• 한국전자통신학회논문지
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• 제13권4호
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• pp.721-728
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• 2018

본 논문은 다양한 구조의 선형 블록 오류정정코드를 소개하고, 이를 회로로 구현하여 비교 분석한 결과를 보여주고 있다. 메모리 시스템에서는 잡음 전력으로 인한 비트 오류를 방지하기 위해 ECC(: Error Correction Code)가 사용되어 왔다. ECC의 종류에는 SEC-DED(: Single Error Correction Double Error Detection)와 SEC-DED-DAEC(: Double Adjacent Error Correction)가 있다. SEC-DED인 Hsiao 코드와 SEC-DED-DAEC인 Dutta, Pedro 코드를 각각 Verilog HDL을 이용해 설계 후 $0.35{\mu}m$ CMOS 공정을 사용해 회로로 합성하였다. 시뮬레이션에 의하면 SEC-DED회로는 인접한 두 개의 비트 오류를 정정하지 못하지만 적은 회로 사용면적과 빠른 지연 시간의 장점이 있으며, SEC-DED-DAEC 회로의 경우 Pedro 코드와 Dutta 코드 간에는 면적, 지연 시간의 차이가 없으므로 오류 정정률이 개선된 Pedro 코드를 사용하는 것이 더 효율적임을 알 수 있다.

• Journal of Microbiology and Biotechnology
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• 제32권8호
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• pp.1034-1040
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• 2022

Fas-associated death domain (FADD) is an adapter molecule that bridges the interaction between receptor-interacting protein 1 (RIP1) and aspartate-specific cysteine protease-8 (caspase-8). As the primary mediator of apoptotic cell death, caspase-8 has two N-terminal death-effector domains (DEDs) and it interacts with other proteins in the DED subfamily through several conserved residues. In the tumor necrosis receptor-1 (TNFR-1)-dependent signaling pathway, apoptosis is triggered by the caspase-8/FADD complex by stimulating receptor internalization. However, the molecular mechanism of complex formation by the DED proteins remains poorly understood. Here, we found that direct DED-DED interaction between FADD and caspase-8 and the structure-based mutations (Y8D/I128A, E12A/I128A, E12R/I128A, K39A/I128A, K39D/I128A, F122A/I128A, and L123A/I128A) of caspase-8 disrupted formation of the stable DED complex with FADD. Moreover, the monomeric crystal structure of the caspase-8 DEDs (F122A/I128A) was solved at 1.7 Å. This study will provide new insight into the interaction mechanism and structural characteristics between FADD and caspase-8 DED subfamily proteins.

• Journal of Preventive Medicine and Public Health
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• 제50권6호
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• pp.369-376
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• 2017

Objectives: Dry eye disease (DED) is an increasingly important public health problem in Korea. Previous studies conducted in Korea have reported inconsistent results regarding the protective effects of vitamin D on DED, and these discrepancies may be related to the relatively simple questionnaire that has been used. Thus, we evaluated the association of serum vitamin D levels with DED using the ocular surface disease index (OSDI). Methods: The present study evaluated data from participants in the Study Group for Environmental Eye Disease (2014-2015). This group included data from 752 participants, and data from 740 participants (253 men and 487 women) were analyzed in the present study. DED severity was evaluated using the OSDI. Results: Higher serum vitamin D levels were associated with a non-significantly reduced risk of DED in the crude analysis (odds ratio [OR], 0.991; 95% confidence interval [CI], 0.971 to 1.011) and in the adjusted analysis (OR, 0.988; 95% CI, 0.966 to 1.010). In the crude analysis of no/mild DED vs. moderate/severe DED, men exhibited a decreased risk with increasing serum vitamin D levels (OR, 0.999; 95% CI, 0.950 to 1.051), while women exhibited an increased risk (OR, 1.003; 95% CI, 0.979 to 1.027). In these analyses, we found no significant associations. Conclusions: The findings of the present study support previous reports that serum vitamin D levels are not associated with DED.

• 한국지능시스템학회논문지
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• 제18권5호
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• pp.611-616
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• 2008

Error correcting codes는 일반적으로 soft error를 막기 위해서 사용된다. single error의 수정과 double error의 검출(SEC-DED) 코드들은 이런 목적으로 사용된다. 본 논문에서는 이러한 회로의 크기, 지연시간, 전력 소비를 선택적으로 최소로 하는 SEC-DED의 설계방법을 제안한다. 이러한 SEC-DED의 설계는 비선형 최적화 문제로 포함되는데 우리는 다목적 유전자 알고리즘을 이용하여 이 문제를 해결한다. 제안하는 방법은 여러 가지 SEC-DED code들을 제공하여 사용자의 환경에 따라 알맞은 회로를 선택할 수 있도록 한다. 제안하는 방법을 효율적인 ECC코드로 알려져 있는 odd-column weight Hsiao code에 적용하여 그 효율성을 입증하였다.

• Corrosion Science and Technology
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• 제18권6호
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• pp.258-266
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• 2019

The objective of this study was to evaluate corrosion resistance of additive manufactured 316L stainless steel and alloy 625 powders widely used in corrosion resistance alloys of marine industry in comparison with cast alloys. Directed Energy Deposition (DED) method was used in this work for sample production. DED parameter adjustment was also studied for optimum manufacturing and for minimizing the influence of defects on corrosion property. Additive manufactured alloys showed lower corrosion resistance in seawater compared to cast alloys. The reason for the degradation of anti-corrosion property was speculated to be due to loss of microstructural integrity intrinsic to the additive manufacturing process. Application of heat treatment with various conditions after DED was attempted. The effect of heat treatments was analyzed with a microstructure study. It was found that 316L and alloy 625 produced by the DED process could recover their expected corrosion resistance when heat treated at 1200 ℃.

• 한국기계가공학회지
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• 제20권6호
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• pp.59-69
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• 2021

Directed energy deposition (DED) is an additive manufacturing technology involving a focused high-power laser or electron beam propagating over the substrate, resulting in melt pool formation while simultaneously supplying metal powder to the melt pool area to deposit the material. DED is performed to repair and strengthen parts in various applications, as it can be easily integrate local area cladding and cross-material deposition. In this study, we characterize stainless steel 316 L parts fabricated via DED based on various deposition conditions and geometries to widen the application of DED. The deposition characteristics are investigated by varying the laser power and powder feed rate. Multilayer deposition with a laser power of 362 W and a powder feed rate of 6.61 g/min indicate a height closest to the design value while affording high surface quality. The microhardness of the specimen increases from the top to the bottom of the deposited area. Tensile tests of specimens with two different deposition directions indicate that horizontally long specimens with respect to a substrate demonstrate a higher ultimate tensile strength and yield strength than vertically long specimens with lower elongation.

• 소성∙가공
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• 제30권3호
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• pp.109-118
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• 2021

Recently, there has been an increased interest in the remanufacturing of mechanical parts using metal additive manufacturing processes in regards to resource recycling and carbon neutrality. DED (directed energy deposition) process can create desired metallic shapes on both even and uneven substrate via line-by-line deposition. Hence, DED process is very useful for the repair, retrofit and remanufacturing of mechanical parts with irregular damages. The objective of the current paper is to investigate the effects DED process parameters, including the effects of power and the scan speed of the laser, on deposition and residual stress characteristics for remanufacturing of mechanical parts using experiments and finite element analyses (FEAs). AISI 1045 is used as the substrate material and the feeding powder. The characteristic dimensions of the bead shape and the heat affected zone (HAZ) for different deposition conditions are obtained from the experimental results. Efficiencies of the heat flux model for different deposition conditions are estimated by the comparison of the results of FEAs with those of experiments in terms of the width and the depth of HAZ. In addition, the influence of the process parameters on residual stress distributions in the vicinity of the deposited region is investigated using the results of FEAs. Finally, a suitable deposition condition is predicted in regards to the bead formation and the residual stress.

• 한국압력기기공학회 논문집
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• 제19권1호
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• pp.11-19
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• 2023

Additive manufacturing technology, called as 3D printing, is one of fourth industrial revolution technologies that can drive innovation in the manufacturing process, and thus should be applied to nuclear industry for various purposes according to the manufacturing trend change in the future. In this paper, we performed tensile tests of 3D printed stainless steel 316L as-built specimens manufactured by two types of technology; DED (Directed Energy Deposition) and PBF (Powder Bed Fusion). Their mechanical properties (tensile strength, yield strength, elongation and reduction of area) were compared. As a result of comparison, the mechanical properties of the PBF specimens were slightly better than those of DED specimens. In the same additive type of specimens, the tensile and yield strength of specimens in the X and Y direction were higher than those in the Z direction, but the elongation and ROA were lower.

• 한국정보통신학회논문지
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• 제26권10호
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• pp.1559-1562
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• 2022

As electronic devices technology scales down into the deep-submicron to achieve high-density, low power and high performance integrated circuits, multiple bit upsets by soft errors have become a major threat to on-chip memory systems. To address the soft error problem, single error correction, double error detection and double adjacent error correction (SEC-DED-DAEC) codes have been recently proposed. But these codes do not troubleshoot mis-correction problem. We propose the SEC-DED_DAEC code with without mis-correction. The decoder for proposed code is implemented as hardware and verified. The results show that there is no mis-correction in the proposed codes and the decoder can be employed on-chip memory system.

• Medical Lasers
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• 제8권2호
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• pp.50-58
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• 2019

Background and Objectives Low-level light therapy (LLLT) is an application of low-power light for various purposes such as promoting tissue repair, reducing inflammation, causing analgesia, etc. A previous study suggested the effect of light emitting diode (LED) light with the wavelength of 740 nm for promoting wound healing of corneal epithelial cells. This current study aimed to confirm the effect of LLLT for managing inflammation of a dry eye disease (DED) mouse model. Materials and Methods A total of 50C57BL/6 female mice were randomly grouped into 5 groups to compare the effect of LLLT:1) Control group, 2) Only LLLT group, 3) Dry eye group, 4) LLLT in dry eye group, and 5) Early treatment group. DED was induced with 4 daily injections of scopolamine hydrobromide and desiccation stress for 17 days, and LLLT at 740 nm was conducted once every 3 days. To analyze the effect of LLLT on the DED mouse model, tear volume, corneal surface irregularities, and fluorescence in stained cores were measured, and the level of inflammation was assessed with immunohistochemistry. Results The DED mouse model showed significant deterioration in the overall eye condition. After LLLT, the amount of tear volume was increased, and corneal surface irregularities were restored. Also, the number of neutrophils and the level of inflammatory cytokines significantly decreased as well. Conclusion This study showed that LLLT at 740 nm was effective in controlling the corneal conditions and the degree of inflammation in DED. Such findings may suggest therapeutic effects of LLLT at 740 nm on DED.