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Respiratory protective effects of Korean Red Ginseng in a mouse model of particulate matter 4-induced airway inflammation

  • Won-Kyung Yang;Sung-Won Kim;Soo Hyun Youn;Sun Hee Hyun;Chang-Kyun Han;Yang-Chun Park;Young-Cheol Lee;Seung-Hyung Kim
    • Journal of Ginseng Research
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    • v.47 no.1
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    • pp.81-88
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    • 2023
  • Background: Air pollution has led to an increased exposure of all living organisms to fine dust. Therefore, research efforts are being made to devise preventive and therapeutic remedies against fine dust-induced chronic diseases. Methods: Research of the respiratory protective effects of KRG extract in a particulate matter (PM; aerodynamic diameter of <4 ㎛) plus diesel exhaust particle (DEP) (PM4+D)-induced airway inflammation model. Nitric oxide production, expression of pro-inflammatory mediators and cytokines, and IRAK-1, TAK-1, and MAPK pathways were examined in PM4-stimulated MH-S cells. BALB/c mice exposed to PM4+D mixture by intranasal tracheal injection three times a day for 12 days at 3 day intervals and KRGE were administered orally for 12 days. Histological of lung and trachea, and immune cell subtype analyses were performed. Expression of pro-inflammatory mediators and cytokines in bronchoalveolar lavage fluid (BALF) and lung were measured. Immunohistofluorescence staining for IRAK-1 localization in lung were also evaluated. Results: KRGE inhibited the production of nitric oxide, the expression of pro-inflammatory mediators and cytokines, and expression and phosphorylation of all downstream factors of NF-κB, including IRAK-1 and MAPK/AP1 pathway in PM4-stimulated MH-S cells. KRGE suppressed inflammatory cell infiltration and number of immune cells, histopathologic damage, and inflammatory symptoms in the BALF and lungs induced by PM4+D; these included increased alveolar wall thickness, accumulation of collagen fibers, and TNF-α, MIP2, CXCL-1, IL-1α, and IL-17 cytokine release. Moreover, PM4 participates induce alveolar macrophage death and interleukin-1α release by associating with IRAK-1 localization was also potently inhibited by KRGE in the lungs of PM4+D-induced airway inflammation model. KRGE suppresses airway inflammatory responses, including granulocyte infiltration into the airway, by regulating the expression of chemokines and inflammatory cytokines via inhibition of IRAK-1 and MAPK pathway. Conclusion: Our results indicate the potential of KRGE to serve as an effective therapeutic agent against airway inflammation and respiratory diseases.

Introducing the Digital Culture Map of Daesoon Jinrihoe: Answering the Need for Information on Daesoon Jinrihoe via the Digital Culture Map of Daesoon Jinrihoe (대순진리회 전자문화지도 개발 시론 - 대순진리회 전자정보 제공 양상과 전자문화지도 개발의 필요성 -)

  • Byun Ji-sun
    • Journal of the Daesoon Academy of Sciences
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    • v.44
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    • pp.97-140
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    • 2023
  • This article is meant to serve as an introduction to the development of digital culture map of Daesoon Jinrihoe. Recently there has been frequent discussion over the need to provide information on the website of Daesoon Jinrihoe's Yeoju Headquarters Temple Complex, and the further need to produce a digital culture map of Daesoon Jinrihoe. The production of digital culture map of Daesoon Jinrihoe has the advantage of being able to publicize and enhance its status worldwide beyond simply building digital archives, collecting data, visualizing Daesoon Jinrihoe materials, and acquiring tools for research on Daesoon Jinrihoe. Therefore, the development of Daesoon Jinrihoe's digital culture map is expected to be a step for Daesoon Jinrihoe to leap forward globally. Next in the process would be the study of data. The current status of Daesoon Jinrihoe's data and analysis of the contents will enable researchers to proceed to the next stage. In the production of digital culture map of Daesoon Jinrihoe, the next step to be studied after data research is to review precedents in the production of digital culture maps related to religion. Researchers will be able to review domestic precedents and overseas precedents, and based on those, it will be possible to suggest a direction for developing Daesoon Jinrihoe's digital culture map.

Analysis of Downstream Water Quality Improvement by Agricultural Reservoir Release Using QUAL2K (QUAL2K 모형을 이용한 농업용 저수지 방류에 따른 하류하천 수질개선효과 분석)

  • Kim, Dong Hyeon;Kim, Sang Min
    • Journal of agriculture & life science
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    • v.50 no.5
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    • pp.205-216
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    • 2016
  • The purpose of this study was to analyze the water quality improvement effect by providing the environmental flows from agricultural reservoir using QUAL2K model. The Bonghyun reservoir, located in Hai-myun, which is in the city of Gosung in the Gyeongnam province, was selected for study area. The stream monitoring was conducted 24 times from 2011 to 2013 and the water quality was monitored in 6 stations including reservoir. Reservoir operation was simulated to determine the environmental flow supply amount from March to October with the constraint that environmental flow supply was restrained when the storage of reservoir was below the one-third of effective storage. The QUAL2K model was selected for water quality simulation. Simulated water quality were compared with the observed for BOD, SS, TN, and TP. R2 were ranged 0.8508~0.9913, RMSE were 0.005~0.52 mg/L, and NSE were 0.949~0.998 for water quality items, respectively. The QUAL2K model simulation results indicated that the water quality improvement effect by providing the environmental flows(3,000 ton/day) were 9.2% for BOD, 21.0% for SS, -9.0% for TN, -2.4% for TP, respectively.

A Study on the Concept and Characteristics of Metaverse based NFT Art - Focused on <Hybrid Nature> (메타버스 기반 NFT 아트 작품 사례 연구 - <하이브리드 네이처>를 중심으로)

  • Bosul Kim;Min Ji Kim
    • Trans-
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    • v.14
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    • pp.1-33
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    • 2023
  • In the Web 3.0 era, the third generation of web technologies that uses blockchain technology to give creators ownership of data, metaverse is a crucial trend for developing a creator economy. Web 3.0 aims for a value in which content creators are compensated from participation without being dependent on the platform. Blockchain NFT technology is crucial in metaverse, a vital component of Web 3.0, to ensure the ownership of digital assets. Based on the theory that investigates the concept and characteristics of metaverse, this study identifies five features of the metaverse based NFT art ①'Continuity', ②'Presence', ③ 'Concurrency', ④'Economy', ⑤ 'Application of technology'. By focusing on metaverse based NFT art <Hybrid Nature> case study, we analyzed how the concepts and characteristics of the metaverse and NFT art were reflected in the work. This study focuses on the concept of NFT art, which is emerging at the intersection of art, technology and industry, and emphasizes the importance of finding creative, aesthetic, and cultural values rather than the NFT art's potential for financial gain. It is still in its early stage for academic studies to focus on the aesthetic qualities of NFT art. Future academics and researchers can find this study to gain deeper understanding of the traits and artistic, creative aspects of metaverse based NFT art.

Effects of Resistance Training on BMD and Bone Metabolism Related Markers in Aging Rats (저항성 훈련이 노화흰쥐의 골밀도 및 골대사 관련 지표에 미치는 영향)

  • Kang, Hyung-Sook;Kim, Sang-Bae;Yoon, Jin-Hwan
    • 한국노년학
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    • v.31 no.2
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    • pp.303-315
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    • 2011
  • The purpose of this study was to investigate effect of resistance training on BMD and bone metabolism related markers in aging rats. Thirty male Spraugue-Daweley rats were divided into sedentary (CON; n=10 ) non-load resistance trained(NLRTG; n=10), and load resistance trained(LRTG; n=10) groups at the age of 64 weeks. The rats in the resistance training groups((NLRTG and LRTG) performed the tower climbing exercise 4 times a week. The LRTG groups were conditioned to climb a vertical ladder with weights appended to their tail 4 days/wk for 12 wks. After 12 weeks of exercise, serum osteocalcin, bone mineral density (BMD), breaking force, ash, Ca, and P in the femur were measured. After training, serum osteocalcin (OC) was significantly (p < 0.05) higher in both LRTG and NLRTG when compared to Control. Right femur BMD was significantly (p < 0.05) greater for LRTG when compared to both NLRTG and Control with no significant difference between NLRTG and Conrtol. The breaking force of femur was significantly (p < 0.05) greater for LRTG and NLRTG when compared to Control. The Ash, Ca, content of femur were significantly increased in resistance training groups than control group. These results suggest that the increase in bone mineral density induced by resistance training is mediated by changes in bone microarchitecture as well as training intensity and osteocalcin.

Searching the Major Research Domains for Establishing the Korean Criminal Psychology (한국 범죄심리학의 학문적 정립을 위한 주요 연구영역의 탐색)

  • Si Up Kim
    • Korean Journal of Culture and Social Issue
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    • v.11 no.2
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    • pp.109-142
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    • 2005
  • This study was conducted to suggest the research domains of Criminal Psychology, which is needed to improve the disciplinary identity of the Korean Criminal Psychology. Some major textbooks of Criminal Psychology, Forensic Psychology, Legal Psychology are written by korean and foreign psychologists. Major definitions and research domains of Criminal Psychology was compared and reviewed. For aggregating the criminal psychological researches were studied by korean psychologists, a total of 211 articles and papers, which was published by Korean Psychological Association, 5 Sub-psychological Associations, and Korean Law Psychological Association, were reviewed. Several the major research domains in Criminal Psychology was suggested as follows: General psychological theories, aggression·anger·morality, adolescent delinquency, mind and motivations of criminals, victims, investigation techniques, testimony, assessment·counseling·correction·rehabilitation of criminals, prediction and prevention of crime.

The Influence of Growth Mindset and Professor Support on School Life Adjustment of Nursing College Freshman in the Era of COVID-19 (코로나19 시대 간호대학 신입생의 성장마인드셋과 교수지지가 학교생활적응에 미치는 영향)

  • Woo-Young Chae
    • Journal of the Korean Applied Science and Technology
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    • v.39 no.6
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    • pp.802-811
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    • 2022
  • The purpose of this study is to confirm the relationship between growth mindset, professor support and school life adjustment of nursing college freshman in the era of COVID-19, and to understand the effect on school life adjustment. The subjects of this study were 248 nursing college freshman located in G Metropolitan City, and data collection was conducted from October 4 to October 31, 2022. The collected data were analyzed by descriptive statistics, t-test, ANOVA, Pearson's correlation coefficients and multiple regression analysis using the SPSS/WIN 28.0 program. As a result of the study, school life adjustment had a significant positive correlation with growth mindset(r=.51, p<.000) and professor support(r=.54, p<.000). Factors affectiong school life adjustment of nursing college freshman were professor support(β=.38, p<.001), subjects who answered very satisfied in major satisfaction(β=.31, p<.001), growth mindset(β=.26, p<.001), subjects who answered satisfied in major satisfaction(β=.16, p=.015), and female students(β=.14, p=.005), which explained 44.0% of variance. The results of this study will be usefully used to develop strategies to improve the school life adjustment of nursing college freshman. In the future, a follow-up study that can expand the subjects and explain the school life adjustment of nursing college freshman is suggested.

Realization on the Integrated System of Navigation Communication and Fish Finder for Safety Operation of Fishing Vessel (어선의 안전조업을 위한 항해통신 및 어탐기의 통합시스템 구현)

  • In-suk Kang;In-ung Ju;Jeong-yeon Kim;Jo-cheon Choi
    • Journal of Advanced Navigation Technology
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    • v.25 no.6
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    • pp.433-440
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    • 2021
  • The problem of maritime accidents due to the carelessness of fishing vessels, which is affected by the aging of fishing vessel operators. And there is navigation, communication and fish finder that is installed inside the narrow bridge of a fishing vessel. Therefore these system are monitors as many as of each terminal, which is bad influence on obscuring view of front sea from a fishing vessel bridge. In addition a large problem, it is occurs to reduce of the information recognition ability due to the confusion, which is can not check the display information each of screen equipments. Therefore, there has been demand to simply integrated the equipment, and it has wanted the integrated support system of these equipment. The display must be provided on a fishing vessels such as electronic charts, communications equipments and fish detection into one case. In this paper, the integrated system will be installed the GPS plotter, AIS, VHF-DSC, V-pass, fish finder and power supply in the narrow wheelhouse on a fishing vessel, which is configured in one case and operated by multi function display (MFD). The MFD is integrated to simplify for several multi terminals and provided necessary information on a single screen. This integration fishery support system will has improved in sea safety operation and fishery environment of fishing vessels by this implementation.

The Survey on the Degree of Link with Internet Space and a Internet Addiction Disposition of Adolescents (청소년의 인터넷 접촉 정도와 중독성향에 대한 조사)

  • Sang-chul Han
    • Korean Journal of Culture and Social Issue
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    • v.9 no.2
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    • pp.19-39
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    • 2003
  • The purpose of this study was to investigate the degree of link with internet media and a internet addiction disposition of adolescents. The subjects were 500 students attending to middle and high schools consisted of male and female. The instruments were "the questionnaire on the present conditions of internet use" consisted of 14 items(Cronbach's α=.71) and "the internet addiction rating scale" consisted of 20 items(Cronbach's α=.73). These questionnaire were revised by this researcher. For data analysis, chisqure and ANOVA were used. The main results were as follows. First, a boy students and the vocational high school and the middle school each have more negative response than a girl students and the humanistic high schools in the present conditions of internet use and the judgement on a harmful object of internet space. Second, a boy students have higher than a girl students in an internet addiction disposition. Third, an internet addiction related with the times link with internet, the type of internet game, and the content of internet space(a lustful and violent objects). The various methods for the prevent with the internet addiction of adolescents discussed with based on the previous studies.

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Study on Domestic Trends of Green Fuel Policy

  • Sangseop Lim;Sang-Mi Im;Seok-Hun Kim
    • Journal of the Korea Society of Computer and Information
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    • v.29 no.4
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    • pp.183-189
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    • 2024
  • Against the backdrop of IMO's stricter environmental regulations due to global warming, Europe's Fit for 55 plan, and other initiatives, the establishment of infrastructure for the supply of environmentally friendly marine fuels and policy analysis are more critical than ever. This study comprehensively analyzes existing research and policies on the supply of environmentally friendly marine fuels, as well as trends in regulations, industry responses, and the current status of infrastructure for the supply of environmentally friendly fuels, to draw insightful conclusions. The results show that the establishment of infrastructure for the supply of environmentally friendly fuels is as important as the introduction of environmentally friendly ships, due to the strengthening of environmental regulations. LNG is a viable option in the short term, but a transition to carbon-free fuels is necessary in the long run. In this regard, a strategic approach is needed to focus support on fuels that are advantageous to produce, considering domestic industrial conditions from a long-term perspective. Therefore, the government should actively promote infrastructure development through measures such as supporting the development and supply of environmentally friendly fuels, improving regulations and providing incentives, attracting private investment, and strengthening international cooperation. This study is expected to serve as a valuable resource for setting policy directions for the transition to an environmentally friendly maritime industry. Future research will include a comparative analysis of the economic viability of environmentally friendly fuels and basic research on the selection of fuels that are advantageous to Korea.