• Title/Summary/Keyword: DCP-1

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In Vitro Cytotoxicity of a Novel Platinum(II) Coordination Complex Containing Diaminocyclohexane and Dichloropropane

  • Rho, Young-Soo;Chang, Sung-Goo;Lee, Woo-Tae;Jung, Jee-Chang
    • The Korean Journal of Physiology and Pharmacology
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    • v.5 no.4
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    • pp.359-366
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    • 2001
  • We have synthesized a novel platinum(II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,3-dichloropropane (DCP) as a leaving group. A new series of [Pt(cis- DACH)(DCP)](PC) was evaluated for its cytotoxic activity on MKN-45 human gastric adenocarcinoma cells and normal primary cultured kidney cells. The new platinum complex has demonstrated high efficacy in the cytotoxicity against MKN-45/P, MKN-45/ADM and MKN-45/CDDP cell-lines. The cytotoxicity of PC against rabbit proximal renal tubular cells, human renal cortical cells and human renal cortical tissues, determined by MTT assay, the $[^3H]-thymidine$ uptake and glucose consumption tests, was found to be quite less than those of cisplatin. Based on these results, this novel platinum(II) coordination complex appears to be better for improving antitumor activities with low nephrotoxicity and is a valuable lead in the development of new, clinically available anticancer chemotherapeutic agents.

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Characterization and Properties of Composites of Woodflour and Polylactic Acid

  • Febrianto, Fauzi;Yoshioka, Mariko;Nagai, Yuko;Syafii, Wasrin;Shiraishi, Nobuo
    • Journal of the Korean Wood Science and Technology
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    • v.34 no.5
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    • pp.67-78
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    • 2006
  • Modification of polylactic acid (PLA) and 10% maleic anhydride (MAH) with 15% dicumyl peroxide (DCP) based on MAH weight was conducted in the kneader at $160^{\circ}C$ and 30~70 rpm, for 15 min. The resulting MAH-modified PLA (PLA-MA) was then evaluated as a compatibilizer for PLA-wood flour (WF) composites. The FTIR and $^1H$-NMR analysis gave evidence of PLA-MA formation. After kneading and reacting with MAH and DCP, the number (Mn) and the weight average (Mw) molecular weights of PLA decreased as compared to the original PLA. The presence of WF in the composites decreased the tensile strength and several other physical properties. The higher the WF loading resulted in the greater the reduction of tensile strength. An addition of 10% PLA-MA as a compatibilizer to the composites improved the tensile strength and several other physical properties, increased the flow temperature, and decreased the melt viscosity. The improved composite revealed 1.42 times increased in tensile strength but not over PLA alone, and absorbed considerably less water compared to those of the composites free-compatibilizer.

Wear Resistance of Crosslinked Ultra-high Molecular Weight Polyethylene (가교된 초고분자량 폴리에틸렌의 내마모성)

  • Im, Chae-Ik;Lee, Gwi-Jong;Jo, Jae-Yeong;Choe, Jae-Bong;Choe, Gwi-Won
    • Journal of Biomedical Engineering Research
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    • v.20 no.1
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    • pp.99-106
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    • 1999
  • Ultra-high molecular weight polyethylene (UHMWPE) was crosslinked in the melt state to enhance wear resistance, Dicumyl peroxide (DCP) and triallyl cyanurate (TAC) was used as a crosslinking agent and a promoter, respectively. With increasing amount of DCP and TAC used, gel content of crosslinked UHMWPE (XUMPE) increased, while the melting temperature, crystallizaiton temperature, crystallinity, and tensile properties decreased. The results of pin-on-disk wear test and ball-on-disk test with small applied load showed reduced wear volumes of XUMPE from that of the unmodified UHMWPE. As the wear mechanism effected in the experimental condition of this study was thought to be deformation rather than adhesion or fatigue, a new parameter, the ratio of maximum contact stress to yield stress, was proposed to correlate well with observed wear resistance. In ball-on-disk wear test with larger applied load, XUMPE showed higher wear volumes than that of the unmodified UHMWPE which were accompanied with increased friction coefficients and surface roughness of the wear tracks. When contact stress was well above yield stress, the failure of XUMPE, as well as deformation, was thought to be much accelerated.

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Analysis of 1,4-Dioxane and Chlorohydrins in Food Additives by Purge & Trap GC (퍼지앤트랩-기체크로마토그래피(PT-GC)를 이용한 식품첨가물 중 1,4-디옥산 및 클로로히드린류 분석)

  • 조태용;신영민;반경녀;오세동;이창희;이영자;문병우
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.32 no.7
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    • pp.965-970
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    • 2003
  • This study has been performed to develope a method for the simultaneous determination of 1,4-dioxane (DOX), epichlorohydrin (EPC), propylene chlorohydrin (PCH), ethylene chlorohydrin (ECH) and 1,3-dichloro-2-pro-panol (DCP) in polysorbates, chloline chloride, choline bitartrate, modified starch and spices by purge and trapgas chromatography. Experimental design was used to select a suitable trap by measuring the limit of detection (LOD) and to investigate the effect of temperature and salt of extraction, and the percentage of recovery in various matrix. The LOD of DOX, EPC, PCH, ECH and DCP were 1.38$\mu\textrm{g}$, 0.23$\mu\textrm{g}$, 3.30$\mu\textrm{g}$, 3.97$\mu\textrm{g}$, 20.43$\mu\textrm{g}$ respectively, by means of using Vorcarb 3000 trap with 5$0^{\circ}C$ sample sparger. Excluding EPC, the recoveries of target compounds were above 90% in all matrix. Target compounds in polysorbates (17), choline chloride (5), choline bitartrate (5), modified starch (8) and spices (25) were not detected. But 2.5 ppm of DOX was detected in Tween 80.

Measurement of the Quantity of Hydrogen Peroxide Produced in the Ultrasound-irradiated Aqueous Solution of Organic Compounds (초음파를 조사(照射)한 유기화합물 수용액 속에서의 과산화수소 생성량의 측정)

  • Mo, Se-Young;Chang, Hong-Ki;Lee, Kyung-Jae;Jang, Gun-Eik;Sohn, Jong-Ryeul
    • Journal of Korean Society of Environmental Engineers
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    • v.22 no.1
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    • pp.61-71
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    • 2000
  • When irradiate the power ultrasound into the aqueous solutions, water vapor is decomposed by the heat of very high temperature in the cavitation bubble to produce OH (hydroxyl radical) and H (hydrogen radical), and these radicals play a role in decomposing the substances in aqueous solution by oxidation and/or reduction, and in producing the hydrogen peroxide. Accordingly it is possible to predict that the quantity of hydrogen peroxide produced may correlate with the sonolysis mechanism of the substance in aqueous solution. Thus to confirm this prediction, the quantities of hydrogen peroxide produced from each of the air saturated distilled water and three aqueous solutions of TCE, benzene, and 2,4-DCP that are prepared by dissolving them into distilled water are measured. As a result, it showed that the quantity of hydrogen peroxide produced from the distilled water and three aqueous solutions are increased in order of distilled water>TCE solution>2,4-DCP solution>benzene solution, and decrease with decrease in concentration of organic substance, which coincide with the sonolysis mechanisms reported that TCE in aqueous solution is decomposed directly by the pyrolysis in and around the cavitation bubbles when its concentration is high and by the radical reaction when low, however, benzene and 2,4-DCP are decomposed not only by the pyrolysis but also by the radical reactions. Effects of such experimental parameters as the acoustic frequency and power and as the concentration showed that the higher the acoustic frequency and the lower the acoustic power, the less the quantity of hydrogen peroxide was produced. This result coincide with the theory of ultrasound for the relation between the cavitation that is the energy source of the power ultrasound in aqueous solution and these experimental parameters.

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Fracture Toughness of the Thermoplastic Vulcanizates from EPDM/PP/Ionomer Ternary Blends (EPDM/PP/Ionomer 삼원 블렌드로 된 열가소성 가황체의 파괴 인성)

  • Kim, K.;Cho, W.J.;Ha, C.S.;Go, J.H.
    • Elastomers and Composites
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    • v.31 no.5
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    • pp.341-346
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    • 1996
  • The fracture mechanics investigation of the thermoplastic vulcanizates(TPV) from EPDM and PP/Ionomer ternary blends was performed in terms of the J-integral by measuring fracture energy via the locus method. The TPV from ternary blends consisting of EPDM, PP and ionomer were prepared in a laboratory integral mixer by blending and vulcanizing simultaneously. Vulcanization was performed with dicumyl peroxide (DCP) and the composition of EPDM and PP was fixed at 50/50 by weight. Two kinds of poly(ethylene-co-methacrylic acid) (EMA) lonomers were used. The J-integral values at crack initiation, Jc, of the dynamically vulcanized EPDM and PP/EMA Ionomer ternary blends were affected by the cation types $(Na^+\;or\;Zn^{2+})$ and contents(5-20wt%) of the added EMA Ionomers. The ternary blend containing 20wt% zinc-neutralized EMA Ionomer and 1.0phr DCP showed the highest Jc values of the blends.

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Feeding Sesbania Leaves as a Sole Feed on Growth and Nutrient Utilization in Goats

  • Shahjalal, M.;Topps, J.H.
    • Asian-Australasian Journal of Animal Sciences
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    • v.13 no.4
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    • pp.487-489
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    • 2000
  • An experiment was conducted for 56 days using nine castrated male Black Bengal goats (initial live weight 9.0 kg) aged about 5 months to study the effects of feeding Sesbania leaves as a sole feed on growth performance and nutrient utilization. The animals were fed ad libitum on either road-side grass, Sesbania aculeata leaves or Sesbania rostrata leaves. Average dry matter (DM) intake was 179, 229 and 259 g/d for goats fed road-side grass, Sesbania aculeata and Sesbania rostrata, respectively. Corresponding mean values for average daily live weight change were -6.6, 9.5 and 38.1 g, respectively. These values were higher (p<0.05) for goats fed Sesbania leaves than those given road-side grass. The apparent digestibility of all the proximate components except CF and the concentrations of DCP, TDN, DOM and ME of Sesbania leaves were higher (p<0.05) than those of road-side grass. Sesbania rostrata was superior (p<0.05) to Sesbania aculeata for nutrient digestibilities (except for NFE) and also for DOM, DCP and ME concentrations. Therefore, it may be concluded that the production of Sesbania rostrata, a legume fodder, should be encouraged for feeding goats.

Characteristics of the sonolytic reaction of refractory aromatic compounds in aqueous solution by ultrasound (초음파에 의한 수중의 난분해성 방향족화합물의 반응특성)

  • Sohn, Jong-Ryueul;Mo, Se-Young
    • Journal of Korean Society on Water Environment
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    • v.18 no.4
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    • pp.411-419
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    • 2002
  • In this study, the series of ultrasonic irradiation for removal of refractory aromatic compounds has been selected as a model reaction in the batch reactor system in order to obtain the reaction kinetics. The products obtained from the ultrasonic irradiation were analysed by GC and GC/MSD. The decomposition of benzene produced toluene, phenol, and C1-C4 compounds, while the intermediates during the ultrasonic irradiation of 2,4-Dichlorophenol(DCP) were phenol, HCl, catechol, hydroquinone, and benzoquinone. It was found that more than 80% of benzene, and 2,4-DCP solutions were removed within 2 hours in all reaction conditions. The reaction order in the degradation of these three compounds was verified as pseudo-zero or first order. From the fore-mentioned results, it can be concluded that the refractory organic compounds could be removed by the ultrasonic irradiation with radicals, such as $H{\cdot}$ and $OH{\cdot}$ radical causing the high increase of pressure and temperature. Finally, it appeared that the technology using ultrasonic irradiation can be applied to the treatment of refractory compounds which are difficult to be decomposed by the conventional methods.

Human Activity Recognition in Smart Homes Based on a Difference of Convex Programming Problem

  • Ghasemi, Vahid;Pouyan, Ali A.;Sharifi, Mohsen
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.11 no.1
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    • pp.321-344
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    • 2017
  • Smart homes are the new generation of homes where pervasive computing is employed to make the lives of the residents more convenient. Human activity recognition (HAR) is a fundamental task in these environments. Since critical decisions will be made based on HAR results, accurate recognition of human activities with low uncertainty is of crucial importance. In this paper, a novel HAR method based on a difference of convex programming (DCP) problem is represented, which manages to handle uncertainty. For this purpose, given an input sensor data stream, a primary belief in each activity is calculated for the sensor events. Since the primary beliefs are calculated based on some abstractions, they naturally bear an amount of uncertainty. To mitigate the effect of the uncertainty, a DCP problem is defined and solved to yield secondary beliefs. In this procedure, the uncertainty stemming from a sensor event is alleviated by its neighboring sensor events in the input stream. The final activity inference is based on the secondary beliefs. The proposed method is evaluated using a well-known and publicly available dataset. It is compared to four HAR schemes, which are based on temporal probabilistic graphical models, and a convex optimization-based HAR procedure, as benchmarks. The proposed method outperforms the benchmarks, having an acceptable accuracy of 82.61%, and an average F-measure of 82.3%.