• Journal of Nutrition and Health
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• 제16권4호
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• pp.273-280
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• 1983

The effect of alteration of light-darkness cycle on the protein metabolism was studied in the rat. The light-darkness cycle was altered either every 3 or 9 days, and animals consumed diets containing 8 or 25% casein. The results were summarized as follows : 1) Food consumptions and body weight gains of the 25% casein groups were higher than those of the 8% casein groups, and, among the animals consumed 25% casein diet, the light-darkness cycle altered group had lower food consumption and body weight gain than the unaltered group. 2) Weights of liver and adrenal gland per l00g body weight were not different with the dietary protein levels, but, at the end of experimental period, the 8% casein diet group of which light-darkness cycle altered every 9 days had the smallest liver weight and the largest adrenal gland weight. 3) Liver nitrogen and plasma protein concentrations of the 25% casein groups were slightly higher than those of the 8% casein groups. 4) Percentages of nitrogen retention of the 25% casein groups at period III were slightly lower in the light-darknerr cycle altered animals than that of the unaltered group.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5725-5730
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• 2013

Cancer patients often suffer from local tumor recurrence after radiation therapy. Cell cycling, an intricate sequence of events which guarantees high genomic fidelity, has been suggested to affect DNA damage responses and eventual radioresistant characteristics of cancer cells. Here, we established a radioresistant lung cancer cell line, A549R, by exposing the parental A549 cells to repeated ${\gamma}$-ray irradiation with a total dose of 60 Gy. The radiosensitivity of A549 and A549R was confirmed using colony formation assays. We then focused on examination of the cell cycle distribution between A549 and A549R and found that the proportion of cells in the radioresistant S phase increased, whereas that in the radiosensitive G1 phase decreased. When A549 and A549R cells were exposed to 4 Gy irradiation the total differences in cell cycle redistribution suggested that G2-M cell cycle arrest plays a predominant role in mediating radioresistance. In order to further explore the possible mechanisms behind the cell cycle related radioresistance, we examined the expression of Cdc25 proteins which orchestrate cell cycle transitions. The results showed that expression of Cdc25c increased accompanied by the decrease of Cdc25a and we proposed that the quantity of Cdc25c, rather than activated Cdc25c or Cdc25a, determines the radioresistance of cells.

• 한국식품영양학회지
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• 제25권1호
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• pp.205-213
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• 2012

This study investigated the life cycle of menus and made suggestions on the appropriate time for when new menus should be developed. For this purpose, a total of 636 customers who visited 'T' Restaurant more than 25 times in the past three years were used for analysis. After estimating product life cycles based on sales and selling period, an empirical study was conducted. In terms of product life cycle, a growth stage was observed in the category of pasta and pizza in both stores A and B, whereas sales in the rice category stayed constant. Regarding trend in seasonal sales, a big difference was detected between the two stores. While store A was already in the decline stage of the life cycle in all menu categories, store B remained in the growth stage. In terms of menu life cycle, the product life cycle of long-lived products was observed in the pasta category in both stores A and B. While the pizza category was in the growth stage, the product life cycle of long-lived products was observed in the rice category. It is expected that the results of this study could be useful in development of new menus and product life cycle management to fulfill diverse customer needs in the dining-out business.

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2017년도 추계학술논문요약집
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• pp.25-26
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• 2017

• 수산해양교육연구
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• 제25권4호
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• pp.998-1007
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• 2013

At container terminals, a major measurement of productivity can be work efficiency. For improving the productivity of container crane, the more efficient container yard operation method is necessary in container terminals. Recently, container terminal operators make an experiment on the dual cycle operation, which ship loading/unloading were carried out simultaneously, for increasing the productivity of container crane. In this paper, propose a system operating efficient dual cycle methods as utilize Ad-hoc technology in distributed port operation system. The dual cycle methods that proposed recognizes position information of Y/T during an action in Ad-hoc networks in case of container transfer works by real time as load an Ad-hoc module to Y/T taking charge of a container transfer with quay and yard. Utilize Ad-hoc networks technology in an operating system of container yard, and efficiently distributed processing done Y/T to container crane compare with operation systems of the existing dedicated method, and an improvement can do an operating system of an yard.

• International Journal of Oral Biology
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• 제39권1호
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• pp.23-33
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• 2014

Several studies have shown that curcumin, which is derived from the rhizomes of turmeric, possesses antimicrobial, antioxidant and anti-inflammatory properties. The antitumor properties of curcumin have also now been demonstrated more recently in different cancers. This study was undertaken to investigate the modulation of cell cycle-related proteins and the mechanisms underlying apoptosis induction by curcumin in the SCC25 human tongue squamous cell carcinoma cell line. Curcumin treatment of the SCC25 cells resulted in a time- and dose-dependent reduction in cell viability and cell growth, and onset of apoptotic cell death. The curcumin-treated SCC25 cells showed several types of apoptotic manifestations, such as nuclear condensation, DNA fragmentation, reduced MMP and proteasome activity, and a decreased DNA content. In addition, the treated SCC25 cells showed a release of cytochrome c into the cytosol, translocation of AIF and DFF40/CAD into the nuclei, a significant shift in the Bax/Bcl-2 ratio, and the activation of caspase-9, caspase-7, caspase-6, caspase-3, PARP, lamin A/C, and DFF45/ICAD. Furthermore, curcumin exposure resulted in a downregulation of G1 cell cycle-related proteins and upregulation of $p27^{KIP1}$. Taken together, our findings demonstrate that curcumin strongly inhibits cell proliferation by modulating the expression of G1 cell cycle-related proteins and inducing apoptosis via proteasomal, mitochondrial, and caspase cascades in SCC25 cells.

• 열처리공학회지
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• 제35권5호
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• pp.239-245
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• 2022

The purpose of this study is to evaluate the degree of microstructural change of materials using ultrasonic nonlinear parameters. For microstructure change, isothermal heat-treated ferritic 2.25Cr steel and low-cycle fatigue-damage copper alloy were prepared. The variation in ultrasonic nonlinearity was analyzed and evaluated through changes in hardness, ductile-brittle transition temperature, electron microscopy, and X-ray diffraction tests. Ultrasonic nonlinearity of 2.25Cr steel increased rapidly during the first 1,000 hours of deterioration and then gradually increased thereafter. The variation in non-linear parameters was shown to be coarsening of carbides and an increase in the volume fraction of stable M6C carbides during heat treatment. Due to the low-cycle fatigue deformation of oxygen-free copper, the dislocation that causes lattice deformation developed in the material, distorting the propagating ultrasonic waves, and causing an increase in the ultrasonic nonlinear parameters.

• Journal of Advanced Marine Engineering and Technology
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• 제36권8호
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• pp.1151-1157
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• 2012

OTEC기술은 신재생에너지 기술 중의 하나로 따듯한 표층수와 차가운 심층수의 온도차를 이용하여 전력을 생산하는 기술이다. 작동유체의 선정과 OTEC 사이클의 상태에 따라 에너지효율과 환경적인 측면에 많은 영향을 준다. OTEC의 작동유체로는 ammonia, R22, R407C, R410A가 있다. 본 논문에서는 OTEC 시스템의 최적화를 위해 $25^{\circ}C$에서의 증발압력를 비교하였다. 또한 밀폐사이클과 재생사이클에서의 작동유체에 따른 출력과 효율에 대하여 연구하였다.

• 한국해양공학회지
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• 제25권1호
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• pp.80-84
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• 2011

The cycle performance of closed ocean thermal energy conversion (OTEC) system with 50 kW gross power was evaluated to obtain the basic data for the optimal design of OTEC using waste heat such as solar power, discharged heat from condenser of power plant. The basic thermodynamic model for OTEC is Rankine cycle, and the surface seawater and deep seawater were used for the heat source of evaporator and condenser, respectively. The cycle performance such as efficiency, heat exchanger capacity, etc. was analyzed on the variation of temperature increase by waste heat. The cycle efficiency increased and necessary capacity of evaporator and condenser decreased under 50kW gross power with respect to the temperature increase of working fluid. Also, when the temperature increase is about $13.5^{\circ}C$, the heat which can be used is generated. By generator with 0.9 effectiveness under the simulated condition, the cycle efficiency was improved approximately 3.0% comparing with the basic cycle.

• 전자공학회논문지
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• 제49권10호
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• pp.142-147
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• 2012

본 논문에서는 다이나믹 주파수 스케일링 (DFS) 카운터를 사용하여 코오스, 파인 조정 기능을 갖는 CMOS 듀티 사이클 보정회로를 제시한다. DFS 카운터는 디지털-아날로그 컨버터의 비트 스위칭 글리치를 감소시키기 때문에 제안하는 CMOS 듀티 사이클 보정회로의 듀티 보정 범위를 증가시키고 지터 특성을 개선한다. 제안하는 회로는 0.18-${\mu}m$ CMOS 공정을 이용하여 설계되었다. 0.5-1.5GHz의 넓은 동작 주파수와 25-75%의 넓은 듀티 사이클 보정 범위 내에서 측정된 최대 출력 듀티 사이클 에러는 ${\pm}1.1%$이다.