• Biomolecules & Therapeutics
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• 제24권6호
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• pp.638-649
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• 2016

In the previous study, the rhizome mixture of Anemarrhena asphodeloides and Coptis chinensis (DW2007), improved TNBS-, oxazolone-, or DSS-induced colitis in mice by regulating macrophage activation. Therefore, to understand the effect of DW2007 on the T cell differentiation involved in the adaptive immunity, we measured its effect on both Th17 and Treg cell differentiation in splenocytes, in the lamina propria of mice with DSS-induced colitis (DIC), and in the spleens of mice with collagen-induced arthritis (CIA). Results showed that DW2007 potently inhibited the differentiation of splenocytes into Th17 cells, but increased Treg cell differentiation in vitro. In the colon of wild type and $TLR4^{-/-}$ mice with DIC, DW2007 potently suppressed DSS-induced colon shortening and myeloperoxidase activity. DW2007 also suppressed collagen-induced paw thickening, clinical index, and myeloperoxidase activity in CIA mice. Overall, DW2007 potently suppressed Th17 cell differentiation in mice with CIA and DIC, but increased Treg cell differentiation. Moreover, DW2007 strongly inhibited the expression of TNF-${\alpha}$ and IL-$1{\beta}$, as well as the activation of NF-${\kappa}B$. Based on these findings, DW2007 may ameliorate inflammatory diseases by regulating the innate immunity via the inhibition of macrophage activation and the adaptive immunity via the correction of disturbed Th17/Treg cells.

• Journal of Nutrition and Health
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• 제43권3호
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• pp.285-293
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• 2010

This study investigated the body image, body stress, eating attitude, and dietary quality in middle school girls. Questionnaires were administered to one hundred fifty seven middle school girls in Seoul area. The subjects were categorized into the five groups according to their body mass index (BMI); 1) severely under-weight (BMI < 16.5 $kg/m^2$), 2) under-weight (16.5 $\leq$ BMI < 18.5 $kg/m^2$), 3) normal weight (18.5 $\leq$ BM I < 23.0 $kg/m^2$), 4) overweight (23.0 $\leq$ BMI < 25.0 $kg/m^2$), and 5) obese (BMI $\geq$ 25 $kg/m^2$). 7.0%, 14.6%, 58.9%, 10.2%, and 10.2% of the subjects were classified as severely under-weight, under-weight, normal weight, overweight and obese groups, respectively. Regardless of the BMI, the subjects had disturbed body image, body stress, and poor eating attitude. The actual BMIs of the normal weight, overweight and obese subjects were significantly different from their desired BMI and perceived BMI, representing these subjects dissatisfied their body shape. Almost all subjects tried to lose their body weight even in the severely under-weight and under-weight groups. There were significant correlations of BMI with body image disturbance (p < 0.05), body stress (p < 0.01) and eating attitude (p < 0.05). These results indicated that middle school girls who have higher BMI seemed to have more body image distortion, body stress and risk of eating disorder. However, any significant difference in dietary quality among the five groups was not observed even though their dietary patterns were not balanced. As a conclusion, it is required that middle school girls should correct their distorted body image and body stress. Also, efforts to improve eating attitude, dietary pattern and nutritional status in the middle school girls are needed.

• Archives of Plastic Surgery
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• 제40권5호
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• pp.621-626
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• 2013

Background Ever since lipoabdominoplasty was first developed to achieve better aesthetic outcomes and less morbidity, the rate of seroma formation, especially in obese patients, has disturbed plastic surgeons. The aim of this study was to evaluate the effect of fibrin sealant in the prevention of seroma formation after lipoabdominoplasty in obese patients. Methods Sixty patients with a body mass index (BMI) between 30 and 39.9 were assigned randomly to 1 of 2 groups (30 patients each). Group A underwent lipoabdominoplasty with fibrin glue, while group B underwent traditional lipoabdominoplasty; both had closed suction drainage applied to the abdomen. The patients' demographics and postoperative complications were recorded. Seroma was detected using abdominal ultrasound examinations at two postoperative periods: between postoperative days 10 and 12 and, between postoperative days 18 and 21. Results The age range was 31 to 55 years ($38.5{\pm}9.5$ years) in group A and 25 to 58 years ($37.8{\pm}9.1$ years) in group B, while the mean BMI was 31.4 to 39.9 $kg/m^2$ (32.6 $kg/m^2$) in group A and 32.7 to 37.4 $kg/m^2$ (31.5 $kg/m^2$) in group B. In group A, the patients had a complication rate of 10% in group A versus 43% in group B (P<0.05). The incidence of seroma formation was 3% in the fibrin glue group but 37% in the lipoabdominoplasty-alone group (P<0.05). Conclusions Lipoabdominoplasty with the use of autologous fibrin sealant is a very effective method that significantly reduces the rate of postoperative seroma.

• 생태와환경
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• 제49권1호
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• pp.1-10
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• 2016

산업 및 기술의 발달과 인간 활동의 증가로 인해 자연적인 질소 순환의 균형이 무너지고 다량의 질소가 대기, 토양 및 물 환경 생태계에 과잉으로 존재하게 되었다. 이로 인한 과잉의 반응성 질소화합물이 토양과 물 환경생태계에 영향을 미치고 있는 것을 국내외 문헌과 사례 조사를 통해 확인하고 유역생태계에서 질소화합물로 인한 토양 및 물 환경 생태계의 산성화 영향 감소방안을 제시하였다. 반응성 질소는 대기, 토양 및 물의 여러 매체를 이동하면서 다른 유형으로 전환될 수 있으며 유형 간 상호작용이 일어나기도 한다. 효과적인 질소관리 방안으로 반응성질소 배출원의 다양성 및 유형에 따른 배출량을 규제하는 정책과, 반응성 질소화합물로 인한 토양 및 물 환경생태계의 환경적 피해 (산성화)를 조사 및 평가 (모니터링 및 안전성 지표 적용)하고 복원하는 전략 (예, 화학적 복원 연구 및 개발)이 필요하다.

• 대한의용생체공학회:의공학회지
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• 제17권3호
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• pp.337-346
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• 1996

The patency of small size vascular grafts is poor, and the blood flow characteristics in the artery graft anastomosis are suspected as one of the important factors influencing intimal hyperplasia. Disturbed flow patterns caused by sixte and compliance mismatch generate unfavorable flow environment which promotes intimal thickening. Tapered vascular yuts are suggested in order to reduce sudden expansion near the anastomosis. The photochromic flow visualization method is used to measure the flout fields in the end-to-end anastomosis model under the carotid and femoral artery flow wave form. The results show that flow disturbance near the anastomosis is diminished in the tapered grafts comparing to the tubular graft. As the divergent ang1e decreases, we can reduce the low and oscillatory wall shear stress zone which is prone to intimal hyperplasia. The flow wave form effects the wall shear rate dis- tribution significantly. The steep deceleration and back flow in the femoral flow wAve form cause low mean wall shear rate and high oscillatory shear index.

• 대한기계학회논문집B
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• 제34권10호
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• pp.893-899
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• 2010

박동유동조건에서 관상동맥 내의 유동특성과 혈류역학적 인자 분포를 선행연구에서 수행하여 혈류역학이 관상동맥 내의 협착현상과 연관관계가 있음을 밝혔다. 동맥경화증의 호발부위인 관상동맥 분지부에서 혈류역학적 변수를 분석하여 동맥경화증의 발생기전을 규명하는 것이 본 연구의 목적이다. 동맥경화증에 의한 협착현상은 혈액과 혈관벽 사이의 생화학 반응뿐 아니라 유동박리나 벽전단응력과 같은 혈류역학적 인자와도 관계 있음을 확인하였다. 관상동맥 분지부의 분지각이 증가할수록 분지부 단면에서의 재순환영역의 크기가 증가하고 교란유동이 발생하게 된다. 이 재순환영역이 관상동맥에서 동맥경화의 시작점으로 의심되는 영역이라 할 수 있다.

• 생명과학회지
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• 제25권4호
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• pp.369-375
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• 2015

식물 보존의 권고지역에서 식물 집단의 공간적 데이터는 여러 목적에서 중요하다. 부산광역시 금정산과 아홉산 의 대사초(Carex siderosticta)의 지리적 거리에 따른 공간적 분포를 분석하였다. 공간적 양상의 분석 방법은 여러 패치 척도, 분산 척도에 의거한 plot(플롯)의 크기에 따라 집단의 균질성 또는 운집을 분석하였다. 대사초의 많은 자연 플롯은 산림군락에서 균질하지 않았다. 예를 들면 균질한 플롯은 6.0 m $\times$ 6.0 m 이내였다. 플롯의 크기가 6.0 m $\times$ 12.0 m 이상이면 운집되었다. 대사초의 이웃 패치는 평균 7.5 m에서 9.0 m사이였다. 그런데 자연집단이 인간의 활동에 의해 교란되면 운집은 9.0 m보다 짧은 거리에서 일어났다. 결론적으로 대사초의 지리적 분포는 플롯의 밀도에 균질하지 않았고 금정산과 아홉산 집단에서 집단 크기에 따라 다르며 인간의 간섭은 플롯에서 밀도 효과를 일으킨다.

• 대한지역사회영양학회지
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• 제24권5호
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• pp.395-407
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• 2019

Objectives: This study examined the association of the sleep quality and patterns with the dietary behavior, including snack and beverage consumption, taste preferences, as well as lifestyle of university students. Methods: The subjects were 406 university students in Cheongju, Korea, and the data were collected using a self-administered questionnaire. They were divided into two groups according to the Pittsburgh Sleep Quality Index (PSQI): good-quality sleepers (PSQI score ≤ 5) and poor-quality sleepers (PSQI score > 5). The data were analyzed using a χ²-test, independent t-test, and analysis of covariance using the SPSS 25.0 program. Results: Fifty-two percent of university students were categorized as poor-quality sleepers by the PSQI. Students classified as poor-quality sleepers had delayed bedtimes, and a shorter duration in bed and total sleep hours than the good-quality sleepers did. Poor-quality sleepers were more prevalent among those who were female, having irregular mealtimes, or frequent late night meals. They also consumed fast food frequently, such as fried chicken and hamburgers, and noodles when adjusted for gender. In addition, drinks with caffeine over milk were dominant among poor-quality sleepers. Furthermore, the preferences for spicy and salty tastes and longer smartphone usage were more prevalent in those with poor-sleep quality. Conclusions: These results showed that more than 50% of university students reported disturbed sleep and poor quality sleep was associated with less desirable snack consumption and taste preference, more smartphone usage, and others. Therefore, nutrition education program along with lifestyle changes promoting sufficient sleep are encouraged to provide for university students, particularly those who have poor sleep quality.

• 한국지반공학회논문집
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• 제23권12호
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• pp.13-23
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• 2007

풍화토는 암석으로부터 풍화되어 그 산물로 나타난다. 또한, 풍화정도에 따라 연암, 풍화암, 잔적토에 이르기까지 그 산물은 다양하다. 일반적으로 풍화정도의 결정은 화학적 방법이나 표준관입시험의 N-value를 이용한다. 그러나 이러한 방법은 약간의 단점을 가지고 있으며, 이에 본 연구에서는 교란시료와 물리적인 방법인 Fall cone test를 이용하여 풍화정도를 결정할 수 있는 방법을 제시하였다. Fall cone test 결과, 동일한 지역에서 풍화정도의 차이를 확인할 수 있었으며, 관입량에 따른 화학적풍화지수(CWI)와 함수비의 관계는 하나의 방정식으로 표현할 수 있었다.

• 한국지반환경공학회 논문집
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• 제25권4호
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• pp.5-12
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• 2024

간석지(공유수면) 내 단지를 조성하는 경우, 해안 퇴적지반 특성상 대규모 성토재가 필요하고, 단지공사 시 불가피하게 발생되는 연약점성토를 성토재료로 활용하는 것이 자원재활용 및 경제적 측면(소요토량감소)에서 필요한 실정이다. 본 연구에서는 연약점성토의 성토재활용에 따른 절취교란된 점성토의 압밀특성변화를 파악하고, 압밀침하량 설계방안에 대하여 제안하였다. 연구 대상지의 압밀시험결과를 통해 교란(절취)에 따른 압밀특성치 변화(압축지수감소, 선행하중산정불가)를 확인하였고, 점성토 성토층을 복합대상층(압밀대상 및 상재하중층)으로 산정(압밀침하량)하는 방안이 실제거동과 부합한 결과로 분석되었다.