• 대한임상독성학회지
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• 제2권2호
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• pp.67-71
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• 2004

Arsenic poisoning has three types of poisoning. First, acute arsenic poisoning is usually caused by oral intake of large amount of arsenic compound with purpose of homicide or suicide. Second, chronic arsenic poisoning is caused by inhalation of arsenic in the occupational setting or by long-term oral intake of arsenic-contaminated well water. Third, arsine poisoning occurs acutely when impurities of arsenic in non-ferrous metal react with acid. Clinical manifestation of acute arsenic poisoning is mainly gastrointestinal symptoms and cardiovascular collapse. Those of chronic poisoning are skin disorder and cancer. Arsine poisoning shows massive intravascular hemolysis and hemoglobinuria with acute renal failure. Exposure evaluation is done by analysis of arsenic in urine, blood, hair and nail. Species analysis of arsenic is very important to evaluate inorganic arsenic acid and mono methyl arsenic acid (MMA) separated from dimethyl arsenic acid (DMA) and trimethyl arsenic acid (TMA) which originate from sea weed and sea food. Treatment with dimercaprol (BAL) is effective in acute arsenic poisoning only.

• 한국식품영양학회지
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• 제14권3호
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• pp.204-210
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• 2001

전통수산 발효식품인 젓갈은 부패를 억제하기 위하여 20∼25%의 식염을 첨가하므로 짠맛이 강하고 성인병 유발과 유관하다는 단점이 있으므로 저식염 젓갈이 개발되고 있으나 저염 젓갈류는 비린내와 부패취가 강하여 기호도가 떨어질 뿐만 아니라 발암성 N-nitosamine(NA)의 생성 가능성이 높아지게 된다. 본 연구에서는 저염 젓갈의 저장성, 기호성 유지 및 NA생성을 억제코져 두류(대두, 검정콩) 및 허브류(애플민트, 페파민트, 레몬밤 및 스파아민트)의 에탄올 추출물을 각각 첨가한 저염 멸치젓을 제조하여 110일간 숙성시키면서 품질과 관련된 여러 인자 및 NA 생성여부를 실험하였다. 저염 멸치젓 숙성 중 PH, 염도 및 산도는 모든 실험군에서 숙성 110일까지 큰 변화를 보이지 않았다. 휘발성 염기질소는 저장기간에 따라 점차 증가하는 경향을 보였는데 애플민트 추출물 첨가군이 가장 큰 폭으로 증가하였다. DMA 및 TMA 질소도 증가하는 경향을 보였는데 숙성 75일째부터 그 증가폭이 두드러졌다. 질산염 질소는 젓갈 숙성 중 점차 증가하는 경향을 보였으며, 아질산염 질소는 약간 증가하는 경향이었다 NA는 N-nitrosodi-methylamine(NDMA)만이 검출되었으며 대조군에 비하여 전 실험군에 더 낮은 함량이었으며 이때 평균회수율은 63.9∼99.7%였다. 허브 추출물 첨가군에서 대조군에 비하여 월등히 낮은 함량은 NDMA가 검출되었는데, 특히 페파민트 추출물 첨가군에서는 숙성 75일까지 흔적량에 불과하였다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.336-336
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• 1994

In order to develope the in vitro short term screen-ing method for carcinogen, we studied a purification method for thymine glycol in oxidaized DNA. Thymine glycol (5,6-dihydroxy-5, 6-dihydrothymine) is the major stable radiolysis poduct in thymine by chemical oxidants and ionzing radiation and it is a useful biomarker among oxidized DNA adducts, related with carcinogenests. Standard thymine glycol was prepared by oxidation of 〔$^3$H〕 thymine with KMnO$_4$ followed by purification with HPLC-LSC system and it was assayed by TLC and gas chromatography-MSD. 〔$^3$H〕 DMA adducts was isolated from E. coli (wild type ) treated with oxidative agents such as benzo(a)pyrene, adriamycin, aflatoxin B$_1$ and KBrO$_3$. These oxidative agents generated free radicals in cells by oxidative metabolism. As a result, thymine glycol was produced in cultured E. coli by four chemicals. This result shows that this methodology should be useful tool in screening oxidative carcinogen.

• 전기학회논문지
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• 제67권2호
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• pp.270-276
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• 2018

Apache Spark is one of the high performance in-memory computing frameworks for big-data processing. Recently, to improve the performance, general-purpose computing on graphics processing unit(GPGPU) is adapted to Apache Spark framework. Previous Spark-GPGPU frameworks focus on overcoming the difficulty of an implementation resulting from the difference between the computation environment of GPGPU and Spark framework. In this paper, we propose a Spark framework based on a heterogenous pipeline computing with OpenCL to further improve the performance. The proposed framework overlaps the Java-to-Native memory copies of CPU with CPU-GPU communications(DMA) and GPU kernel computations to hide the CPU idle time. Also, CPU-GPU communication buffers are implemented with switching dual buffers, which reduce the mapped memory region resulting in decreasing memory mapping overhead. Experimental results showed that the proposed Spark framework based on a heterogenous pipeline computing with OpenCL had up to 2.13 times faster than the previous Spark framework using OpenCL.

• 조명전기설비학회논문지
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• 제17권6호
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• pp.39-46
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• 2003

본 논문에서는 디지털화 경향에 맞추어 변압기를 보호함과 아울러 감시 및 계측 등의 기능을 갖춘 변압기용 디지털 보호계전기를 개발하기 위한 하드웨어 및 실시간 처리가 가능한 소프트웨어의 구현 방법 등을 제시하였다. 특히 보호계전기의 모든 알고리즘 및 보조 프로그램들이 단일 프로세서에 의해 실시간으로 수행될 수 있도록 DSP의 DMA 제어기를 이용하여 아날로그 입력 데이터를 처리하였다. 아울러 비휘발성 메모리 (EEPROM, flash memory)에 보호계전 알고리즘의 수행에 필요한 각종 설정치, 이벤트 및 고장데이터를 저장하고 UART를 이용하여 데이터를 분석할 수 있도록 하였다. 그리고 시험용 변압기용 디지털 보호계전기를 제작하여 일본 NF 사의 보호계전기 시험기를 이용하여 변압기 보호기능 및 동작특성을 시험하여 그 성능을 입증하였다.

• 품질경영학회지
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• 제41권4호
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• pp.555-566
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• 2013

Purpose: The purpose of this study is to develop innovation index of hospital service integrating 6 sigma and SERVQUAL. Methods: This study used DMA(Define, Measure and Analysis) from 6 sigma and 5 Factors from SEVQUAL. To test data, chi-squire text, association analysis and behavior analysis was conducted. Results: This study indicated the management index through CTQ (Critical to Quality) and Chosen few X using 6 sigma process. Finally, And this study developed 5 Factors; Equipment Utilization in Tangibility, Ratio of Patients/Disease/Behavior/Treatment in Reliability, Survival RAte, Canselation Rate of Reservation, Churn Rate, Interval of Treatment and Confidence in Responsiveness, Frequency of Patients/Disease/Behavior/Treatment in Assurance and Contrast to Best Department/Best Doctor/Best Doctor in Faculty/Average of Mine in Empathy. Conclusion: This study developed innovation index of hospital service. Managing this index, hospital is able to achieve the decline of total treatment cycle, adjustment of patients behavior and increase of equipment utilization. Ultimately, hospital is able to accomplish innovation of healthcare service.

• 한국염색가공학회지
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• 제31권4호
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• pp.354-362
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• 2019

In order to apply thermoplastic composites using PETG resin to various industrial fields such as bicycle frames and industrial parts, it is necessary to verify the impact resistance, durability and mechanical properties of the manufactured composite materials. To improve the mechanical properties, durability and impact resistance of PETG resin, an amorphous resin, in this study, compound and injection molding process were carried out using various additives such as TiO2, carbon black, polyolefin elastomer, and PETG amorphous resin. The thermal and mechanical properties of the thermoplastic composites, and the Charpy impact strength. The analysis was performed to evaluate the characteristics according to the types of additives. DSC and DMA analyzes were performed for thermal properties, and tensile strength, flexural strength, and tensile strength change rate were measured using a universal testing machine to evaluate mechanical properties. Charpy impact strength test was conducted to analyze the impact characteristics, and the fracture section was analyzed after the impact strength test. In the case of POE material-added thermoplastic composites, thermal and mechanical properties tend to decrease, but workability and impact resistance tend to be superior to those of PETG materials.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 추계학술대회 논문집 학회본부 C
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• pp.822-824
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• 1998

The lithium polymer battery with polymer electrolyte is expected as a safe and long cycle life battery. This paper reports primarily the recent development results of a solid polymer electrolyte, which is a key point of the secondary battery system. The new type of polymer electrolyte was prepared under a dry Ar atmosphere by dissolving $LiCIO_4$ in a matrix of EC, PC and then dispersing polyacrylonitrile(PAN). Also adding some inorganic filler $Al_2O_3$. The dispersed solution heated at $120^{\circ}C$. The polymer electrolyte were characterized by EIS(Electrochemical Impedance Spectroscopy), TGA(Thermo Gravimetric analysis), DMA(Dynamic Mechanical Analyzer), DSC (Differential Scanning Calorimetry). The lithium ion yield is 0.29 when PAN-$Al_2O_3$ which was applied DC 5mV. The ionic conductivity of PAN, PAN-$Al_2O_3$ polymer electrolytes were showed $1.0{\times}10^{-4}S/cm$, $8.4{\times}10^{-4}S/cm$ at room temperature. When inorganic filler was added in the polymer electrolyte, ionic conductivity and lithium yield more larger than without inorganic filler.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2008년도 학술발표회 논문집
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• pp.1536-1539
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• 2008

본 연구는 하천을 가로막고 있는 기능을 상실한 횡단구조물 철거를 통하여 하천 생물들이 자유로이 이동할 수 있는 생태통로를 복원하기 위한 연구이다. 이를 위하여 기능을 상실한 보인 경기도 연천군 전곡읍 한탄강 소재의 길이 190m, 높이 2.8m 규모의 고탄보를 철거하여 철거에 의한 보 상하류에서 하상변동과 하천형태 변화와 같은 물리적 영향, 수질 변화와 같은 화학적 영향, 보 상하류에서의 어류/저서동물/식생의 생태 서식처 변화와 같은 생물적 영향을 분석하였다. 그 결과, 어류의 경우, 철거 이전에 보 최상류역 대조구간에서 조사된 16종이 26종으로 늘어났으며, 특히, 뱀장어, 강준치, 쏘가리와 같은 어류의 개체수가 증가되었다. 보 철거를 통하여 이동통로가 확보됨으로써 종다양도 지수가 전반적으로 상회하는 경향을 나타내었다. 저서무척추동물의 경우, 보 철거로 인하여 정수역었던 곳이 유수역으로 변모함에 따라 철거 전에 출현했던 잠자리와 다슬기 종류는 발견되지 않았던 반면, 철거 전에 출현되지 않았던 날도래류가 출현하는 등 출현 종에 다소의 변화를 보였다.

• 약학회지
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• 제38권2호
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• pp.184-190
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• 1994

The activities of nitric oxide synthase and the contents of methylarginines were investigated in the pancreatic tissues of various animals by citrulline-forming method and HPLC, respectively. The high level of in vitro NO synthase activity was detected in chicken pancreas whereas MMA, the strong competitive inhibitor for NO synthase, was detected as trace in the same tissue. On the other hand, the low level of NO synthase activity was observed in the porcine pancreas while the contents of MMA were high. However, it was not possible to find any relationship between NO synthase activities and the contents of dimethylarginines at present time. D'MA was equally distributed among the pancreatic tissues of various animals but DMA was not.