• Korean Journal of Construction Engineering and Management
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• v.20 no.5
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• pp.52-60
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• 2019

The APR1400 is a 1400MWe nuclear power plant developed through national technology development project over a period about 10years. Approximately 65,000 design drawings are produced for APR1400 construction. In order to maintain consistency among numerous drawings, the highest level of design bases drawings (DBDs) are created according to design bases and this is used in the subsequent design. However, DBDs are produced and managed on a document basis and they are managed various field, it was difficult to accurately reflect the design bases information in the subsequent design. Therefore, this study recognizes limitations of the document based DBDs and develops a system that can accurately reflect the design bases information to subsequent design by adopting BIM based design bases integrated information system. Especially, by introducing DBIL(Design Bases Information Layer) concept, DBIL was created and analyzed based on five design bases(Physical protection, Fire protection, Internal missile protection, Internal flood protection, Radiation protection) applied to APR1400. In the final result DBIL set and Datasheet are integrated of room, design bases information, building data(wall, slab, door, window, penetrations). So it can be used for subsequent design automation and design verification. Furthermore, it is expected that APR1400 DBILs data can be used extensively in constructability and design economics analysis through comparison with next generation nuclear power plant.

• Korean Journal of Construction Engineering and Management
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• v.20 no.2
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• pp.28-36
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• 2019

The APR1400 (Advanced Power Reactor 1400MW) nuclear power plant is a large-scale national infrastructure facility with a total project cost of 8.6 trillion won and a project period of 10 years or more. The total project area is about 2.17 million square meters and consists of more than 20 buildings and structures. And the total number of drawings required for construction is about 65,000. In order to design such a large facility, it is important to establish a design standard that reflects the design intent and can increase conformity between documents (drawings). To this end, a design bases document (DBD) reflecting the design bases that extracted in regulatory requirements (e.g. 10CFR50, Korean Law, etc.) is created. However, although the design bases are important concepts that are a big framework for the whole design of the nuclear power plant, they are managed in 2-dimensional by the experts in each field fragmentarily. Therefore, in order to improve the usability of building information, we developed BIM(Building Information Model) based 3-dimensional design bases management system. For this purpose, the concept of design bases information layer (DBIL) was introduced. Through the simulation of developed system, design bases attribute and element data extraction for each DBIL was confirmed, and walls, floors, doors, and penetrations with DBIL were successfully extracted.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1997.10a
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• pp.277-281
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• 1997

Reliab~l~ty englneerlng IS regarded as the major and important roll for all Industry And advanced nianufactur~ng systems w~th h~gh speed and lntell~gent ha\\ulcorner been dcvelop~ng for betterment of lnachln~ng db~l~ty In th~study, Me have rystem~~ed c\, ~luat~on c r f relidb~litl for nldchlntry system We proposed the rel~ab~l~ty asvxmcnt and dci~yned and manufactured r~ildb~llty tcst-bed to eualuate rcl~dbil~ty In ddd~t~on we acquired relldb~l~ty data uslng test-bed sydem and mde database to handle relrab~l~t) data And also he not only use rel~ab~l~ty data by andlyzlng rel~ab~l~ty, but also apply design revlew method usmg analycing crltlcal unlt5 of machlnery system From th~s stud), he u ~ l l expect to gu~de md Increase the rel~ab~l~t) englneerlng in devclop~ng and procerslng phase of h~gh qualrty product

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.11
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• pp.1642-1647
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• 2014

In this study, we investigated the hepatoprotective effects of garlic extracts fermented with Lactobacillus plantarum on alcohol-induced fatty liver damage in C57BL/6J mice. The weight of liver tissue of the lactic acid-fermented garlic extract (LAFGE) diet groups decreased in a dose-dependent manner compared to that of the normal diet group. The activities of typical serum enzymes such as ALT, AST, and ALP were low in the LAFGE 200 mg/kg administered group. The LAFGE 200 mg/kg administered group significantly decreased values of TBIL and DBIL, which are an important index of liver damage. LAFGE also ameliorated alcohol-induced hepatic lipid accumulation in histological analysis dose-dependently. In addition, total GSH and reduced GSH levels in LAFGE-treated groups were gradually recovered up to normal levels. The present study revealed that LAFGE improved unique tastes and odors of raw garlic through lactic acid fermentation technology and thus could be a commercially potential material for hepatoprotective functional foods against alcoholic fatty liver.

• Toxicological Research
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• v.25 no.2
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• pp.85-92
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• 2009

4,4'-Methylenedianiline (MDA) is an aromatic amine that is widely used in the industrial synthetic process. Genotoxic MDA forms DNA adducts in the liver and is known to induce liver damage in human and rats. To elucidate the molecular mechanisms associated with MDA-induced hepatotoxicity, we have identified genes differentially expressed by microarray approach. BALB/c male mice were treated once daily with MDA (20 mg/kg) up to 7 days via intraperitoneal injection (i.p.) and hepatic damages were revealed by histopathological observation and elevation of serum marker enzymes such as AST, ALT, ALP, cholesterol, DBIL, and TBIL. Microarray analysis showed that 952 genes were differentially expressed in the liver of MDA-treated mice and their biological functions and canonical pathways were further analyzed using Ingenuity Pathways Analysis (IPA). Toxicological functional analysis showed that genes related to hepatotoxicity such hyperplasia/hyperproliferation (Timp1), necrosis/cell death (Cd14, Mt1f, Timp1, and Pmaip1), hemorrhaging (Mt1f), cholestasis (Akr1c3, Hpx, and Slc10a2), and inflammation (Cd14 and Hpx) were differentially expressed in MDA-treated group. This gene expression profiling should be useful for elucidating the genetic events associated with aromatic amine-induced hepatotoxicity and for discovering the potential biomarkers for hepatotoxicity.