Browse > Article

Study of Gene-gene Interaction within GNB3, ACE, ADRB3, ADRB2 among Korean Female Subject  

Choi Hyun (Department of Physiology, College of Oriental Medicine, KyungHee University)
Bae Hyun su (Department of Physiology, College of Oriental Medicine, KyungHee University, Purimed R&D Institute)
Hong Moo chang (Department of Physiology, College of Oriental Medicine, KyungHee University)
Shin Hyun Dae (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, KyungHee University)
Shin Min Kyu (Department of Physiology, College of Oriental Medicine, KyungHee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.5, 2004 , pp. 1426-1436 More about this Journal
Abstract
There have been several reports on the relationship between G protein β3 subunit gene (GNB3), angiotensin converting enzyme gene (ACE), β3-adrenergic receptor gene (ADRB3), and β2-adrenergic receptor gene (ADRB2) genotype and obesity or obesity related disease. The objective of this study was to examine the relationship between the combinations of these four genes' polymorphism and probability of obesity related disease in Korean female subjects. The experimental group was consisted of 85 obese Korean female subjects (body mass index, BMI≥27㎏/㎡). To determine the polymorphism, genomic DNA was isolated, and PCR was performed. Serological examinations (fasting plasma glucose, FPG; aspartate aminotranferase, AST; alanine aminotransferase, ALT; total cholesterol, TC; triglyceride, TG; high density lipoprotein-cholesterol, HDL; low density lipoprotein-choles terol, LDL) were carried by an autoanalyzer and serological methods. BMI, waist circumference (WC), hip circumference and waist hip ratio (WHR) were measured. Consequencely in the analysis with grouping of general genotyping and variant allele carrier/non-carrier, the result was not significantly different within all gene combinations and polymorphic pairings except higher waist circumference in Arg16Arg group of ADRB2 codon16 (P=0.024). And there was no significantly contrast result about age, height, weight, AST and ALT that are index feature of liver and gall bladder disease in polymorphic pairings of gene combinations. However, the statistical analysis of waist-hip ratio and waist circumference that could be recognized as the physical type of obesity showed T-Arg16 pairing carrier in GNB3-ADRB2 codon16 combination had increased WHR and WC significantly (P=0.046 and P=0.015 respectively). Futhermore, the levels of total cholesterol (TC) and low density lipoprotein choresteral (LDL) were significantly lower in C-I pairing of GNB3-ACE combination (P=0.032 and P=0.005). These results suggest that the T-Arg16 pairing carrier in GNB3-ADRB2 codon16 gene might have increased waist circumference and C-I pairing carrier in GNB3-ACE combination have lower possibility of contraction of cardiovascular disease related cholesterol and LDL despite of obese state.
Keywords
$\beta$2-adrenergic receptor gene; $\beta$3-adrenergic receptor gene; angiotensin converting enzyme gene; G protein $\beta$3 gene; gene-gene interaction; obesity; cardiovascular disease;
Citations & Related Records
연도 인용수 순위
  • Reference
1 The search for human obesity genes /
[ Comuzzie AG;Allison DB. ] / Science
2 비만의 유형과 심혈관계질환 위험인자와의 관련성 /
[ 홍명호;이영미;최윤선;김순덕 ] / 대한가정의학회지
3 Genes and obesity: Is there reason to change our behaviors? /
[ Weinsier RL. ] / Ann. Intern. Med.
4 Gene-diet interactions in obesity /
[ Perusse L;Bouchard C. ] / Am. J. Clin. Nutr.
5 Genetic and environmental factors in relative body weight and human adiposity /
[ Maes HH;Neale MC;Eaves LJ. ] / Behav. Genet.
6 The genetics of obesity: What have genetic studies told us about the environment /
[ Hewitt JK. ] / Behav. Genet.
7 Genetic analysis of the thermolabile variant of 5, 10-methylenetetra- hydrofolate reductase as a risk factor for ischemic stroke /
[ Harmon DL;Doyle RM;Meleady R;Doyle M;Shields DC;Barry R;Coakley D;Graham IM;Whitehead AS. ] / Arterioscler. Thromb. Vasc. Biol.
8 Genes and obesity /
[ Andersson LB. ] / Ann.Med.
9 The body-mass index of twins who have been reared apart /
[ Stunkard AJ;Harris JR;Pedersen NL;McClearn GE. ] / N. Engl. J. Med.
10 Evaluation of genetic risk factors for silent brain infarction /
[ Notsu Y;Nabika T;Park HY;Masuda J;Kobayashi S. ] / Stroke   ScienceOn
11 Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample /
[ Oizumi T;Daimon M;Saitoh T;Kameda W;Yamaguchi H;Ohnuma H;Igarashi M;Eguchi H;Manaka H;Tominaga M;Kato T. ] / Diabetes Care
12 Angiotensin converting enzyme and endothelial nitric oxide synthase DNA polymorphisms and late onset Alzheimer's disease /
[ Alvarez R;Alvarez V;Lahoz CH;Martinez C;Pena J;Sanchez JM;Guisasola LM;Salas-Puig J;Moris G;Vidal JA;Ribacoba R;Menes BB;Uria D;Coto E. ] / J. Neurol. Neurosurg. Psychiatry
13 G protein beta 3 subunit 825T allele, hypertension, obesity, and diabetic nephropathy /
[ Siffert W. ] / Nephrol. Dial. Transplant.
14 Association of polymorphisms in the beta2- adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitus /
[ Ishiyama-Shigemoto S;Yamada K;Yuan X;Ichikawa F;Nonaka K. ] / Diabetologia
15 The association between Trp64Arg polymorphism of the beta3-adrenergic receptor and autonomic nervous system activity /
[ Shihara N;Yasuda K;Moritani T;Ue H;Adachi T;Tanaka H;Tsuda K;Seino Y. ] / J. Clin. Endocrinol. Metab.
16 Association of beta3-adrenergic receptor gene polymorphism with insulin resistance in Japanese-American men /
[ Kawamura T;Egusa G;Okubo M;Imazu M;Yamakido M. ] / Metabolism
17 Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals /
[ Siffert W;Forster P;Jockel KH;Mvere DA;Brinkmann B;Naber C;Crookes R;Du P Heyns A;Epplen JT;Fridey J;Freedman BI;Muller N;Stolke D;Sharma AM;Al Moutaery K;Grosse-Wilde H;Buerbaum B;Ehrlich T;Ahmad HR;Horsthemke B;Du Toit ED;Tiilikainen A;Ge J;Wang Y;Rosskopf D(et al.) ] / J. Am. Soc. Nephrol.
18 ACE gene polymorphism as a prognostic indicator in patients with type 2 diabetes and established renal disease /
[ Fava S;Azzopardi J;Ellard S;Hattersley AT. ] / Diabetes Care
19 한국인 비만자에서 PPAR<TEX>${\gamma}$</TEX>2 유전자 Pro12Ala 다형성과 체지방분포 /
[ 서영성;김대현;김승기;이인규;김흥식 ] / 대한비만학회지
20 A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies /
[ Lahiri DK;Nurnberger JI Jr. ] / Nucleic Acids Res.
21 Polymorphism of the tumor necrosis factor-alpha receptor 2 gene is associated with obesity, leptin levels, and insulin resistance in young subjects and diet-treated type 2 diabetic patients /
[ Fernandez-Real JM;Vendrell J;Ricart W;Broch M;Gutierrez C;Casamitjana R;Oriola J;Richart C. ] / Diabetes Care
22 Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA with obesity or type 2 diabetes mellitus in Pima Indians /
[ Jenkinson CP;Hanson R;Cray K;Wiedrich C;Knowler WC;Bogardus C;Baier L. ] / Int. J. Obes. Relat. Metab. Disord.
23 Modulation of blood pressure and obesity with the dopamine D2 receptor gene TaqI polymorphism /
[ Thomas GN;Tomlinson B;Critchley JA. ] / Hypertension
24 Linkages and associations between the leptin receptor (LEPR) gene and human body composition in the Quebec Family Study /
[ Chagnon YC;Chung WK;Perusse L;Chagnon M;Leibel RL;Bouchard C. ] / Int. J. Obes. Relat. Metab. Disord.
25 A Novel homozygous missense mutation of melanocortin-4 receptor (MC4R) in a Japanese woman with severe obesity /
[ Kobayashi H;Ogawa Y;Shintani M;Ebihara K;Shimodahira M;Iwakura T;Hino M;Ishihara T;Ikekubo K;Kurahachi H;Nakao K ] / Diabetes
26 Management of obesity as a chronic disease: nonpharmacologic, pharma cologic, and surgical options /
[ Fujioka K. ] / Obes. Res.
27 Interaction of the ACE D allele and the GNB3 825T allele in myocardial infarction /
[ Naber CK;Husing J;Wolfhard U;Erbel R;Siffert W. ] / Hypertension
28 Obesity and disease management: effects of weight loss on comorbid conditions /
[ Anderson JW;Konz EC. ] / Obes. Res.
29 Treating obesity: a new target for prevention of coronary heart disease /
[ Aronne LJ. ] / Prog. Cardiovasc. Nurs.
30 Calorie restriction in obesity: prevention of kidney disease in rodents /
[ Stern JS;Gades MD;Wheeldon CM;Borchers AT. ] / J. Nutr.
31 Significance of beta2-adrenergic receptor gene polymorphism in obesity and type 2 diabetes mellitus in Korean subjects /
[ Kim SH;Kim DJ;Seo IA;Min YK;Lee MS;Kim KW;Lee MK. ] / Metabolism
32 Excess energy intake and low energy expenditure as predictors of obesity /
[ Roberts SB;Leibel RL. ] / Int. J. Obes. Relat. Metab. Disord.
33 한국인 비만증에서 β3 아드레날린 수용체 유전자 다형성의 의의 /
[ 김병준;김성훈;김동준;함종렬;김진석;안규정;정재훈;민용기;이명식;이문규;김광원 ] / 당뇨병
34 한국인에서 렙틴수용체 유전자 다형성과 체지방분포 /
[ 서영성;김대현;이인규 ] / 대한비만학회지
35 Overweight, obesity, and health risk. National Task Force on the Prevention and Treatment of Obesity /
[ National Institute of Diabetes and Digestive and Kidney Diseases in U.S.A. ] / Arch. Intern. Med.
36 The disease burden associated with overweight and obesity /
[ Must A;Spadano J;Coakley EH;Field AE;Colditz G;Dietz WH. ] / JAMA.
37 Is obesity a disease? /
[ Heshka S;Allison DB. ] / Int. J. Obes. Relat. Metab. Disord.
38 A twin study of human obesity /
[ Stunkard AJ;Foch TT;Hrubec Z. ] / JAMA.
39 Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function /
[ Large V;Hellstrom L;Reynisdottir S;Lonnqvist F;Eriksson P;Lannfelt L;Arner P. ] / J. Clin. Invest.
40 Adoption study of environmental modifications of the genetic influences on obesity /
[ Sorensen TI;Holst C;Stunkard AJ. ] / Int. J. Obes. Relat. Metab. Disord.
41 Leptin and the regulation of body weight in mammals /
[ Friedman JM;Halaas JL. ] / Nature
42 The role of beta(2)-adrenergic receptor variation in human hypertension /
[ Bray MS;Boerwinkle E. ] / Curr. Hypertens. Rep.
43 Beta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes /
[ Bengtsson K;Orho-Melander M;Melander O;Lindblad U;Ranstam J;Rastam L; Groop L. ] / Hypertension
44 G-protein beta(3) subunit gene (GNB3) 825T allele is associated with enhanced renal perfusion in early hypertension /
[ Zeltner R;Delles C;Schneider M;Siffert W;Schmieder RE. ] / Hypertension
45 Beta 3-adrenoceptor: an update /
[ Giacobino JP. ] / Eur. J. Endocrinol.
46 Analysis of 825C/T polymorphism of G protein beta3 subunit in obese/diabetic Japanese /
[ Ohshiro Y;Ueda K;Wakasaki H;Takasu N;Nanjo K. ] / Biochem. Biophys. Res. Commun.
47 Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction /
[ Cambien F;Poirier O;Lecerf L;Evans A;Cambou JP;Arveiler D;Luc G;Bard JM;Bara L;Ricard S;Tiret L;Amouyel P;Alhenc-Gelas F;Soubrier F. ] / Nature
48 Plasma level and gene polymorphism of angiotensin- converting enzyme in relation to myocardial infarction /
[ Cambien F;Costerousse O;Tiret L;Poirier O;Lecerf L;Gonzales MF;Evans A;Arveiler D;Cambou JP;Luc G. ] / Circulation
49 Brown adipose tissue, beta 3-adrenergic receptors, and obesity /
[ Lowell BB;Flier JS. ] / Annu. Rev. Med.
50 Role of <TEX>${\beta}$</TEX>3 Adrenoreceptor /
[ 최웅환 ] / 대한비만학회지
51 The <TEX>${\beta}$</TEX> adrenoceptor /
[ Johnson M. ] / Am. J. Respir. Crit. Care Med.
52 Implications of genetic variability of human beta 2-adrenergic receptor structure /
[ Green SA;Turki J;Hall IP;Liggett SB. ] / Pulm. Pharmacol.
53 Adrenoceptor genes in human obesity /
[ Arner P;Hoffstedt J. ] / J. Intern. Med.
54 Gene-gene interaction between fetal MTHFR 677C>Tand transcobalamin776C>Gpolymorphisms in human spontaneous abortion /
[ Zetterberg H;Zafiropoulos A;Spandidos DA;Rymo L;Blennow K ] / Hum. Reprod.
55 The different effects of a Gln27Glu beta 2-adrenoceptorgene polymorphism on obesity in males and in females /
[ Hellstrom L;Large V;Reynisdottir S;Wahrenberg H;Arner P. ] / J. Intern. Med.
56 /
[ 신홍일(註解) ] / 東醫壽世保元註解
57 /
[ 송일병 ] / 알기쉬운 사상의학
58 Obesity genes. /
[ Sorensen TI;Echwald SM. ] / BMJ.
59 Are there persons who are obese, but metabolically healthy? /
[ Sims EA. ] / Metabolism   ScienceOn