• Title/Summary/Keyword: Cumulative Criteria

검색결과 142건 처리시간 0.024초

Radiosurgery for Recurrent Brain Metastases after Whole-Brain Radiotherapy : Factors Affecting Radiation-Induced Neurological Dysfunction

  • Gwak, Ho-Shin;Yoo, Hyung-Jun;Youn, Sang-Min;Lee, Dong-Han;Kim, Mi-Sook;Rhee, Chang-Hun
    • Journal of Korean Neurosurgical Society
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    • 제45권5호
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    • pp.275-283
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    • 2009
  • Objective : We retrospectively analyzed survival, local control rate, and incidence of radiation toxicities after radiosurgery for recurrent metastatic brain lesions whose initial metastases were treated with whole-brain radiotherapy. Various radiotherapeutical indices were examined to suggest predictors of radiation-related neurological dysfunction. Methods : In 46 patients, total 100 of recurrent metastases (mean 2.2, ranged 1-10) were treated by CyberKnife radiosurgery at average dose of 23.1 Gy in 1 to 3 fractions. The median prior radiation dose was 32.7 Gy, the median time since radiation was 5.0 months, and the mean tumor volume was $12.4cm^3$. Side effects were expressed in terms of radiation therapy oncology group (RTOG) neurotoxicity criteria. Results : Mass reduction was observed in 30 patients (65%) on MRI. After the salvage treatment, one-year progression-free survival rate was 57% and median survival was 10 months. Age(<60 years) and tumor volume affected survival rate(p=0.03, each). Acute (${\leq}$1 month) toxicity was observed in 22% of patients, subacute and chronic (>6 months) toxicity occurred in 21 %, respectively. Less acute toxicity was observed with small tumors (<$10cm^3$. p=0.03), and less chronic toxicity occurred at lower cumulative doses (<100 Gy, p=0.004). "Radiation toxicity factor" (cumulative dose times tumor volume of <1,000 Gy${\times}cm^3$) was a significant predictor of both acute and chronic CNS toxicities. Conclusion: Salvage CyberKnife radiosurgery is effective for recurrent brain metastases in previously irradiated patients, but careful evaluation is advised in patients with large tumors and high cumulative radiation doses to avoid toxicity.

Earthquake risk assessment of concrete gravity dam by cumulative absolute velocity and response surface methodology

  • Cao, Anh-Tuan;Nahar, Tahmina Tasnim;Kim, Dookie;Choi, Byounghan
    • Earthquakes and Structures
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    • 제17권5호
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    • pp.511-519
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    • 2019
  • The concrete gravity dam is one of the most important parts of the nation's infrastructure. Besides the benefits, the dam also has some potentially catastrophic disasters related to the life of citizens directly. During the lifetime of service, some degradations in a dam may occur as consequences of operating conditions, environmental aspects and deterioration in materials from natural causes, especially from dynamic loads. Cumulative Absolute Velocity (CAV) plays a key role to assess the operational condition of a structure under seismic hazard. In previous researches, CAV is normally used in Nuclear Power Plant (NPP) fields, but there are no particular criteria or studies that have been made on dam structure. This paper presents a method to calculate the limitation of CAV for the Bohyeonsan Dam in Korea, where the critical Peak Ground Acceleration (PGA) is estimated from twelve sets of selected earthquakes based on High Confidence of Low Probability of Failure (HCLPF). HCLPF point denotes 5% damage probability with 95% confidence level in the fragility curve, and the corresponding PGA expresses the crucial acceleration of this dam. For determining the status of the dam, a 2D finite element model is simulated by ABAQUS. At first, the dam's parameters are optimized by the Minitab tool using the method of Central Composite Design (CCD) for increasing model reliability. Then the Response Surface Methodology (RSM) is used for updating the model and the optimization is implemented from the selected model parameters. Finally, the recorded response of the concrete gravity dam is compared against the results obtained from solving the numerical model for identifying the physical condition of the structure.

원산지 교차누적 효과 분석: 한-캐나다 FTA를 활용한 대(對)미 자동차 부품 수입을 중심으로 (The Effect of Cross-Cumulation of Rule of Origin: Case Study of Korea-Canada FTA in terms of Auto Parts Import from U.S.)

  • 김규림;나희량
    • 무역학회지
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    • 제43권1호
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    • pp.109-130
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    • 2018
  • 원산지결정기준 중 하나인 누적기준은 원산지결정기준을 완화 할 수 있는 방안으로 특정 조건들을 충족했을 때 비원산지재료도 원산지재료로 인정해주는 규정이다. 한-캐나다 FTA에서는 자동차 품목의 경우 기존의 일반적인 누적기준이 아닌 교차누적기준을 적용하였다. 이는 원산지결정기준의 확장과 편리함을 위한 것으로 제3국의 원재료나 중간재에도 원산지자격을 부여한다. 본 논문에서는 한-캐나다 FTA 발효 이전과 이후 교차누적의 대상 품목인 84, 85, 87, 94류의 대미자동차 부품 수입액의 변화의 여부를 실증분석하고 교차누적의 실효성을 살펴보았다. 분석대상은 각 류에서 자동차 부품으로 지정된 품목만 선택하여 분석하였는데 분석대상 품목 35개 품목 중 21개 품목에서 유의한 변화가 나타났다. 2015년 1월 기준으로 수입액이 단기적으로 큰 폭으로 증가하였거나, 추세적 증가율이 전보다 상승한 것으로 나타났다. 이러한 결과는 교차누적의 도입으로 우리나라 자동차 수출기업들이 한-캐나다 FTA의 교차누적을 활용하고 있음을 반증하는 것이라고 할 수 있다. 또한 수출확대와 시장확보를 위해 FTA 체결 시 교차누적의 도입을 적극적으로 검토할 필요성이 있다.

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해상 부유체 모델의 표본 데이터에 대해서 최대우도를 갖는 누적분포함수 추정 (Estimating Cumulative Distribution Functions with Maximum Likelihood to Sample Data Sets of a Sea Floater Model)

  • 임정빈;양원재
    • 한국항해항만학회지
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    • 제37권5호
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    • pp.453-461
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    • 2013
  • 본 논문에서는 소형 해상 부유체의 위기 평가를 위한 확률기반 위기평가기법(PET)에서 표본 데이터에 최적인 누적분포함수(CDF) 추정에 관한 평가절차와 실험결과를 기술하였다. CDF는 PET에서 부유체의 위기수준을 평가하기 위한 위기허용기준의 참조 값을 제공하기 위한 것으로, 부유체 모델의 롤(Roll), 피치(pitch), 히브(Heave) 등의 운동응답함수에 대한 표본 데이터에서 추정할 수 있다. 본 연구에서는 여덟가지 정형화된 분포함수와 최대우도추정기법을 적용하여 표본 데이터에 대해서 최대우도를 갖는 CDF들을 평가하였다. 분포함수들의 적합도 검정 실험을 통해서, 베타 분포가 롤과 피치 표본 데이터에 대해서 평균 확률오차 $\bar{\delta}(0{\leq}\bar{\delta}{\leq}1.0)$가 가장 작은 0.024와 0.022로 최적임을 나타냈고, 히브 표본 데이터에 대해서는 감마 분포가 $\bar{\delta}$가 가장 작은 0.027로 최적임을 나타냈다. 본 연구에서 제안한 방법은 표본 데이터의 최적분포 추정을 위한 다양한 분야에 적용 가능할 것으로 기대된다.

Estimation of radionuclides leaching characteristics in different sized geopolymer waste forms with simulated spent ion-exchange resin

  • Younglim Shin;Byoungkwan Kim;Jaehyuk Kang;Hyun-min Ma;Wooyong Um
    • Nuclear Engineering and Technology
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    • 제55권10호
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    • pp.3617-3627
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    • 2023
  • This study presents a method to solidify spent ion-exchange resin (IER) in a metakaolin-based geopolymer and shows results of mechanical strength, immersion, leaching, irradiation, and thermal cycling tests for waste acceptance criteria (WAC) to repository. The geopolymer waste form with 20 wt% of simulated spent IER met the WAC in South Korea (ROK), and the leaching tests of various sized-waste forms up to 15.0 × 30.0 cm and waste loadings up to 20 wt% for 1-5 d and 1-90 d achieved a leachability index, Li > 6. In a leaching test for 5 d, the cumulative fraction leached (CFL) for Cs, which leached the most, was linearly correlated with the square root of leaching time for all waste forms, and Li increased as the size of the waste form increased. The CFL was also correlated with elapsed time in the 90 d leaching test. The correlations among CFL, time, and volume-to-surface area ratio of waste forms used to estimate the Li of Cs of a 200-L sized geopolymer with 15 wt% IER showed the Li values as 14.73 (5 d) and 17.71 (90 d), respectively, indicating that the large-sized geopolymer waste form met the WAC.

머신러닝 기법을 이용한 재해강도 분류모형 개발 (Development of disaster severity classification model using machine learning technique)

  • 이승민;백선욱;이준학;김경탁;김수전;김형수
    • 한국수자원학회논문집
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    • 제56권4호
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    • pp.261-272
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    • 2023
  • 최근 급격한 도시화와 기후변화에 따라 재난에 의한 피해가 증가하고 있다. 국내 기상청에서는 표준 경보(주의보, 경보)를 전국적으로 통일된 표준 경보 기준(3시간 및 12시간 최대 누적강우량)에 따라 발령하여 재해에 따른 지역별, 재난 사상별 특성이 고려되지 않은 문제점이 있다. 따라서 본 연구에서는 서울특별시, 인천광역시, 경기도의 호우·태풍에 대한 재해 피해액 및 누적강우량을 활용하여 대상지역별 재해강도에 따른 단계별 기준을 설정하고, 강우에 따라 발생할 수 있는 재해의 강도를 분류하는 모형을 개발하고자 하였다. 즉, 본 연구에서는 호우·태풍에 의한 재해 피해액 누적 분포 함수의 분위별로 재해강도의 범주(관심, 주의, 경계, 심각 단계)를 분류하였고, 재해강도의 범주에 따른 누적강우량 기준을 대상 지자체별로 제시하였다. 그리고 지자체별 재해강도 분류모형 개발을 위해 4가지(의사결정나무, 서포트 벡터 머신, 랜덤 포레스트, XGBoost)의 머신러닝 모형을 활용하였는데 강우량, 누적강우량, 지속시간 최대 강우량(3시간, 12시간), 선행강우량을 독립변수로 이용하여 종속변수인 지자체별 재해강도를 분류하였다. 각 모형별 F1 점수를 이용한 정확도 평가 결과, 의사결정나무의 F1 점수가 0.56으로 가장 우수한 정확도를 보였다. 본 연구에서 제시한 머신러닝 기반 재해강도 분류모형을 활용하면 호우·태풍에 의한 재해에 대한 지자체별 위험 상태를 단계별로 파악할 수 있어, 재난 담당자들의 신속한 의사결정을 위한 기초 자료로 활용될 수 있을 것으로 판단된다.

골다공증환자에서 임프란트의 생존율에 대한 후향적 연구 (A retrospective study of survival rate of dental implants placed in osteoporosis patients)

  • 이근;엄유정;정의원;김창성;최성호;조규성;채중규
    • Journal of Periodontal and Implant Science
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    • 제39권4호
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    • pp.413-423
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    • 2009
  • Purpose: The presented study aims to evaluate the effects of osteoporosis on dental implants by analyzing a 12-year cumulative survival rate of implants placed in patients with osteoporosis. Methods: 37 patients with history of osteoporosis were selected from a pool of dental implant patients treated at the Department of Periodontology in Yonsei University Hospital between 1993 and 2007. The cumulative survival rate is quantified using data collected from 164 placed implants in the selected 37 patients. Results: 3 out of the 164 implants failed and the cumulative survival rate was observed at 95.1%. The survival rates of the implants according to patients' age were 97.41% (<60) and 100% ($60\leq$). The lower survival rate was directly proportional to younger age, and this relationship is statistically significant (P<0.05). The survival rates of implants according to diagnostic criteria were 95.45% (osteopenia) and 98.59% (osteoporosis; 2 out of 142 implants placed in osteoporosis patients failed). The difference in the two survival rates is statistically significant (P<0.05). The survival rates according to the region of implants do not have statistically significant difference. The survival rates according to the different length and diameter of the implants do not have statistically significant difference. The survival rates of implants accompanied and not accompanied by bone augmentation were 92.11% and 100%, respectively. The difference in the two survival rates is statistically significant (P<0.05). The survival rates of implants placed in patients with and without history of medication for osteoporosis treatment are 96.67% and 99.04%, respectively. The difference in the two survival rates is statistically significant (P<0.05). Conclusions: A high cumulative survival rate of dental implants, similar to one found in non-osteoporosis patients, is observed in osteoporosis patients, indicating the possibility that placing dental implants on patients with osteoporosis can be considered with high treatment predictability.

독립성분의 순서화 방법 비교 (Comparison of several criteria for ordering independent components)

  • 최은빈;조수림;박미라
    • 응용통계연구
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    • 제30권6호
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    • pp.889-899
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    • 2017
  • 독립성분분석은 혼합된 신호에서 원신호들을 분리하기 위해서 사용되는 다변량 분석방법으로서, 블라인드 음원 분리 중 가장 널리 사용되는 방법이다. 독립성분분석은 주성분분석이나 요인분석과 같이 선형변환을 사용하지만, 원신호들의 통계적 독립과 비정규성 가정을 필요로 한다는 점에서 다르다. 설명되는 분산의 누적비율이 클수록 더 중요한 성분을 의미하게 되는 주성분분석과 달리, 독립성분분석에서는 독립성분들의 중요순서를 결정하는데 적절한 유일한 기준이 정해지지 않는다. 군집분석이나 차원축소된 그래프 작성 등과 같은 후속 연구를 진행하기 위해서는 일부의 주요 독립성분을 사용하게 되므로, 성분의 순서를 정하는 것은 의미가 있다. 본 연구에서는 성분의 순서를 결정하기 위한 몇 가지 기준의 성능을 비교하였다. 첨도와 첨도의 절댓값, 음의 엔트로피, 콜모고로프-스미르노프 통계량, 계수제곱합을 이용한 방법이 고려되었다. 이들은 알려진 그룹을 분류하는 능력을 기준으로 평가되었다. 두 가지 형태의 자료를 이용한 분석결과를 제시하였다.

동적 EMC를 이용한 고속도로 초기우수 처리 기준 산정 (Determination of First Flush Criteria in Highway Stormwater Runoff using Dynamic EMCs)

  • 김이형;이은주;고석오;김성길;이병식;이주광;강희만
    • 한국물환경학회지
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    • 제22권2호
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    • pp.294-299
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    • 2006
  • The Ministry of Environment in Korea has introduced Total Pollution Load Management System (TPLMS) in major 4 large rivers to protect the water quality from possible pollutants. In order to successfully achieve the TPLMS, the nonpoint source should be controled by applying the best management practices in highly polluted areas. Of the various nonpoint sources, the highways are stormwater intensive landuses because of its high imperviousness and high pollutant mass emissions. The EMC (Event Mean Concentration) is an important parameter to correctly determine the pollutant mass loadings from nonpoint sources. However, it has wide ranges because of various reasons such as first flush phenomenon, rainfall and watershed characteristics. Even though the EMC is closely related to the first flush phenomenon, the relationship have not proven until present. Therefore, in this paper, the dynamic EMC method will be introduced to clearly make the relationship between EMC and first flush phenomenon. Also by applying the dynamic EMC method to monitored data, we found that the highly concentrated stormwater runoff was washed off within 20~50 minutes storm duration. The first flush criteria for economical treatment was also determined to 5~10 mm (mean=7.4 mm) as a cumulative rainfall.

기간별 한계강우량 산정을 통한 변화 특성 분석 (Analysis of change characteristics through estimating the limit rainfall by period)

  • 황정근;조재웅;강호선;이한승;문혜진
    • 한국수자원학회:학술대회논문집
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    • 한국수자원학회 2020년도 학술발표회
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    • pp.99-99
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    • 2020
  • The frequency and scale of domestic flood damage continues to increase, but the criteria for responding to flood damage have not been established. To this end, research is underway to estimate the amount of rainfall in each region so that it can be used to respond to flood damage. The limit rainfall is defined as the cumulative maximum rainfall for each duration that causes flooding, and this research purpose to improve the threshold rainfall by estimating the damage based on the damage history in units of 5 years and analyzing changes over time. The limit rainfall based on the damage history was estimated by using the NDMS past damage history of the Ministry of the Interior and Safety and the rainfall minutes data of AWS and ASOS. The period for estimating the limit rainfall is 2013 ~ 2017, 2015 ~ 2019, and the limit rainfall is estimated by analyzing the relationship between the flood damage history and the rainfall event in each period. Considering changes in watershed characteristics and disaster prevention performance, the data were compared using 5-year data. As a result of the analysis, the limit rainfall based on the damage history could be estimated for less than about 10.0% of the administrative dongs nationwide. As a result of comparing the limit rainfall by period, it was confirmed that the area where the limit rainfall has increased or decreased This was analyzed as a change due to rainfall events or urbanization, and it is judged that it will be possible to improve the risk criteria of flooding.

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