• Bulletin of the Korean Chemical Society
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• v.17 no.7
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• pp.599-604
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• 1996

The synthesis is reported of p-nitrophenyl glycosides of D-galactose modified at C-4 with azido- (5), amino- (6) group and fluorine (13). 4-Azido-2,3,6-tri-O-benzoyl-4-deoxy-α-D-galactopyranosyl chloride and 2,3,6-tri-O-benzoyl-4-deoxy-4-fluoro-α-D-galactopyranosyl bromide were coupled with potassium p-nitrophenoxide in the presence of 18-crown-6 giving the corresponding p-nitrophenyl 4-azido-and 4-fluoro-4-deoxy-β-D-galactopyranoside derivatives. p-Nitrophenyl 4-amino-4-deoxy-β-D-galactopyranoside (6) was obtained by selective reduction of p-nitrophenyl 4-azido-4-deoxy-β-D-galactopyranoside (5) using 1,3-propane dithioltriethylamine. These galactoside analogs were slowly hydrolyzed in the increasing rate order of 5, 6 and 13 by β-galactosidase from Escherichia coli.

• Food Science and Biotechnology
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• v.16 no.5
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• pp.807-811
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• 2007

Diabetes is marked by high glucose levels and is associated with decreased bone mass and increased fracture rates. To determine if [6]-gingerol could influence osteoblast dysfunction induced by 2-deoxy-D-ribose (dRib), osteoblastic MC3T3-E1 cells was treated with dRib and [6]-gingerol and markers of osteoblast function and oxidized protein were examined. [6]-Gingerol ($10^{-7}\;M$) significantly increased the growth of MC3T3-E1 cells in the presence of 30 mM dRib (p<0.05). [6]-Gingerol ($10^{-7}\;M$) caused a significant elevation of alkaline phosphatase (ALP) activity, collagen content, and osteocalcin secretion in the cells. We then examined the effect of [6]-gingerol on the production of osteoprotegerin and protein carbonyl in osteoblasts. Treatment with [6]-gingerol ($10^{-9}$ and $10^{-7}\;M$) increased osteoprotegerin secretion in osteoblastic cells. Moreover, [6]-gingerol ($10^{-9}$ and $10^{-7}\;M$) decreased protein carbonyl contents of osteoblastic MC3T3-E1 cells in the presence of 30 mM dRib. Taken together, these results demonstrate that [6]-gingerol inhibits dRib-induced damage and may be useful in the treatment of diabetes related bone diseases.

• Journal of the Korean Chemical Society
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• v.18 no.3
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• pp.157-170
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• 1974

The effects of ionic strength on the polynucleation reaction of tungstate ions and the protonized reaction of polytungstate ions have been investigated in the range of ionic strength from 1 M to 4 M KCl.The hexatungstate ions and the protonized forms of hexatungstate ions are formed in the tungstate solutions whose ionic strengths are 1 M to 4 M KCl. The equilibrium constants for the formation of hexatungstate ions and the protonized forms of hexatungstate ions are calculated in the range of ionic strength from 1 M to 4M KCl. The enthalpy changes for the formation of hexatungstate ions and the protonized forms of hexatungstate ions are as follows; $7H^++{6WO_4}^{2-}={HW_6O_{21}}^{5-}+3H_2O\;\;{\Delta}H^{\circ}=-62.4{\pm}0.6$$H^++{HW_6O_{21}}^{5-}={H_2W_6O_{21}}^{4-}\;\;{\Delta}H+_1^{\circ}=-4.12{\pm}0.10$$H^++{H_2W_6O_{21}}^{4-}={ H_3W_6O_{21}}^{3-}\;\;{\Delta}H_2^{\circ}=-4.36{\pm}0.30$ The free energy and entropy changes for the above reactions have been also calculated. A linear relation is formed between $log k_{6,7}$ and ionic strength, and $log k_1\;or\;log k_2\;vs{\cdot}{\mu}.$ $log k_{6,7}\;=\;D{\mu}+I,\;\;where\;D\;=\;1.66{\pm}0.02$$log k_1\;=\;D_1{\mu}+I_1,\;\;where\;D_1\;=\;-8.065{\pm}0.001$$log k_2\;=\;D_2{\mu}+I_2,\;\;where\;D_2\;=\;-0.376{\pm}0.006$

• Korean Journal of Pharmacognosy
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• v.31 no.1
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• pp.34-38
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• 2000

Three compounds were isolated from the roots of Astragalus membranaceus (Leguminosae). On the basis of spectroscopic evidences, the structures were characterized as $3-0-{\beta}-D-xylopyranosyl-(2',3'-O-diacetyl)-6-0-{\beta}-D-glucopyranosyl-3{\beta},6{\alpha},16{\beta},25-tetrahydroxy-20(R)$,24(S)-epoxy-cycloartane(Astragaloside I), $3-0-{\beta}-D-xylopyranosyl-(2'-O-acetyl)-6-0-{\beta}-D-glucopyranosyl-3{\beta},6{\alpha},16{\beta},25-tetrahydroxy-20(R)$,24(S)-epoxy-cycloartane(Astragaloside II), $3-0-{\beta}-D-xylopyranosyl-(2',4'-O-diacetyl)-6-0-{\beta}-D-glucopyranosyl-3{\beta},6{\alpha},16{\beta},25-tetrahydroxy-20(R)$,24(S)-epoxycycloartane(Isoastragaloside I). Full data of NMR including HMBC and 1D-TOCSY experiment of these compounds were reported for the first time.

• Korean Journal of Crystallography
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• v.7 no.2
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• pp.120-125
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• 1996

Single crystals of deoxy-thymidine diphosphate-D-gluxose-4,6-dehydratase(abbreviated as dTDP-D-glucose dehydratase) from Escherichia coli Strain BL21 clone which harbors the gene of dTDP-D-glucose dehydratase in Salmonella typhimurium LT2 have been grown with and whithout substrates by sitting drop vapor diffusion at room temperature. The precipitating agent was 1.6 to 2.0 M Na, K phosphate buffer(pH 8.0). The crystals diffract to at least 2.5Å and belong to the hexagonal space group P61 with cell dimensions a=b=168.54Å, c=81.08Å. The asymmetric unit contains one dimer with a crystal volume per protein mass(VM) of 2.4Å3/Da and solvent content (Vsol) of 64% by volume.

• Journal of IKEEE
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• v.3 no.1 s.4
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• pp.69-78
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• 1999

In this paper, direct conversion receiver was designed to even harmonic anti-paralled diode pair ring mixer. Using a second harmonic component of LO instead of LO signal and RF signal are mixed by SHP(Sub Harmonic Pumped) mixer with anti-parallel diode pair. Canceling the harmonics of LO signal in ring mixer, SHP mixer using anti-parallel diode pair could mostly reduce the radiation of LO signal through a input port the most, good isolation characteristic, and low spurious characteristic by LO signal was shown over broad band. The produced SHP mixer showed LO/IF, RF/IF and LO/RF isolation was 24.6dB,36.2dB and 22.5dB respectively. And conversion loss was measured 15.6dB, IF output -35.6dBm with -20dBm RF input and 5.5dBm LO signal. 1dB compression point of If signal, in respect to RF signal, was found at the 0dbm RF signal.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.11C
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• pp.963-969
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• 2008

This paper presents 6bit 100MHz Interpolation Flash Analog-to-Digital Converter, which can be applied to the Receiver of Wireless Tele-communication System. The 6bit 100MHz Flash Analog-to-Digital Converter simplifies and integrates S-R latch which multiplies as the resolution increases. Whereas the conventional NAND based S-R latch needed eight MOS transistors, this Converter was designed with only six, which makes the Dynamic Power Dissipation of the A/D Converter reduced up to 12.5%. The designed A/D Converter went through $0.18{\mu}m$ CMOS n-well 1-poly 6-metal process to be a final product, and the final product has shown 282mW of power dissipation with 1.8V of Supply Voltage, 100MHz of conversion rate. And 35.027dBc, 31.253dB SFDR and 4.8bits, 4.2bits ENOB with 12.5MHz, 50MHz of each input frequency.

• Journal of Korean Ophthalmic Optics Society
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• v.9 no.2
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• pp.431-437
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• 2004

This research reviewed the objects of 384 persons (male:86, female:298) from 6 to 50 years old visited the S. Optical shop at Mokpo over two times from Mar. 2002 to Feb. 2004. We obtained the following results by analyzing the visual acuity prescription to keeping at S. Optical shop. 1. The abnormal refraction eyes were 191 persons(49.74%) for simple myopia, 2 persons(0.52%) for myopic simple astigmatism, 180 persons(46.88%) for myopic compound astigmatism, and 1 person(0.26%) for simple hyperopia, 2 persons(0.52%) for hyperopic simple astigmatism, 8 persons(2.08%) for hyperopic compound astigmatism, respectively. 2. Classifying of correction power for 373 persons (male:84, female:289) myopia, so that showed 166 persons(male:36, female) between $$0.25D{\leq_-}2.00D$$, 194 persons(male:46, female:148) between $$2.25D{\leq_-}6.00D$$, 13 persons(male:2, female:11) for over 6.250 respectively. 3. According to the kinds of 192 persons astigmatism subjects(male:53, female:148), direct astigmatism was 145 persons(male:32, female:113), oblique astigmatism 33 persons (male:12, female:21), reverse astigmatism 14 persons(male:5, female:9). 4. The variation of spherical power for myopia showed 299 persons(male:71, female:228) between $$0.00D{\leq_-}0.50D$$, 64 persons(male:11, female:53) between $$0.51D{\leq_-}1.00D$$, 9 persons(male:2, female:7) between $$1.01D{\leq_-}1.50D$$, 1 person(male:0, female:1) between $$1.51D{\leq_-}2.00D$$ variation respectively. Hyperopia showed 8 persons(male:1, female:7) between $$0.00D{\leq_-}0.50D$$, 3 persons(male:1, female:2) between $$0.51D{\leq_-}1.00D$$ variation respectively. 5. The variation of astigmatism power showed 181 persons(male:48 female:113) between $$0.00D{\leq_-}0.25D$$, 25 persons(male:9, female:16) between $$0.26D{\leq_-}0.50D$$, 6 persons(male:0, female:6) between $$0.51D{\leq_-}0.75D$$ astigmatism variation respectively.

• The Journal of the Acoustical Society of Korea
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• v.27 no.2
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• pp.57-65
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• 2008

Setting parameters of Ultrasonic scanners influence the quality of ultrasonic images. In order to obtain optimized images sonographers need to understand the effects of the setting parameters on ultrasonic images. The present study considered typical four parameters including TGC (Time Gain Control), Gain, Frequency, DR (Dynamic Range). LCS (low contrast sensitivity) was chosen to quantitatively compare the quality of the images. In the present experiment LCS targets of a standard ultrasonic test phantom (539, ATS, USA) were imaged using a clinical ultrasonic scanner (SA-9000 PRIME, Medison, Korea). Altering the settings in the parameters of the ultrasonic scanner, 6 LCS target images (+15 dB, +6 dB, +3 dB, -3 dB, -6 dB, -15 dB) to each setting were obtained, and their LCS values were calculated. The results show that the mean pixel value (LCS) is the highest at the max setting in TGC, mid to max in gain and pen mode in frequency and 40-66 dB in DR. Among all images, the image being the highest in LCS was obtained at the setting of DR 40 dB. It is expected that the results will be of use in setting the parameters when ultrasonically examining masses often clinically found In either solid lesions (similar to +15, +6, +3 dB targets) or cystic lesions (similar to -15, -6, -3 dB targets).

• Journal of Korean Ophthalmic Optics Society
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• v.13 no.1
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• pp.101-105
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• 2008

Purpose: In this study we measured the mean value of the distance stereoacutiy for adult subjects and evaluated the variation of the distance stereoacuity according to correction of phoria using the Pola Test E-II of Carl Zeiss. Methods: We investigated the distance stereoacuity for 50 adults (male: 29, female: 21) ranging in age from 19 to 46 years using D6 Circle chart and D8 Line chart in the Pola Test E-II. Results: The mean values of the distance stereoacuity measured on the D6 Circle test and D8 Line test were 159.6 and 149.4 seconds of arc respectively. The mean variations of the distance stereoacuity according to correction of phoria in D6 Circle test were increased 43.2 seconds of arc in exophoria and 51 seconds of arc in esophoria, and those in D8 Line test were increased 42 seconds of arc in exophoria and 70.2 seconds of arc in esophoria. Conclusions: We knew from these results that the distance stereoacuity after prescription of phoria improved more esophoria than exophoria.