• 한국미생물·생명공학회지
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• 제34권4호
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• pp.289-298
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• 2006

3',5'-cyclic adenosine monophosphate (cAMP) is an important molecule, which mediates diverse cellular processes. For example, it is involved in regulation of sugar uptake/catabolism, DNA replication, cell division, and motility in various acterial species. In addition, cAMP is one of the critical regulators for syntheses of virulence factors in many pathogenic bacteria. It is believed that cAMP acts as a signal for environmental changes as well as a regulatory factor for gene expressions. Therefore, intracellular concentration of cAMP is finely modulated by according to its rates of synthesis (by adenylate cyclase), excretion, and degradation (by cAMP phosphodiesterase). In the present review, we discuss the bacterial physiological characteristics governed by CAMP and the molecular mechanisms for gene regulation by cAMP. Furthermore, the effect of cAMP on phosphotransferase system is addressed.

• 한국지능시스템학회논문지
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• 제16권4호
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• pp.396-401
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• 2006

순환결합형 신경회로망은 복수 개의 리미트사이클을 생성하며 따라서, 많은 동적 정보를 저장할 수 있는 메모리 시스템으로 사용할 수 있다는 것이 알려져 있다. 본 논문에서는 각 뉴런이 최근접 뉴런에만 이진화한 결합하중 ${\pm}1$로 연결된 연속 시간모델 순환결합형 신경회로망을 구현하였다. 그리고 이런 회로망을 통해 생성되는 리미트사이클의 수와 패턴을 시뮬레이션을 통하여 나타내었다. 또한 카오스 신호를 인가하여 리미트사이클 사이의 천이 가능성을 입증하였다. 특히, 카오스 신호 이외의 랜덤 노이즈를 이용한 해석을 통하여 동적 신경회로망에 카오스 노이즈를 인가하는 경우의 유효성을 검토하였다.

• 한국통신학회논문지
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• 제39B권10호
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• pp.700-707
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• 2014

본 논문에서는 순환적 전치 부호를 가지는 시스템에서 수신기에 나타나는 잡음신호를 제거하는 기법에 대해 다룬다. 수신된 블록의 SNR을 추정하여 잡음신호가 작을 때 수신된 블록으로부터 자기상관행렬을 구하고, 신호 부분공간(signal subspace)에 속하는 고유벡터를 자기상관행렬의 고유치 분해를 통해 얻는다. 신호 고유벡터를 위한 자기상관행렬은 수신된 블록의 순환적 특성을 사용하여 얻는다. 일반적인 OFDM 시스템에서는 순환적 전치 부호를 가지는 심볼을 전송하기 때문에 본 논문에서 제안한 방법은 송 수신기의 구조를 변경하지 않는 장점을 가진다. 고유필터를 위해 얻어진 신호 고유벡터를 사용하여 수신된 블록을 필터링함으로써 잡음신호를 제거한다. 제안된 방법의 타당성 검증을 위해 송신 신호에 대한 영구 여기(persistency of excitation) 조건을 확인하고 시뮬레이션을 통해 검증한다.

• ETRI Journal
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• 제36권4호
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• pp.545-553
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• 2014

This paper proposes an algorithm to sense orthogonal frequency-division multiplexing (OFDM) signals in cognitive radio (CR) systems. The basic idea behind this study is when a primary user is occupying a wireless channel, the covariance matrix is non-diagonal because of the time domain cross-correlation of the cyclic prefix (CP). In light of this property, a new decision metric that measures the power of the data found on two minor diagonals in the covariance matrix related to the CP is introduced. The impact of synchronization errors on the signal detection is analyzed. Besides this, a likelihood-ratio test is proposed according to the Neyman-Pearson criterion after deriving probability distribution functions of the decision metric under hypotheses of signal presence and absence. A threshold, subject to the requirement of probability of false alarm, is derived; also the probabilities of detection and false alarm are computed accordingly. Finally, numerical simulations are conducted to demonstrate the effectiveness of the proposed algorithm.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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• pp.269-269
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• 2013

Redox cycling in between the two working electrodes in an electrochemical cell can lead a great signal enhancement. In this work, we report on a systematic examination of current amplification along with the decrease in the gap distance of a nanogap device which was fabricated by the combination of photo and chemical lithography [1]. The gap distance was controlled by the chemical lithographic process of surfacecatalyzed growth of metallic layer on pre-defined electrodes with wider initial gap. Enhancement of the redox current of ferri/ferrocyanide was observed upon gap distance reduction and the current is amplified about a thousand times in this redox system when the gap distance was decreased from 200 nm to 30 nm. The experimental results were discussed on the basis of the cyclic voltammetry (CV), atomic force microscopy (AFM) and scanning electron microscopy (SEM).

• 비파괴검사학회지
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• 제27권6호
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• pp.541-549
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• 2007

This work describes an investigation into the feasibility of using an acoustic emission (AE) technique to evaluate the integrity of a composite actuator with a PZT ceramic under electromechanical cyclic loading. AE characteristics have been analyzed in terms of the behavior of the AE count rate and signal waveform in association with the performance degradation of the composite actuator during the cyclic tests. The results showed that the fatigue cracking of the composite actuator with a PZT ceramic occurred only in the PZT ceramic layer, and that the performance degradation caused by the fatigue damage varied immensely depending on the existence of a protecting composite bottom layer. We confirmed the correlations between the fatigue damage mechanisms and AE signal types for the actuators that exhibited multiple modes of fatigue damage; transgranular micro damage, intergranular fatigue cracking, and breakdown by a short circuiting were related to a burst type signal showing a shortly rising and slowly decaying waveform with a comparably low voltage, a continuous type signal showing a gradual rising and slowly decaying waveform with a very high voltage and a burst and continuous type signal with a high voltage, respectively. Results from the present work showed that the evolution of fatigue damage in the composite actuator with a PZT ceramic can be nondestructively identified via in situ AE monitoring and microscopic observations.

• 방송공학회논문지
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• 제19권2호
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• pp.195-204
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• 2014

이 논문에서는 순환정상 프로세스의 고차 통계 특성을 바탕으로 2-FSK, 4-FSK, 8-FSK, MSK, BPSK, QPSK, 8-PSK, 16-QAM, 32-QAM, 64-QAM 등 10개의 기저대역 디지털 변조신호를 자동으로 인식하는 방법을 제안하였다. 변조신호의 고유한 성질을 나타내는 특징변수로는 1차 순환 모멘트와 고차 순환 큐뮬런트를 이용하였다. 제안한 변조인식기는 크게 두 단계로 구성되며, 첫 번째 단계에서는 1차 순환 모멘트가 나타내는 첨두치를 이용하여 M-FSK와 비FSK로 변조신호를 분류한다. 두 번째 단계에서는 비FSK를 분류하기 위해 고차 순환 큐뮬런트 값을 이용하는 Gaussian 혼합 모델 기반의 분류기를 적용하였다. 제안한 방법의 성능을 검증하기 위해서 모의실험을 실시하였다. 모의실험 결과 제안한 분류기는 주파수와 위상 옵셋이 존재하는 환경에서도 우수한 분류확률을 나타내었다.

• Molecules and Cells
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• 제25권4호
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• pp.479-486
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• 2008

Mitogen-activated protein kinases (MAPKs) play an indispensable role in activation of the myogenic program, which is responsive to mechanical stimulation. Although there is accumulating evidence of mechanical force-mediated cellular responses, the role of MAPK in regulating the myogenic process in myoblasts exposed to cyclic stretch is unclear. Cyclic stretch induced the proliferation of C2C12 myoblasts and inhibited their differentiation into myotubes. In particular, it induced persistent phosphorylation of p38 kinase, and decreased the level of phosphorylation of extracellular-signal regulated kinase (ERK). Partial inhibition of p38 phosphorylation increased cellular levels of MyoD and p-ERK in stretched C2C12 cells, along with increased myotube formation. Treatment with $10{\mu}M$ PD98059 prevented myogenin expression in response to a low dose of SB203580 ($3{\mu}M$) in the stretched cells, suggesting that adequate ERK activation is also needed to allow the cells to differentiate into myotubes. These results suggest that cyclic stretch inhibits the myogenic differentiation of C2C12 cells by activating p38-mediated signaling and inhibiting ERK phosphorylation. We conclude that p38 kinase, not ERK, is the upstream signal transducer regulating cellular responses to mechanical stretch in skeletal muscle cells.

• 한국연소학회:학술대회논문집
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• 한국연소학회 2002년도 제25회 KOSCI SYMPOSIUM 논문집
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• pp.223-229
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• 2002

Spark plug ionization signal could be useful in an internal combustion engine as a feedback signal for combustion diagnostics such as misfire detection, knocking detection and lambda control, but the signal has high level of cyclic fluctuation in an internal combustion engine due to residual gas, pressure, temperature, mixture composition in the spark gap. Because of this reason it is very difficult to apply ion signal to commercial engine control. In this Study, a correlation between A/F and spark plug ionization signal was studied in a constant volume chamber. Constant volume chamber with gas phase fuel(Propane) has homogeneous fuel composition , no mixture flow, same pressure and temperature on each test. The results show that mean chemi-ion signal has the highest correlation with A/F and intial pressure change has on effect on the thermal-ion signal and not on chemi-ion signal.

• 생물정신의학
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• 제18권4호
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• pp.189-196
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• 2011

Major depressive disorder is characterized by cellular and molecular alterations resulting in the depressive behavioral phenotypes. Preclinical and clinical studies have demonstrated the deficits, including cell atrophy and loss, in limbic and cortical regions of patients with depression, which is restored with antidepressants by reestablishing proper molecular changes. These findings have implicated the involvement of relevant intracellular signaling pathways in the pathogenetic and therapeutic mechanisms of depressive disorders. This review summarizes the current knowledge of the signal transduction mechanisms related to depressive disorders, including cyclic-AMP, mitogen-activated protein kinase, Akt, and protein translation initiation signaling cascades. Understanding molecular components of signaling pathways regulating neurobiology of depressive disorders may provide the novel targets for the development of more efficacious treatment modalities.