• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.7A
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• pp.746-754
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• 2007

In this paper, we propose a fast handoff algorithm for micromobility management enhancement in HMIPv6 networks, which eliminates the DAD procedure involved in the regular HMIPv6 in order to o decrease handoff latency and increase the resource utilization efficiency. In the proposed scheme, the MAP is designed to guarantee the uniqueness of MN's interface identifier within a MAP domain as long as the MN moves in a MAP domain, so that the MN configures the new address without the DAD procedure resulting in the decreased handoff latency significantly When the MN resides in a subnet, MIPv6 is used adaptively as a mobility management protocol, which is to reduce bandwidth waste from the IP packet header overhead of IP-in-IP tunneling from the regular HMIPv6. We evaluate the performance of the proposed handoff micromobility algorithm in terms of handoff delay and packet loss thru computer simulation. Thru various computer simulation results, we verified the superior performance of the proposed scheme by comparing with the results of other schemes, MIPv6 and HMIPv6.

• The Journal of Korean Medicine
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• v.25 no.3
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• pp.45-54
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• 2004

Objectives : This study was aimed to evaluate marker substances in Gami-Honghwa-Tang (KH-19) by high performance liquid chromatography-photodiode array detector (HPLC-DAD). Gami-Honghwa-Tang is composed of nine crude herbs, Rehmanniae Radix Preparata, Angelicae Gigantis Radix, Cnidii Rhizoma, Paeoniae Radix, Corni Fructus, Moutan Cortex Radicis, Lycii Fructus, Carthami Flos and Glycyrrhizae Radix. Methods : The separation was performed on an Aquasil C18 (4.6×250mm) column by gradient elution with 0.05% TFA in H2O - 0.05% TFA in acetonitrile (0 min 100:0, 20 min 90:10, 40 min 70:30, 60 min 50:50, 80 min 0:100, 90 min 100:0) as the mobile phase at a flow-rate of 1.0 ml/min with detection at 190-800nm. Also we examined the contents for bacteria, pesticide residue and harmful heavy metals. Results : HPLC-DAD was employed to determine the quantities and the qualities of several marker substances such as 5­hydroxymethyl-2-furaldehyde (5-HMF), paeonol, loganin, paeoniflorin, glycyrrhizin, and decursin in the KH-19. There were no bacterial contents, pesticide residues, or harmful heavy metals. Conclusions : We suggest these results could be a useful evidence for quality control of KH-19. This method permits fingerprints of selected individual marker substances from herbal prescriptions without derivatization, multiple purification steps, or lengthy separation times.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.139-139
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• 2016

가능최대홍수량(Probable Maximum Flood, PMF)이란 대규모 수공구조물을 설계하고자 할 때 막대한 경제적 손실 및 인명피해 등을 막기 위해 기준으로 삼는 설계홍수량이며, 통계학적으로는 약 10,000년 빈도에 해당된다. 우리나라의 호우 특성은 방위, 진행방향 및 위에 따른 해석이 매우 복잡하여 강우를 정형화하기 어렵다. Kim and Won(2004)은 이동성 호우의 경우 강우의 깊이-면적-지속기간(Rainfall Depth-Area-Duration)의 분석결과에서 상당한 오차를 야기하는 문제점을 지닌다고 주장하였다. 따라서 오차를 포함한 DAD의 산정결과는 가능최대강수량(Probable Maximum Precipitation, PMP) 및 가능최대홍수량 산정에도 영향을 미치기 때문에 정확도 높은 DAD 분석을 통한 PMF 산정이 요구된다. 본 연구에서는 유역을 선정하고 각 지점의 시계열 강우 자료를 활용하여 공간분포화한 강우자료에 격자기반의 자동 강우장 탐색기법을 이용하여 DAD 분석을 실시하였다. 기존의 PMP 산정방법에서는 한반도 전역에서 발생했던 130 mm이상의 호우사상을 선정한 후에 각 호우의 범위에 있는 우량관측소의 강우자료를 이용하여 PMP를 산정한다. 그렇기 때문에 만약 상대적으로 긴 지속기간의 경우 호우의 범위가 우리나라 전역을 포함할 가능성이 크기 때문에 PMP 산정방법은 복잡하고, 기상이변이 잦지 않는 지역에서 산정된 PMP를 이용하여 PMF를 산정할 경우, 유역의 특성을 반영하지 않았기 때문에 과대산정의 우려가 있다. 이에 따라 본 연구에서는 먼저 연구대상유역을 선정한 뒤, 유역 내에 발생했던 호우경보와 호우주의보를 기준으로 호우사상을 선정하여 DAD 분석 후 PMP를 산정하였다. 그 후, 강우-유출관계를 파악하여 PMF를 산정하였다.

• Proceedings of the Korea Information Processing Society Conference
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• 2014.11a
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• pp.1163-1166
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• 2014

태양광 시장이 증가되면서 데이터가 표준화되지 않고 다양한 태양광 인버터 등의 설비들이 설치되어 운영되고 있다. 또한 현재 인버터 제조업체가 태양광 모니터링을 주도하고 있으나 인버터 제조업체 입장에서는 돈이 되지 않는 서비스 품목으로 인식하고 있으며, 다양한 태양광 설비들의 유지보수를 위해서는 각 설비마다 태양광 발전상태 모니터링이 절실히 필요하다. 본 논문에서는 다양한 태양광 설비들을 위한 멀티프로토콜 파서를 갖는 DAD(Data Acquisition Device)설계하고자 한다.

• Analytical Science and Technology
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• v.10 no.5
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• pp.315-324
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• 1997

The retention behaviors of 16 PAHs and 4 nitro-PAHs were studied with several parameters involved numbers of carbon atoms, F factor, aqueous solubility, L/B ratio, and numbers of interfering hydrogen atom pairs on the chemical structures of PAHs by using reversed-phase liquid chromatography/diode array detection method (RPLC/DAD) and gradient elution method. It was obtain that the log k' for most of PAHs with increasing the number of carbon and the F factor in their molecules. Chromatographic retention of PAH isomers and nitro-PAHs were examined with aqueous solubility, L/B ratio and number of interfering hydrogen atom pairs. As a result of comparison with these factors and retention times, it was found that those solutes having larger aqueous solubilities and greater L/B ratios were retained longer on stationary phase. This tendency was also occured in the molecules having the more number of interfering hydrogen atom pairs. Detection limits of PAHs which were obtained with three times measurements by RPLC/DAD were in the range of 100~500ng/mL and method detection limit(MDL) for water sample were in the range of 0.1~0.5ng/mL.

• Korean Journal of Food Science and Technology
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• v.52 no.1
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• pp.26-30
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• 2020

This study was undertaken to determine the characteristics of xanthoangelol, the major chalcone constituent derived from the extracts of different parts of Lespedeza bicolor. Xanthoangelol was isolated from the root extract using column chromatography and used as a standard for quantitative analysis. The structure of the isolated compound was established based on spectroscopic evidence. The HPLC-DAD method was validated for specificity, linearity, precision, accuracy, limit of detection, and limit of quantitation. The calibration curve of xanthoangelol had significant linearity (R²>0.9999). Limit of detection and limit of quantitation 0.018 and 0.059 ㎍/mL, respectively. The relative standard deviation values of precision test, and intra- and inter-day tests were less than 0.22 and 0.40%, respectively. In the recovery test, the accuracy ranged from 98.98-102.78% with RSD values less than 0.13%. The method validation parameters indicate the applicability of the HPLC method for quality control of food or drug formulations containing L. bicolor.

• Tuberculosis and Respiratory Diseases
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• v.61 no.5
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• pp.479-483
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• 2006

Acute fibrinous and organizing pneumonia (AFOP) is a histological pattern consisting of prominent intra-alveolar fibrin and organizing pneumonia, with out hyaline membranes or prominent eosinophilia. The clinical manifestations of AFOP resemble those of acute lung injury such as acute interstitial pneumonia (AIP). However, the classic histological patterns of AFOP differ from diffuse alveolar damage (DAD), bronchiolitis obliterans with organizing pneumonia (BOOP) or acute eosinophilic pneumonia (AEP). The characteristic intra-alveolar fibrin ball and lack of classic hyaline membrane are the predominant histological features of AFOP. Although some reports suggest that its clinical course is less catastrophic than DAD, the clinical entity that distinguishes AFOP from DAD has not been established. We present a case of pathologically demonstrated AFOP in a 79-year-old man. The radiological findings of our case were similar to those of DAD, presented with diffuse bilateral lung infiltrations. However, despite the rapid development of respiratory failure, the patient had a better response and outcome to steroid therapy than what would be expected for DAD.

• Journal of Korea Water Resources Association
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• v.48 no.2
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• pp.115-126
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• 2015

In recent years, debris flow disaster has occurred in multiple locations between high and low mountainous areas simultaneously with a flooding disaster in urban areas caused by heavy and torrential rainfall due to the changing global climate and environment. As a result, these disasters frequently lead to large-scale destruction of infrastructures or individual properties and cause psychological harm or human death. In order to mitigate these disasters more effectively, it is necessary to investigate what causes the damage with an integrated model of both disasters at once. The objectives of this study are to analyze the mechanism of debris flow for real basin, to determine the PMP and run-off discharge due to the DAD analysis, and to estimate the influence range of debris flow for fan area according to the scenario. To analyse the characteristics of debris flow at the real basin, the parameters such as the deposition pattern, deposit thickness, approaching velocity, occurrence of sediment volume and travel length are estimated from DAD analysis. As a results, the peak time precipitation is estimated by 135 mm/hr as torrential rainfall and maximum total amount of rainfall is estimated by 544 mm as typhoon related rainfall.

• Journal of the Korean Society of International Agriculture
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• v.30 no.4
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• pp.339-346
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• 2018

Cyanazine is a member of the triazine family of herbicides. Cyanazine is used as a pre- and post-emergence herbicide for the control of annual grasses and broadleaf weeds. This experiment was conducted to establish a determination method for cyanazine, as domestic unregistered pesticide, residue in major agricultural commodities using HPLC-DAD/MS. Cyanazine was extracted with acetone from representative samples of five raw products which comprised apple, green pepper, Kimchi cabbage, hulled rice and soybean. The extract was diluted with saline water and partitioned to dichloromethane for remove polar extractive in the aqueous phase. For the hulled rice and soybean samples, n-hexane/acetonitrile partition was additionally employed to remove non-polar lipids. The extract was finally purified by optimized florisil column chromatography. On a $C_{18}$ column in HPLC, cyanazine was successfully separated from co-extractives of sample, and sensitively quantitated by diode array detection at 220 nm. Accuracy and precision of the proposed method was validated by the recovery experiment on every major agricultural commodity samples fortified with cyanazine at 3 concentration levels per agricultural commodity in each triplication. Mean recoveries were ranged from 83.6 to 93.3% in five major representative agricultural commodities. The coefficients of variation were all less than 10%, irrespective of sample types and fortification levels. Limit of quantitation(LOQ) of cyanazine was 0.02 mg/kg as verified by the recovery experiment. A confirmatory method using LC/MS with selected-ion monitoring(SIM) technique was also provided to clearly identify the suspected residue.

• Journal of Life Science
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• v.33 no.4
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• pp.349-356
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• 2023

Gout, a chronic inflammatory arthritic disease, is characterized by hyperuricemia. Gout can be induced by an inflammatory response to monosodium urate (MSU) crystals mediated by pro-inflammatory cytokine release following activation of the NOD-like receptor protein 3 (NLRP3) inflammasome. Many sulfur-containing phytochemical compounds in garlic (Allium sativum L.) are considered active ingredients because of their potential pharmacological benefits for various diseases, but their efficacy in NLRP3 inflammasome activation-mediated gout has not been demonstrated. In this study, we investigated whether diallyl disulfide (DADS) and diallyl trisulfide (DATS), representative garlic-derived sulfur compounds, have an inhibitory effect on MSU-induced NLRP3 inflammasome activation. Our results showed that under non-cytotoxic conditions, DADS and DATS significantly blocked nitric oxide production and interleukin (IL)-1β release in response to MSU in lipopolysaccharide (LPS)-primed RAW 264.7 macrophages. DADS and DATS also attenuated enhanced expression of NLRP3 and its adapter protein, apoptosis-associated speck-like protein, which was associated with downregulation of and caspase-1 p20 and IL-1β expression, suggesting that MSU-induced LRP3 inflammasome activation was counteracted by DADS and DATS. Furthermore, DADS and DATS blocked oxidative stress, an upstream event for NLRP3 inflammasome activation, as evidenced by the fact that they scavenged reactive oxygen species (ROS) production. Taken together, our findings demonstrate that DADS and DATS suppressed NLRP3 inflammasome activation by inhibiting the ROS/NLRP3 pathway and that they have potential as treatments for NLRP3-dependent gouty arthritis.