• 한국의류학회지
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• 제32권1호
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• pp.12-23
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• 2008

The purpose of this study is in planning clothing and bag design and VMD. For this purpose, the pret-a-porter fashion collection is divided into the following sectors: brands, years, and seasons, focusing on the design elements. The results of this study are as follows: 1. It is these three ways that determine the relevance of clothing and bag design planning. first, we have analyzed design properties analogously with one design element, like Louis Vuitton. Second, we considered design properties analogously with two design elements, like Chanel, Gucci, Prada. Third, we examined design properties analogously with three design elements, like Christian dior, Fendi, Etro. 2. The comparison of clothing and bag design properties year by year shows that they were mainly designed with an analogous aspect with pattern and decoration. 3. Clothing does well to match a bag between analogous design properties of design elements to express similarity coordination and between contrast design properties of design elements to express plus one coordination or crossover coordination. 4. The aspect of coordination of clothing and bags year by year is different period. This is because of clothing and bag design's change according fashion trend. 5. S/S coordination of clothing and bags is effective to present plus one coordination or crossover coordination. And F/W coordination of clothing and bags is effective to present similarity in coordination.

• 한국자동차공학회논문집
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• 제6권4호
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• pp.76-85
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• 1998

Recently, Genetic Algorithm(GA) is widely adopted into a search procedure for structural optimization, which is a stochastic direct search strategy that mimics the process of genetic evolution. This methods consist of three genetics operations maned selection, crossover and mutation. Contrast to traditional optimal design techniques which use design sensitivity analysis results, GA, being zero-order method, is very simple. So, they can be easily applicable to wide area of design optimization problems. Also, owing to multi-point search procedure, they have higher probability of converge to global optimum compared to traditional techniques which take one-point search method. In this study, a method of finding the optimum values of suspension parameters is proposed by using the GA. And vehicle is modelled as planar vehicle having 5 degree-of-freedom. The generalized coordinates are vertical motion of passenger seat, sprung mass and front and rear unsprung mass and rotate(pitch) motion of sprung mass. For rapid converge and precluding local optimum, share function which distribute chromosomes over design bound is introduced. Elitist survival model, remainder stochastic sampling without replacement method, multi-point crossover method are adopted. In the sight of the improvement of ride comfort, good result can be obtained in 5-D.O.F. vehicle model by using GA.

• Archives of Pharmacal Research
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• 제18권4호
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• pp.237-242
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• 1995

For the vioequivalence study of two ceftriaxone injection formulations ($Rocephin{\circledR}$ ; Roche, and Triaxone ; Hanmi0, the HPLC analytical method for the analysis of ceftriaxone in plasma was used. Fourteen healthy volunteers completed the study and each subject were IM in jected signle doses (1 g) of the test and the reference formulations in a two-way crossover design with an one week drug free interval between doses. Following each administration, plasma concentrations of ceftrixone were monitored over a period of 24 h. Bioequivalence parameters $AUC_{24th}, {\;}T_{max}, {\;}C_{max}$ and MRT determined from the data obtained for the two formulations were examined by analyses of variance (ANOVA) and other criteria and tests for bioequivalence. Results of ANOVA and confidence limits of test/reference ratios of $AUC_{24th}, {\;}T_{max}, {\;}C_{max}$ and MRT, and statistical tests indicated the bioequivalence of the two formulations (i.e., test/reference ratio was within $100{\pm}20%$) except for $T_{max}$ The mean of $T_{max}$ showed only 6. 9% difference from the reference but the detection limit was 22.5% which is slightly over the 20% criteria. No pharmacokinetic parameters including Ka, Kel, Vd and Cl indicated significant difference in between the two fomulations. It was concluded that the data yielded fro the two cefriaxone formulations demonstrated that they were bioequivalent.

• 응용통계연구
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• 제23권1호
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• pp.139-150
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• 2010

최근들어 복제약(generic drug)의 개발이 활발히 이루어지고 있다. 현재 국내 생물학적 동등성 시험은 기존의 오리지널제제에 대하여 개발된 복제약이 동일한 질(quality), 안전성(safety) 그리고 효과(efficucy)를 갖는다는 것을 평균 생물학적 동등성(ABE)에 기초하여 증명하고 있다. 그러나 최근에 생물학적 동등성의 개념이 기존의 오리지널제제에 대하여 바꾸어 복용(switchability)할 수 있다는 개인 생물학적 동등성(IBE)의 개념으로 확장되었다. 미국 식약청은 개인 생물학적 동등성(IBE)을 평가하기 위하여 $2\;{\times}\;4$ 교차설계법을 권장하고 있다. 그러나 $2\;{\times}\;4$ 교차설계법은 실험기간이 길기 때문에 비용이나 피험자관리에 여러 가지 문제가 있어 실험기간을 줄인 $2\;{\times}\;3$교차설계법과 Chow 등 (2002)의 $2\;{\times}\;3$ 잉여대조 (extra-reference) 설계법이 제안되었다. 본 논문에서는 실험기간이 짧으면서 개인 생동성을 평가할 수 있는 $3\;{\times}\;2$ 교차설계법을 제안하고 모의실험을 통하여 $2\;{\times}\;3$ 교차설계법과 $2\;{\times}\;3$ 잉여대조 설계법과 비교 및 그 결과를 고찰하였다.

• Journal of Microbiology and Biotechnology
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• 제30권3호
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• pp.469-475
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• 2020

During meiosis I, programmed DNA double-strand breaks (DSBs) occur to promote chromosome pairing and recombination between homologs. In Saccharomyces cerevisiae, Mec1 and Tel1, the orthologs of human ATR and ATM, respectively, regulate events upstream of the cell cycle checkpoint to initiate DNA repair. Tel1^ATM and Mec1^ATR are required for phosphorylating various meiotic proteins during recombination. This study aimed to investigate the role of Tel1^ATM and Mec1^ATR in meiotic prophase via physical analysis of recombination. Tel1^ATM cooperated with Mec1^ATR to mediate DSB-to-single end invasion transition, but negatively regulated DSB formation. Furthermore, Mec1^ATR was required for the formation of interhomolog joint molecules from early prophase, thus establishing a recombination partner choice. Moreover, Mec1^ATR specifically promoted crossover-fated DSB repair. Together, these results suggest that Tel1^ATM and Mec1^ATR function redundantly or independently in all post-DSB stages.

• 한국연소학회:학술대회논문집
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• 한국연소학회 2004년도 제28회 KOSCO SYMPOSIUM 논문집
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• pp.102-111
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• 2004

Partial quenching structure of turbulent diffusion flames in a turbulent mixing layer is investigated by the method of flame hole dynamics to develope a prediction model for the turbulent lift off. The present study is specifically aimed to remedy the problem of the stiff transition of the conditioned partial burning probability across the crossover condition by adopting level-set method which describes propagating or retreating flame front with specified propagation speed. In light of the level-set simulations with two model problems for the propagation speed, the stabilizing conditions for a turbulent lifted flame are suggested. The flame hole dynamics combined with level-set method yields a temporally evolving turbulent extinction process and its partial quenching characteristics is compared with the results of the previous model employing the flame-hole random walk mapping. The probability to encounter reacting' state, conditioned with scalar dissipation rate, demonstrated that the conditional probability has a rather gradual transition across the crossover scalar dissipation rate in contrast to the stiff transition of resulted from the flame-hole random walk mapping and could be attributed to the finite response of the flame edge propagation.

• 한국지진공학회논문집
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• 제11권2호
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• pp.1-9
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• 2007

유전자 알고리즘을 이용하여 구조물의 지진응답해석에 사용할 인공 가속도시간이력을 작성하는 방법을 제시한다. 유전자 알고리즘을 적용하기 위해서 유전원질에 해당되는 결정변수로서 응답스펙트럼 값을 계산할 진동수를 결정하고, 산술평균 교차연산자와 산술비 돌연변이연산자를 제안한다. 이들 연산자와 전형적인 단순 교차연산자를 사용하여 설계응답스펙트럼에 부합하는 인공 지진파 작성에 사용한다. 또한 작성된 인공 가속도시간이력은 실제 계측되는 지진파의 몇 가지의 외형적 특성을 가져야 하므로 이를 고려한 인공 가속도시간이력이 작성되도록 한다. 이 외형적 특성으로는 가속도시간이력의 포락형태, 지진파의 2수평성분간의 상관관계, 지반의 최대가속도 - 최대속도 - 최대변위 관계 등이다.

• 한국산업정보학회논문지
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• 제21권3호
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• pp.7-12
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• 2016

인터넷의 적대적인 환경에서 보안성을 향상시키기 위해 스테가노그래피는 커버 매체 내부에 비밀 메시지를 숨기는데 초점을 두고 있다. 즉 암호화의 보완이다. 이 논문에서 한글을 이용한 텍스트 스테가노그래피 기법을 제안한다. 보안 수준을 높이기 위해 비밀 메시지는 유전 알고리즘 연산자 교차를 통해 암호화한다. 커버 매체의 특성과 구조 변화가 없는 스테고 텍스트 형태를 만들기 위한 커버 텍스트로 메시지를 삽입한다. 커버 매체에 3.69% 삽입 용량을 유지하기 위해, 스테고 텍스트의 크기가 14%로 증가되는 것을 확인할 수 있다.

• 한국연소학회지
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• 제9권2호
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• pp.18-29
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• 2004

Partial quenching structure of diffusion flames in a turbulent mixing layer has been investigated by the method of flame hole dynamics in oder to develope a prediction model for the phenomenon of turbulent flame lift off. The present study is specifically aimed to remedy the shortcoming of the stiff transition of the conditioned partial burning probability across the crossover condition by employing the level-set method which enables us to include the effect of finite flame edge propagation speed. In light of the level-set simulation results with two models for the edge propagation speed, the stabilizing conditions for turbulent lifted flame are suggested. The flame hole dynamics combined with the level-set method yields a temporally evolving turbulent extinction process and its partial quenching characteristics is compared with the results of the previous model employing the flame-hole random walk mapping based on three critical scalar dissipation rates. The probability to encounter reacting state, conditioned with scalar dissipation rate, demonstrated that the conditional probability has a rather gradual transition across the crossover scalar dissipation rate. Such a smooth transition is attributed to the finite response of the flame edge propagation.

• Journal of Microbiology and Biotechnology
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• 제27권2호
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• pp.405-411
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• 2017

Homologous recombination occurs between homologous chromosomes and is significantly involved in programmed double-strand break (DSB) repair. Activation of two recombinases, Rad51 and Dmc1, is essential for an interhomolog bias during meiosis. Rad51 participates in both mitotic and meiotic recombination, and its strand exchange activity is regulated by an inhibitory factor during meiosis. Thus, activities of Rad51 and Dmc1 are coordinated to promote homolog bias. It has been reported that Hed1, a meiosis-specific protein in budding yeast, regulates Rad51-dependent recombination activity. Here, we investigated the role of Hed1 in meiotic recombination by ectopic expression of the protein after pre-meiotic replication in Saccharomyces cerevisiae. DNA physical analysis revealed that the overexpression of Hed1 delays the DSB-to-joint molecule (JM) transition and promotes interhomolog JM formation. The study indicates a possible role of Hed1 in controlling the strand exchange activity of Rad51 and, eventually, meiotic crossover formation.