• 대한한방부인과학회지
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• 제18권1호
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• pp.169-180
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• 2005

Objective : Spatholobus Suberectus Dunn stems, Chinese vine plants, have been used for the relief of menstrual disorders and rheumatic arthralgia. In this study, we investigated the antitumor effect of Spatholobus Suberectus Dunn on cervical cancer in vitro. Methods : HeLA cervical cancer cell lines were used as targets. We examined the effect of water extract from Spatholobus Suberectus Dunn on cell proliferation, cell cycle regulation and cell cycle-regulating gene expression. Further, we investigated the apoptotic effects of Spatholobus Suberectus Dunn on cervical cancer cell lines. Results : Spatholobus Suberectus Dunn significantly inhibited the proliferation of cervical cancer cell lines in a dose-dependent and time dependent manner. Fluorescence activated cell sorter (FACS) analysis indicated that Spatholobus Suberectus Dunn induced G1 cell cycle arrest. Spatholobus Suberectus Dunn enhanced the expression of $p21^{waf1}$ and $p27^{kip1}$ with cell cycle arrest. Further, Spatholobus Suberectus Dunn stimulated apoptosis via caspase3 pathway. Conclusions : These findings suggest that Spatholobus Suberectus Dunn is a candidate agent for the treatment of cervical cancer. p21waf1 and $p21^{waf1}$ and $p27^{kip1}$ may play an important role in Spatholobus Suberectus Dunn-induced cell cycle arrest and cell growth inhibition.

• 한국미생물·생명공학회지
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• 제47권1호
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• pp.34-42
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• 2019

Apigenin, a common natural product that is found in many plants and vegetables, has been reported to have many biological activities, including antioxidative, anti-inflammatory, and anticancer effects. The triple-negative breast carcinoma cell line MDA-MB-231 is known to be highly invasive and resistant to chemotherapy. In this study, we investigated the anticancer effect of apigenin on human MDA-MB-231 cells. First, the cytotoxicity of apigenin toward MDA-MB-231 cells was analyzed by MTT assay. Then, the cell cycle and apoptotic effects of apigenin were examined, and the molecular mechanism underlying its anticancer activity was explored. Apigenin inhibited the growth of the cells in a dose-dependent manner, correlating with the cell cycle arrest at the G2-M phase as well as an increase of early apoptosis. The cell-cycle inhibitory effect was highly associated with the increased expression of p21 and decreased expression of CDK6, cyclin D1, and cyclin B1. The induction of apoptosis by apigenin was associated with the upregulated expression of cleaved PARP and cleaved caspase-3, -7, and -9.

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2004년도 학술논문집
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• pp.386-395
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• 2004

The Korean fuel cycle scenario has been modeled by using the dynamic analysis method. For once-through fuel cycle model, the nuclear power plant construction plan was considered, and the nuclear demand growth rate from the year 2016 was assumed to be 1%. After setup the once-thorough fuel cycle model, the DUPIC and fast reactor scenarios were modeled to investigate the environmental effect of each fuel cycle. Through the calculation of the amount of spent fuel, and the amounts of plutonium and minor actinides were estimated and compared to those of the once-through fuel cycle. The results of the once-through fuel cycle shows that the demand grows to 64 GWe and the total amount of the spent fuel would be 100 kt in the year 2100, while the total spent fuel can be reduced by 50% when the DUPIC scenario is implemented

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2008년도 추계종합학술대회 B
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• pp.854-857
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• 2008

무선 센서 네트워크의 센서 노드는 내부 전원을 사용함으로 인해 수명이 제한적이다. 기존의 여러 MAC 프로토콜은 무선 센서 네트워크에서 에너지 절약을 위해 sleep/listen cycle을 스케쥴링한다. 또한, MAC프로토콜의 duty-cycle은 사용자의 조정에 의해 낮은 duty cycle로 변화할 수 있으며, 이는 프레임에서 sleep 시간을 결정하게 된다. 이러한 duty cycle의 크기는 MAC 프로토콜의 성능에 직접적인 영향을 미친다. 본 논문에서는 NS-2 환경에서 서로 다른 duty cycle을 갖는 TEEM과 SMAC을 시뮬레이션하고 두 개의 프로토콜의 에너지 소비와 성능 측면에서 duty cycle을 분석한다.

• Journal of Advanced Marine Engineering and Technology
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• 제29권2호
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• pp.185-193
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• 2005

The present study composed a diesel-atkinson cycle of high expansion as a method of achieving high efficiency in diesel cycle engines. It also interpreted the cycle engine thermodynamically analysis to determine the possibility of the improvement of thermal efficiency and clarified the characteristics of several factors . According to the result of theoretical analysis, heat efficiency was highest when expansion-compression ratio Reど:1. In addition. diesel engines with high apparent compression ratio had higher expansion-compression ratio than otto engines and consequently their effect of high expansion was high. which in turn enhanced thermal efficiency. When the atkinson cycle was implemented in a real diesel engine by applying the miller cycle through the variation of the closing time of the intake valve, the effective compression ratio and the quantify of intake air decreased and as a result, the effect of high expansion was not observed. Accordingly. the atkinson cycle can be implemented when the quantity of intake air is compensated by supercharge and the effective compression ratio is maintained at its initial level through the reduction of the clearance volume. In this case. heat efficiency increased by $4.1\%$ at the same expansion-compression ratio when the apparent compression ratio was 20 and the fuel cut off ratio was 2. As explained above, when the atkinson cycle was used for diesel cycle. heat efficiency was improved. In order to realize high expansion through retarding the intake value closing time, the engine needs to be equipped with variable valve timing equipment, variable compression ratio equipment and supercharged Pressure equipment. Then a diesel-atkinson cycle engine is realized.

• PNF and Movement
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• 제20권1호
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• pp.91-101
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• 2022

Purpose: The purpose of this study was to examine the effect of cycle ergometer exercise inducing movement of the affected side on knee joint function after total knee arthroplasty (TKA). Methods: The primary experiment was conducted on 19 members of the cycle ergometer exercise group to measure the muscle activity of the rectus femoris, hamstring, tibialis anterior, and gastrocnemius muscles during cycle ergometer exercise that induced the affected side's movement. In the second experiment, after receiving physiotherapeutic intervention for 30 min, the general bicycle exercise group and cycle ergometer exercise group performed the corresponding exercise for 15 min, 5 times per week, for 2 weeks. The ROM, muscle strength, pain, and balance were then measured and compared between the two groups. Results: In the results of the primary experiment, cycle ergometer exercise inducing movement of the affected side showed a significantly larger increase in the activity of leg muscles (rectusfemoris, hamstring, tibialis anterior, gastrocnemius) on the affected side than the general bicycle exercise (p <0.05). In the second experiment, the cycle ergometer exercise group showed a significantly larger increase in range of movement of affected side knee flexion and muscle strength of affected side knee flexion, knee extension, and plantarflexion than the general bicycle exercise (p <0.05). No significant between-group difference was observed in pain and balance before or after the intervention (p >0.05). Conclusion: Cycle ergometer exercise inducing movement of the affected side increases use of the muscles around the affected side knee joint after TKA more than general bicycle exercise and produces better effects for enhancing muscle strength. The application of cycle ergometer exercise inducing movement of the affected side is expected to reduce the patients' unbalanced use during the early postoperative period and help them to quickly return to normal daily life through rapid muscle strength recovery.

• 열처리공학회지
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• 제4권3호
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• pp.31-38
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• 1991

Effect of thermal cycling on shape memory effect and stabilization of austenite was investigated in Fe-21%Mn alloy. The thermal cyclic treatment was carried out with two types, room temperature${\leftrightarrow}215^{\circ}C$ and room temperature${\leftrightarrow}260^{\circ}C$. In case of the room temperature${\leftrightarrow}215^{\circ}C$, the SME was rapidly increased up to 3 cycles and maintained nearly constant value regardless of further cycles. In case of the room temperature${\leftrightarrow}260^{\circ}C$, however, the SME was increased with increasing the thermal cycle up to 5 cycles and decreased gradually with further cycle. The variation of the ${\varepsilon}$ martensite volume pet with the thermal cycle was in good agreement with the variation of the SME. Therefore, the change of the SME due to the cyclic treatment was explained with the change of the ${\varepsilon}$ martensite content. As the thermal cycle was increased, the $M_s$ temperature was decreased, and the $A_s$ and $A_f$ temperatures were increased, respectively.

• 토지주택연구
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• 제2권4호
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• pp.503-507
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• 2011

신도시 A에 저탄소 녹색 마을(약 40만$m^2$)을 개발하고자 한다. 저탄소 녹색 마을의 조성을 위해서는 수문 순환의 복원 또는 물순환의 복원은 필수적이다. 저탄소 녹색 마을의 자연계 물순환 복원을 위해 LID-분산형 빗물 관리 시설의 설치를 계획하였다. 물순환에 미치는 영향 분석은 저탄소 녹색마을 개발 이전과 개발 후, 그리고 LID 시설(빗물정원, 인공습지, 빗물이용시설 등)을 설치한 후의 조건에서 EPA에서 개발된 SWMM-LID 모델을 이용하여 수행하였다. 개발 전의 침투 영역의 특성, 개발 후의 상당한 녹지 공간 탓으로, 수문 순환을 복원하기 위한 LID 설치 계획은 뚜렷한 효과를 보여주지 않고 있다. 그러나 LID 시설 설치에 의한 물순환의 가능성을 볼 수는 있었다. 이는 본 연구에서 제시한 LID 시설의 설치 계획이 해당 개발 지역의 물순환을 위해서는 더 확대되어야 함을 의미한다.

• International Journal of Automotive Technology
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• 제2권1호
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• pp.25-31
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• 2001

It is necessary to understand the combustion process and cycle-by-cycle variation in combustion to improve the engine stability and consequently to improve the fuel economy and exhaust emissions. The pressure related parameters instead of mass fraction burned were compared for the effect of initial combustion pressures on the following combustion and the analysis of cycle-by-cycle variation in combustion for two pen injected SI engines. The correlation between IMEP and pressures at referenced crank angles showed almost the same trends for equivalence ratios, but the different mixture preparations indicated different tendency. The dependency of IMEP on pressure at the referenced crank angles increases as the mixture becomes leaner for both engines. The mixture distribution in the combustion chamber was varied with the coolant temperature and intake valve deactivation due to the evaporation of fuel and air motion. The correlation between pressure related parameters were also compared for the coolant temperatures and air motion.

• 약학회지
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• 제39권6호
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• pp.689-694
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• 1995

Sphingolipids play important roles in cell regulation and signal transduction. Recently, a sphinogomyelin cycle has been described in which activation of neutral sphingomyelinase leads to the breakdown of sphingomyelin and the generation of ceramide. Ceramide, in turn, has emerged as a candidate intracellular mediator for the action of certain cell agonists and has multiple biologic actions. Ceramide is a potent suppressor of cell growth and an inducer of apoptosis. The present studies show that exposure of IM-9 cells to ceramide resulted in internucleosomal cleavage of DNA, yielding laddered patterns of oligonucleosomal fragments characteristic of apoptosis. DNA fragmentation induced by ceramide was also confirmed by diphenylamine assay. The effect of ceramide on cell cycle progression was also studied. The addition of ceramide increase G$_{1}$ phase distribution in cell cycle. Cell cycle-related cyclin D$_{1}$ gene expression was decreased in a time-dependent manner. These results suggest that apoptosis induced by ceramide is related to cell cycle associated with the alteration of cell cycle in IM-9 cells.