anaphylaxis induced by compound 48/80 in mice. When TCAE was pretreated at the same concentrations with systemic anaphylaxis, the plasma histamine levels were reduced in a dose-dependent manner. TCAE (0.1 and 1 g/kg) also significantly inhibited local anaphylaxis activated by anti-DNP IgE. TCAE (0.001 to 1 mg/ml) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. Moreover, TCAE (0.01 and 0.1 mg/ml) had a significant inhibitory effect on anti-DNP IgE-mediated tumor necrosis $factor-{\alpha}$ $(TNF-{\alpha})$ production from RPMC. These results provide evidence that anal therapy of TCAE may be beneficial in the treatment of systemic and local mast cell-dependent anaphylaxis.

• Biomolecules & Therapeutics
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• v.16 no.3
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• pp.237-242
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• 2008

The effect of Picrorrhiza Rhizoma (PR) aqueous extracts were evaluated on 2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis, type I allergic model. Contact dermatitis was induced by sensitization with dinitrophenyl-derivatized ovalbumin (DNP-OVA) and DNFB challenge as antigen. Three different concentrations of PR extracts (300,150 and 75mg/kg) were orally administered to DNP-OVA sensitization mice once a day for 7 days with reference materials; dexamethasone (15mg/kg, intraperitoneal treatment). End of 7 days oral administration of PR extracts or intraperitoneal treatment of dexamethasone, the changes on the edematous changes and scratching behavior were measured. Immediate after DNFB challenge on ear or paw of DNP-OVA sensitized mice, increases of ear and paw thicknesses and weights were detected with anterior ear skin (dermis to epidermis) thickness and paw scratching behavior increases. However, these DNFB-induced increases on ear and paw thicknesses, weights and scratching behaviors were decreased by treatment of all three different dosages of PR extracts and dexamethasone, respectively. In addition, the increases of anterior skin thicknesses were also dramatically inhibited by treatment of all three different dosages of PR extracts and dexamethasone at histopathological observations. The results obtained in this study suggest that oral treatment of PR extracts also has relatively favorable effects on allergic dermatitis.