• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.5
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• pp.1426-1436
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• 2004

There have been several reports on the relationship between G protein β3 subunit gene (GNB3), angiotensin converting enzyme gene (ACE), β3-adrenergic receptor gene (ADRB3), and β2-adrenergic receptor gene (ADRB2) genotype and obesity or obesity related disease. The objective of this study was to examine the relationship between the combinations of these four genes' polymorphism and probability of obesity related disease in Korean female subjects. The experimental group was consisted of 85 obese Korean female subjects (body mass index, BMI≥27㎏/㎡). To determine the polymorphism, genomic DNA was isolated, and PCR was performed. Serological examinations (fasting plasma glucose, FPG; aspartate aminotranferase, AST; alanine aminotransferase, ALT; total cholesterol, TC; triglyceride, TG; high density lipoprotein-cholesterol, HDL; low density lipoprotein-choles terol, LDL) were carried by an autoanalyzer and serological methods. BMI, waist circumference (WC), hip circumference and waist hip ratio (WHR) were measured. Consequencely in the analysis with grouping of general genotyping and variant allele carrier/non-carrier, the result was not significantly different within all gene combinations and polymorphic pairings except higher waist circumference in Arg16Arg group of ADRB2 codon16 (P=0.024). And there was no significantly contrast result about age, height, weight, AST and ALT that are index feature of liver and gall bladder disease in polymorphic pairings of gene combinations. However, the statistical analysis of waist-hip ratio and waist circumference that could be recognized as the physical type of obesity showed T-Arg16 pairing carrier in GNB3-ADRB2 codon16 combination had increased WHR and WC significantly (P=0.046 and P=0.015 respectively). Futhermore, the levels of total cholesterol (TC) and low density lipoprotein choresteral (LDL) were significantly lower in C-I pairing of GNB3-ACE combination (P=0.032 and P=0.005). These results suggest that the T-Arg16 pairing carrier in GNB3-ADRB2 codon16 gene might have increased waist circumference and C-I pairing carrier in GNB3-ACE combination have lower possibility of contraction of cardiovascular disease related cholesterol and LDL despite of obese state.

• Journal of Technology Innovation
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• v.26 no.3
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• pp.69-97
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• 2018

This study explored the influence of failure experience of Korean pharmaceutical industries on the innovative activities of corporations from the perspectives of R&D and knowledge search. Previous studies have defined the cause of the failure or studied the reasons for the decline. However, studies analyzing the influence of failure on the innovative activities of corporations are rare. This study set a research period of 10 years for the Korean pharmaceutical industry to conduct a longitudinal analysis of the influence of the influence of failure on innovation activities and the influence of innovation activities on radical innovation. A summary of the research results is as follows. Firstly, failure of corporations induce exploratory innovation activities, and the extent differs greatly from the size of financial slack resource. Secondly, experiences of corporations' failure were not significant from the perspective of knowledge search. Thirdly, the interaction between the corporation's exploratory innovation activities and knowledge search had a positive (+) relationship with radical innovation performance. This study is significant in that it suggested empirical evidence by verifying the positive influence of failure to learning and innovation unlike previous researches viewing failure negatively, and suggested the direction of future studies based on these research results.

• Proceedings of the Korea Water Resources Association Conference
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• 2006.05a
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• pp.291-295
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• 2006

비상대처계획(EAP, Emergency Action Plan) 수립 및 홍수위험지도 작성의 목적은 댐.제방 붕괴 등 비상상황이 발생하였을 때 하류부의 생명과 재산 손실을 최소화하기 위한 것으로서 댐 운영 및 관리책임자가 극한홍수 및 지진발생 조건하에서 댐의 물리적, 지형적, 구조적 특성에 따른 발생 가능한 비상상황을 예상하고 이에 효율적으로 대처하기 위한 가능한 최선의 사전계획을 수립하는 것이다. 또한, 댐의 비상상황에 대처하기 위한 비상대처계획 수립 의무화 및 이에 대한 실제적인 모의훈련 등에 필요한 기초자료를 체계적으로 제공하고자 함에 있다. 국내에서 EAP를 수립하여야 할 대상 댐 저수지는 한국수자원공사에서 관리하는 다목적댐, 생공용수댐과 한국농촌공사에서 관리하는 농업용저수지, 한국수력원자력주식회사에서 관리하는 수력발전댐 및 지방자치단체에서 관리하는 댐 등이 해당된다. 제방의 경우 인구가 밀집되어 있는 전 지역이 그 대상이 될 수 있다. EAP의 주요 내용에는 만약에 발생할 수 있는 붕괴 사고시 인명의 손실이나 재산상의 피해를 발생시킬 수 있는 댐 저수지들에 대해서는 EAP를 수립하거나 갱신하기 위한 지침들이 포함되어 있어야 한다. 댐으로부터의 하류 연안지역의 개발이나 소유권은 다양하며, 이로 인해 댐의 운영이나 붕괴로 인한 잠재적 인명손실 또한 다양할 수 있다. 따라서 모든 EAP는 댐, 저수지 하류부 현장 조건에 맞도록 구성되어야 한다. EAP 수립의 주체는 댐 및 저수지 관리자이며 EAP에는 비상상황 확인, 평가, 등급분류, 비상연락체계 및 경보전달체계 수립, 비상시 응급행동요령, 홍수범람예측지도 작성, 비상주민대피계획 및 훈련방안, 부록, 주기적 또는 필요시마다 보완 계획 등이 포함되어야 하며, EAP의 주요 구성요소인 홍수위험지도에는 홍수위험정보 및 대피정보를 제시함으로써 실제 주민 대피계획시 실제적이고 효율적인 대피계획 수립에 활용될 수 있다. 있는 기술가치평가 모형의 구축이 요구된다. 이에 본 연구에서는 효율적인 R&D 투자 정책 수립과 정부정책수립에 기여하고자 AHP(Analytic Hierarchy Process, 계층 분석 과정)기법을 이용, 수자원의 지속적 확보기술의 특성에 따른 4개의 평가기준과 26개의 평가속성으로 이루어진 2단계 기술가치평가 모형을 구축하였으며 2개의 개별기술에 대한 시범적용을 실행하였다.하는 것으로 추정되었다.면으로의 월류량을 산정하고 유입된 지표유량에 대해서 배수시스템에서의 흐름해석을 수행하였다. 그리고, 침수해석을 위해서는 2차원 침수해석을 위한 DEM기반 침수해석모형을 개발하였고, 건물의 영향을 고려할 수 있도록 구성하였다. 본 연구결과 지표류 유출 해석의 물리적 특성을 잘 반영하며, 도시지역의 복잡한 배수시스템 해석모형과 지표범람 모형을 통합한 모형 개발로 인해 더욱 정교한 도시지역에서의 홍수 범람 해석을 실시할 수 있을 것으로 판단된다. 본 모형의 개발로 침수상황의 시간별 진행과정을 분석함으로써 도시홍수에 대한 침수위험 지점 파악 및 주민대피지도 구축 등에 활용될 수 있을 것으로 판단된다. 있을 것으로 판단되었다.4일간의 기상변화가 자발성 기흉 발생에 영향을 미친다고 추론할 수 있었다. 향후 본 연구에서 추론된 기상변화와 기흉 발생과의 인과관계를 확인하고 좀 더 구체화하기 위한 연구가 필요할 것이다.게 이루어질 수 있을 것으로 기대된다.는 초과수익률이 상승하지만, 이후로는 감소하므로, 반전거래전략을 활용하는 경우 주식투자기간은 24개월이하의 중단기가 적합함을 발견하였다. 이상의 행태적 측면과 투자성과측면의 실증결과를 통하여 한국주식시장에 있어서 시장수익률을 평균적으로 초과할 수 있는 거래전략은 존재하므로 이러한 전략을 개발 및 활용할 수 있으며, 특히, 한국주식시장에 적합한 거래전략은 반전거래전략이고, 이 전략의 유용성은 투자자가 설정한 투자기간보다 더욱 긴 분석기간의 주

• Geophysics and Geophysical Exploration
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• v.13 no.3
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• pp.249-255
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• 2010

Since the 1990's, a number of ULF geomagnetic disturbance associated with earthquake occurrences have actively been reported, and polarization analysis of geomagnetic fields becomes one of potential candidates to be capable of predicting short-term earthquake. This study develops the modified polarization analysis method based on the previous studies, and analyzes three-component geomagnetic fields obtained at Cheongyang geomagnetic observatory using the developed method. A daily polarization value (the ratio of spectral power of horizontal and vertical geomagnetic field) is calculated with a focus on the 0.01 Hz band, which is known to be the most sensitive to seismogenic ULF radiation. We analyze a total of 10 months of geomagnetic data obtained at Cheongyang observatory, and compare the polarization values with the Kp index and the earthquake occurred in the analysis period. The results show that there is little correlation between the temporal variations of polarization values and Kp index, but remarkable increases in polarization values are identified which are associated with two earthquakes. Comparison the polarization values obtained at Cheongyang and Kanoya observatory indicates that the increases of polarization values at Cheongyang might be due to not global geomagnetic induction but the locally occurred earthquakes. Furthermore, these features are clearly shown in normalized polarization values, which take account in the statistical characteristics of each geomagnetic field. On the basis of these results, polarization analysis can be used as promising tool for monitoring the earthquake-precursory phenomenon.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.7 no.1
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• pp.1-6
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• 1974

Meretrix lusoria is one of the most favorite edible bivalves inhabiting wide inter-tidal flats along the western coast of Korea. Over the period of July to September 1973, some specimens from a tidal flat near AnMyun Island were submerged in sea water with various concentrations of ammo-mum hydroxide added and careful observations were made on their fertilization, early development, and metamorphosis of the larvae. The highest rate of fertilization was demonstrated by individuals treated with 1/1000 normal solution of ammonium hydroxide, and their fertilized eggs followed normal development, i. e., two cell stage in 1.2 hours after fertilization, gastrula stage after 4.7 hours, and trochophore stage after 5.6 hours. Within 24 hours after fertilization M. lusoria larvae have acquired the form of early straight-hinge veliger with the mean prodissoconch I length of $112\mu$. It takes seven days to get the umbo stage with the mean shell length of $172\mu$ and twenty days to get the metamorphosing stage with the mean shell length of $232\mu$. The larvae were cultured to the metamorphosing stage with the shell length of $272\mu$ in the laboratory condition. The relationship between the shell length (L) and the shell height (H) in veliger stage is shown as H=1.02325L-24.46425 with a significant difference.

• Journal of the Korea Concrete Institute
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• v.19 no.5
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• pp.529-537
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• 2007

The purpose of this study is to discuss how strength and ductility of each system in low-rise reinforced concrete buildings composed of extremely brittle, shear and flexural failure lateral-load resisting systems have influence on seismic capacities of the overall system, which is based on nonlinear seismic response analyses of single-degree-of-freedom structural systems. In order to simulate the triple lateral-load resisting system, structures are idealized as a parallel combination of two modified origin-oriented hysteretic models and a degrading trilinear hysteretic model that fail primarily in extremely brittle, shear and flexure, respectively. Stiffness properties of three models are varied in terms of story shear coefficients, and structures are subjected to various ground motion components. By analyzing these systems, interaction curves of demand strengths of the triple system for various levels of ductility factors are finally derived for practical purposes. The result indicates that demand strength levels derived can be used as a basic information for seismic evaluation and design criteria of low-rise reinforced concrete buildings having the triple lateral-load resisting system.

• Tunnel and Underground Space
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• v.13 no.4
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• pp.270-278
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• 2003

Transparency on the Total System Performance Assessment (TSPA) is the key issue to enhance the public acceptance for a permanent high level radioactive repository. Traditionally, the study on features, events and processes (FEPs) and associated scenarios has been regarded as the starting point to open the communicative discussion on TSPA such as what to evaluate, how to evaluate and how to translate outcomes into more friendly language that many stakeholders can easily understand and react with. However, in most cases, it has been limited to one way communication, because it is difficult for stakeholders outside the performance assessment field to assess the details on the story of the safety assessment, scenario and technical background of it. Fortunately, the advent of the internet era opens up the possibility of two way communication from the beginning of the performance assessment so that every stakeholder can exchange their keen opinions on the safety issues. To achieve it, KAERI develops the systematic approach from the FEPs to Assessment methods flow chart. All information is integrated into the web based program named FEAS (FEp to Assessment through Scenario development) under development in KAERI. In parallel, two independent systems are also under development the web based QA(Quality Assurance) system and the PA(Performance Assessment) input database. It is ideal to integrate the input data base with the QA system so that every data in the system can checked whenever necessary. Throughout the next phase R&D starting from the year 2003, these three systems will be consolidated into one unified system.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.10
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• pp.89-100
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• 2018

The precedent study stage of defense programs is a project stage that is conducted to support the determination of an efficient acquisition method of the weapon system determined by the requirement. In this study, the FTA/FMEA technique was used in the safety analysis process to identify elements to be conducted in the precedent study stage and a methodology for deriving the key review elements through conceptualization and tailoring was suggested. To supplement the key elements derived from the existing research, it is necessary to analyze various events that may arise from key elements. To accomplish this, the HAZOP technique for safety analysis in other industrial fields was used to supplement the results of kdy element derivation. We analyzed and modeled the execution procedure by establishing input/output information and association with the key elements of the precedent study stage derived by linking HAZOP/FTA/FMEA techniques. In addition, performance maturity was evaluated for performance of precedent study, and a risk-based response manual was generated based on inter-working information with key elements with low maturity. Based on the results of this study, it is possible to meet the performance, cost, and schedule of the project implementation through application of the key elements and procedures and the risk management response manual in the precedent study stage of the defense program.

• Applied Biological Chemistry
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• v.39 no.1
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• pp.1-8
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• 1996

A one-stage, continuous-flow bioreactor with both immobilized and suspended cells was used to investigate the roles of lipid supplements in ethanol production by Saccharomyces cerevisiae. The reactor performance and the level of alcohol dehydrogenase(ADH) activities of the suspended cells, grown under various conditions, were measured. When ergosterol and/or oleic acid were added with surfactants to the yeast culture grown under non-aerated conditions, remarkable increases in ethanol production and cell growth was achieved, but specific ADH activities were not affected. Especially, no difference of specific ADH activities of the suspended cells grown under aerated and non-aerated condition was observed. The addition of the surfactant as a supplement also resulted in significant increases in ethanol production, cell growth, and specific ADH activity. When ergosterol and oleic acid were added to the yeast culture exposed to higher ethanol concentration($>40\;g/{\ell}$) level, ethanol production, cell growth, and specific ADH activity were increased, but the addition of surfactant was as effective as at lower ethanol concentration level. The results indicated that lipid supplements were more effective at higher ethanol concentration level than at lower ethanol concentration level during ethanol production. ADH isozyme patterns of the yeast cultures grown under various conditions on starch gel electrophoresis showed only one major band, probably ADH I. The migrating distance of the major isozyme, however, varied slightly according to the culture conditions of the cells. No apparent correlation was found between specific ADH activity and amount of ethanol produced. Cell mass was more important factor for ethanol production than specific ADH activity of the cells.

• Journal of the Korean Society for information Management
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• v.23 no.2
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• pp.265-285
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• 2006

In text categorization a certain level of correctness of labels assigned to training documents is assumed without solid knowledge on that of real-world collections. Our research attempts to explore the quality of pre-assigned subject categories in a real-world collection, and to identify the relationship between the quality of category assignment in training set and text categorization performance. Particularly, we are interested in to what extent the performance can be improved by enhancing the quality (i.e., correctness) of category assignment in training documents. A collection of 1,150 abstracts in computer science is re-classified by an expert group, and divided into 907 training documents and 227 test documents (15 duplicates are removed). The performances of before and after re-classification groups, called Initial set and Recat-1/Recat-2 sets respectively, are compared using a kNN classifier. The average correctness of subject categories in the Initial set is 16%, and the categorization performance with the Initial set shows 17% in $F_1$ value. On the other hand, the Recat-1 set scores $F_1$ value of 61%, which is 3.6 times higher than that of the Initial set.