• Journal of the Korean Chemical Society
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• v.52 no.3
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• pp.257-265
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• 2008

The synthesis, characterization and bioevaluation of five new tetrahydroquinazolines was reported. Initially cyclohexanones were prepared and they were used as synthons to get the target molecules. These were condensed with substituted benzaldehydes and the resulting chalcones were treated with guanidine hydrochloride . All the molecules were non-toxic to human cells and showed significant antibacterial activity.

• Bulletin of the Korean Chemical Society
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• v.5 no.6
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• pp.240-244
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• 1984

8-Oxyquinoline dihydroboronite is prepared by mixing equimolar amounts of 8-hydroxyquinoline and borane-dimethyl sulfide complex in tetrahydrofuran at room temperature and its structure is determined by spectroscopic methods. The reagent is shown to be an extremely mild reducing agent and reduces aldehydes, cyclohexanones, and acid chlorides to some extent. The reagent in the presence of 0.1 equiv of boron trifluoride etherate in tetrahydrofuran at room temperature reduces selectively aldehydes in the presence of ketones, while the reagent in the presence of 1 equiv of boron trifluoride etherate rapidly reduces simple aldehydes and ketones but does not reduce carboxylic acids, esters, and amides.