• IMMUNE NETWORK
• /
• 제20권4호
• /
• pp.31.1-31.14
• /
• 2020

The effectiveness of current influenza vaccines is considered suboptimal, and 1 way to improve the vaccines is using adjuvants. However, the current pool of adjuvants used in influenza vaccination is limited due to safety concerns. Aloe vera, or aloe, has been shown to have immunomodulatory functions and to be safe for oral intake. In this study, we explored the potential of orally administered processed Aloe vera gel (PAG) as an adjuvant for influenza vaccines in C57BL/6 mice. We first evaluated its adjuvanticity with a split-type pandemic H1N1 (pH1N1) Ag by subjecting the mice to lethal homologous influenza challenge. Oral PAG administration with the pH1N1 Ag increased survival rates in mice to levels similar to those of alum and MF59, which are currently used as adjuvants in influenza vaccine formulations. Similarly, oral PAG administration improved the survival of mice immunized with a commercial trivalent influenza vaccine against lethal homologous and heterologous virus challenge. PAG also increased hemagglutination inhibition and virus neutralization Ab titers against homologous and heterologous influenza strains following immunization with the split-type pH1N1 Ag or the commercial trivalent vaccine. Therefore, this study demonstrates that PAG may potentially be used as an adjuvant for influenza vaccines.

• 한국정보디스플레이학회:학술대회논문집
• /
• 한국정보디스플레이학회 2008년도 International Meeting on Information Display
• /
• pp.3-3
• /
• 2008

The TFT-LCD industry has shown dramatic growth by making technological advances and satisfying consumer needs. It now stands at the heart of the display industry. However, the TFT-LCD market is maturing and is unlikely to sustain the fast pace of growth in years to come. There has been an oversupply in the LCD sector entering 2008 due to capacity expansion aimed at fueling growth coupled with softening demand amid the global economic slowdown and recent financial turmoil. The LCD industry has successfully coped with oversupply on several occasions. Each time, LCD makers faced up to the challenge and responded with a pioneering spirit. They continued to grow by turning crisis into opportunity. LG Display aims to create new markets by developing products based on innovative technology and providing more attractive products through a value-added product planning that incorporates consumer needs. Through a continuous cost innovation targeted at stimulating demand by making products more economical to consumers, we will be at the forefront of overcoming the current oversupply and sustaining robust growth for the TFT-LCD industry. Depending on our management of the situation, the current oversupply could prove to be an opportunity to create even bigger markets for the future.

• Archives of Plastic Surgery
• /
• 제41권3호
• /
• pp.231-240
• /
• 2014

Cartilage has a limited regenerative capacity. Faced with the clinical challenge of reconstruction of cartilage defects, the field of cartilage engineering has evolved. This article reviews current concepts and strategies in cartilage engineering with an emphasis on the application of nanotechnology in the production of biomimetic cartilage regenerative scaffolds. The structural architecture and composition of the cartilage extracellular matrix and the evolution of tissue engineering concepts and scaffold technology over the last two decades are outlined. Current advances in biomimetic techniques to produce nanoscaled fibrous scaffolds, together with innovative methods to improve scaffold biofunctionality with bioactive cues are highlighted. To date, the majority of research into cartilage regeneration has been focused on articular cartilage due to the high prevalence of large joint osteoarthritis in an increasingly aging population. Nevertheless, the principles and advances are applicable to cartilage engineering for plastic and reconstructive surgery.

• EDISON SW 활용 경진대회 논문집
• /
• 제6회(2017년)
• /
• pp.428-432
• /
• 2017

Silicon 기반 Metal-oxide-semiconductor field-effect transistor (MOSFET)의 크기가 감소함에 따라 silicon자체의 물성적 한계가 나타나고 있다. 이를 극복하고자 III-V 화합물 반도체가 채널소자로서 각광받고 있다. 본 연구에서는 III-V 화합물반도체 중 $In_xGa_{1-x}As$는 Indium 조성에 따른 전자구조 및 n-type MOSFET의 소자 특성을 본다. Indium의 조성이 증가함에 따라 subband의 개수와 간격이 증가하게 되어 Density of state가 감소하게 된다. 이로 인하여 Indium의 조성이 증가함에 따라 $In_xGa_{1-x}As$ 채널 MOSFET에서 상대적으로 Fermi level을 더 많이 상승시키게 되어 potential barrier를 얇아지게 만들며 또한 에너지에 따른 전류 밀도를 넓게 분포하도록 만든다. 이로 인하여 단채널에서는 In 조성이 증가함에 따라 direct source-to-drain tunnelling current이 증가하게 된다. 이로 인하여 In 조성의 증가에 따라 subthreshold swing과 ON-state current가 저하된다.

• 한국정보디스플레이학회:학술대회논문집
• /
• 한국정보디스플레이학회 2000년도 제1회 학술대회 논문집
• /
• pp.223-224
• /
• 2000

As technology level of TFT-LCD advances, application to TV becomes an emerging important area for LCD makers. In this paper, we review current LCD technology level to be used in TV such as liquid crystal response behavior, color accuracy, contrast ratio, brightness and panel size. Based on the understanding of current limitations in LCD compared with CRT, the improvement plan to render 'near perfect motion picture' reproduction with LCD is proposed. Digital TV is a great opportunity for digital LCD panels, but we have to solve remaining technical and cost issue in order to be competitive with other large size TV technologies such as PDP, CRT or projection type. In preparing the upcoming digital TV era with advanced TFT-LCD, the hurdles and prospect of larger size LCD-TV panels will be discussed.

• Journal of international Conference on Electrical Machines and Systems
• /
• 제1권3호
• /
• pp.360-365
• /
• 2012

Cascaded H-Bridge rectifier (CHBR) is a more attractive solution in traction application for its transformerless structure. Because of the currents of different cells are exactly the same one, it is a challenge job to regulate the voltages of cells with only one current controller. In this paper, a PI-based control scheme is presented to deal with the voltages balance issue in CHBR. To satisfy the demand of rectifier such as unity power factor and regulated output DC voltages, the proposed control scheme consists of two parts. One is for shaping the grid current waveform and regulating the sum of DC-link voltages of all the cells; the other one is for balancing DC-link voltages. The latter is more concerned in this paper and is discussed in detail especially. Simulations and experiments are carried on. The results verified the feasibility and effectiveness of the proposed scheme.

• EDISON SW 활용 경진대회 논문집
• /
• 제5회(2016년)
• /
• pp.357-361
• /
• 2016

Si와 InAs 두 가지 채널 물질을 가지고 3가지 수송 방향 <100>, <110>, <111>으로 변화시키며 각각의 Nanowire nMOSFETs을 가지고 ballistic quantum transport simulation을 진행하였다. 각각의 경우에 대해 E-k curve를 구한 다음에 band curvature로 캐리어의 유효질량을 계산하고, 이를 통해 MOSFET의 전류 세기를 결정짓는 DOS와 carrier injection velocity를 구하여 어떤 경우에 가장 높은 ON-current를 흐르게 하는지 확인해 보았다. 하지만 예상과 달리 나노와이어의 직경이 1.4nm으로 매우 작기 때문에 valley-splitting이 일어나 Si<110>의 경우에 가장 작은 캐리어 유효 질량을 갖고 있는 사실을 확인할 수 있었다. 결론적으로 Si<100>의 경우에 trade-off 관계에 있는 DOS와 carrier injection velocity가 6가지 경우 중 최적의 조합을 가짐으로써 가장 높은 ON-current를 흐르게 하였다.

• Toxicological Research
• /
• 제26권2호
• /
• pp.95-100
• /
• 2010

Nanoparticle exposure assessment presents a unique challenge in the field of occupational and environmental health. With the commercialization of nanotechnology, exposure usually starts from the workplace and then spreads to environment and consumer exposure. This report discusses the current trends of nanoparticle exposure assessment, including the definition of nanotechnology relevant terms, essential physicochemical properties for nanomaterial characterization, current international activities related nanomaterial safety, and exposure assessment standard development for nanotechnology. Further this report describes challenges of nanoparticle exposure assessment such as background measurement, metrics of nanoparticle exposure assessment and personal sampling.

• Mass Spectrometry Letters
• /
• 제9권1호
• /
• pp.1-16
• /
• 2018

Microfluidic technologies hold high promise and emerge as a potential molecular tool to facilitate the progress of fundamental and applied biomedical researches by enabling miniaturization and upgrading current biological research tools. In this review, we summarize the state of the art of existing microfluidic technologies and its' application for characterizing biophysical properties of individual cells. Microfluidic devices offer significant advantages and ability to handle in integrating sample processes, minimizing sample and reagent volumes, and increased analysis speed. Therefore, we first present the basic concepts and summarize several achievements in new coupling between microfluidic devices and mass spectrometers. Secondly, we discuss the recent applications of microfluidic chips in various biological research field including cellular and molecular level. Finally, we present the current challenge of microfluidic technologies and future perspective in this study field.

• Nuclear Engineering and Technology
• /
• 제40권1호
• /
• pp.1-8
• /
• 2008

One of the major current challenges to nuclear energy lies in its competitiveness. To stay competitive the industry needs to reduce maintenance and fuel cycle costs, while enhancing safety features. Extended burnup is one of the methods applied to meet these objectives However, there are a number of potential fuel failure causes related to increased burnup, as follows: l) Corrosion of zirconium alloy cladding and the water chemistry parameters that enhance corrosion; 2) Dimensional changes of zirconium alloy components, 3) Stresses that challenge zirconium alloy ductility and the effect of hydrogen (H) pickup and redistribution as it affects ductility, 4) Fuel rod internal pressure, 5) Pellet-cladding interactions (PCI) and 6) pellet-cladding mechanical interactions (PCMI). This paper discusses current and potential failure mechanisms of these failure mechanisms.