• Journal of Acupuncture Research
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• v.31 no.1
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• pp.95-103
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• 2014

Objectives : The aim of this study is to evaluate the effect of Paljeong-san pharmac-opuncture(PJS) on the rat model of benign prostatic hyperplasia(BPH). Methods : Rats were divided into 5 groups, with 6 rats in each group. The 5 groups included sham-operated group(sham group), BPH model group(BPH group), finasteride-treated group (fina group), PJS-treated groups(PJS 10 and PJS 100 group). Testosterone was injected subcutaneously to the castrated rats except sham group for BPH model. During 4-week experimental period, finasteride(5 mg/kg) was administrated orally once daily in fina group, PJS in PJS 10(10 mg/kg) and PJS 100(100 mg/kg) group and normal saline in sham and BPH group were injected subcutaneously once daily at Jungwan($CV_{12}$). We checked prostate weights, serum concentration of dihydrotestosterone(DHT), morphologic changes of the prostate, and the amount of expression of the proliferating cell nuclear antigen(PCNA) and $5{\alpha}$-reductase gene to evaluate the effect of PJS after 4-week experimental period. Results : 1. PJS and finasteride treatment reduced prostate weights comparing with BPH group, but PJS-treated groups showed no significant changes, unlikely fina group. 2. PJS-treated groups showed significant degreases in concentration of DHT. 3. PJS-treated groups showed significant degreases concentration-dependently in the amount of expression of the PCNA and $5{\alpha}$-reductase gene. 4. PJS treatment showed shrinking of thickness in the prostatic epithelial tissue. Conclusions : PJS has the effects that improve the symptoms of BPH through inhibiting proliferation of the prostatic tissues.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.24 no.10
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• pp.1325-1330
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• 2020

New-born babies who require special attention medically are admitted often to incubator. Incubators are well equipped to fulfill take care of infants, but they have to hospital and so expensive. This paper proposes a smart incubator that can solve the problem of convenience and cost aspect of these incubators. Developed incubator enables near-field monitoring using Arduino Uno as the main control device and Bluetooth communication. The environment in the incubator measures temperature and humidity using a DHT22 sensor and the sound using a P5510 microphone. If the temperature and humidity data set by the user are lower or higher than the reference value, it is designed to operate the heating pad using the controller or turn on the fan to allow air circulation. The measured values in the incubator are displayed in real time on the user's smartphone monitoring screen and are programmed using app inventor. Developed incubators can help take care of infants at low cost in the home.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.1
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• pp.146-152
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• 2022

Information collected from temperature, humidity, inclination, and pressure sensors using Raspberry Pi or Arduino is used in automatic constant temperature and constant humidity systems. In addition, by using it in the agricultural and livestock industry to remotely control the system with only a smartphone, workers in the agricultural and livestock industry can use it conveniently. In general, temperature and humidity are expressed in a line graph, etc., and the change is monitored in real time. The technology to visually express the temperature has recently been used intuitively by using an infrared device to test the fever of Corona 19. In this paper, the information collected from the Raspberry Pi and the DHT11 sensor is used to predict the temperature change in space through intuitive visualization and to make a immediate response. To this end, an algorithm was created to effectively visualize temperature and humidity, and data representation is possible even if some sensors are defective.

• Journal of Ginseng Research
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• v.46 no.3
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• pp.473-480
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• 2022

Background: Benign prostatic hyperplasia (BPH) is a disease characterized by abnormal proliferation of the prostate, which occurs frequently in middle-aged men. In this study, we report the effect of red ginseng oil (KGC11o) on BPH. Methods: The BPH-induced Sprague-Dawley rats were divided into seven groups: control, BPH, KGC11o 25, 50, 100, 200, and finasteride groups. KGC11o and finasteride were administered for 8 weeks. The BPH biomarkers, DHT, 5AR1, and 5AR2, androgen receptor, prostate-specific antigen (PSA), Bax, Bcl-2, and TGF-β were determined in the serum and prostate tissue. The cell viability after KGC11o treatment was determined using BPH-1 cells, and, androgen receptor, Bax, Bcl-2, and TGF-β were confirmed by western blotting. Results: In the in vivo study, administration of KGC11o reduced prostate weight by 18%, suppressed DHT (up to 22%) and 5AR2 (up to 12%) levels from administration of 100 mg/kg KGC11o (P < 0.05). PSA was significantly downregulated dose-dependently from at the concentration of 50 mg/kg KGC11o (P < 0.05). BPH-1 cell viability significantly reduced through the treatment with KGC11o. In vitro and vivo, AR, Bcl-2 TGF-β levels reduced significantly but Bax was increased (P < 0.05). Conclusion: These results suggest that KGC11o may inhibit the development of BPH by significantly reducing the levels of BPH biomarkers via 5ARI, anti-androgenic effect, and anti-proliferation effect, serving as a potential functional food for treating BPH.

• The Korean Journal of Pain
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• v.36 no.1
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• pp.51-59
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• 2023

Background: This study investigated the effect of an excess and a deficit of spinal 5-hydroxytryptamine (5-HT) on the mechanical allodynia and neuroglia activation in a rodent pain model of carrageenan inflammation. Methods: Male Sprague-Dawley rats were implanted with an intrathecal (i.t.) catheter to administer the drug. To induce an excess or deficit of 5-HT in the spinal cord, animals were given either three i.t. 5-HT injections at 24-hour intervals or a single i.t. injection of 5,7-dihydroxytryptamine (5,7-DHT) before carrageenan inflammation. Mechanical allodynia was measured using the von Frey test for 0-4 hours (early phase) and 24-28 hours (late phase) after carrageenan injection. The changes in the activation of microglia and astrocyte were examined using immunofluorescence of the dorsal horn of the lumbar spinal cord. Results: Both an excess and a deficit of spinal 5-HT had no or a minimal effect on the intensity of mechanical allodynia during the early phase but prevented the attenuation of mechanical allodynia during the late phase, which was observed in animals not treated with i.t. 5-HT or 5,7-DHT. Animals with an excess or deficit of 5-HT showed stronger activation of microglia, but not astrocyte, during the early and late phases, than did normal animals. Conclusions: Imbalance in the descending 5-HT pathway in the spinal cord could aggravate the mechanical allodynia and enhance the activation of microglia, suggesting that the spinal 5-HT pathway plays an essential role in maintaining the nociceptive processing in balance between facilitation and inhibition in inflammatory pain caused by carrageenan inflammation.

• The Journal of the Korea institute of electronic communication sciences
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• v.18 no.6
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• pp.1239-1244
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• 2023

In this study, we developed an IoT-based management system to manage a can/PET crusher. Various sensors such as two load cells, DHT22 temperature and humidity sensor, and fine dust meter were interfaced with ESP32 to construct an IoT device, and a management server was built using Node-RED. The system monitors the weight of pressed cans and shredded PET bottles in real time and sends a text message to the manager when the weight exceeds the predetermined threshold for timely collection. The results of the operational test confirmed that the system provides accurate monitoring and efficient notification functions, and offers the possibility of solving environmental problems by improving the efficiency of waste management such as cans and PET bottles.

• Journal of the Korean Society of Food Science and Nutrition
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• v.24 no.5
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• pp.720-726
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• 1995

Chemical components relevant to the characteristic taste of the Korean native persimmon(Diospyros kaki, Thumb) leaf tea were analyzed. Samples were processed by using three different methods ; SHT(steamed and then hot-air dried), DHT(dried in the shade, steamed and then hot-air dried) and RHT(roasted and then hot-air dried). The components analyzed were general compositions of dried perisimmon leaves and extracted solution. The composition of moisture, ash, crude lipid and total nitrogen did not show significant variation among different processing methods of the persimmonleaf tea. The contents of caffeine, tannin and vitamin C in persimmon leaf tea were in the range of $178.4~209.8{\mu}mol/g$, 29.1~38.5mg% and 325.3~2084.7mg%, respectively. The vitamin C content was significantly higher in the RHT than other treatments. The contents of caffeine, tannin and vitamin C in the tea extracted solution were in the range of $101.5~130.1{\mu}mol/g$, 15.4~25.9mg% and 111.0~1274.3mg%, respectively. The vitamine C in the tea solution was the highest in the RHT treatment and 61.1% of vitamin C in the leaf tea was extracted out in these processing methods. The major amino acids contained in the leaf tea were in decreasing order glutamic acid, aspartic acid, leucine and phenylalanine, these four amino acids consisting 38.9~39.8% of the total amino acid contained in the persimmon leaf tea. The major amino acids contained in the tea solution were glutamic acid, proline, histidine and arginine. Six kinds of 5'-nucleotides, CMP, AMP, UMP, IMP, GMP and hypoxanthine were detected and CMP was the most abundant component in fresh leaf, leaf tea and tea solution. The second highest 5'-nucleotides in both leaf tea and tea solutions were GMP, AMP and UMP in all processing method. The highest free sugar contained in the fresh leaf tea and tea solution was sucrose.

• Corrosion Science and Technology
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• v.4 no.2
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• pp.60-63
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• 2005

A high temperature resistant coating has been developed, which is mainly for heavy oil production pipes deserved the serious corrosion. The coating has excellent physical and mechanical performance and corrosion resistance at room and high temperature. In order to simulate the underground working condition of heavy oil pipes, the heat resistance of the high temperature resistant coating has been studied. The development and a study on the heat resistance of the DHT high temperature resistance coating have been introduced in this paper.

• Proceedings of the Korean Information Science Society Conference
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• 2004.10c
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• pp.682-684
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• 2004

IPv4 주소공간의 고갈 문제를 해결하기 위해 많은 사람들은 IPv6의 도입을 추진하고 있다. 따라서 본격적인 보급을 눈앞에 두고 있는 IPv6은 6BONE과 같은 실험망에서 IPv6을 이용하여 개발된 여러 응용프로그램들로 그 성능 및 효용성을 테스트 받고 있다. IPv6 기반 P2P 확장 프로토콜 연구 및 응용 서비스 개발의 일환으로 Distributed Hash Table(DHT)을 이용한 P2P 오버레이 네트워크를 형성하는 툴을 소개한다. 이 툴은 인스턴트 메신저 기능을 함과 동시에 로그인한 사용자 모두를 대상으로 하는 파일 검색 및 공유 기능도 제공한다. 본 논문에서는 P2P 오버레이 네트워크의 구축 과정과 인스턴트 메신저의 친구 목록을 이용한 효과적인 파일 검색 기법을 중점적으로 설명한다.

• Proceedings of the Korean Information Science Society Conference
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• 2004.10c
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• pp.697-699
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• 2004

최근 MANET(Mobile Ad-hoc Networks)에서의 P2P 응용을 이용한 서비스 개발이 활발히 진행 중이다. 이와 함께 에드혹 환경에서의 적합한 P2P 모델에 관한 연구로 기존 P2P 모델인 Gnutella, DHT등을 에드혹에 적용한 연구 역시 활발히 이루어지고 있다. 본 논문에서는 on-demand 방식의 에드혹 라우팅 프로토콜인 AODV(Ad-hoc On-Demand Distance Vector)상에서, 대표적인 P2P 응용인 Gnutella의 동작 과정을 통해 P2P 응용이 갖는 문제점을 분석하고, P2P 응용의 검색과정에서 발생하는 오버헤드를 줄이기 위한 방안을 제안한다. 그리고 위의 연구 결과를 바탕으로 현재 IPv6 AODV상에서 MANET을 위한 응용인 DiPP(Fully Distributed Peer-to-Peer)시스템을 구현한다. DiPP 시스템은 MANET상에서의 메신저와 파일공유를 위한 기능을 위해 동작한다.