• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.5A
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• pp.447-456
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• 2009

The design comparison and flexural reliability analysis of continuous span composite plate girder bridges are performed. The girders are designed by the methods of allowable stress design (ASD) and load and resistance factor design (LRFD). For the LRFD design, the design specification under development mainly by KBRC, based on AASHTO-LRFD specification in case of steel structures, is applied with the newly proposed design live load which has been developed by analyzing domestic traffic statistics from highways and local roads. For the ASD based design, the current KHBDC code with DB-24 and DL-24 live loads is used. The longest span length for the 3-span continuous bridges with span arrangement ratio of 4:5:4 is assumed to be from 30 m to 80 m. The amount of steel, performance ratios, and governing design factors for the sections designed by the ASD and LRFD methods are compared. In the reliability analysis for the flexural failure of the sections designed by two methods, the statistical properties on flexural resistance based on the yield strength statistics for over 16,000 domestic structural steel samples are applied.

• Journal of Information Management
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• v.24 no.1
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• pp.1-20
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• 1993

KTRC(Korea Telecom Research Center) has developed the KTRIMS(Korea Telecom Research Information Management System) to keep and share the full text of the various up-to-date research information which many research institutes in KT have produced. This paper has presented the structure and the features of the KTRIMS.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2021.11a
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• pp.23-24
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• 2021

Since 2011, apartment houses account for about 41% of the fires in residential facilities for the past 10 years. Fire-resistant performance of fire doors is becoming more important to prevent the spread of fire in apartment houses. This research analyzed the structure of fire door through each 10 DB based on the quality inspection report of Continuous Acquisition & Life-cycle Support(CALS) from 2016 to 2020, which passed the fire performance test based on the laws and notices of domestic fire door. Therefore, based on the results of the analysis of DB in the future, we will conduct a study on structural improvement and addition for fireproof performance improvement of fire door.

• Nutrition Research and Practice
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• v.10 no.6
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• pp.569-574
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• 2016

BACKGROUND/OBJECTIVES: We investigated the anti-osteoarthritic effects of deer bone extract on the gene expressions of matrix metalloproteinases (MMPs) and collagen type II (COL2) in interleukin-$1{\beta}$-induced osteoarthritis (OA) chondrocytes. MATERIALS/METHODS: Primary rabbit chondrocytes were treated as follows: CON (PBS treatment), NC (IL-$1{\beta}$ treatment), PC (IL-$1{\beta}+100{\mu}g/mL$ glucosamine sulphate/chondroitin sulphate mixture), and DB (IL-$1{\beta}+100{\mu}g/mL$ deer bone extract). RESULTS: The results of the cell viability assay indicated that deer bone extract at doses ranging from 100 to $500{\mu}g/mL$ inhibits cell death in chondrocytes induced by IL-$1{\beta}$. Deer bone extract was able to significantly recover the mRNA expression of COL2 that was down-regulated by IL-$1{\beta}$ (NC: 0.79 vs. DB: 0.87, P < 0.05) and significantly decrease the mRNA expression of MMP-3 (NC: 2.24 vs. DB: 1.75) and -13 (NC: 1.28 vs. DB: 0.89) in OA chondrocytes (P < 0.05).CONCLUSIONS: We concluded that deer bone extract induces accumulation of COL2 through the down-regulation of MMPs in IL-$1{\beta}$-induced OA chondrocytes. Our results suggest that deer bone extract, which contains various components related to OA, including chondroitin sulphate, may possess anti-osteoarthritic properties and be of value in inhibiting the pathogenesis of OA.

• Journal of Microbiology and Biotechnology
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• v.28 no.8
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• pp.1247-1259
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• 2018

Raspberries are polyphenol-rich fruits with the potential to reduce the severity of the clinical signs associated with obesity, a phenomenon that may be related to changes in the gut microbiota. The aim of this study was to investigate the effect of raspberry supplementation on the fecal microbiota using an in vivo model of obesity. Obese diabetic db/db mice were used in this study and assigned to two experimental groups (with and without raspberry supplementation). Fecal samples were collected at the end of the supplementation period (8 weeks) and used for bacterial 16S rRNA gene profiling using a MiSeq instrument (Illumina). QIIME 1.8 was used to analyze the 16S data. Raspberry supplementation was associated with an increased abundance of Lachnospiraceae (p = 0.009), a very important group for gut health, and decreased abundances of Lactobacillus, Odoribacter, and the fiber degrader S24-7 family as well as unknown groups of Bacteroidales and Enterobacteriaceae (p < 0.05). These changes were enough to clearly differentiate bacterial communities accordingly to treatment, based on the analysis of UniFrac distance metrics. However, a predictive approach of functional profiles showed no difference between the treatment groups. Fecal metabolomic analysis provided critical information regarding the raspberry-supplemented group, whose relatively higher phytosterol concentrations may be relevant for the host health, considering the proven health benefits of these phytochemicals. Further studies are needed to investigate whether the observed differences in microbial communities (e.g., Lachnospiraceae) or metabolites relate to clinically significant differences that can prompt the use of raspberry extracts to help patients with obesity.

• Applied Microscopy
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• v.51
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• pp.6.1-6.9
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• 2021

Histopathology is a well-established standard diagnosis employed for the majority of malignancies, including breast cancer. Nevertheless, despite training and standardization, it is considered operator-dependent and errors are still a concern. Fractal dimension analysis is a computational image processing technique that allows assessing the degree of complexity in patterns. We aimed here at providing a robust and easily attainable method for introducing computer-assisted techniques to histopathology laboratories. Slides from two databases were used: A) Breast Cancer Histopathological; and B) Grand Challenge on Breast Cancer Histology. Set A contained 2480 images from 24 patients with benign alterations, and 5429 images from 58 patients with breast cancer. Set B comprised 100 images of each type: normal tissue, benign alterations, in situ carcinoma, and invasive carcinoma. All images were analyzed with the FracLac algorithm in the ImageJ computational environment to yield the box count fractal dimension (Db) results. Images on set A on 40x magnification were statistically different (p = 0.0003), whereas images on 400x did not present differences in their means. On set B, the mean Db values presented promising statistical differences when comparing. Normal and/or benign images to in situ and/or invasive carcinoma (all p < 0.0001). Interestingly, there was no difference when comparing normal tissue to benign alterations. These data corroborate with previous work in which fractal analysis allowed differentiating malignancies. Computer-aided diagnosis algorithms may beneficiate from using Db data; specific Db cut-off values may yield ~ 99% specificity in diagnosing breast cancer. Furthermore, the fact that it allows assessing tissue complexity, this tool may be used to understand the progression of the histological alterations in cancer.

• Korean Journal of Plant Resources
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• v.24 no.2
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• pp.174-180
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• 2011

This study was conducted to investigate the optimum condition of extraction from fronds of Osmunda japonica to increase antioxidant compounds and antioxidant activity. Powder (1 g) of lyophilized fronds were mixed with three different solvents (MeOH, 80% EtOH and water). Extraction was carried out using not only by immersion (room temp.), heating ($60^{\circ}C$) and stirring (200 rpm) for 6 h, but also by sonication in 42 kHz ultrasonic bath for 15, 30 and 45 min. Extracts were filtered, and adjusted up to 50 mL to determine contents of soluble solids, total polyphenols and total flavonoids. Antioxidant capacity was measured by radical scavenging activity of 0.15 mM DPPH (2,2-diphenyl-1-picrylhydrazyl) and 7.4 mM ABTS [2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] radical. Among the solvents, MeOH and 80% EtOH appeared to be effective for extraction. Extract obtained from sonication in MeOH for 15 min resulted high polyphenol contents (45.15 $mg{\cdot}g^{-1}$ db) and DPPH radical scavenging activity ($RC_{50}$= 0.35 $mg{\cdot}mL^{-1}$). The highest flavonoid contents was obtained from immersion or heating extraction with MeOH (38.10~38.10 $mg{\cdot}g^{-1}$ db). ABTS radical scavenging was high in same extraction with 80% EtOH ($RC_{50}$= 0.21~0.22 $mg{\cdot}mL^{-1}$). Altogether, our results indicate that the extraction using ultrasonic bath with MeOH as a solvent (for 15~30 minutes) was the most effective way not only for increasing various antioxidant activities but also for saving labor and time in case of fronds of Osmunda japonica.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2004.04a
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• pp.201-208
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• 2004

To substitute conventional reinforced-concrete bridge deck, glass composite precast bridge deck - Delta Deck/sup TM/, which possesses advantages of light weight, high strength, corrosion resistance and durability, is developed for the DB24 truck load. Pultruded composite bridge deck is designed and fabricated. To verify serviceability and structural safety, finite element analysis, structural testing such as flexural test, local fatigue test, flexural fatigue test and field tests are conducted. In this paper structural characteristics of developed deck and its field application in Korea is presented.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2005.04a
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• pp.113-120
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• 2005

To substitute conventional reinforced-concrete bridge deck glass composite precast bridge deck - Delta $Deck^{TM}$, which possesses advantages of light weight, high strength, corrosion resistance and durability, is developed for the DB24 truck load. Pultruded composite bridge deck is designed and fabricated. In this paper some field applications and field load test of developed composite deck bridge are presented.

• 기계와재료
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• v.24 no.1
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• pp.72-79
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• 2012

최근 미국 멕시코만에서의 대형 오일 누출 사고에서 보듯이 에너지플랜트에서의 사고는 막대한 인명피해, 경제적 피해를 유발한다. 최근 플랜트 설계의 주요 관심사는 플랜트의 생애주기에서 사고에 의한 위험도(RISK)를 적정 수준 아래로 제어하는 것이다. 이를 위해 플랜트 설계 단계에서 필요한 정량적 위험도 분석(Qualitative Risk Assessment) 방법론을 개괄하였다. 아울러 QRA의 핵심이 되는 플랜트 기기 고장률 DB 구축의 필요성을 논하였다.