• Title/Summary/Keyword: DBT

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A 4-weeks Oral Toxicity of Dangguibohyel-tang in Sprague-Dawley Rats (당귀보혈탕(當歸補血湯)의 SD계 흰쥐에 대한 아급성경구독성시험)

  • Kang, Soon-Ah;Chang, Mun-Seog;Oh, Myung-Sook;Park, Wan-Su;Kim, Won-Nam;Yang, Woog-Mo;Lee, Byong-Hee;Park, Seong-Kyu
    • The Korea Journal of Herbology
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    • v.21 no.2
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    • pp.159-163
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    • 2006
  • Objectives : The subacute toxicity was investigated in Sprague-Dawley rats orally treated with Dangguibohyel-tang (DBT). DBT has been used for anemia, in Korean medicine. Methods : Sprague-Dawley rats were administered orally with DBT at the dosages of 1,000 mg/kg for 14 days. We daily examined number of deaths, clinical signs, body weights and gross findings during the 14 days. Results : There were no clinical signs and pathological changes compared with control group. Body weights were not significantly changed between control and treatment groups. In hematological and biochemical serum parameters, all mean values appear to be within the normal range. Conclusion : These results suggest that DBT dose not induce any significant subacute oral toxicities in Sprague-Dawley rats.

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Joint Control of Duty Cycle and Beacon Tracking in IEEE 802.15.4 LR-WPAN (IEEE 802.15.4 저속 WPAN에서 듀티 사이클과 비콘 추적의 통합 제어)

  • Park, Sung-Woo
    • The Journal of the Korea institute of electronic communication sciences
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    • v.11 no.1
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    • pp.9-16
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    • 2016
  • Since most of devices in the IEEE 802.15.4 LR-WPAN are expected to operate on batteries, they must be designed to consume energy in a very conservative way. Two energy conservation algorithms are proposed for the LR-WPAN: DDC (Dynamic Duty Cycle) and DBT (Dynamic Beacon Tracking). The DDC algorithm adjusts duty cycle dynamically depending on channel conditions. The DBT algorithm switches beacon tracking mode on and off adaptively depending on traffic conditions. Combining the two algorithms reduces energy consumption more efficiently for a wide range of input loads, while maintaining frame delivery ratio and average delay at satisfactory levels.

높은 유상비에서 Rhodococcus rhodochrous IGTS8를 이용한 탈황효율의 분석과 5-L 배양기에의 적용

  • Kim, Jin-Hong;Park, Hong-U
    • 한국생물공학회:학술대회논문집
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    • 2002.04a
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    • pp.121-125
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    • 2002
  • Rhodococcus rhodochrous IGTSS (ATCC 5396S) can break organo sulfur compounds such as dibenzothiophene. Since the environment for biodesulfurization process is invariably hydrophobic, parameters in hydrophobic systems should be examined. For the model oil, hexadecane-containing 5.43mM dibenzothiophene, the volumetric desulfurization rate was decreased with the oil-to-aqueous phase ratio up to 50%. The rate declined sharply after 48h because the cell activity, which is refreshed by medium exchange, was lost. To supply the exhausted nutrients, medium exchange was performed. At 30% oil phase, most of DBT was removed by medium exchange on 48h, and the rate was 2.03mg $DBT_{removed}/L_{dispersion}-hr.$ At 50% oil phase, medium exchange on 60h was performed and the rate was 1.79mg $DBT_{removed}/L_{dispersion}-hr.$ The 300mL flask system was scaled up to a 5-L bioreactor system. On 60 h, a medium exchange was performed and the rate was 5.28mg $DBT_{removed}/L_{dispersion}-hr.$ and all of DBT was removed. It means that we can use the biodesulfurization process even 10 the high oil-to-water phase by some appropriate methods such as controlled feeding of key nutrients and the dilution or removal of some toxic metabolites by continuous reactor.

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A Study on the Photodegradative Behavior of the Dibenzothiophene (DBP) in Water System (수용액중의 디벤조치오펜의 광화학적 분해반응의 연구)

  • Kim, Jae-Hyoun
    • Environmental Analysis Health and Toxicology
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    • v.14 no.3
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    • pp.121-126
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    • 1999
  • The present paper describes a study of the photochemical kinetics and its oxidation mechanism of DBT. The photolysis of DBT in aqueous solution media have shown to have significant oxidation activities for the photolytic desulfurization of DBT. The oxidation effect was more pronounced in 4 % NaCl solution. A mechanism was proposed that the desulfurization process arise from the substution of sulfur by the hydroxyl radicals in different aqueous medium.

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Hydrodesulfurization of Dibenzothiophene by Sulfided $Ni-W/\gamma-Al_2O_3$ Catalyst (황화 $Ni-W/\gamma-Al_2O_3$ 촉매에 의한 Dibeenzothiophene의 수첨탈황반응)

  • 김경림;정지원
    • Journal of Korean Society for Atmospheric Environment
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    • v.2 no.2
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    • pp.51-59
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    • 1986
  • Hydrodesulfurization of dibenzothiophene (DBT) dissolved in n-heptane was studied over sulfided $Ni - W/\gamma - Al_2O_3$ catalyst at temperature ranges from 513 to 573 K and at pressure ranges from 20 to 60 x $10^5$ Pa. Hydrogenation of biphenyl (BP) and cyclohexylbenzene (CHB) observed in products were also run. The products were almost biphenyl and cyclohyxylbenzene, and the conversion of DBT was very sensitive to temperature. Concerning the products distribution while the formation of biphenyl decreased, the formation of cyclohexylbenzene increased in the range of high pressure. The reaction network was found to be sequential reaction which formed cyclohexybenzent through the intermediate of biphenyl. The disappearances of DBT and biphenyl were the first order with respect to DBT and biphenyl and their activation energys were 24.3 and 13.6 Kcal/mol, respectively.

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Digital Breast Tomosynthesis in Addition to Conventional 2D-Mammography Reduces Recall Rates and is Cost-Effective

  • Agostino, Pozzi;Angelo, Della Corte;el Lakis, Mustapha A;Heon-Jae, Jeong
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.7
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    • pp.3521-3526
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    • 2016
  • Digital breast tomosynthesis (DBT) as a breast cancer screening modality, through generation of three-dimensional images during standard mammographic compression, can reduce interference from breast tissue overlap, increasing conspicuity of invasive cancers while concomitantly reducing false-positive results. We here conducted a systematic review on previous studies to synthesize the evidence of DBT efficacy, eventually 18 articles being included in the analysis. The most commonly emerging topics were advantages of DBT screening tool in terms of recall rates, cancer detection rates and cost-effectiveness, preventing unnecessary burdens on women and the healthcare system. Further research is needed to evaluate the potential impact of DBT on longer-term outcomes, such as interval cancer rates and mortality, to better understand the broader clinical and economic implications of its adoption.

Biodesulfurization of Dibenzothiophene and Its Derivatives Using Resting and Immobilized Cells of Sphingomonas subarctica T7b

  • Gunam, Ida Bagus Wayan;Yamamura, Kenta;Sujaya, I. Nengah;Antara, Nyoman Semadi;Aryanta, Wayan Redi;Tanaka, Michiko;Tomita, Fusao;Sone, Teruo;Asano, Kozo
    • Journal of Microbiology and Biotechnology
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    • v.23 no.4
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    • pp.473-482
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    • 2013
  • The desulfurization ability of Sphingomonas subarctica T7b was evaluated using resting and immobilized cells with dibenzothiophene (DBT), alkyl DBTs, and commercial light gas oil (LGO) as the substrates. The resting cells of S. subarctica T7b degraded 239.2 mg of the initial 250 mg of DBT/l (1.36 mM) within 24 h at $27^{\circ}C$, while 127.5 mg of 2-hydroxybiphenyl (2-HBP)/l (0.75 mM) was formed, representing a 55% conversion of the DBT. The DBT desulfurization activity was significantly affected by the aqueous-to-oil phase ratio. In addition, the resting cells of S. subarctica T7b were able to desulfurize alkyl DBTs with long alkyl chains, although the desulfurization rate decreased with an increase in the total carbon number of the alkylated DBTs. LGO with a total sulfur content of 280 mg/l was desulfurized to 152 mg/l after 24 h of reaction. Cells immobilized by entrapment with polyvinyl alcohol (PVA) exhibited a high DBT desulfurization activity, including repeated use for more than 8 batch cycles without loss of biodesulfurization activity. The stability of the immobilized cells was better than that of the resting cells at different initial pHs, higher temperatures, and for DBT biodesulfurization in successive degradation cycles. The immobilized cells were also easily separated from the oil and water phases, giving this method great potential for oil biodesulfurization.

Effects of Combined Application of Rice Bran and Chemical Fertilizer on the Phytochemical Contents of Rice

  • Kang, Mi-Young;Kim, Joo-Hee;Heo, Kyu-Hong;Cho, Sun-Shik;Esguerra, Manuel Q.;Rico, Cyren M.;Son, Tae-Kwon;Lee, Sang-Chul
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.53 no.spc
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    • pp.65-71
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    • 2008
  • The effect of rice bran (RB) applied alone or in combination with chemical fertilizer at different application rate on the phytochemical and antioxidant properties of rice was investigated. The treatments were 3 levels of RB namely: 200% RB (500 kg $10a^{-1}$), 100% RB (250 kg $10a^{-1}$), 50% RB (125 kg $10a^{-1}$), Recommended fertilizer dose (RF: $N-{P_2}{O_5}{K_2}O$, 11-5.5-4.8 kg $10a^{-1}$) combined with each RB, Half-recommended fertilizer dose (HRF: $N-{P_2}{O_5}{K_2}O$, 5.5-2.75-2.4 kg $10a^{-1}$) combined with each RB, RF and HRF applied at 1, 5, 10 days before rice transplanting (DBT). The parameters investigated were antioxidant, phytosterol and fatty acid contents. Results showed that the antioxidant property and phytosterol contents were high at 10 DBT HRF plus RB, 5 DBT RF plus RB, and 1 DBT 100 and 200% RB. However, total polyphenols increased from 10 to 1 DBT. In the case of fatty acids, no general trend was observed between treatments at different application times. Linoleic acid was high at 10 DBT HRF plus RB while linolenic acid was not affected at different application times. Palmitoeic and oleic acids were not also affected at 5 and 10 DBT. Saturated fatty acids were not also affected by any treatment at different application times except for palmitic acid.Most parameters obtained higher values at 100 and 200% RB treatments in 1 DBT.

Diagnostic Performance of Digital Breast Tomosynthesis with the Two-Dimensional Synthesized Mammogram for Suspicious Breast Microcalcifications Compared to Full-Field Digital Mammography in Stereotactic Breast Biopsy (정위적 유방 조직검사 시 미세석회화 의심 병변에서의 디지털 유방단층영상합성법과 전역 디지털 유방촬영술의 진단능 비교)

  • Jiwon Shin;Ok Hee Woo;Hye Seon Shin;Sung Eun Song;Kyu Ran Cho;Bo Kyoung Seo
    • Journal of the Korean Society of Radiology
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    • v.83 no.5
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    • pp.1090-1103
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    • 2022
  • Purpose To evaluate the diagnostic performance of digital breast tomosynthesis (DBT) with the two-dimensional synthesized mammogram (2DSM), compared to full-field digital mammography (FFDM), for suspicious microcalcifications in the breast ahead of stereotactic biopsy and to assess the diagnostic image visibility of the images. Materials and Methods This retrospective study involved 189 patients with microcalcifications, which were histopathologically verified by stereotactic breast biopsy, who underwent DBT with 2DSM and FFDM between January 8, 2015, and January 20, 2020. Two radiologists assessed all cases of microcalcifications based on Breast Imaging Reporting and Data System (BI-RADS) independently. They were blinded to the histopathologic outcome and additionally evaluated lesion visibility using a fivepoint scoring scale. Results Overall, the inter-observer agreement was excellent (0.9559). Under the setting of category 4A as negative due to the low possibility of malignancy and to avoid the dilution of malignancy criteria in our study, McNemar tests confirmed no significant difference between the performances of the two modalities in detecting microcalcifications with a high potential for malignancy (4B, 4C, or 5; p = 0.1573); however, the tests showed a significant difference between their performances in detecting microcalcifications with a high potential for benignancy (4A; p = 0.0009). DBT with 2DSM demonstrated superior visibility and diagnostic performance than FFDM in dense breasts. Conclusion DBT with 2DSM is superior to FFDM in terms of total diagnostic accuracy and lesion visibility for benign microcalcifications in dense breasts. This study suggests a promising role for DBT with 2DSM as an accommodating tool for stereotactic biopsy in female with dense breasts and suspicious breast microcalcifications.

Distribution of Butyltin Compounds in Surface Sediments inside Hallim Harbor of Jeiu Island, Korea (제주도 한림항내 표층퇴적물 중의 부틸주석화합물의 분포)

  • 감상규;김현정;허철구;최영찬;이민규
    • Journal of Environmental Science International
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    • v.12 no.7
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    • pp.753-762
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    • 2003
  • Butyltin compounds (BTs), namely tributyltin (TBT), dibutyltin (DBT) and monobutyltin (MBT), were measured in surface sediments collected in 2001 inside Hallim Harbor where a lot of shipping occurs as one of major harbors of Jeju Island, in order to evaluate their distribution. BTs were detected in surface sediments of all stations and their concentrations were comparable to those in surface sediments of other sites of domestic and foreign countries. The main species among BTs was MBT, although there was a little difference with a survey site. No correlations were obtained between organic matter or particles size of surface sediments and total BTs, indicating that these factors did not affect on the distribution of BTs. It was estimated that more complex factors including BTs loads and surrounding sedimentary environments, affected on the distribution of BTs. The high correlations between BTs indicated that DBT and MBT were mainly degraded from TBT based on antifouling paints of vessel etc. and other sources, such as DBT and MBT, could be ignored. The butyltin degradation indexes ([DBT] + [MBT]/[TBT]) Ivere in the range of 1.5∼3.3 (mean 2.5), indicating that the parent compound, TBT, were inflowed into the surface sediments a long years ago and degraded.