• Title/Summary/Keyword: D-alaninepeptidase

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D-Alaninepeptidase Increases the Vulnerability of Bacterial Cells to Osmotic Stress and Antibiotics (D-Alaninepeptidase에 의한 세균의 삼투압 및 항생제에 대한 취약성 증가)

  • Song, Jin-Sue;Lee, Young-Nam
    • Korean Journal of Microbiology
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    • v.42 no.4
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    • pp.299-305
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    • 2006
  • D-Alaninepeptidase purified from Bacillus amyloliquefaciene CMB01 caused a reduction of survival of Proteus vulgaris, Klebsiella oxytoca, and Staphylococcus aureus placed under the osmotic pressure. D-Alaninepeptidase caused an increase of susceptibility of bacteria to antibiotics. An increased number of malformed cells in bacterial groups exposed to D-alaninepeptidase was observed by scanning electron microscopy. These data suggested that bacterial cells exposed to D-alaninepeptidase resulted in an increase of vulnerability of bacterial cells toward environmental stress, such as osmotic pressure and antibiotic substances.