Browse > Article

D-Alaninepeptidase Increases the Vulnerability of Bacterial Cells to Osmotic Stress and Antibiotics  

Song, Jin-Sue (Division of Life Sciences, Collegeof Natural Sciences, Chungbuk National University)
Lee, Young-Nam (Biotechnology Research Institute, Chungbuk National University)
Publication Information
Korean Journal of Microbiology / v.42, no.4, 2006 , pp. 299-305 More about this Journal
Abstract
D-Alaninepeptidase purified from Bacillus amyloliquefaciene CMB01 caused a reduction of survival of Proteus vulgaris, Klebsiella oxytoca, and Staphylococcus aureus placed under the osmotic pressure. D-Alaninepeptidase caused an increase of susceptibility of bacteria to antibiotics. An increased number of malformed cells in bacterial groups exposed to D-alaninepeptidase was observed by scanning electron microscopy. These data suggested that bacterial cells exposed to D-alaninepeptidase resulted in an increase of vulnerability of bacterial cells toward environmental stress, such as osmotic pressure and antibiotic substances.
Keywords
antibiotic susceptibility; D-alaninepeptidase; malformed cells; osmotic pressure; survival;
Citations & Related Records
Times Cited By KSCI : 8  (Citation Analysis)
연도 인용수 순위
1 윤은정, 김현지, 권애란, 최성숙, 심미자, 최응칠. 2006. 안개형 저지원을 갖는 MLS 내성 황색포도상 구균의 내성 기전. 약학회지 50, 199-203   과학기술학회마을
2 Asano, Y., A. Nakazawa, Y. Kato, and K. Kondo. 1989. Properties of a noble D-stereospecific aminopeptidase from Ochrobactrum anthropi. J. Biol. Chem. 264, 14233-14239
3 Babic, M., A.M. Hujer, and R. Bonomo. 2006. What's new in antibiotic resistance? Focus on $\beta$-lactamase. Drug resist. Updates 9, 142-156   DOI   ScienceOn
4 Baek, D.H., S.J. Kwon, J.S. Park, S.G. Lee, n. Mheen, and M.H. Sung. 1999. Discovery of D-stereospecific dipeptidase from thermophilic Bacillus sp. BCS-l and its application for synthesis of Damino acid containing peptide. J. Microbiol. Biotechnol. 9, 646-649
5 Bambeke, F., M. Chauvel, P.E. Reynolds, H.Y. Fraimow, and P. Courvalin. 1999. Vancomycin-dependent Enterococcus faecalis clinical isolates and revertant mutants. Antimicrob. Agents Chemother. 43, 41-47   DOI
6 Dmitriev, B., F. Toukach, and S. Ehlers. 2005. Towards a comprehensive view of the Bacteriol cell wall. Trends Microbiol. 13, 569-574   DOI   ScienceOn
7 El-Naggar, M.Y., S.A. El-Assar, and S.M. Abdul-Gawad. 2006. Meroparamycin production by newly isolated Streptomyces sp. strain MAR01: taxonomy, fermentation, purification and structural elucidation. J. Microbiol. 44, 432-438   과학기술학회마을
8 Fathalla, O.A., S.M. Awad, and M.S. Mohamed. 2005. Synthesis of new 2-thiouracil-5-sulphonamide derivatives with antiBacteriol and antifungal activity. Arch. Pharm. Res. 28, 1205-1212   과학기술학회마을   DOI
9 Fraise, A.P. 2006. Tiecycline: The answer to beta-lactam and fluoroquinolone resistance? J. Infec. 53, 293-300   DOI   ScienceOn
10 Gill, M.J., N.P. Brenwald, and R. Wise. 1999. Identification of an efflux pump gene, pmrA, associated with tluoroquinolone resistance in Streptococcus pnuernoniae. Antimicrob. Agents Chemother. 43, 187-189   DOI
11 Hedge, V., M. Patel, A. Horan, V. Gullo, and J. Marquez. 1992. Macrolactams: A novel class of antifungal antibiotics produced by Actinomadura spp. J. Antibiotics (Tokyo) 45, 624-632   DOI
12 Mine, T., Y. Morita, A. Kataoka, T. Mizushima, and T. Tsuchiya. 1999. Expression in Escherichia coli of a new multidrug efflux pump MexXY, from Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 43, 415-417   DOI
13 Johnson, D.M., M.G. Stilwell, T.R. Fritsche, and R.J. Jones. 2006. Emergence of multidrug-resistnat Streptococcus pneumoniae: report from the SENTRY antiMicrobiol surveillance Program(1999-2003). Diagnostic Microbiol. Infect. Dis. 56, 69-74   DOI   ScienceOn
14 Knapp, J.S., J.M. Zenilman, J.W. Biddle, G.H. Perkins, W.E. DeWitt, M.L. Thomas, S.R. Johnson, and S.A. Morse. 1987. Frequency and distribution in the United States of strains of Neisseriae gonorrhoeae with plasmid mediated, high level resistance to tetracycline. J. Infect. Dis. 155, 819-822   DOI   ScienceOn
15 Madigan, M.T., J.M. Martinko, and J. Packer. 2003. Brock's Biology of Microorganims (10th), p. 75-79, Prentice Hall, Upper Saddle River, NJ, USA
16 Selwyn, Q., T. Imai, Y. Mikaml, K. Yazawa, E.R. Dabbs, N. Morisaki, S. Iwasaki, Y. Hashimoro, and K. Furihata. 1999. ADP-ribosylation as an intermediate step in inactivation of rifampin by a Mycobacterial gene. Antimicrob. Agents Chemother. 43, 181-184
17 임상수, 김미광, 민정범, 김민정, 박순낭, 황호길, 국중기. 2006. 감염근관에서 분리 배양한 세균의 수종 항생제에 대한 감수성 조사. 미생물학회지 42, 185-194   과학기술학회마을
18 Fanuel, L., I. Thamm, V. Kostanjevecki, B. Joris, C. Goffin, J. Brannigan, J. van Beeumen, and J.M. Frere. 1999. Two new aminopeptidase from Ochrobactrum anthropi active on D-alanly-pnitroanilide. Cell Mol. Life. Sci. 55, 812-818   DOI   ScienceOn
19 Hasegawa, T., M. Kakushima, M. Hatori, S. Aburaki, S. Kakimura, T. Furumai, and T. Oki. 1993. Pradimicins T1 and T2, New antifungal antibiotics produced by an Actinomyces II. Structure and biosynthesis. J. Antibiotics (Tokyo) 46, 598-605   DOI   ScienceOn
20 윤은정, 윤종민, 최성숙, 권애란, 심미자, 최응칠. 2006. 임상분리 그람 양성 구균에 대한 MLS계 항생물질의 내성. 약학회지 50, 204-207   과학기술학회마을
21 Rao, M.B., A.M. Tanksale, M.S. Ghatge, and V.V. Deshpande. 1998. Molecular and biotechnological aspects of Microbiol protease. Microbiol. Mol. Biol. Rev. 62, 597-635
22 Ormerod, L.P., J.M. Harrison, and P.A. Wright. 1990. Drug resistance trend in Mycobacterium tuberculosis: Blackburn 1985-89. Tubercle 71, 283   DOI   ScienceOn
23 Rajasekaran, A., S. Murugesan, and K. Anandarajagopal. 2006. AntiBacteriol, antifungal and anticovulsant evaluation of novel newly synthesized 1-[2-(1H-tetrazol-5-yl)ethyl]-1H-benzo[d][1,2,3]triazoles. Arch. Pharm. Res. 29, 535-540   과학기술학회마을   DOI
24 Asano, Y., H. Ito, T. Dairi, and Y. Kato. 1996. An alkaline D-stereospecific endopeptidase with D-lactamases activity from Bacillus cereus. J. Biol. Chem. 271, 30256-30262   DOI   ScienceOn
25 Paulsen, I.T., M.H. Brown, and R.A. Skurray. 1996. Proton-dependent multidrug efflux systems. Microbiol. Rev. 60, 575-608
26 Zhao, P-J., L-M. Fan, G-H. Li, N. Zhu, and Y-M. Shen. 2005. Antibacterial and antitumor macrolides from Streptomyces sp. Is9131. Arch. Pharm. Res. 28, 1228-1232   과학기술학회마을   DOI
27 Sieradzki, K. and A. Tomasz. 2003. Alterations of cell wall structure and metabolism accompany reduced susceptibility to vancomycin in an isogenic series of clinical isolates of Staphylococcus aureus. J. Bacteriol. 185, 103-7110
28 Amsterdam, D. 1992. Susceptibility. p. 161-163. In J. Lederberg(ed.), Encyclopedia of Microbiology. Vol. 4. Academic Press, Tokyo, Japan
29 Baron, E.J., R.S. Chang, D.H. Howard, J.N. Miller, and J.A. Turner. 1993. Medical Microbiology. A short course, p. 397-399, Wiley-Liss. New York, USA
30 이동석. 2005. 필수임상미생물학, p. 32-35, 라이프사이언스, 서울
31 Sin, E., H.-G. Hong, Y. Ike, K. Lee, Y.H. Park, D.T. Lee, and Y. Lee. 2006. VanB-VanA incongruent VRE isolated from animals and humans in 1999. J. Microbiol. 44, 453-456   과학기술학회마을
32 Asano, Y., Y. Kato, A. Yamada, and K. Kondo. 1992. Structural similarity of D-aminopeptidase to carboxypeptidase DD and $\beta$-lactamases. Biochemistry 31, 2316-2328   DOI   ScienceOn
33 Kim, B.S. and B.K. Hwang. 1993. Production, purification and antifungal activity of antibiotic substances produced by Pseudomonas aeruginosa strain B5. Kor. J. Appl. Microbiol. Biotechnol. 3, 12-18
34 Song, J.S. 2002. Master's Thesis. Chungbuk National University, Cheongju
35 Omura, S. 1992. The Search for bioactive compounds from microorganisms. Springer-Verlag, Tokyo, Japan
36 Hoban, D.J., S.K. Bouchillon, J.L. Johnson, G.G. Zhanel, D.L. Bulter, K.A. Saunders, L.A. Miller, J.A. Poupard, and the Surveillance Study Research Group. 2003. Comparative in vitro potency of amoxycillin-clavulanic acid and four oral agents against North American clinical isolates from a global surveillance study. Int. J. Antimicrob. Agents 21, 425-433   DOI   ScienceOn
37 Walsh, C. 2003. Natural and producer immunity versus acquired resistance, pp. 91-106. In Antibiotics, actions, origins, resistance. ASM Press, Washington DC, USA
38 Dmitriev, B., E.V. Toukach, O. Holst, E.T. Rietchel, and S. Ehlers. 2004. Tertiary structure of Staphylococcus aureus cell wall murein. J. Bacteriol. 186, 7141-7148   DOI   ScienceOn
39 Silver, L.L. and K.A. Bostian. 1993. Discovery and development of new antibiotics: the problem of antibiotic resistance. Antimicrob. Agents Chemother. 37, 377-383   DOI   ScienceOn
40 Baglan, P., H.G. Bozdayi, M. Ozkan, K. Ahmed, A.M. Bozdayi, and A. Ozden. 2006. Clarithromycin resistance prevalence and Icea Gene status in Helicobacter pyroli clinical isolates in Turkish patients with duodenal ulcer and functional dyspepsia. J. Microbiol. 44, 409-416   과학기술학회마을
41 Ban. O.-H., S.-S. Han, and Y.N. Lee. 2003. Identification of a potent protease producing bacterial isolate, Bacillus amyloliquefaciens CMB01. Ann. Microbiol. 53, 95-103
42 Song, J.S. and Y.N. Lee. 2002. Purification and characterization of D-alaninepepdidase from Bacillus amyloliquefaciens CMB01. p.248, Abstr. 9th Int. Sym. Gen. Ind. Microorg. Gyeongju, 2002
43 Holtje, J.-V. 1998. Growth of the stress bearing and shape maintaining murein sacchulus of Escherichia coli. Microbiol. Mol. Biol. Rev. 62, 181-203
44 Harold, J.B. 1985. AntiMicrobiol sensitivity testing, p. 138-144. In Microbiological Applications. Wm. C. Brown Publishers, New York, USA