• Investigative Magnetic Resonance Imaging
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• 제16권1호
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• pp.25-30
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• 2012

목적: 3-T 자기공명영상장치에서 시행한 3D-FLAIR 및 3D-T1-FFE-FS영상에서의 정상안면신경의 조영증강 양상의 비교가 그 목적이다. 대상과 방법: 측두골 자기공명영상을 촬영한 환자 중 안면신경이상의 과거력이 없는 20명의 환자를 대상으로 하였다. 두 명의 영상의학전문의가 정상안면신경의 조영증강을 평가하기 위해 조영증강 전후의 3D-T1-FFE-FS영상과 3D-FLAIR영상을 2주 간격으로 독립적으로 분석하였다. 안면신경은 5개의 분절로 나누었고 조영증강의 정도는 없거나 약하게 혹은 강하게 되는 경우로 나누어 분석하였다. 결과: 3D-FLAIR영상에서 한 명의 평가자가 두 예의 안면신경 슬부에 약한 조영증강이 있다고 보았다. 3D-T1-FFE-FS영상에서는 13예의 안면신경에서 최소 한 분절 이상 조영증강이 있다고 하였고, 최소 한 명의 평가자가 안면신경의 총 100개 분절 중 17개의 분절에서 조영증강이 있다고 분석하였으며, 유양분절의 빈도가 가장 높았다. 3D-T1-FFE-FS영상에서 정상안면신경의 조영증강에 대한 평가자간의 일치도는 ${\kappa}$값 0.589로 우수하였다. 결론: 3D-T1-FFE-FS영상과 달리 3D-FLAIR영상에서 정상안면신경은 거의 조영증강되지 않는다.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2006년도 6th International Meeting on Information Display
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• pp.1311-1313
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• 2006

Stereoscopic/autostereoscopic systems have been developed in order to express true 3D images, but have never had great success in the practical use. In order to apply 3D display to promising applications such as advertisements and games, we've developed a 42" 2D/3D switchable display. It has characteristics that don't require special glasses for 3D images, use multi-view technology for improving 3D viewing characteristics, and has a 2D/3D switching function to express dynamic 3D contents as well as conventional 2D contents.

• 한국환경성돌연변이발암원학회지
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• 제24권2호
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• pp.51-66
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• 2004

Retinoids, better known as vitamin A, have been reported to inhibit the growth of several breast cancer cell lines in culture and to reduce breast tumor growth in animal models. Furthermore, retinoids can augment the action of other breast cancer cell growth inhibitors both in vitro and in vivo. Clinically, interest has increased in the potential use of retinoids for the prevention and treatment of human breast cancer. We have examine the effect of all-trans retinoic acid(tRA) and 9-cis retinoic acid(9-cis RA) on human breast cancer cell(MCF-10A, T47-D, MCF-7) proliferation using MTT assay and cell cycle analysis(FACS). Overexpression of cyclin D1 protein is observed in the majority of breast cancers, suggesting that dysregulated expression of cyclin D1 might be a critical event in breast cancer carcinogenesis. We investigated whether tRA and 9-cis RA might affect expression of cyclin D1 on human breast cancer cells(MCF-10A, T47-D, MCF-7) using RT-PCR and west-ern bolt. In MCF-10A cells, either tRA or 9-cis RA treatment did not affect the cell proliferation. In T47-D cells and MCF-7 cells, either tRA or 9-cis RA treatment showed the inhibition of the cell proliferation over control cells and also inhibit the estrogen stimulated cell proliferation when it was given together with estrogen. The effect of retinoids was dose- and time- dependent. T47-D cells treated with 1.0 $\muM$ tRA undergo G0/G1-phase arrest by Day 5. MCF-7 cells treated with 1.0 $\muM$ tRA undergo S-phase arrest by Day 5. All-trans retinoic acid(tRA) and 9-cis retinoic acid(9-cis RA) inhibited the cyelin D1 mRNA and protein expression levels of human MCF-7 and T47-D breast carcinoma cells in vitro. The data indicate that retinoids can reduce cyclin D1 expression levels in a variety of breast cell lines in vitro and result in inhibition of cell proliferation. tRA-mediated growth inhibition and cyclin D1 expression inhibition is more potent than 9-cis RA mediated that. tRA-mediated inhibition effect is more potent on T47-D cells than on MCF-7 cells. Our data suggest that retinoids activity is different according to property of cell lines. Future chemoprevention of breast cancer studies using retinoids will be necessary to determine the mechanism of the retinoids-mediated growth inhibition.

• Journal of Periodontal and Implant Science
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• 제52권4호
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• pp.282-297
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• 2022

Purpose: To explore differences in the subgingival microbiome according to the presence of periodontitis and/or type 2 diabetes mellitus (T2D), a metagenomic sequencing analysis of the subgingival microbiome was performed. Methods: Twelve participants were divided into 4 groups based on their health conditions (periodontitis, T2D, T2D complicated with periodontitis, and generally healthy). Subgingival plaque was collected for metagenomic sequencing, and gingival crevicular fluids were collected to analyze the concentrations of short-chain fatty acids. Results: The shifts in the subgingival flora from the healthy to periodontitis states were less prominent in T2D subjects than in subjects without T2D. The pentose and glucuronate interconversion, fructose and mannose metabolism, and galactose metabolism pathways were enriched in the periodontitis state, while the phosphotransferase system, lipopolysaccharide (LPS) and peptidoglycan biosynthesis, bacterial secretion system, sulfur metabolism, and glycolysis pathways were enriched in the T2D state. Multiple genes whose expression was upregulated from the red and orange complex bacterial genomes were associated with bacterial biofilm formation and pathogenicity. The concentrations of propionic acid and butyric acid were significantly higher in subjects with periodontitis, with or without T2D, than in healthy subjects. Conclusions: T2D patients are more susceptible to the presence of periodontal pathogens and have a higher risk of developing periodontitis. The pentose and glucuronate interconversion, fructose and mannose metabolism, galactose metabolism, and glycolysis pathways may represent the potential microbial functional association between periodontitis and T2D, and butyric acid may play an important role in the interaction between these 2 diseases. The enrichment of the LPS and peptidoglycan biosynthesis, bacterial secretion system, and sulfur metabolism pathways may cause T2D patients to be more susceptible to periodontitis.

• Clinical and Experimental Reproductive Medicine
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• 제50권4호
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• pp.292-298
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• 2023

Objective: Ovarian torsion is a gynecological disorder that causes ischemia-reperfusion injuries in the ovary. Our study investigated berberine's short- and long-term effects on ovarian ischemia-reperfusion injuries. Methods: This study included 28 Wistar albino female rats weighing 180 to 220 g, which were divided into four groups: sham (S), torsion/detorsion (T/D), torsion/ detorsion+single dose berberine (T/D+Bb), and torsion/detorsion+15 days berberine (T/D+15Bb). The torsion and detorsion model was applied in all non-sham groups. In the T/D+Bb group, a single dose of berberine was administered, while in the T/D+15Bb group, berberine was administered over a period of 15 days. After the rats were euthanized, their ovaries were excised. The left ovaries were used for histopathologic evaluation, which included ovarian injury scoring and follicle count, while the right ovaries were used for biochemical analyses (tissue transforming growth factor-β [TGF-β] and alpha-smooth muscle actin [α-SMA] levels). Results: The histopathologic evaluation scores for the ovaries were significantly lower in the T/D+B group (p<0.05) and the T/D+15B group (p<0.005) than in the T/D group. The follicle counts in the T/D group were lower than those in both the sham and treated groups (p<0.005). The TGF-β levels were significantly lower in the T/D+15B group (p<0.005), whereas the α-SMA levels did not show a significant difference. Conclusion: Both short- and long-term berberine use could potentially have therapeutic effects on ovarian torsion. Long-term berberine use exhibited anti-inflammatory effects by reducing TGF-β levels, thereby preventing ischemia-reperfusion injuries. Therefore, we suggest that long-term berberine use could be beneficial for ovarian torsion.

• 대한수학회지
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• 제45권4호
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• pp.903-921
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• 2008

A continuous linear operator $T\;:\;X{\rightarrow}X$ is called hypercyclic if there exists an $x\;{\in}\;X$ such that the orbit ${T^nx}_{n{\geq}0}$ is dense. We consider the problem: given an operator $T\;:\;X{\rightarrow}X$, hypercyclic or not, is the restriction $T|y$ to some closed invariant subspace $y{\subset}X$ hypercyclic? In particular, it is well-known that any non-constant partial differential operator p(D) on $H({\mathbb{C}}^d)$ (entire functions) is hypercyclic. Now, if q(D) is another such operator, p(D) maps ker q(D) invariantly (by commutativity), and we obtain a necessary and sufficient condition on p and q in order that the restriction p(D) : ker q(D) $\rightarrow$ ker q(D) is hypercyclic. We also study hypercyclicity for other types of operators on subspaces of $H({\mathbb{C}}^d)$.

• 대한수학회지
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• 제44권4호
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• pp.863-872
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• 2007

Let D be an integral domain with quotient field K, A a nonempty set of height-one maximal t-ideals of D, F$({\Lambda})={I{\subseteq}D|I$ is an ideal of D such that $I{\subseteq}P$ for all $P{\in}A}$, and $D_F({\Lambda})={x{\in}K|xA{\subseteq}D$ for some $A{\in}F({\Lambda})}$. In this paper, we prove that if each $P{\in}A$ is the radical of a finite type v-ideal (resp., a principal ideal), then $D_{F({\Lambda})}$ is a weakly Krull domain (resp., generalized weakly factorial domain) if and only if the intersection $D_{F({\Lambda})}={\cap}_{P{\in}A}D_P$ has finite character, if and only if $F({\Lambda})$ is a t-splitting set of ideals, if and only if $F({\Lambda})$ is v-finite.

• 한국전자통신학회논문지
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• 제15권4호
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• pp.759-764
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• 2020

4차 산업혁명에 맞춰 제조·생산의 패러다임 또한 변경되고 있는 상황에서 인더스트리 4.0에 대한 사회적 요구 및 방향은 이미 되돌릴 수 없으며, 그로 인하여 3D프린팅 기술의 확장성과 범용성이 주목받고 있다. 3D 프린터는 제품 개발 비용 감소를 위한 목적으로 개발된 기술로, 최근 3D 프린터 기술특허가 만료되면서 관련 기술이 공개되었고 이를 적용한 다양한 기술이 연구 개발되고 있으며 이로 인해 다양한 특이점이 발견 및 보완되고 있다. 이에 본 연구에서는 3D 프린터 사용에 있어 오프라인에서 기계를 직접 조정하고, 모델링 데이터의 직접 입력을 통해 3D프린팅 시작해야 하는 현재 출력방식에 대한 불편함을 보완하기 위해 다중 3D 프린터에 대한 실시간 온라인 출력요청 및 정상적인 출력물을 기대할 수 있는 모니터링 기능 그리고 다중 3D 프린터에 대한 온라인 실시간 원격관리 기능을 수행하기 위해 IoT 시스템에 대한 설계를 제안한다.

• 한국위성정보통신학회논문지
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• 제10권1호
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• pp.56-61
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• 2015

본 논문에서는 사물인터넷(IoT, Internet of Things) 사용자가 안드로이드 플랫폼 기반의 홈 허브가 유니티 3D 모델링으로 사물인터넷 센서의 3D 위치표출 방안이 제안되었다. 특별히, 3차원 공간에서 IoT 센서는 설치 공간별로 클러스링을 통해 IoT센서 속성과 배터리 상태를 모니터링 방식을 설계한다. 또한, 3차원 공간상에서 신규 설치한 IoT 센서가 인접 센서들의 무선신호의 비콘신호 및 도착시간 분석에 따른 센서의 위치를 추적하는 방식은 센서의 무선신호세기(RSSI, received signal strength indicator)와 방위각을 기반으로 3차원 공간상에서 수신 각도에 따른 센서의 3D 위치를 표출할 수 있다. 이때 유니티 런쳐가 탑재된 스마트 허브 플랫폼은 사물인터넷 센서의 동작상태 모니터링이 가능하며, 다양한 센서의 생애주기를 관리할 수 있도록 동영상이 3차원 텍스쳐가 동시에 연동하도록 활용할 수 있다.

• 한국환경보건학회지
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• 제35권5호
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• pp.365-375
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• 2009

Agriculture reservoirs need a systematic approach that can control water purity and water improvement. The area under study, Bunam Lake exceeds the agricultural water standard level due to contamination from the upper stream. When the Taean Enterprise City was planned, the water quality improvement plan was applied to minimize the environmental change. However, in order to continuously maintain the water quality in the Bunam Lake, it was essential to apply the Total Pollution Load Management System (TPLMs). In order to achieve the targeted water quality in the Bunam Lake, standard flow rates and targeted water quality levels were applied to obtain the loading capacity which is as follows : BOD 1,891.2 kg/d, T-N 1,945.7 kg/d, T-P 131.7 kg/d. Also, the regional development load was calculated as, BOD 1,083.6 kg/d, T-N 942.2 kg/d, T-P 61.8 kg/d, which is required to be deceased :- by BOD 378.4 kg/d, T-N 198.9 kg/d, T-P 31.6 kg/d in order to safely achieve the targeted water quality in the Bunam Lake.