• Title/Summary/Keyword: D.P.R.K

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Comparison of Nutritional Status and Inflammational Markers in DM and nonDM Hemodialysis Patients (당뇨와 비당뇨 유지 혈액투석 환자의 영양상태와 염증지표의 상관성 비교)

  • Kim, Su-An;Sohn, Cheong-Min;Chae, Dong-Wan
    • Korean Journal of Community Nutrition
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    • v.10 no.5
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    • pp.693-699
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    • 2005
  • Protein-calorie malnutrition is common in maintenance dialysis patients. Indeed, diabetic patients with chronic renal failure are considered to be at increased risk of malnutrition. The aim of this study was to compare the nutritional status and markers of inflammation of hemodialysis patients with and without type 2 diabetes. We compared nutritional parameters and C-reactive protein (CRP) as a marker of inflammation in 30 type 2 diabetic patients and age-matched 30 non-diabetic patients with hemodialysis. Serum albumin was significantly lower in patients with type 2 diabetes $(3.45\pm0.43g/dL)$ than in non-diabetic patients $(3.64\pm0.36 g/dL)$ (p<0.05). In contrast, the concentration of serum CRP was significantly higher in type 2 diabetes $(1.42\pm1.8mg/dL)$ (p<0.05). There were significant negative-relationships between serum albumin and CRP level in both diabetic (r=-0.553, p<0.01) and non-diabetic (r=-0.579, p<0.01) patients. In diabetic patients, serum albumin level was significantly correlated with hemoglobin (r = 0.488, p < 0.01) and hematocrit (r=0.386, p < 0.01). Diabetic patients as compared to non-diabetic patients showed a significant (p < 0.01) increased serum triglyceride (TG) $(153.1\pm80.1mg/dL\;vs\;101.6\pm62.4mg/dL)$ and decreased serum HDL cholesterol $(36.89\pm13.48mg/dL\;vs\;47.00\pm14.02mg/dL,\;P<0.05)$. There were significant correlations in the intake of calorie and serum albumin levels in both diabetic (r=0.438, p< 0.05) and non-diabetic (r=0.527, p<0.05) patients. Serum CRP level was negatively correlated with calorie (r= -0.468, p < 0.05), protein (r=-0.520, p < 0.01) and fat intakes (r=-0.403, p < 0.05) in diabetic patients and calorie (r=-0.534, p<0.05) and protein intakes (r=-0.559, p<0.05) in non-diabetic patients. The prevalence of protein malnutrition and the risk factors of cardiovascular disease were significantly higher in type 2 diabetic patients than in non-diabetic hemodialysis patients. Thus, we can suggest that the higher comorbidity and mortality rate in diabetic hemodialysis patients are partially explained by malnutrition and inflammation.

Expression of the EPO-like Domains of Human Thrombopoietin in Escherichia coli

  • Koh, Yeo-Wook;Koo, Tai-Young;Ju, Sang-Myoung;Kwon, Chang-Hyuk;Chung, Joo-Young;Park, Myung-Hwan;Yang, Jai-Myung;Park, Seung-Kook
    • Journal of Microbiology and Biotechnology
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    • v.8 no.6
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    • pp.553-559
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    • 1998
  • cDNA of human thrombopoietin (hTPO) amplified by polymerase chain reaction from a cDNA library of human fetal liver was cloned. EPO-like domains ($hTPO_{153} \;or\; hTPO_{l63})\; of\; hTPO(hTPO_{332}$) were expressed in Escherichin coli using several kinds of expression systems, such as ompA secretion, thioredoxin fusion, and the $P_L$ and T7 expression systems. To obtain $hTPO_{153}$ in soluble form, $hTPO_{153}$ cDNA was fused in-frame behind the gene encoding ompA signal sequence and thioredoxin protein. When fused with either of the genes, $hTPO_{153}$ was not expressed to the detectable level. However, a high level expression of the EPO-like domain of hTPO was obtained using the PL and T7 expression system. $hTPO_{153} \;or\; hTPO_{l63} cDNA were subcloned into the pLex and pET-28a(+) vectors under the control of the inducible$ P_L\;T_7$ promoter, respectively. Proteins expressed using pl.ex vector and pET-28a(+) detected in insoluble forms with an expression level of about 14% and 9% of total cellular proteins, respectively, and the level of expression was rapidly diminished in 2 h after the maximum level of expression was reached.

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Characterization of Fruitbody Morphology on Various Environmental Conditions in Pleurotus ostreatus

  • Jang, Kab-Yeul;Jhune, Chang-Sung;Park, Jeong-Sik;Cho, Soo-Muk;Weon, Hang-Yeon;Cheong, Jong-Chun;Choi, Sun-Gyu;Sung, Jae-Mo
    • Mycobiology
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    • v.31 no.3
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    • pp.145-150
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    • 2003
  • This study investigated the morphological differences of P. ostreatus grown in the artificial environmental conditions such as humidity, temperature, ventilation, and watering. Oyster mushroom, which was cultivated on artificial environmental condition, was shown to have different morphology of fruitbodies. The optimum $CO_2$ concentration for good morphology of P.ostreatus was 0.3%. But most fruitbody showed the morphologically low qualities in more than 0.5% of $CO_2$ concentration. In the humidity in excess of 80% at $13{\sim}16^{\circ}C$, the best morphology of P. ostreatus was investigated. The growth of fruitbodies of P. ostreatus in the ventilation system was good at the wind velocity ranging from $0.2{\sim}0.5$ fpms and expouring type. In other conditions, P. ostreatus generally showed the morphology closing to malformation.

In vitro Antibacterial Activities of Novel Fluoroquinolone DWP20367 (신합성 플로로퀴놀론계 항생물질인 DWP20367의 In vitro 항균효과)

  • Kim, Ji-Yeon;Choi, Moon-Jung;Han, Seung-Hee;Shim, Jeom-Soon;Jung, Yeon-Eui;Son, Ho-Jung;Lee, Jae-Wook;Yu, Young-Hyo;Park, Myung-Hwan
    • YAKHAK HOEJI
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    • v.41 no.2
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    • pp.225-232
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    • 1997
  • The in vitro antibacterial activity of DWP20367 (1-Cyclopropyl-6-fluoro-8-chloro-7-(2,7-diazabicyclo[3,3,0]oct-4-ene-7-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid), a new broad-spectrum fluoroquinolone, was compared with those of ciprofloxacin (CPFX), sparfloxacin (SPFX) and ofloxacin (OFLX). DWP20367 was showed antibacterial activity much higher than CPFX, SPFX and OFLK against gram-positive bacteria, while it was slightly more superior to quinolones against gram-negative bacteria. DWP20367 was particularly effective against MRSA, and its $MlC_{90}$ against clinical isolates of methicillin-susceptible S. aureus, low methicillin-resistant S. aureus and high methicillin-resistant S. aureus were 0.098, 0.781 and 1.563 micro g/ml, respectively. Against S. pneumoniae, MIC90 of DWP20367 was 2- to 8-fold higher than those of CPFX. With a view of MIC90, DWP20367 showed slightly more potent activity against P. aeruginosa and E. coli isolates than the control quinolones. DWP20367 activity was not affected by inoculum size and medium pH. But addition of $Mg^{2+}, \;Ca^{2+} $Mg2+, Ca2+ or horse serum (25%) decreased its antibacterial activity. DWP20367 was showed rapidly bactericidal activity within 2 to 4 h, and regrowth was not observed even after 24 h incubation at concentrations near the 4-fold of MIC.

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NOTES ON CARLESON TYPE MEASURES ON BOUNDED SYMMETRIC DOMAIN

  • Choi, Ki-Seong
    • Communications of the Korean Mathematical Society
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    • v.22 no.1
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    • pp.65-74
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    • 2007
  • Suppose that $\mu$ is a finite positive Borel measure on bounded symmetric domain $\Omega{\subset}\mathbb{C}^n\;and\;\nu$ is the Euclidean volume measure such that $\nu(\Omega)=1$. Suppose 1 < p < $\infty$ and r > 0. In this paper, we will show that the norms $sup\{\int_\Omega{\mid}k_z(w)\mid^2d\mu(w)\;:\;z\in\Omega\}$, $sup\{\int_\Omega{\mid}h(w)\mid^pd\mu(w)/\int_\Omega{\mid}h(w)^pd\nu(w)\;:\;h{\in}L_a^p(\Omega,d\nu),\;h\neq0\}$ and $$sup\{\frac{\mu(E(z,r))}{\nu(E(z,r))}\;:\;z\in\Omega\}$$ are are all equivalent. We will also show that the inclusion mapping $ip\;:\;L_a^p(\Omega,d\nu){\rightarrow}L^p(\Omega,d\mu)$ is compact if and only if lim $w\rightarrow\partial\Omega\frac{\mu(E(w,r))}{\nu(E(w,r))}=0$.

A Fundamental Approach for Developing Deformation Strength Based on Rutting Characteristics of Asphalt Concrete (소성변형과의 상관성에 근거한 아스팔트 콘크리트의 변형강도 개발을 위한 기초연구)

  • Kim, Kwang-Woo;Lee, Moon-Sup;Kim, Jun-Eun;Choi, Sun-Ju
    • International Journal of Highway Engineering
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    • v.4 no.4 s.14
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    • pp.23-39
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    • 2002
  • This study dealt with developing a new approach for finding properties which might represent rut resistance characteristics of asphalt mixture under static loading. Two aggregates, a normal asphalt (pen 60-80) and 5 polymer-modified asphalts were used in preparation of 12 dense-graded mixtures. Marshall mix design was used in determination of OAC and each mixture at the OAC was prepared for a newly-developed Kim test on Marshall specimen (S=10cm) and gyratory specimen (S=15cm), and for wheel tracking test. Kim test used Marshall loading frame and specimens were conditioned for 30min at $60^{\circ}C$ before loading through Kim tester an apparatus consisting of a loading column and a specimen and column holder Diameter (D) of column was 3cm and 4cm with each column having different radius (r) of round cut at the bottom. The static load was applied at 50mm/min in axial direction of the specimen, not in diametral direction. The maximum load ($P_{max}$) and vertical deformation (y) at $P_{max}$ point were obtained from the test. A strength value was calculated based on the $P_{max}$ r, D and y by using the equation $K_D = 4P_{max}/{\pi}(D-2(r-\sqrt{2ry-y^2}))^2$ and is defined as the deformation strength ($kgf/cm^2$). The values of $P_{max}$/y and $K_I=K_D/y$ were also calculated. In general the leading column diameter and radius of round cut were significant factors affecting $K_D$ and $P_{max}$ values while specimen diameter was not. The statistical analyses showed the $K_D$ had the best correlation with rut depth and dynamic stability. The next best correlation was found from $P_{max}$ which was followed by $P_{max}$/y and $K_I$ in order.

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SYMMETRIC BI-DERIVATIONS IN PRIME RINGS

  • Jung, Yong-Soo
    • Journal of applied mathematics & informatics
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    • v.5 no.3
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    • pp.819-826
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    • 1998
  • The purpose of this paper is to prove the following results; (1) Let R be a prime ring of char $(R)\neq 2$ and I a nonzero left ideal of R. The existence of a nonzero symmetric bi-derivation D : $R\timesR\;\longrightarrow\;$ such that d is sew-commuting on I where d is the trace of D forces R to be commutative (2) Let m and n be integers with $m\;\neq\;0.\;or\;n\neq\;0$. Let R be a noncommutative prime ring of char$ (R))\neq \; 2-1\; p_1 \;n_1$ where p is a prime number which is a divisor of m, and I a nonzero two-sided ideal of R. Let $D_1$ ; $R\;\times\;R\;\longrightarrow\;and\;$ $D_2\;:\;R\;\times\;R\;longrightarrow\;R$ be symmetric bi-derivations. Suppose further that there exists a symmetric bi-additive mapping B ; $R\;\times\;R\;\longrightarrow\;and\;$ such that $md_1(\chi)\chi + n\chi d_2(\chi)=f(\chi$) holds for all $\chi$$\in$I, where $d_1 \;and\; d_2$ are the traces of $D_1 \;and\; D_2$ respectively and f is the trace of B. Then we have $D_1=0 \;and\; D_2=0$.

Transformation of the ${\beta}-Isopropylmalate$ Dehydrogenase Gene of Flammulina velutipes into Pleurotus florida (팽나무버섯 Leu 2 gene(${\beta}-isopropylmalate$ dehydrogenase)의 사철 느타리버섯 형질전환)

  • Byun, Myung-Ok;Yoo, Young-Bok;Go, Seung-Joo;You, Chang-Hyun;Cha, Dong-Yul;Park, Yong-Hwan
    • The Korean Journal of Mycology
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    • v.17 no.1
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    • pp.27-30
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    • 1989
  • F. velutipes Leu 2 gene (${\beta}-isopropylmalate$ dehydrogenase gene) was used for transformation of P. florida leucine requiring auxotrophic mutant P101. Transformation frequency was very low but the transformed colony can grow on minimal medium very slowly. Transformation was identified by Southern hybridization and reverse transformation into E. coli using chromosome DNA isolated from transformed P. florida.

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Electra-Optic and Ionic Properties of Twisted Nematic Cells With Different Chiral Pitch

  • Kim, Sung-Woon;Park, Hee-Do;Kim, Hee-Cheol;Park, Young-Il;Suh, Dong-Hae;Lee, Won-Geon;Park, Hae-Sung
    • 한국정보디스플레이학회:학술대회논문집
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    • 2002.08a
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    • pp.504-507
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    • 2002
  • We investigated electro-optic and ionic properties of twisted nematic cells by using control of chiral pitch. These properties are observed in practical experiment and simulations. C-V and V-T curve characteristics were obtained from three types of cells with d/p. It is shown that d/p ratio of short cells exhibit faster response time improved by 20% than normal cell. Also, inter-gray response time is improved each rise time and decay time. And, the increase of saturation voltage is happened because of the small twist angel change from initial state at high voltage near 5V. To compensate for longer black level tail, gamma curve index was varied from g = 2.2 to g = 2.7 in module status. Additionally, adding chiral dopant into TN cells improved ionic characteristics such as increasing VHR, Ion density and DC Hysteresis were decreased..

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