YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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NO Synthase Activities and Methylarginines Contents in the Pancreatic Tissues of Various Animals

수종동물의 췌장조직내 NO Synthase 활성도 및 Methylarginines 함량

  • Kim, Yong-Kee (Department of Biochemistry, College of Pharmacy, Sung Kyun Kwan University) ;
  • Park, Seung-Hee (Department of Biochemistry, College of Pharmacy, Sung Kyun Kwan University) ;
  • Nam, Suk-Woo (Department of Biochemistry, College of Pharmacy, Sung Kyun Kwan University) ;
  • Seo, Dong-Wan (Department of Biochemistry, College of Pharmacy, Sung Kyun Kwan University) ;
  • Hong, Sung-Youl (Department of Genetic Engineering, College of Life Science and Natural Resources Sung Kyun Kwan University) ;
  • Lee, Hyang-Woo (Department of Biochemistry, College of Pharmacy, Sung Kyun Kwan University)
  • Published : 1994.04.30
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Abstract

The activities of nitric oxide synthase and the contents of methylarginines were investigated in the pancreatic tissues of various animals by citrulline-forming method and HPLC, respectively. The high level of in vitro NO synthase activity was detected in chicken pancreas whereas MMA, the strong competitive inhibitor for NO synthase, was detected as trace in the same tissue. On the other hand, the low level of NO synthase activity was observed in the porcine pancreas while the contents of MMA were high. However, it was not possible to find any relationship between NO synthase activities and the contents of dimethylarginines at present time. D'MA was equally distributed among the pancreatic tissues of various animals but DMA was not.

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