• Journal of Gynecologic Oncology
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• v.29 no.6
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• pp.89.1-89.8
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• 2018

Objective: Highly effective chemotherapy for patients with low-risk gestational trophoblastic neoplasia (GTN) is associated with almost a 100% cure rate. However, 20%-30% of patients treated with chemotherapy need to change their regimens due to severe adverse events (SAEs) or drug resistance. We examined the treatment outcomes of second-line chemotherapy for patients with low-risk GTN. Methods: Between 1980 and 2015, 281 patients with low-risk GTN were treated. Of these 281 patients, 178 patients were primarily treated with 5-day intramuscular methotrexate (MTX; n=114) or 5-day drip infusion etoposide (ETP; n=64). We examined the remission rates, the drug change rates, and the outcomes of second-line chemotherapy. Results: The primary remission rates and drug resistant rates of 5-day ETP were significantly higher (p<0.001) and significantly lower (p=0.002) than those of 5-day MTX, respectively. Forty-seven patients (26.4%) required a change in their chemotherapy regimen due to the SAEs (n=16) and drug resistance (n=31), respectively. Of these 47 patients failed the first-line regimen, 39 patients (39/47, 82.9%) were re-treated with single-agent chemotherapy, and 35 patients (35/39, 89.7%) achieved remission. Four patients failed second-line, single-agent chemotherapy and eight patients (17.0%) who failed first-line regimens were treated with combined or multi-agent chemotherapy and achieved remission. Conclusions: Patients with low-risk GTN were usually treated with single-agent chemotherapy, while 20%-30% patients had to change their chemotherapy regimen due to SAEs or drug resistance. The second-line regimens of single-agent chemotherapy were effective; however, there were several patients who needed multiple agents and combined chemotherapy to achieve remission.

• Journal of the Korea Concrete Institute
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• v.15 no.1
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• pp.117-124
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• 2003

Reinforced concrete structures under sever conditions such as marine structures, bridges and structures constructed with aggregates(dredged from sea), can be deteriorated from corrosion of the reinforcing bars. The purpose of this study is to evaluate the anti-corrosive performance of coated steel using polymer cement slurry. Polymer cement slurry with various polymer dispersions and corrosion inhibiting agent were coated to the surface of bars, and tested for accelerated corrosion tests. Tests include immersion in NaCl 10% solution, chloride ion spray, autoclave cure, autoclave cure after carbonation, penetration of NaCl 10 % solution, carbonation after penetration of NaCl 10% solution. Test results, show that the anti-corrosive performace is considerably improved by using polymer cement slurry at surface of steel. And this trend is marked by adding of corrosion inhibiting agent. This difference of the anti-corrosive properties is hardly recognized according to types of polymer dispersions. The coated steel using polymer cement slurry will be improved to a great extent compared to those of plain steel when increasing content of chloride ion in cement concrete.

• Applied Chemistry for Engineering
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• v.9 no.4
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• pp.608-613
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• 1998

The purpose of this experiment was the physical properties of rubber compounds with DPCB and pure carbon black. Si-O peak in the silcia surface was observed at the range of wavenumber from 1,100 to 1,200 in the DPCB by FT-IR analysis. Cure rate of rubber compounds containing DPCB and organic silane coupling agent were (Si69) delayed compared with those containing pure carbon black. 300% modulus and interaction coefficient of DPCB with silane coupling agent were higher than those of pure carbon black and PICO weight loss amount showed constant value. It was found that $0^{\circ}C$ tan$\delta$ of rubber compounds with DPCB was larger than those of pure carbon black at 2.0% silane coupling agent based on 50 phr DPCB and $60^{\circ}C$ tan$\delta$ of rubber compounds with DPCB decreased as increasing the usage coupling agent. Consequently, it is postulated that DPCB is strong candidate material for lowering rolling resistance under constant abrasion resistance.

• Journal of Conservation Science
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• v.28 no.3
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• pp.265-276
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• 2012

Physicochemical properties of HBA epoxy resins were controlled by varying hardener mixture and reactive diluent to improve applicability for stone conservation. The epoxy risen comprises hydrogenated Bisphenol-A based epoxide (HBA), fast curing agent (FH), slow curing agent poly(propyleneglycol)bis(2- aminopropylether) (SH) and difunctional polyglycidyl epoxide (DPE). Talc was used as an inorganic additive. The changes in viscosity and temperature during curing reactions depending on the composition of the epoxy resins were investigated. Additionally, bending, tensile and adhesive strengths were measured to identify the effective mechanical strength in stone conservation. Finally various compositions of epoxy resin/inorganic additives were developed for stone conservation by controlling cure kinetics and mechanical properties.

• Journal of the Korean GEO-environmental Society
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• v.20 no.5
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• pp.31-38
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• 2019

Recently, there has been an increasing number of ground subsidence (sink-hole) in the downtown areas, and in such a case, it is important to minimize accidents and passages through prompt recovery. With respect to the present recovery method for ground subsidence, the methods of applying the back filling after excavating the ground subsidence or using the grouting injected materials to restore the ground are mostly used, but there has been few studies on materials used for recovering the ground subsidence. Therefore, in order to clarify the characteristics of back filling materials used in the ground subsidence, this study uses the environment-friendly hardening agent to improve the dredged clay, and then, the mixture ratio of hardening agent and mixture ratio of decomposed granite soil is changed to cure for 3, 7, 14 and 28 days to analyze the intensity characteristics of the unconfined compression, and it was compared with the unconfined compression intensity for the previously used cement, a hardening agent. In order to evaluate the characteristics of intensity on the back filling materials, the C.B.R test was carried out, and for the review on whether the back filling materials influence on corrosion of water and sewer pipes and others, the soil non-resistance test was carried out. As a result of the test, for the case of the recovery work of the ground subsidence that requires urgency, it is considered as prudent if the hardening agents of 12% are integrated to cure for 3 days or longer, and for not having the influence on the corrosion of the gas tube or water pipes, it is proposed to mix for 30% or more of the decomposed granite soil. Door model test were conducted To confirm the bearing capacity characteristics of the solidified layer.

• The Journal of Korean Academy of Prosthodontics
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• v.46 no.4
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• pp.372-380
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• 2008

Purpose: The purpose of this study was to evaluate the effect of various methods of dentin bonding agent application on microtensile bond strength between dentin and resin, using a 2-step etch-and-rinse dentin bonding agent. Material and methods: Twenty freshly extracted human molars were obtained and divided into 4 groups of 5 teeth. 2-step etch-and-rinse dentin bonding agent was used for all groups. The control specimens were prepared using a direct immediate bonding technique. The delayed dentin sealing (A, C) specimens were prepared using an indirect approach with delayed dentin sealing. For group A, resin was built-up on uncured dentin bonding agent, and for group C, resin was built-up on pre-cured dentin bonding agent. Preparation of the immediate dentin sealing (B) specimens also used an indirect approach with immediate dentin sealing immediately following preparation. All teeth were prepared for a microtensile bond strength test. Specimens were stored in water for 24 hours. Ten beams (1.0 ${\times}$ 1.0 ${\times}$ 11 mm) from each tooth were selected for testing. Bond strength data (MPa) were analyzed with a one-way ANOVA test, and post hoc comparison was done using the Scheffe's test. Results: The mean microtensile bond strengths of control group, B and C (DDS with pre-cure) were not statisticaaly different from each other at 32.7, 33.3, 34.2 MPa. the bond strength for group A (DDS without pre-cure), 19.5 MPa, was statistically different (P < .01) from the other 3 groups. Conclusion: When preparing teeth for indirect bonded restorations, DDS with pre-curing dentin bonding agent and IDS results in the same bond strength between dentin and resin. On the contrast, the bond strength was decreased when DDS without pre-curing dentin bonding agent was used.

• Textile Coloration and Finishing
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• v.32 no.2
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• pp.96-102
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• 2020

Recently, it was reported that chitosan or APTMS(3-aminopropyltrimethoxysila ne) treatment to cotton using the simple pad-dry-cure method has potential to prepare textile materials for military chemical warfare protective clothing. However, it is not confirmed which method is more efficient. Therefore, this study aims to quantitatively compare detoxification properties of chitosan treated cotton fabric with those of APTMS treated cotton fabric. Detoxification properties were evaluated using the well-known organic phosphorous nerve agent stimulant, diisopropylfluorophosphate(DF P). With the same amount of chitosan and APTMS on the surface of the cotton fabrics, APTMS treated cotton fabric exhibited 10% higher detoxification properties than chitosan treated cotton fabric based on the rate of DFP hydrolysis and half-live of DFP calculated from the DFP decontamination ratios of the treated cotton fabrics through time. Therefore, APTMS treatment can be more efficient method to prepare the textile materials for military protective clothing than chitosan treatment.

• Journal of the Korean Applied Science and Technology
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• v.28 no.3
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• pp.345-350
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• 2011

Antioxidant agent, 1,1,3-tris(2-methyl-4-hydroxy-5-tert-butylphenyl)butane were prepared and investigated the antioxidant activity on recycled rubber mat manufactured with waste tire powder. Mechanical properties of rubber mat are influenced by many factor such as compounding ingredients and state of cure, process of rubber, and fillers. Our study aim is to investigate influence of antioxidant activities on ozone cracking and the thermal aging time. In this work, the degradation of recycled rubber mat was studied and suggested mechanism to involve two-type of degradation, thermal aging and cracking both of which can be contained antioxidant or non-antioxidant agent.

• The Journal of Korean Obstetrics and Gynecology
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• v.33 no.2
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• pp.29-43
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• 2020

Objectives: The purpose of this study is to review and evaluate the effectiveness of oriental medicine per oral for recurrent vulvovaginal candidiasis (RVVC). Methods: We searched articles from Korean journal databases including Journal of Korean Obstetrics and Gynecology, Korean studies Information Service Studies, and Chinese National Knowledge Infrastructure, Cochrane Library, PubMed. Searched keywords were "재발성 칸디다성 외음질염", "recurrent vulvovaginal candidiasis", "㚆发性外阴阴道假丝酵母菌病", "中藥". Results: 10 randomized controlled trials with 700 patients were identified and reviewed. 8 studies compared combination of oriental medicine and anti-fungal agent with anti-fungal agent, and 6 of them reported that treatment group (TG) showed statistically higher total effective rate or cure rate and lower recurrence rate. One study compared oriental medicine and anti-fungal agent and TG showed statistically higher total effective rate and lower recurrence rate after 1 month. One study compared combination of oriental medicine and lacto bacillus capsule with lacto bacillus capsule, and TG showed statistically higher total effective rate and lower positive fungul test rate after 6 months. No severe adverse response was reported. Conclusions: Our review found that oriental medicine per oral is effective for alleviating symptoms, lowering recurrence rate and positive fungal test in RVVC patients. We recommend standardized randomized controlled trial guideline should be made to obtain stronger evidence and well designed trials with larger sample sizes are needed.

• Journal of Microbiology and Biotechnology
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• v.17 no.8
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• pp.1338-1343
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• 2007

Angiogenesis is an essential step in tumor progress and metastasis. Accordingly, small molecules that inhibit angiogenesis would appear to be a promising way to cure angiogenesis-related diseases, including cancer. In the present study, we report that streptochlorin, a small molecule from marine actinomycete, exhibits a potent antiangiogenic activity. The compound potently inhibited endothelial cell invasion and tube formation stimulated with vascular endothelial cell growth factor (VEGF) at low micromolar concentrations where it showed no cytotoxicity to the cells. In addition, streptochlorin inhibited TNF-${\alpha}$-induced $NF-{\kappa}B$ activation in the newly developed cell-based reporter gene assay. These data demonstrate that streptochlorin is a new inhibitor of $NF-{\kappa}B$ activation and can be a basis for the development of novel anti-angiogenic agents.