• Applied Biological Chemistry
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• 제18권3호
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• pp.167-176
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• 1975

ATP-저해 ribonuclease는 Bacillus subtilis와 같은 Bacillus속에서만 발견 되는 것으로서 이들 효소의 생리적 역활을 규명할 목적으로 Bacillus subtilis 균주를 사용하여 ATP저해성 negative ribonuclease변이주의 취득을 시도하고 선정된 균주가 생산하는 ribonuclease의 정제 및 몇 가지 성질에 대하여 실험한 결과는 아래와 같다. 1. Bacillus subtilis로 부터 ATP-저해 ribonuclease negative mutant의 취득을 시도한 결과 시험된 1817주의 균중에서 101균주가 변이주주로 선정 되었다. 2. 수개의 개별적인 column chromatography에 의하여 당균주가 생산하는 ATP-저해성 ribonuclease의 정제를 시도한 결과 DEAE-Sephadex A-50 column chromatography을 이용한 경우는 30배의 정제 효과와 99%의 회수율을 나타냈고 Sephadex G-75 column의 경우는 20배의 정제 효과와 98%의 회수율을 각각 나타냈다. 3. pH 5침전, 유안염석, Sephadex G-75 및 CM Sephadex를 연속적으로 통과시켜 당효소에 대한대량정제 시험을 시도한 결과 최초의 step(crude extract) 과정에 비하여 60배의 정제효과를 나타냈다. 4. 본정제 효소액에 대하여 전기영동을 실시한 결과 비정제 효소액에 비하여 매우 감소된 수의 담백 pattern을 나타냈다. 5. 당균주가 생산하는 ATP저헤 ribonuclease는 single stranded RNA를 분해하여 2',3'-cyclic AMP, 2',3'-cyclic CMP, 2',3'-cyclic GMP, 2',3'-cyclic UMP와 몇종의 미지물을 생성하였고 또한 본효소는 double stranded RNA를 분해하지 않었다.

• 열처리공학회지
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• 제31권1호
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• pp.18-23
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• 2018

In this study, low cyclic fatigue test was carried out at room temperature condition for rolled STS304 steel. The results of this study show that rolled STS304 steel has excellent static tensile strength and fatigue characteristics. The relationship between plastic strain range and fatigue life was examined using the triangular wave in order to predict the low cycle fatigue life of rolled STS304 steel by Coffin-Manson equation. Cyclic behavior of rolled STS304 steel was characterized by cyclic hardening with increasing number of cycle through the Hysteresis loop analysis and cyclic response of maximum stress versus number of cycles. It is found that the plastic deformation energy consumed per cycle is reduced by calculating the area of the hysteresis loop.

• 대한한방부인과학회지
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• 제33권2호
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• pp.112-123
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• 2020

Objectives: The purpose of this study is to review the research in the cyclic treatment of endometriosis in traditional Korean medicine. Methods: By October 2019, the relevant studies on the periodic therapy of endometriosis were searched using the Chinese National Knowledge Infrastructure Database (CNKI) and Oriental Medicine Advanced Searching Integrated System (OASIS). Results: Finally, three Randomized controlled trials, one case study, two clinical observational studies were selected. In all studies, herbal medicine periodic therapy has been effective in improving symptoms of endometriosis. Blood-activating and stasis-dispelling medicinal were the most commonly used before menstruation and during menstruation, and tonifying and replenishing medicinal were the most commonly used after menstruation. According to the one study, which reported safety, herbal medicine was safe. Conclusions: Although limited due to a lack of literature, periodic therapy is effective in improving endometriosis related symptoms and preventing recurrence. A well-designed study and experimental studies for the identification of the mechanism are needed.

• 한국산업융합학회 논문집
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• 제23권4_1호
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• pp.531-539
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• 2020

When injection mold is repeatedly used for mass production, fatigue phenomenon due to cyclic stress may occur. The surface and interior of structure might be damaged due to cyclic stress or strain. The objective of this study was to analyze failure of SCM435 high-tension bolts connecting upper and lower parts of a three-stage injection molding machine. These bolts have to undergo an accurate heat treatment to prevent the formation of chromium carbide and the action of dynamic stresses. Bolts were fractured by cyclic bending stress in the observation of ratchet marks and beach marks. Damaged specimen showed an acicular microstructure. Impurity was observed. Chromium carbide was observed near the crack origin. Both shape parameters of the Vickers hardness were similar. However, the scale parameter of the damaged specimen was about 20% smaller than that of the as-received specimen. Much degradation occurred in the damaged specimen. Bolts should undergo an accurate heat treatment to prevent the formation of chromium carbide. They must prevent the action of dynamic stresses. Bolts need accurate tightening and accuracy of heat treatment and screws need compression residual stress due to peening.

• 대한소아치과학회지
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• 제40권2호
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• pp.133-140
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• 2013

주기성 호중구 감소증은 호중구의 수가 감소하였다가 다시 정상으로 회복되는 반응이 주기적으로 나타나는 혈액질환이다. 임상적 증상으로 발열, 실신, 두통 등이 있으며 구강 내 증상으로 동통성 연조직 궤양이 특징적인데 특히 입술, 혀, 협점막, 치은이 흔하게 이환 된다. 또한, 치조골 파괴를 동반한 급진성 치주조직 상실을 보이기도 한다. 본 증례의 환아는 4세 1개월의 남아로서 잇몸이 붓고 이가 흔들린다는 것을 주소로 본과에 내원하였다. 환아는 주기성 호중구 감소증 환자로서 하악 전치부 5개 치아를 제외한 모든 유치에 우식이 있었으며 동요를 보이는 하악 좌 우 제1유구치의 국소적 치조골 소실을 확인할 수 있었다. 환아는 주기성 호중구 감소증에 기인한 광범위한 치아우식증, 치은염, 국소적 치주염으로 진단되었고 치료를 시행하였다. 주기성 호중구 감소증 환자에게는 정기적인 구강위생관리와 함께 치아우식, 치은염에 대한 시기적절한 치료가 필요하며 특히 어린 환자들에 있어서 영구치열 형성에 장애가 발생하지 않도록 조기에 개입을 하는 것이 중요하다.

• 한국해양공학회지
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• 제27권2호
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• pp.69-74
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• 2013

In this study, the crack healing effects of $Al_2O_3$ ceramics based on the heat treatment conditions were investigated. The influence of the additive amounts of SiC nanoparticles and the cycling process of indentation-heat treatment on the crack healing effect of $Al_2O_3$ ceramics were also examined. Three-point bending tests were carried out and the morphological changes in the fracture surface were observed by using FE-SEM. As a result, heat-treated samples in a vacuum or air atmosphere showed improved bending strengths compared to un-heat treated samples. This means that cracked specimens can be healed by heat treatment in a vacuum or air atmosphere. The crack healing effect of $Al_2O_3$ ceramics that were heat treated in an air atmosphere was much higher than that of those heat treated in a vacuum. After heat treatment, the $Al_2O_3$ ceramics with 30 wt% SiC nanoparticles showed a higher bending strength than those with 15 wt% SiC. The cyclic indentation and heat treatment did not remarkably affect the crack healing effect. The SEM images showed that the median crack, indenter mark on the surface, and pores in the fracture surface of a specimen almost disappeared after being heat treated in an air atmosphere.

• 대한한방내과학회지
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• 제45권3호
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• pp.519-531
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• 2024

Objectives: This case study reports the effectiveness of Korean medical treatment in a patient with cyclic vomiting syndrome. Methods: A 29-year-old female Korean patient with cyclic vomiting syndrome received acupuncture, electroacupuncture, herbal medicine, and moxibustion for 2 weeks in hospital. Changes in symptoms were evaluated using the Gastrointestinal Symptom Rating Scale (GSRS), Visual Analog Scale (VAS), Index for Nausea, Vomiting, and Retching (INVR), Nausea Severity Scale (NSS), Nepean Dyspepsia Index-Korean version (NDI-K), quality of life using the Functional Dyspepsia Related Quality of Life questionnaire (FD-QoL), and gastric motility using electrogastrography (EGG). Results: Post-treatment, the patient showed high satisfaction and improvement in symptoms of nausea and vomiting. The following changes were observed in scores: GSRS: 23 to 19; VAS of nausea: 88 to 95; VAS of dyspepsia: 95 to 12; INVR: 13 to 1; NSS: 17 to 5; NDI-K: 107 to 78; and FD-QoL 84 to 27. We also found positive results in Channel 3 of EGG parameters, implying the improvement of gastric motility disorder. Conclusion: Korean medical treatment can be a therapeutic option for cyclic vomiting syndrome.

• 대한치과교정학회지
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• 제16권2호
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• pp.53-67
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• 1986

The physical tooth movement by orthodontic force is based upon alveolar bone resorption at compression site and new bone formation at tension site of the alveolar socket. The function of the cyclic AMP is to participate not only in initial action of bone cells by mechanical forces but also in the continuous cellular response leading to bone remodelling. This experiment was performed to clarify the role of cyclic AMP in bone remodelling by mechanical force in the NORMAL group, the DIABETES group and the INSULIN TREATED group. The 72 rats were divided into the NORMAL group, the DIABETES group and the INSULIN TREATED group. The same orthodontic forces were applied to the rats of 3 groups. These rats were treated for periods of time ranging from 1 hour, 1 day, 7 days, 14 days, 21 days and 28 days. The samples of alveolar bones were obtained from compression and tension sites surrounding the tipping teeth from NORMAL, DIABETE and INSULIN TREATED rats. The samples were assayed for cyclic AMP by the cyclic AMP RIA kit. The results were as follows: 1. The cyclic AMP levels of alveolar bone in compression and tension sites showed initial decrease, then increased and .remained elevated by the time consuming. 2. The highest cyclic AMP level showed in the DIABETES group and the lowest level was in the NORMAL group. 3. The cyclic AMP levels in the INSULIN TREATED group was similar with the NORMAL group in control and tension sites, but in the compression sites it was similar with the DIABETES group.

• 열처리공학회지
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• 제4권4호
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• pp.24-33
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• 1991

The effects of thermomechanical treatments on microstructure and fatigue properties of 7050 Al alloy were investigated. The precipitation kinetics changed to a faster rate due to cold deformation employed in this special TAHA thermomechanical treatments including pre-aging, plastic deformation and two step final-aging. The G.P. zones in the under-aged condition were cut by dislocations and dissolved during the plastic deformation. During the low cycle fatigue, the T6' condition showed cyclic hardening behavior whereas the TMT5, TMT27 and T76 conditions showed cyclic softening at above 0.7% total strain amplitudes. The ${\Delta}K_{th}$ value of TMT27 was improved more than two times, compared with that of T76 condition. The T6' with small shearable precipitates resulted in the markedly high ${\Delta}K_{th}$ value. This is thought to be resulted from dislocation reversibility and roughness-induced crack closure due to planarity of slip.

• Asian-Australasian Journal of Animal Sciences
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• 제17권11호
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• pp.1570-1574
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• 2004

A flock of AA breed chickens were reared in peterstme brood-vait chamber and were provided with high energy pelleted feed. At 14 d of age, a total of 350 birds were randomly divided into 3 groups as follows: 100 birds were exposed to normal ambient temperature of 20$^{\circ}C$ for control group; 150 birds were exposed to lower ambient temperature of 11$^{\circ}C$ to induce ascites (treatment I); and another group of 100 birds were exposed to lower ambient temperature of 11$^{\circ}C$ and fed diet containing 1% L-arginine for ascitic prophylactic treatment (treatment II). Samples were collected from blood and abdominal fluid of chicken at 3, 4, 5, 6 and 7 wk of age subsequently, to analysis the contents of plasma endothelin (ET-1), angiotensin II (Ang II), cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP). The results indicated that the contents of cAMP, cGMP, and Ang II in reatment I and ascitic broilers were higher than the corresponding control group (p<0.01, p<0.05), ET-1 of preascitic broilers were control group (p<0.05), while there was an insignificant difference with later ascitic broilers. The contents of cAMP and cGMP in treatment II were higher than the treatment I and control groups (p<0.01, p<0.05), whereas, the contents of Ang II were gradually decreased compared to the control group (p<0.05), the contents of ET-1 were insignificantly different. On further analysis, the increased plasma Ang II at low ambient temperature condition in broilers made endothelium cell secretion of increased ET-1, cAMP, cGMP and decreased NO. Therefore, low temperature accelerated ascites syndrome in broilers. Supplemently L-arginine can decrease ET-1, and increase cAMP and cGMP. It is concluded that cAMP mediated in broilers pulmonary hypertension syndrome.