• Archives of Plastic Surgery
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• v.35 no.2
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• pp.121-126
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• 2008

Purpose: Poly-N-acetyl glucosamine(PGlcNAc) nanofiber-based materials, produced by a marine microalga, have been characterized as effective hemostatic and angiogenic agents. The similarity between PGlcNAc patch and the natural extracellular matrix allows it to support new healthy tissue growth in an injured area and to encourage fluid absorption. In this study, we hypothesized that a poly-N-acetyl glucosamine fiber patch(PGlcNAc patch) may enhance wound healing in the db/db mouse. Methods: PGlcNAc patches were applied on one square centimeter, full-thickness, skin wounds in the db/db mouse model. Wounds(n=15 per group) were dressed with a PGlcNAc nanofiber patch for 1 hour(1 h), 24 hours(24 h) or left untreated(NT). After the application time, patches were removed and wounds were allowed to heal spontaneously. The rate of wound closure was evaluated by digital analysis of unclosed wound area in course of time. At day 10, wounds(n=7 per group) were harvested and quantified with immunohistochemical markers of proliferation(Ki-67) and vascularization (platelet endothelial cell adhesion molecule, PECAM-1). Results: Wounds dressed with PGlcNAc patches for 1 hour closed faster than control wounds, reaching 90% closure in 16.6 days, nine days faster than untreated wounds. Granulation tissue showed higher levels of proliferation and vascularization following 1 h treatment than the 24 h and NT groups. In addition to its hemostatic properties, the PGlcNAc material also appears to accelerate wound closure in healing-impaired genetically diabetic mice. Conclusion: This material, with its combination of hemostatic and wound healing properties, has the potential to be effective agent for the treatment of complicated wounds.

• Biomolecules & Therapeutics
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• v.27 no.5
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• pp.457-465
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• 2019

Patients with diabetes mellitus (DM) often suffer from diverse skin disorders, which might be attributable to skin barrier dysfunction. To explore the role of lipid alterations in the epidermis in DM skin disorders, we quantitated 49 lipids (34 ceramides, 14 free fatty acids (FFAs), and cholesterol) in the skin epidermis, liver, and kidneys of db/db mice, a Type 2 DM model, using UPLC-MS/MS. The expression of genes involved in lipid synthesis was also evaluated. With the full establishment of hyperglycemia at the age of 20 weeks, remarkable lipid enrichment was noted in the skin of the db/db mice, especially at the epidermis and subcutaneous fat bed. Prominent increases in the ceramides and FFAs (>3 fold) with short or medium chains ($LXR{\alpha}/{\beta}$ and $PPAR{\gamma}$, nuclear receptors promoting lipid synthesis, lipid synthesis enzymes such as elongases 1, 4, and 6, and fatty acid synthase and stearoyl-CoA desaturase were highly expressed in the skin and livers of the db/db mice. Collectively, our study demonstrates an extensive alteration in the skin and systemic lipid profiles of db/db mice, which could contribute to the development of skin disorders in DM.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.24 no.1
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• pp.123-134
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• 2014

As the data gets bigger recently, the demand for relational database management system (RDBMS) and NoSQL DBMS to process big data has been increased consistently. The digital forensic investigation method for RDBMS has been studied actively, but that for NoSQL DBMS, which is popularly used nowadays, has almost no research. This paper proposes the digital forensic investigation process and method for MongoDB, the most popularly used among NoSQL DBMS.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 1999.11a
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• pp.373-378
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• 1999

얼굴 및 얼굴표정 연구의 기초 자료를 제공하고 실제 표정을 디자인하는 작업의 지침으로 사용되도록 하기 위하여 대규모의 표정 DB를 구축하였다. 이 DB 내에는 여러 가지 방법으로 수집된 배우 24명의 자연스럽고 다양한 표정 영상자료 약 1,500장이 저장되어 있다. 수집된 표정자료 각각에 대하여 내적상태의 범주모형과 차원모형을 모두 고려하여 다수의 사람들이 반응한 내적상태 평정 정보를 포함하도록 하였으며 사진별로 평정의 일치율을 기록함으로써 자료 이용에 참고할 수 있도록 하였다. 표정인식 및 합성 시스템에 사용될 수 있도록 각 표정자료들을 한국인 표준형 상모형에 정합하였을 때 측정된 MPEG-4 FAP 기준 39개 꼭지점들(vertices)의 좌표값들 및 표정추출의 맥락정보를 저장하였다. 실제 DB를 사용할 사람들이 가진 한정된 정보로써 전체 DB의 영상자료들을 용이하게 검색할 수 있도록 사용자 인터페이스를 개발하였다.

• The Korean Journal of Applied Statistics
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• v.30 no.1
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• pp.13-24
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• 2017

The Sample Cohort DB supplied by the National Health Insurance Service is a valuable resource for statistical studies as well as for health and medical studies. It takes significant time and effort to extract data from this Cohort DB having a large size. As such, we introduce a database system, conveniently called the National Health Insurance Service Cohort DB Extract Tool (NICE Tool), which supports several useful operations for effectively and efficiently managing the Cohort DB. For example, researchers can extract variables and cases related with study by simply clicking a computer mouse without any prior knowledge regarding SAS DATA step or SQL. We expect that NICE Tool will facilitate the faster extraction of data and eventually lead to the active use of the Cohort DB for research purposes.

• Proceedings of the Acoustical Society of Korea Conference
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• autumn
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• pp.21-24
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• 1999

본 논문에서는 가변어휘 음성인식기의 성능개선 작업에 관한 내용을 기술하고 있다. 묵음을 포함한 총 40개의 문맥독립 음소모델을 사용한다. LDA 기법을 이용하여 동일차수의 특징벡터내에 보다 유용한 정보를 포함시키고, likelihood 계산시 가우시안 분포와 mixture weight에 대한 가중치를 달리 함으로써 성능향상을 볼 수 있었다. ETRI POW 3848 DB만을 사용하여 실험한 경우, $21.7\%$의 오류율 감소를 확인할 수 있었다. 잡음환경 및 어휘독립환경을 고려하여 POW 3848 DB와 PC 168 DB 및 PBW445 DB를 사용한 실험도 행하였으며, PBW 445 DB를 사용한 어휘독립 인식실험의 경우 $56.8\%$의 오류율 감소를 얻을 수 있었다.

• The Journal of Information Technology and Database
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• v.1 no.2
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• pp.3-24
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• 1994

기존의 데이타 모델 및 설계 방법론들은 실세계의 데이타 객체에 대해 고정된 한 측면의 모델 표현만을 허용하기 때문에 여러 측면으로 관측이 가능한 실세계 객체들의 표현에 어려움을 갖는다. 제시한 객체 중심 측면 모델(OOAM : Object-Oriented Entity Aspect Model)은 실세계의 각 객체에 대해 다수의 측면 표현을 가능하게 한 객체 중심의 데이타 모델로 데이타와 지식 표현에 유용한 모델이다. 데이타베이스 시스템과 지식베이스 시스템 중 어느 하나의 시스템이 다른 시스템의 특징을 빌리거나 통합할 수 있다면 두 시스템에게 서로 이득이 될 수 있다. 이러한 KB/DB(Knowledge Base/Data Base)의 통합은 최근에 객체 지향 개념과 연역 개념에 의해 연구가 활발히 진행되고 있다. 본 논문에서는 객체의 측면 개념을 제공하는 OOAM의 기본 개념을 보여주고 OOAM에 의해 구축되는 데이타베이스 스키마의 시맨틱을 분석하고 서술하기 위해 OOAM을 형식적으로 정의하였다. 그리고 KB/DB 통합에 관련된 연구들을 분석하고 데이타베이스에 관련된 지식의 종류를 서술한 후 OOAM을 사용하여 KB/DB 통합을 위한 지식베이스와 데이타베이스의 개발 방법론을 제시하였다.

• The Korean Journal of Malacology
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• v.31 no.3
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• pp.243-247
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• 2015

A stand-alone BLAST server is available that provides a convenient and amenable platform for the analysis of molluscan sequence information especially the EST sequences generated by traditional sequencing methods. However, it is found that the server has limitations in the annotation of molluscan sequences generated using next-generation sequencing (NGS) platforms due to inconsistencies in molluscan sequence available at NCBI. We constructed a web-based interface for a new stand-alone BLAST, called PANM-DB (Protostome DB) for the analysis of molluscan NGS data. The PANM-DB includes the amino acid sequences from the protostome groups-Arthropoda, Nematoda, and Mollusca downloaded from GenBank with the NCBI taxonomy Browser. The sequences were translated into multi-FASTA format and stored in the database by using the formatdb program at NCBI. PANM-DB contains 6% of NCBInr database sequences (as of 24-06-2015), and for an input of 10,000 RNA-seq sequences the processing speed was 15 times faster by using PANM-DB when compared with NCBInr DB. It was also noted that PANM-DB show two times more significant hits with diverse annotation profiles as compared with Mollusks DB. Hence, the construction of PANM-DB is a significant step in the annotation of molluscan sequence information obtained from NGS platforms. The PANM-DB is freely downloadable from the web-based interface (Malacological Society of Korea, http://malacol.or/kr/blast) as compressed file system and can run on any compatible operating system.

• Restorative Dentistry and Endodontics
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• v.35 no.3
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• pp.222-228
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• 2010

The purpose of this study was to compare mineral trioxide aggregate (MTA; Dentsply, Tulsa Dental, Tulsa, OK, USA), which is widely used as root-end filling material, with DiaRoot BioAggregate (DB; Innovative BioCaramix Inc, Vancouver, BC, Canada), newly developed product, by using MG63 osteoblast-like cells. MTA, DB, and Intermediate Restorative Material (IRM; Dentsply Caulk, Milford, DE, USA) were used for root-end filling material while tissue culture plastic was used for control group. Each material was mixed and, the mixtures were left to set for 24 hours. MG63 cells were seeded to each group and then they were cultured for attachment for 4 hours. Following the attachment of cells to the root-end filling material, early cellular response was observed. After another 12 hours'culture, the level of attachment between cells and material was observed and in order to identify the effect of each material to bone formation, transforming growth factor beta1 ($TGF{\beta}1$) and osteocalin (OC) were estimated by using enzyme-linked immunosorbent assay (ELISA), and the amount of alkaline phosphatase (ALP) was also measured. The data were analyzed using one-way ANOVA. As a result, only at OC and the number of cells which were attached to materials, there was no statistical difference between MTA and DB. At other items, there was statistically significant difference in all groups. Although DB has not shown exactly the same cellular response like that of MTA, the number of attached cells shows that biocompatibility of the material and OC indicates bone formation rate. Therefore, if DB is used for root end filling material, it is expected to lead to similar results to MTA.

• Journal of the Korean Society of Hazard Mitigation
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• v.10 no.5
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• pp.35-40
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• 2010

The present study proposes the strengthening method to use Conclinic Advanced FiberWrep(CAF) so as to improve Load Carrying Capacity of the RC slab bridge. In order to evaluate the strengthening performance, we strengthen 50cm per unit-width of CAF to the slab's bottom of the test bridge that designed with DB 18, then perform Static and Dynamic Field Load Test. As a result of this, 14.7% of the maximum displacement, 5.0% of the strain and 33.7% of the impact factor are reduced after strengthening. At the middle of the test spans, nominal resisting ratio is increased by 27% and Service Load Carrying Capacity is increased by 44.6%, 48.9% of each span 1 and 2. In conclusion, this study indicates that the strengthening method using CAF is very effective to improve the deteriorated RC slab bridge designed with DB 18, to the DB 24 of the first class bridge design load.